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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for PITX3
Z-value: 1.10
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Transcription factors associated with PITX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX3 | hg19_v2_chr10_-_104001231_104001274 | -0.44 | 2.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | GO:0031424 | keratinization(GO:0031424) |
| 0.2 | 6.5 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 6.2 | GO:0009435 | NAD biosynthetic process(GO:0009435) |
| 0.6 | 5.6 | GO:1903027 | regulation of opsonization(GO:1903027) |
| 0.8 | 4.1 | GO:0051622 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 1.2 | 3.6 | GO:0014839 | myoblast migration involved in skeletal muscle regeneration(GO:0014839) |
| 0.1 | 3.5 | GO:0048265 | response to pain(GO:0048265) |
| 0.7 | 3.3 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.8 | 3.2 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 1.0 | 3.0 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 4.0 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 4.0 | GO:0031674 | I band(GO:0031674) |
| 0.5 | 3.8 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.1 | 3.5 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 3.2 | GO:0044215 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.3 | 3.0 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 3.0 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 2.9 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.0 | 2.9 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.1 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 1.6 | 6.3 | GO:0050262 | ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769) |
| 0.8 | 4.1 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.5 | 3.6 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.3 | 3.0 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 3.0 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 2.9 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.7 | 2.8 | GO:0004948 | calcitonin receptor activity(GO:0004948) |
| 0.5 | 2.8 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.1 | 2.7 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 2.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.4 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 2.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 2.2 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 2.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 2.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 3.5 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 3.3 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.2 | 3.0 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 2.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 2.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 2.6 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 2.5 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.0 | 2.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 2.1 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |