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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PITX2

Z-value: 0.30

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.11 paired like homeodomain 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg19_v2_chr4_-_111544254_111544270,
hg19_v2_chr4_-_111563076_111563172,
hg19_v2_chr4_-_111558135_111558198		-0.349.7e-02Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_126237554 1.77 ENST00000394329.3
FAT4
FAT atypical cadherin 4
chr19_+_2476116 0.96 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr15_+_41221536 0.50 ENST00000249749.5
DLL4
delta-like 4 (Drosophila)
chr12_+_6949964 0.42 ENST00000541978.1
ENST00000435982.2
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chr6_-_111804905 0.38 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr19_-_49843539 0.37 ENST00000602554.1
ENST00000358234.4
CTC-301O7.4
CTC-301O7.4
chrX_+_107069063 0.35 ENST00000262843.6
MID2
midline 2
chr17_+_4643337 0.34 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chr14_+_75988768 0.32 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr6_+_130339710 0.30 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr17_+_4643300 0.29 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr6_+_35310312 0.25 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
PPARD
peroxisome proliferator-activated receptor delta
chr2_+_120770581 0.22 ENST00000263713.5
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr8_-_27462822 0.20 ENST00000522098.1
CLU
clusterin
chr10_-_49482907 0.18 ENST00000374201.3
ENST00000407470.4
FRMPD2
FERM and PDZ domain containing 2
chr3_+_158787041 0.17 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr12_-_90049878 0.17 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr11_-_119217365 0.17 ENST00000360167.4
ENST00000555262.1
ENST00000449574.2
ENST00000445041.2
MFRP
C1QTNF5
membrane frizzled-related protein
C1q and tumor necrosis factor related protein 5
chr12_-_90049828 0.16 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr1_+_201979645 0.16 ENST00000367284.5
ENST00000367283.3
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr7_+_73868439 0.14 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr6_+_35310391 0.14 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
PPARD
peroxisome proliferator-activated receptor delta
chr14_+_75988851 0.13 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr7_+_73868220 0.13 ENST00000455841.2
GTF2IRD1
GTF2I repeat domain containing 1
chr3_-_50388522 0.13 ENST00000232501.3
NPRL2
nitrogen permease regulator-like 2 (S. cerevisiae)
chr9_-_95166841 0.12 ENST00000262551.4
OGN
osteoglycin
chr6_+_46661575 0.11 ENST00000450697.1
TDRD6
tudor domain containing 6
chr18_-_47017956 0.11 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr22_-_30234218 0.10 ENST00000307790.3
ENST00000542393.1
ENST00000397771.2
ASCC2
activating signal cointegrator 1 complex subunit 2
chr12_-_53189892 0.10 ENST00000309505.3
ENST00000417996.2
KRT3
keratin 3
chr2_+_120770645 0.10 ENST00000443902.2
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr16_-_5116025 0.10 ENST00000472572.3
ENST00000315997.5
ENST00000422873.1
ENST00000350219.4
C16orf89
chromosome 16 open reading frame 89
chr9_-_110251836 0.09 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr10_+_103986085 0.08 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chrX_+_15767971 0.07 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr22_-_39096661 0.07 ENST00000216039.5
JOSD1
Josephin domain containing 1
chrM_+_9207 0.07 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr8_-_133123406 0.06 ENST00000434736.2
HHLA1
HERV-H LTR-associating 1
chr13_-_36429763 0.06 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr11_+_61522844 0.05 ENST00000265460.5
MYRF
myelin regulatory factor
chr5_+_64920543 0.04 ENST00000399438.3
ENST00000510585.2
TRAPPC13
CTC-534A2.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr7_-_122840015 0.04 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr17_-_46657473 0.03 ENST00000332503.5
HOXB4
homeobox B4
chr16_-_68014732 0.03 ENST00000268793.4
DPEP3
dipeptidase 3
chr16_+_28722684 0.02 ENST00000331666.6
ENST00000395587.1
ENST00000569690.1
ENST00000564243.1
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr11_-_5248294 0.02 ENST00000335295.4
HBB
hemoglobin, beta
chrX_-_6146876 0.02 ENST00000381095.3
NLGN4X
neuroligin 4, X-linked
chr3_+_119421849 0.02 ENST00000273390.5
ENST00000463700.1
MAATS1
MYCBP-associated, testis expressed 1
chr2_+_3622893 0.02 ENST00000407445.3
ENST00000403564.1
RPS7
ribosomal protein S7
chr7_-_128415844 0.01 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr13_-_95131923 0.01 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr11_-_96076334 0.01 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chrX_-_54384425 0.01 ENST00000375169.3
ENST00000354646.2
WNK3
WNK lysine deficient protein kinase 3
chr19_+_48325097 0.00 ENST00000221996.7
ENST00000539067.1
CRX
cone-rod homeobox

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.5 GO:0072554 blood vessel lumenization(GO:0072554)
0.1 0.3 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.3 GO:0071386 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.0 1.0 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.4 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.2 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.1 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740) positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.4 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.0 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.2 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.4 GO:0042276 error-prone translesion synthesis(GO:0042276)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.2 GO:0097418 neurofibrillary tangle(GO:0097418)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.4 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)