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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for PITX1
Z-value: 1.11
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Transcription factors associated with PITX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX1 | hg19_v2_chr5_-_134369973_134369988 | 0.04 | 8.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_184058125 Show fit | 1.33 |
ENST00000310585.4
|
family with sequence similarity 131, member A |
|
| chr11_+_60197069 Show fit | 1.16 |
ENST00000528905.1
ENST00000528093.1 |
membrane-spanning 4-domains, subfamily A, member 5 |
|
| chr17_-_5095126 Show fit | 1.14 |
ENST00000576772.1
ENST00000575779.1 |
zinc finger protein 594 |
|
| chr17_+_47448102 Show fit | 1.07 |
ENST00000576461.1
|
Uncharacterized protein |
|
| chr14_+_74058410 Show fit | 0.89 |
ENST00000326303.4
|
acyl-CoA thioesterase 4 |
|
| chr17_-_40264692 Show fit | 0.81 |
ENST00000591220.1
ENST00000251642.3 |
DEXH (Asp-Glu-X-His) box polypeptide 58 |
|
| chr3_-_196242233 Show fit | 0.81 |
ENST00000397537.2
|
single-pass membrane protein with coiled-coil domains 1 |
|
| chr8_-_102275131 Show fit | 0.77 |
ENST00000523121.1
|
KB-1410C5.2 |
|
| chrX_-_153482755 Show fit | 0.77 |
ENST00000369932.3
|
testis expressed 28 pseudogene 1 |
|
| chrX_-_153445634 Show fit | 0.77 |
ENST00000369941.4
|
testis expressed 28 pseudogene 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | GO:0050427 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 0.3 | 2.0 | GO:0098989 | NMDA selective glutamate receptor signaling pathway(GO:0098989) |
| 0.0 | 1.7 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.2 | 1.3 | GO:0035803 | egg coat formation(GO:0035803) |
| 0.0 | 1.3 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 1.2 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.0 | 1.2 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.0 | 1.2 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.2 | 1.0 | GO:0019605 | butyrate metabolic process(GO:0019605) |
| 0.0 | 1.0 | GO:0045943 | positive regulation of transcription from RNA polymerase I promoter(GO:0045943) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 1.0 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 0.9 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.0 | 0.8 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.7 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 0.6 | GO:0002081 | outer acrosomal membrane(GO:0002081) |
| 0.0 | 0.6 | GO:0090543 | Flemming body(GO:0090543) |
| 0.0 | 0.6 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.6 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.1 | 0.5 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.3 | 2.0 | GO:0047685 | amine sulfotransferase activity(GO:0047685) |
| 0.1 | 1.3 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 1.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 1.0 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.1 | 1.0 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 0.9 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.8 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 0.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 0.6 | GO:0032090 | Pyrin domain binding(GO:0032090) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.5 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 0.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.3 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 0.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.2 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.8 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 2.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.0 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.0 | 1.0 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 0.9 | REACTOME METABOLISM OF RNA | Genes involved in Metabolism of RNA |
| 0.0 | 0.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.7 | REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.7 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 0.7 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |