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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for PBX3
Z-value: 1.27
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Transcription factors associated with PBX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PBX3 | hg19_v2_chr9_+_128509624_128509658 | 0.54 | 5.4e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_100111580 Show fit | 6.50 |
ENST00000605497.1
|
palmdelphin |
|
| chr1_+_100111479 Show fit | 6.28 |
ENST00000263174.4
|
palmdelphin |
|
| chr16_-_30032610 Show fit | 6.01 |
ENST00000574405.1
|
double C2-like domains, alpha |
|
| chr3_+_193853927 Show fit | 4.08 |
ENST00000232424.3
|
hes family bHLH transcription factor 1 |
|
| chr4_-_149363662 Show fit | 3.79 |
ENST00000355292.3
ENST00000358102.3 |
nuclear receptor subfamily 3, group C, member 2 |
|
| chr3_-_148804275 Show fit | 3.71 |
ENST00000392912.2
ENST00000465259.1 ENST00000310053.5 ENST00000494055.1 |
helicase-like transcription factor |
|
| chr12_-_42983478 Show fit | 3.54 |
ENST00000345127.3
ENST00000547113.1 |
prickle homolog 1 (Drosophila) |
|
| chr9_+_40028620 Show fit | 3.40 |
ENST00000426179.1
|
AL353791.1 |
|
| chr14_-_91526922 Show fit | 3.34 |
ENST00000418736.2
ENST00000261991.3 |
ribosomal protein S6 kinase, 90kDa, polypeptide 5 |
|
| chr9_+_75766763 Show fit | 3.15 |
ENST00000456643.1
ENST00000415424.1 |
annexin A1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PBX3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.4 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.1 | 6.1 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.2 | 5.6 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 1.4 | 4.1 | GO:0021558 | trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of pro-B cell differentiation(GO:2000974) |
| 1.2 | 3.7 | GO:0014839 | myoblast migration involved in skeletal muscle regeneration(GO:0014839) |
| 0.0 | 3.7 | GO:0006301 | postreplication repair(GO:0006301) |
| 0.9 | 3.5 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.9 | 3.5 | GO:0021592 | fourth ventricle development(GO:0021592) |
| 0.7 | 3.3 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.1 | 3.2 | GO:0090083 | regulation of inclusion body assembly(GO:0090083) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.1 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 5.1 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.5 | 3.7 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 3.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.7 | 3.3 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.0 | 3.2 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.2 | 2.9 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 2.7 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.0 | 2.7 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 2.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.0 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 6.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 5.6 | GO:0044390 | ubiquitin-like protein conjugating enzyme binding(GO:0044390) |
| 0.0 | 4.3 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 4.2 | GO:0005112 | Notch binding(GO:0005112) |
| 0.5 | 3.7 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 3.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 3.4 | GO:0005496 | steroid binding(GO:0005496) |
| 0.1 | 3.3 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 3.1 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 3.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 2.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 2.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 2.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 2.5 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.2 | 2.3 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 2.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.1 | PID ARF6 PATHWAY | Arf6 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 4.8 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.3 | 4.2 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 4.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 3.5 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 3.4 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 3.3 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 3.2 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 2.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.8 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |