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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PDX1

Z-value: 0.60

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Transcription factors associated with PDX1

Gene Symbol Gene ID Gene Info
PDX1
ENSG00000139515.5 pancreatic and duodenal homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PDX1hg19_v2_chr13_+_28494130_28494168-0.301.5e-01Click!

Activity profile of PDX1 motif

Sorted Z-values of PDX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_92777606 1.65 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr9_-_16728161 1.11 ENST00000603713.1
ENST00000603313.1
BNC2
basonuclin 2
chr15_-_55562479 1.06 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr8_+_50824233 1.00 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr18_+_57567180 0.98 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr15_+_75080883 0.97 ENST00000567571.1
CSK
c-src tyrosine kinase
chr8_+_32579341 0.93 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr15_-_55563072 0.93 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr15_-_55562582 0.90 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr18_+_55888767 0.84 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr17_-_77924627 0.80 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1D16
TBC1 domain family, member 16
chr15_+_28624878 0.79 ENST00000450328.2
GOLGA8F
golgin A8 family, member F
chr1_+_160160283 0.79 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr2_-_145277569 0.79 ENST00000303660.4
ZEB2
zinc finger E-box binding homeobox 2
chr12_-_16761007 0.77 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_+_111717600 0.77 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111717511 0.77 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr1_+_160160346 0.75 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr18_-_33709268 0.74 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr4_-_139163491 0.73 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr3_+_111718036 0.71 ENST00000455401.2
TAGLN3
transgelin 3
chr1_+_107683436 0.69 ENST00000370068.1
NTNG1
netrin G1
chr1_+_28586006 0.68 ENST00000253063.3
SESN2
sestrin 2
chr1_+_107683644 0.65 ENST00000370067.1
NTNG1
netrin G1
chr18_+_59000815 0.59 ENST00000262717.4
CDH20
cadherin 20, type 2
chr10_+_24497704 0.59 ENST00000376456.4
ENST00000458595.1
KIAA1217
KIAA1217
chr21_-_35899113 0.59 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr5_-_142780280 0.58 ENST00000424646.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr2_-_208031943 0.57 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr9_+_135457530 0.57 ENST00000263610.2
BARHL1
BarH-like homeobox 1
chr5_+_66300446 0.57 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr14_-_69261310 0.55 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chr7_-_115670792 0.55 ENST00000265440.7
ENST00000393485.1
TFEC
transcription factor EC
chr6_-_87804815 0.54 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr11_-_102496063 0.52 ENST00000260228.2
MMP20
matrix metallopeptidase 20
chr13_-_84456527 0.52 ENST00000377084.2
SLITRK1
SLIT and NTRK-like family, member 1
chr4_+_86525299 0.51 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr2_-_136678123 0.51 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chr20_-_50418972 0.49 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr7_-_115670804 0.49 ENST00000320239.7
TFEC
transcription factor EC
chr20_-_50418947 0.49 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr6_-_100912785 0.47 ENST00000369208.3
SIM1
single-minded family bHLH transcription factor 1
chr6_+_150920999 0.45 ENST00000367328.1
ENST00000367326.1
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr12_-_86650045 0.45 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr5_+_98109322 0.44 ENST00000513185.1
RGMB
repulsive guidance molecule family member b
chr7_-_81399411 0.43 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr4_-_123377880 0.43 ENST00000226730.4
IL2
interleukin 2
chr1_+_68150744 0.43 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chrX_+_144908928 0.42 ENST00000408967.2
TMEM257
transmembrane protein 257
chr5_-_36301984 0.42 ENST00000502994.1
ENST00000515759.1
ENST00000296604.3
RANBP3L
RAN binding protein 3-like
chr4_-_119759795 0.41 ENST00000419654.2
SEC24D
SEC24 family member D
chr1_+_101003687 0.40 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chr4_+_169013666 0.40 ENST00000359299.3
ANXA10
annexin A10
chr11_-_85430163 0.40 ENST00000529581.1
ENST00000533577.1
SYTL2
synaptotagmin-like 2
chr18_+_32173276 0.39 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr11_-_85430204 0.39 ENST00000389958.3
ENST00000527794.1
SYTL2
synaptotagmin-like 2
chrX_-_21676442 0.39 ENST00000379499.2
KLHL34
kelch-like family member 34
chr11_-_85430088 0.38 ENST00000533057.1
ENST00000533892.1
SYTL2
synaptotagmin-like 2
chr3_+_149191723 0.37 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chr7_-_27169801 0.37 ENST00000511914.1
HOXA4
homeobox A4
chr20_+_52105495 0.37 ENST00000439873.2
AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr16_+_6533729 0.36 ENST00000551752.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr4_+_70796784 0.36 ENST00000246891.4
ENST00000444405.3
CSN1S1
casein alpha s1
chr4_-_39979576 0.35 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr2_-_180427304 0.35 ENST00000336917.5
ZNF385B
zinc finger protein 385B
chr17_-_39165366 0.35 ENST00000391588.1
KRTAP3-1
keratin associated protein 3-1
chr7_-_73038867 0.34 ENST00000313375.3
ENST00000354613.1
ENST00000395189.1
ENST00000453275.1
MLXIPL
MLX interacting protein-like
chr1_+_50574585 0.34 ENST00000371824.1
ENST00000371823.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr7_-_73038822 0.34 ENST00000414749.2
ENST00000429400.2
ENST00000434326.1
MLXIPL
MLX interacting protein-like
chr8_-_131399110 0.34 ENST00000521426.1
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chrX_-_110655306 0.34 ENST00000371993.2
DCX
doublecortin
chr8_+_77593474 0.33 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr6_-_9933500 0.32 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr8_+_77593448 0.32 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr4_-_103749205 0.32 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr14_+_22554680 0.32 ENST00000390451.2
TRAV23DV6
T cell receptor alpha variable 23/delta variable 6
chr5_+_156712372 0.31 ENST00000541131.1
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr1_+_62439037 0.31 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr12_-_53730147 0.31 ENST00000536324.2
SP7
Sp7 transcription factor
chr12_-_91576429 0.30 ENST00000552145.1
ENST00000546745.1
DCN
decorin
chr19_+_641178 0.30 ENST00000166133.3
FGF22
fibroblast growth factor 22
chr3_-_167191814 0.30 ENST00000466903.1
ENST00000264677.4
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr15_-_100882191 0.29 ENST00000268070.4
ADAMTS17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr6_+_34204642 0.29 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr8_-_37457350 0.29 ENST00000519691.1
RP11-150O12.3
RP11-150O12.3
chr8_-_42234745 0.29 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr11_-_36619771 0.29 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2
recombination activating gene 2
chr12_-_53729525 0.29 ENST00000303846.3
SP7
Sp7 transcription factor
chr12_+_81110684 0.28 ENST00000228644.3
MYF5
myogenic factor 5
chr1_-_2458026 0.28 ENST00000435556.3
ENST00000378466.3
PANK4
pantothenate kinase 4
chr10_+_114710425 0.28 ENST00000352065.5
ENST00000369395.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr12_+_41831485 0.27 ENST00000539469.2
ENST00000298919.7
PDZRN4
PDZ domain containing ring finger 4
chr11_+_130318869 0.27 ENST00000299164.2
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr5_+_172068232 0.27 ENST00000520919.1
ENST00000522853.1
ENST00000369800.5
NEURL1B
neuralized E3 ubiquitin protein ligase 1B
chr4_-_116034979 0.27 ENST00000264363.2
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr17_-_38911580 0.27 ENST00000312150.4
KRT25
keratin 25
chr7_-_99717463 0.26 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr20_+_43538692 0.26 ENST00000217074.4
ENST00000255136.3
PABPC1L
poly(A) binding protein, cytoplasmic 1-like
chr12_+_107712173 0.26 ENST00000280758.5
ENST00000420571.2
BTBD11
BTB (POZ) domain containing 11
chr2_+_45168875 0.25 ENST00000260653.3
SIX3
SIX homeobox 3
chr9_-_14722715 0.25 ENST00000380911.3
CER1
cerberus 1, DAN family BMP antagonist
chr1_-_152386732 0.25 ENST00000271835.3
CRNN
cornulin
chr2_-_99871570 0.25 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr20_+_43538756 0.25 ENST00000537323.1
ENST00000217073.2
PABPC1L
poly(A) binding protein, cytoplasmic 1-like
chr14_-_77889860 0.24 ENST00000555603.1
NOXRED1
NADP-dependent oxidoreductase domain containing 1
chr4_-_41884582 0.24 ENST00000499082.2
LINC00682
long intergenic non-protein coding RNA 682
chr20_+_43990576 0.24 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr8_+_22424551 0.24 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr12_-_109221160 0.23 ENST00000326470.5
SSH1
slingshot protein phosphatase 1
chr19_-_56110859 0.23 ENST00000221665.3
ENST00000592585.1
FIZ1
FLT3-interacting zinc finger 1
chr20_+_11008408 0.23 ENST00000378252.1
C20orf187
chromosome 20 open reading frame 187
chr1_+_28261533 0.22 ENST00000411604.1
ENST00000373888.4
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr9_-_123639304 0.22 ENST00000436309.1
PHF19
PHD finger protein 19
chr2_+_90060377 0.22 ENST00000436451.2
IGKV6D-21
immunoglobulin kappa variable 6D-21 (non-functional)
chr14_-_61116168 0.22 ENST00000247182.6
SIX1
SIX homeobox 1
chr1_+_36621529 0.21 ENST00000316156.4
MAP7D1
MAP7 domain containing 1
chr9_+_125132803 0.21 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr8_+_55528627 0.21 ENST00000220676.1
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr2_-_89459813 0.21 ENST00000390256.2
IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chr14_+_100485712 0.21 ENST00000544450.2
EVL
Enah/Vasp-like
chr6_+_45296391 0.20 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr4_-_41884620 0.20 ENST00000504870.1
LINC00682
long intergenic non-protein coding RNA 682
chr7_+_129015484 0.20 ENST00000490911.1
AHCYL2
adenosylhomocysteinase-like 2
chr20_+_60174827 0.20 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr2_+_166152283 0.20 ENST00000375427.2
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr10_-_1779663 0.19 ENST00000381312.1
ADARB2
adenosine deaminase, RNA-specific, B2 (non-functional)
chr5_-_140998481 0.19 ENST00000518047.1
DIAPH1
diaphanous-related formin 1
chr14_-_57272366 0.19 ENST00000554788.1
ENST00000554845.1
ENST00000408990.3
OTX2
orthodenticle homeobox 2
chr2_-_190927447 0.19 ENST00000260950.4
MSTN
myostatin
chr4_-_103749105 0.18 ENST00000394801.4
ENST00000394804.2
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr20_-_50419055 0.18 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr10_-_21435488 0.18 ENST00000534331.1
ENST00000529198.1
ENST00000377118.4
C10orf113
chromosome 10 open reading frame 113
chr4_-_53525406 0.18 ENST00000451218.2
ENST00000441222.3
USP46
ubiquitin specific peptidase 46
chr5_-_76935513 0.18 ENST00000306422.3
OTP
orthopedia homeobox
chr10_+_118083919 0.18 ENST00000333254.3
CCDC172
coiled-coil domain containing 172
chr5_-_140998616 0.18 ENST00000389054.3
ENST00000398562.2
ENST00000389057.5
ENST00000398566.3
ENST00000398557.4
ENST00000253811.6
DIAPH1
diaphanous-related formin 1
chrX_-_130423200 0.18 ENST00000361420.3
IGSF1
immunoglobulin superfamily, member 1
chr2_+_196313239 0.18 ENST00000413290.1
AC064834.1
AC064834.1
chr16_+_6533380 0.17 ENST00000552089.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_-_182641037 0.17 ENST00000483095.2
RGS8
regulator of G-protein signaling 8
chr16_+_49407710 0.17 ENST00000299191.3
C16orf78
chromosome 16 open reading frame 78
chr15_+_59279851 0.17 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr18_+_32558208 0.17 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr1_-_183622442 0.17 ENST00000308641.4
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr14_+_74034310 0.17 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2
chr17_-_40337470 0.17 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr2_+_228736335 0.16 ENST00000440997.1
ENST00000545118.1
DAW1
dynein assembly factor with WDR repeat domains 1
chr1_-_182640988 0.16 ENST00000367556.1
RGS8
regulator of G-protein signaling 8
chr17_-_4458616 0.16 ENST00000381556.2
MYBBP1A
MYB binding protein (P160) 1a
chr1_-_1709845 0.16 ENST00000341426.5
ENST00000344463.4
NADK
NAD kinase
chr21_-_32253874 0.16 ENST00000332378.4
KRTAP11-1
keratin associated protein 11-1
chr17_-_6983594 0.16 ENST00000571664.1
ENST00000254868.4
CLEC10A
C-type lectin domain family 10, member A
chr7_-_81399329 0.16 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr17_-_6983550 0.15 ENST00000576617.1
ENST00000416562.2
CLEC10A
C-type lectin domain family 10, member A
chr2_-_166930131 0.15 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr12_+_50144381 0.15 ENST00000552370.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr12_-_86650077 0.15 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr4_+_151503077 0.15 ENST00000317605.4
MAB21L2
mab-21-like 2 (C. elegans)
chrX_+_49020882 0.15 ENST00000454342.1
MAGIX
MAGI family member, X-linked
chr16_-_52640834 0.15 ENST00000510238.3
CASC16
cancer susceptibility candidate 16 (non-protein coding)
chr8_+_9953214 0.14 ENST00000382490.5
MSRA
methionine sulfoxide reductase A
chr7_+_50348268 0.14 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr17_-_9694614 0.14 ENST00000330255.5
ENST00000571134.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr15_+_34261089 0.14 ENST00000383263.5
CHRM5
cholinergic receptor, muscarinic 5
chr17_-_39623681 0.14 ENST00000225899.3
KRT32
keratin 32
chr4_-_103749313 0.14 ENST00000394803.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr14_-_95236551 0.14 ENST00000238558.3
GSC
goosecoid homeobox
chr4_-_155533787 0.14 ENST00000407946.1
ENST00000405164.1
ENST00000336098.3
ENST00000393846.2
ENST00000404648.3
ENST00000443553.1
FGG
fibrinogen gamma chain
chr13_-_28545276 0.14 ENST00000381020.7
CDX2
caudal type homeobox 2
chr6_+_29079668 0.14 ENST00000377169.1
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr8_-_10512569 0.14 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr3_+_35722487 0.14 ENST00000441454.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr21_-_31538971 0.13 ENST00000286808.3
CLDN17
claudin 17
chr3_+_108541608 0.13 ENST00000426646.1
TRAT1
T cell receptor associated transmembrane adaptor 1
chr7_-_100860851 0.13 ENST00000223127.3
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr4_-_70518941 0.13 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr8_+_9953061 0.13 ENST00000522907.1
ENST00000528246.1
MSRA
methionine sulfoxide reductase A
chr15_+_62853562 0.13 ENST00000561311.1
TLN2
talin 2
chr7_-_151217001 0.13 ENST00000262187.5
RHEB
Ras homolog enriched in brain
chr3_+_108541545 0.13 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr1_-_13002348 0.13 ENST00000355096.2
PRAMEF6
PRAME family member 6
chr14_-_47351391 0.13 ENST00000399222.3
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr11_+_15136462 0.12 ENST00000379556.3
ENST00000424273.1
INSC
inscuteable homolog (Drosophila)
chr3_+_111718173 0.12 ENST00000494932.1
TAGLN3
transgelin 3
chr13_+_102104980 0.12 ENST00000545560.2
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr15_+_93443419 0.12 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chrX_+_133930798 0.12 ENST00000414371.2
FAM122C
family with sequence similarity 122C
chr4_+_119809984 0.11 ENST00000307142.4
ENST00000448416.2
ENST00000429713.2
SYNPO2
synaptopodin 2
chr20_+_42984330 0.11 ENST00000316673.4
ENST00000609795.1
ENST00000457232.1
ENST00000609262.1
HNF4A
hepatocyte nuclear factor 4, alpha
chr13_+_102104952 0.11 ENST00000376180.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr7_+_114055052 0.11 ENST00000462331.1
ENST00000408937.3
ENST00000403559.4
ENST00000350908.4
ENST00000393498.2
ENST00000393495.3
ENST00000378237.3
ENST00000393489.3
FOXP2
forkhead box P2
chr12_+_49621658 0.11 ENST00000541364.1
TUBA1C
tubulin, alpha 1c
chr4_-_103749179 0.11 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr7_-_25268104 0.10 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr15_+_51669444 0.10 ENST00000396399.2
GLDN
gliomedin
chr6_+_13272904 0.10 ENST00000379335.3
ENST00000379329.1
PHACTR1
phosphatase and actin regulator 1
chr15_+_69854027 0.10 ENST00000498938.2
RP11-279F6.1
RP11-279F6.1
chr3_+_115342349 0.10 ENST00000393780.3
GAP43
growth associated protein 43
chr17_+_43238438 0.10 ENST00000593138.1
ENST00000586681.1
HEXIM2
hexamethylene bis-acetamide inducible 2
chr9_-_5339873 0.10 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PDX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.9 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.2 0.6 GO:1904580 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.2 0.5 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.2 0.7 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 0.5 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.2 0.8 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 1.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 1.6 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.9 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 0.8 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.8 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 1.0 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.1 0.4 GO:0061743 motor learning(GO:0061743)
0.1 0.7 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 1.2 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 0.3 GO:0014016 proximal/distal axis specification(GO:0009946) neuroblast differentiation(GO:0014016)
0.1 0.3 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 1.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.2 GO:1904717 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.1 0.6 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.3 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.1 1.0 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.1 0.2 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.1 0.4 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 0.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.3 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.7 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.1 0.3 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.1 0.2 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.1 GO:0061346 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0 0.1 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.0 0.3 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.3 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 1.1 GO:0043586 tongue development(GO:0043586)
0.0 0.4 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.5 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.2 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.2 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.2 GO:0051025 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.3 GO:0030091 protein repair(GO:0030091)
0.0 0.3 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.2 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.2 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.2 GO:0060013 righting reflex(GO:0060013)
0.0 0.4 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.1 GO:0009732 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.3 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.8 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0046549 photoreceptor cell outer segment organization(GO:0035845) retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.3 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.6 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.2 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0 0.0 GO:0003358 noradrenergic neuron development(GO:0003358)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.1 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 1.4 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.1 GO:0035973 aggrephagy(GO:0035973)
0.0 0.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.0 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.2 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.5 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.3 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.1 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.1 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0014802 terminal cisterna(GO:0014802)
0.2 2.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.0 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 0.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.9 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.8 GO:0005771 multivesicular body(GO:0005771)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.6 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.5 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 2.9 GO:0031489 myosin V binding(GO:0031489)
0.1 0.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.7 GO:0070728 leucine binding(GO:0070728)
0.1 0.9 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.6 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.8 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.3 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.3 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134) glycosphingolipid binding(GO:0043208)
0.1 1.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.0 0.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 1.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.6 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.2 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.3 GO:0016015 morphogen activity(GO:0016015)
0.0 1.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0034711 inhibin binding(GO:0034711)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.3 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.1 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.4 PID BMP PATHWAY BMP receptor signaling
0.0 1.0 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 2.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 1.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.6 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 1.0 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.9 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.6 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 1.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.3 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.7 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression