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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PKNOX1_TGIF2

Z-value: 0.93

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Transcription factors associated with PKNOX1_TGIF2

Gene Symbol Gene ID Gene Info
PKNOX1
ENSG00000160199.10 PBX/knotted 1 homeobox 1
TGIF2
ENSG00000118707.5 TGFB induced factor homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TGIF2hg19_v2_chr20_+_35202909_35203075-0.582.2e-03Click!
PKNOX1hg19_v2_chr21_+_44394620_44394737-0.193.7e-01Click!

Activity profile of PKNOX1_TGIF2 motif

Sorted Z-values of PKNOX1_TGIF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_84418860 4.63 ENST00000521743.1
SNAP91
synaptosomal-associated protein, 91kDa
chr6_-_84418841 4.63 ENST00000369694.2
ENST00000195649.6
SNAP91
synaptosomal-associated protein, 91kDa
chr7_+_79765071 3.62 ENST00000457358.2
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr3_+_38017264 2.09 ENST00000436654.1
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr10_+_94608245 2.08 ENST00000443748.2
ENST00000260762.6
EXOC6
exocyst complex component 6
chr10_+_94608218 2.07 ENST00000371543.1
EXOC6
exocyst complex component 6
chr4_-_149365827 2.04 ENST00000344721.4
NR3C2
nuclear receptor subfamily 3, group C, member 2
chr17_-_34122596 1.94 ENST00000250144.8
MMP28
matrix metallopeptidase 28
chr2_+_233925064 1.83 ENST00000359570.5
ENST00000538935.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr17_+_39382900 1.74 ENST00000377721.3
ENST00000455970.2
KRTAP9-2
keratin associated protein 9-2
chr2_+_191208196 1.67 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
INPP1
inositol polyphosphate-1-phosphatase
chr18_+_54318566 1.65 ENST00000589935.1
ENST00000357574.3
WDR7
WD repeat domain 7
chr4_-_175443788 1.63 ENST00000541923.1
HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr8_-_8318847 1.56 ENST00000521218.1
CTA-398F10.2
CTA-398F10.2
chr1_+_207262578 1.47 ENST00000243611.5
ENST00000367076.3
C4BPB
complement component 4 binding protein, beta
chr1_+_207262170 1.45 ENST00000367078.3
C4BPB
complement component 4 binding protein, beta
chr1_+_207262627 1.44 ENST00000391923.1
C4BPB
complement component 4 binding protein, beta
chr1_+_63989004 1.42 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr1_+_207262881 1.42 ENST00000451804.2
C4BPB
complement component 4 binding protein, beta
chr1_+_207262540 1.39 ENST00000452902.2
C4BPB
complement component 4 binding protein, beta
chr1_+_210406121 1.38 ENST00000367012.3
SERTAD4
SERTA domain containing 4
chr15_+_57668695 1.32 ENST00000281282.5
CGNL1
cingulin-like 1
chr13_+_33160553 1.28 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr9_-_100459639 1.27 ENST00000375128.4
XPA
xeroderma pigmentosum, complementation group A
chr11_+_6411670 1.19 ENST00000530395.1
ENST00000527275.1
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr4_-_114682364 1.18 ENST00000511664.1
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr4_-_114682224 1.16 ENST00000342666.5
ENST00000515496.1
ENST00000514328.1
ENST00000508738.1
ENST00000379773.2
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr18_+_48918368 1.16 ENST00000583982.1
ENST00000578152.1
ENST00000583609.1
ENST00000435144.1
ENST00000580841.1
RP11-267C16.1
RP11-267C16.1
chr4_-_175443484 1.14 ENST00000514584.1
ENST00000542498.1
ENST00000296521.7
ENST00000422112.2
ENST00000504433.1
HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr15_-_31283798 1.13 ENST00000435680.1
ENST00000425768.1
MTMR10
myotubularin related protein 10
chr14_+_61995722 1.08 ENST00000556347.1
RP11-47I22.4
RP11-47I22.4
chr11_+_827553 1.06 ENST00000528542.2
ENST00000450448.1
EFCAB4A
EF-hand calcium binding domain 4A
chr12_-_31882108 1.06 ENST00000281471.6
AMN1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr7_-_156685841 1.05 ENST00000354505.4
ENST00000540390.1
LMBR1
limb development membrane protein 1
chr7_-_132261253 1.05 ENST00000321063.4
PLXNA4
plexin A4
chr14_-_105635090 1.05 ENST00000331782.3
ENST00000347004.2
JAG2
jagged 2
chr2_+_234959323 1.03 ENST00000373368.1
ENST00000168148.3
SPP2
secreted phosphoprotein 2, 24kDa
chr11_+_6411636 1.03 ENST00000299397.3
ENST00000356761.2
ENST00000342245.4
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr12_-_121019165 0.98 ENST00000341039.2
ENST00000357500.4
POP5
processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
chr4_+_86396265 0.94 ENST00000395184.1
ARHGAP24
Rho GTPase activating protein 24
chr8_-_17555164 0.91 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr12_-_15114191 0.90 ENST00000541380.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr16_-_30457048 0.86 ENST00000500504.2
ENST00000542752.1
SEPHS2
selenophosphate synthetase 2
chr6_+_31674639 0.86 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F
MEGT1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr20_-_36156293 0.85 ENST00000373537.2
ENST00000414542.2
BLCAP
bladder cancer associated protein
chr7_-_156685890 0.84 ENST00000353442.5
LMBR1
limb development membrane protein 1
chr22_+_39052632 0.82 ENST00000411557.1
ENST00000396811.2
ENST00000216029.3
ENST00000416285.1
CBY1
chibby homolog 1 (Drosophila)
chr17_+_76374714 0.82 ENST00000262764.6
ENST00000589689.1
ENST00000329897.7
ENST00000592043.1
ENST00000587356.1
PGS1
phosphatidylglycerophosphate synthase 1
chr19_+_39759154 0.81 ENST00000331982.5
IFNL2
interferon, lambda 2
chr14_+_38677123 0.81 ENST00000267377.2
SSTR1
somatostatin receptor 1
chr20_-_36156125 0.80 ENST00000397135.1
ENST00000397137.1
BLCAP
bladder cancer associated protein
chr4_+_86396321 0.78 ENST00000503995.1
ARHGAP24
Rho GTPase activating protein 24
chr6_+_168841817 0.77 ENST00000356284.2
ENST00000354536.5
SMOC2
SPARC related modular calcium binding 2
chr13_-_41837620 0.76 ENST00000379477.1
ENST00000452359.1
ENST00000379480.4
ENST00000430347.2
MTRF1
mitochondrial translational release factor 1
chr7_-_148580563 0.76 ENST00000476773.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr8_+_97657449 0.74 ENST00000220763.5
CPQ
carboxypeptidase Q
chr9_-_86432547 0.73 ENST00000376365.3
ENST00000376371.2
GKAP1
G kinase anchoring protein 1
chr14_-_50474238 0.73 ENST00000399206.1
C14orf182
chromosome 14 open reading frame 182
chr15_+_43477455 0.73 ENST00000300213.4
CCNDBP1
cyclin D-type binding-protein 1
chr6_-_29324054 0.72 ENST00000543825.1
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr2_-_183106641 0.70 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr5_+_43603229 0.69 ENST00000344920.4
ENST00000512996.2
NNT
nicotinamide nucleotide transhydrogenase
chr4_+_159593418 0.69 ENST00000507475.1
ENST00000307738.5
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr7_+_73442457 0.68 ENST00000438880.1
ENST00000414324.1
ENST00000380562.4
ELN
elastin
chr8_-_99837856 0.65 ENST00000518165.1
ENST00000419617.2
STK3
serine/threonine kinase 3
chr8_+_47752497 0.65 ENST00000521715.1
ENST00000518962.1
LINC00293
long intergenic non-protein coding RNA 293
chr9_-_124989804 0.65 ENST00000373755.2
ENST00000373754.2
LHX6
LIM homeobox 6
chr15_+_51200871 0.65 ENST00000560508.1
AP4E1
adaptor-related protein complex 4, epsilon 1 subunit
chr8_+_11666649 0.64 ENST00000528643.1
ENST00000525777.1
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr17_-_66951474 0.63 ENST00000269080.2
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr1_-_201081579 0.61 ENST00000367338.3
ENST00000362061.3
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr10_-_16859442 0.61 ENST00000602389.1
ENST00000345264.5
RSU1
Ras suppressor protein 1
chr19_+_11909329 0.60 ENST00000323169.5
ENST00000450087.1
ZNF491
zinc finger protein 491
chr1_+_74701062 0.60 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr17_-_72358001 0.59 ENST00000375366.3
BTBD17
BTB (POZ) domain containing 17
chr1_-_45672221 0.58 ENST00000359600.5
ZSWIM5
zinc finger, SWIM-type containing 5
chr3_-_3221358 0.58 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN
cereblon
chr18_+_3449330 0.57 ENST00000549253.1
TGIF1
TGFB-induced factor homeobox 1
chr3_-_169587621 0.56 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31
leucine rich repeat containing 31
chr7_+_99971129 0.56 ENST00000394000.2
ENST00000350573.2
PILRA
paired immunoglobin-like type 2 receptor alpha
chr7_+_73442422 0.56 ENST00000358929.4
ENST00000431562.1
ENST00000320492.7
ENST00000438906.1
ELN
elastin
chr3_+_52828805 0.55 ENST00000416872.2
ENST00000449956.2
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr5_-_81046841 0.54 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
SSBP2
single-stranded DNA binding protein 2
chr9_+_125027127 0.53 ENST00000441707.1
ENST00000373723.5
ENST00000373729.1
MRRF
mitochondrial ribosome recycling factor
chr2_-_3504587 0.53 ENST00000415131.1
ADI1
acireductone dioxygenase 1
chr20_+_12930980 0.52 ENST00000432244.1
RP11-157E14.1
RP11-157E14.1
chr9_-_99180597 0.52 ENST00000375256.4
ZNF367
zinc finger protein 367
chr11_+_120207787 0.52 ENST00000397843.2
ENST00000356641.3
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr7_-_104909435 0.52 ENST00000357311.3
SRPK2
SRSF protein kinase 2
chr9_+_133454943 0.51 ENST00000319725.9
FUBP3
far upstream element (FUSE) binding protein 3
chr8_-_17752912 0.51 ENST00000398054.1
ENST00000381840.2
FGL1
fibrinogen-like 1
chr18_-_54305658 0.50 ENST00000586262.1
ENST00000217515.6
TXNL1
thioredoxin-like 1
chrX_+_135730297 0.50 ENST00000370629.2
CD40LG
CD40 ligand
chrX_+_135730373 0.50 ENST00000370628.2
CD40LG
CD40 ligand
chr1_+_2036149 0.50 ENST00000482686.1
ENST00000400920.1
ENST00000486681.1
PRKCZ
protein kinase C, zeta
chr15_+_25068773 0.49 ENST00000400100.1
ENST00000400098.1
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr15_+_43477580 0.48 ENST00000356633.5
CCNDBP1
cyclin D-type binding-protein 1
chr12_-_30887948 0.47 ENST00000433722.2
CAPRIN2
caprin family member 2
chr2_+_16080659 0.47 ENST00000281043.3
MYCN
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr15_-_77197620 0.47 ENST00000565970.1
ENST00000563290.1
ENST00000565372.1
ENST00000564177.1
ENST00000568382.1
ENST00000563919.1
SCAPER
S-phase cyclin A-associated protein in the ER
chr1_-_214638146 0.46 ENST00000543945.1
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr18_+_39535152 0.46 ENST00000262039.4
ENST00000398870.3
ENST00000586545.1
PIK3C3
phosphatidylinositol 3-kinase, catalytic subunit type 3
chr16_-_70557430 0.46 ENST00000393612.4
ENST00000564653.1
ENST00000323786.5
COG4
component of oligomeric golgi complex 4
chr17_-_39661849 0.46 ENST00000246635.3
ENST00000336861.3
ENST00000587544.1
ENST00000587435.1
KRT13
keratin 13
chr2_-_203103185 0.45 ENST00000409205.1
SUMO1
small ubiquitin-like modifier 1
chr1_-_225615599 0.45 ENST00000421383.1
ENST00000272163.4
LBR
lamin B receptor
chr15_+_49170083 0.45 ENST00000530028.2
EID1
EP300 interacting inhibitor of differentiation 1
chr4_+_88928777 0.45 ENST00000237596.2
PKD2
polycystic kidney disease 2 (autosomal dominant)
chr7_+_73442487 0.44 ENST00000380575.4
ENST00000380584.4
ENST00000458204.1
ENST00000357036.5
ENST00000417091.1
ENST00000429192.1
ENST00000442310.1
ENST00000380553.4
ENST00000380576.5
ENST00000428787.1
ENST00000320399.6
ELN
elastin
chr18_+_3449695 0.44 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr12_+_55248289 0.41 ENST00000308796.6
MUCL1
mucin-like 1
chr10_-_11574274 0.41 ENST00000277575.5
USP6NL
USP6 N-terminal like
chr5_-_81046904 0.41 ENST00000515395.1
SSBP2
single-stranded DNA binding protein 2
chr7_-_42276612 0.40 ENST00000395925.3
ENST00000437480.1
GLI3
GLI family zinc finger 3
chr6_-_132967142 0.39 ENST00000275216.1
TAAR1
trace amine associated receptor 1
chr19_-_38743878 0.39 ENST00000587515.1
PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr2_-_152589670 0.39 ENST00000604864.1
ENST00000603639.1
NEB
nebulin
chr17_-_1420182 0.38 ENST00000421807.2
INPP5K
inositol polyphosphate-5-phosphatase K
chr9_-_111696340 0.38 ENST00000374647.5
IKBKAP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr7_+_99971068 0.38 ENST00000198536.2
ENST00000453419.1
PILRA
paired immunoglobin-like type 2 receptor alpha
chr6_+_26124373 0.38 ENST00000377791.2
ENST00000602637.1
HIST1H2AC
histone cluster 1, H2ac
chr2_-_74780176 0.38 ENST00000409549.1
LOXL3
lysyl oxidase-like 3
chr18_-_46987000 0.38 ENST00000442713.2
ENST00000269445.6
DYM
dymeclin
chr1_-_63988846 0.38 ENST00000283568.8
ENST00000371092.3
ENST00000271002.10
ITGB3BP
integrin beta 3 binding protein (beta3-endonexin)
chr2_+_85804614 0.37 ENST00000263864.5
ENST00000409760.1
VAMP8
vesicle-associated membrane protein 8
chr2_-_211179883 0.36 ENST00000352451.3
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr1_-_179198702 0.36 ENST00000502732.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr12_-_71003568 0.36 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
PTPRB
protein tyrosine phosphatase, receptor type, B
chr18_-_67872891 0.36 ENST00000454359.1
ENST00000437017.1
RTTN
rotatin
chr1_+_66258846 0.36 ENST00000341517.4
PDE4B
phosphodiesterase 4B, cAMP-specific
chr6_-_28220002 0.35 ENST00000377294.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr1_+_246729724 0.35 ENST00000366513.4
ENST00000366512.3
CNST
consortin, connexin sorting protein
chr6_+_150070831 0.35 ENST00000367380.5
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr3_-_113160334 0.34 ENST00000393845.2
ENST00000295868.2
WDR52
WD repeat domain 52
chr2_-_203103281 0.34 ENST00000392244.3
ENST00000409181.1
ENST00000409712.1
ENST00000409498.2
ENST00000409368.1
ENST00000392245.1
ENST00000392246.2
SUMO1
small ubiquitin-like modifier 1
chr18_+_905104 0.34 ENST00000579794.1
ADCYAP1
adenylate cyclase activating polypeptide 1 (pituitary)
chr7_+_63774321 0.33 ENST00000423484.2
ZNF736
zinc finger protein 736
chr13_+_57741718 0.33 ENST00000445351.1
PRR20E
proline rich 20E
chr2_+_233271546 0.33 ENST00000295453.3
ALPPL2
alkaline phosphatase, placental-like 2
chr17_+_68071458 0.32 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr10_-_99052382 0.31 ENST00000453547.2
ENST00000316676.8
ENST00000358308.3
ENST00000466484.1
ENST00000358531.4
ARHGAP19-SLIT1
ARHGAP19
ARHGAP19-SLIT1 readthrough (NMD candidate)
Rho GTPase activating protein 19
chr17_+_68071389 0.31 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr2_+_234959376 0.30 ENST00000425558.1
SPP2
secreted phosphoprotein 2, 24kDa
chr1_-_179112189 0.30 ENST00000512653.1
ENST00000344730.3
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr19_+_36393422 0.30 ENST00000437550.2
HCST
hematopoietic cell signal transducer
chr2_+_175260451 0.30 ENST00000458563.1
ENST00000409673.3
ENST00000272732.6
ENST00000435964.1
SCRN3
secernin 3
chr21_+_38792602 0.29 ENST00000398960.2
ENST00000398956.2
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr18_+_54318616 0.29 ENST00000254442.3
WDR7
WD repeat domain 7
chr8_-_66474884 0.29 ENST00000520902.1
CTD-3025N20.2
CTD-3025N20.2
chr2_+_33661382 0.28 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr14_-_21994525 0.28 ENST00000538754.1
SALL2
spalt-like transcription factor 2
chr19_-_11849697 0.28 ENST00000586121.1
ENST00000431998.1
ENST00000341191.6
ENST00000545749.1
ENST00000440527.1
ZNF823
zinc finger protein 823
chr9_-_115653176 0.28 ENST00000374228.4
SLC46A2
solute carrier family 46, member 2
chr9_-_123605177 0.28 ENST00000373904.5
ENST00000210313.3
PSMD5
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
chr9_-_127703333 0.28 ENST00000373555.4
GOLGA1
golgin A1
chr21_-_34144157 0.27 ENST00000331923.4
PAXBP1
PAX3 and PAX7 binding protein 1
chr8_+_97506033 0.27 ENST00000518385.1
SDC2
syndecan 2
chr6_+_26501449 0.27 ENST00000244513.6
BTN1A1
butyrophilin, subfamily 1, member A1
chr17_-_1420006 0.26 ENST00000320345.6
ENST00000406424.4
INPP5K
inositol polyphosphate-5-phosphatase K
chr12_-_104531785 0.26 ENST00000551727.1
NFYB
nuclear transcription factor Y, beta
chr1_+_154966058 0.26 ENST00000392487.1
LENEP
lens epithelial protein
chr2_+_113033164 0.26 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr17_-_35969409 0.26 ENST00000394378.2
ENST00000585472.1
ENST00000591288.1
ENST00000502449.2
ENST00000345615.4
ENST00000346661.4
ENST00000585689.1
ENST00000339208.6
SYNRG
synergin, gamma
chr7_-_99332719 0.26 ENST00000336374.2
CYP3A7
cytochrome P450, family 3, subfamily A, polypeptide 7
chr12_+_129028500 0.25 ENST00000315208.8
TMEM132C
transmembrane protein 132C
chr5_-_52405564 0.25 ENST00000510818.2
ENST00000396954.3
ENST00000508922.1
ENST00000361377.4
ENST00000582677.1
ENST00000584946.1
ENST00000450852.3
MOCS2
molybdenum cofactor synthesis 2
chr11_+_129245796 0.25 ENST00000281437.4
BARX2
BARX homeobox 2
chr21_-_43735446 0.25 ENST00000398431.2
TFF3
trefoil factor 3 (intestinal)
chr4_+_71588372 0.25 ENST00000536664.1
RUFY3
RUN and FYVE domain containing 3
chr7_+_39605966 0.24 ENST00000223273.2
ENST00000448268.1
ENST00000432096.2
YAE1D1
Yae1 domain containing 1
chr21_-_10990830 0.24 ENST00000361285.4
ENST00000342420.5
ENST00000328758.5
TPTE
transmembrane phosphatase with tensin homology
chr3_-_27763803 0.24 ENST00000449599.1
EOMES
eomesodermin
chr14_-_106573756 0.23 ENST00000390601.2
IGHV3-11
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr19_-_39322497 0.23 ENST00000221418.4
ECH1
enoyl CoA hydratase 1, peroxisomal
chr17_-_26220366 0.23 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYRM9
RP1-66C13.4
LYR motif containing 9
Uncharacterized protein
chr16_+_20817839 0.23 ENST00000348433.6
ENST00000568501.1
ENST00000566276.1
AC004381.6
Putative RNA exonuclease NEF-sp
chr1_-_247335269 0.23 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
ZNF124
zinc finger protein 124
chr21_+_31768348 0.23 ENST00000355459.2
KRTAP13-1
keratin associated protein 13-1
chr5_+_95187934 0.23 ENST00000357880.3
ENST00000436592.1
C5orf27
chromosome 5 open reading frame 27
chr17_-_15501932 0.23 ENST00000583965.1
CDRT1
CMT1A duplicated region transcript 1
chr1_-_179112173 0.23 ENST00000408940.3
ENST00000504405.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr12_+_59989918 0.22 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr19_+_9296279 0.22 ENST00000344248.2
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr10_+_121485588 0.21 ENST00000361976.2
ENST00000369083.3
INPP5F
inositol polyphosphate-5-phosphatase F
chr11_+_55578854 0.21 ENST00000333973.2
OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr20_-_31124186 0.21 ENST00000375678.3
C20orf112
chromosome 20 open reading frame 112
chr3_+_49726932 0.21 ENST00000327697.6
ENST00000432042.1
ENST00000454491.1
RNF123
ring finger protein 123
chr11_-_2924720 0.21 ENST00000455942.2
SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr16_+_20818020 0.21 ENST00000564274.1
ENST00000563068.1
AC004381.6
Putative RNA exonuclease NEF-sp
chr18_+_3451584 0.21 ENST00000551541.1
TGIF1
TGFB-induced factor homeobox 1
chr19_-_12595586 0.21 ENST00000397732.3
ZNF709
zinc finger protein 709
chr4_+_84457250 0.21 ENST00000395226.2
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr1_+_28844648 0.21 ENST00000373832.1
ENST00000373831.3
RCC1
regulator of chromosome condensation 1
chr16_-_20817753 0.20 ENST00000389345.5
ENST00000300005.3
ENST00000357967.4
ENST00000569729.1
ERI2
ERI1 exoribonuclease family member 2
chr3_-_49726486 0.20 ENST00000449682.2
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr19_+_36393367 0.20 ENST00000246551.4
HCST
hematopoietic cell signal transducer
chrX_+_101380642 0.20 ENST00000372780.1
ENST00000329035.2
TCEAL2
transcription elongation factor A (SII)-like 2
chr16_+_20817761 0.20 ENST00000568046.1
ENST00000261377.6
AC004381.6
Putative RNA exonuclease NEF-sp
chr1_-_51425902 0.20 ENST00000396153.2
FAF1
Fas (TNFRSF6) associated factor 1
chr6_-_32920794 0.20 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA
XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha
Uncharacterized protein

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX1_TGIF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.2 GO:1903027 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.6 1.8 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.4 1.2 GO:0021793 chemorepulsion of branchiomotor axon(GO:0021793)
0.4 1.9 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.3 2.2 GO:0023021 termination of signal transduction(GO:0023021)
0.3 9.3 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.3 0.9 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.3 3.6 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.3 0.8 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.2 2.0 GO:2001300 lipoxin metabolic process(GO:2001300)
0.2 2.3 GO:1901725 regulation of histone deacetylase activity(GO:1901725)
0.2 0.6 GO:2001151 regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
0.2 0.8 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.2 0.8 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.2 0.5 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.2 0.5 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.1 0.4 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 1.0 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.1 0.7 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.9 GO:0071461 cellular response to redox state(GO:0071461)
0.1 0.6 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.1 0.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 0.4 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
0.1 0.4 GO:0009726 detection of endogenous stimulus(GO:0009726) kidney smooth muscle tissue development(GO:0072194)
0.1 0.5 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.3 GO:0097359 UDP-glucosylation(GO:0097359)
0.1 0.4 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.1 1.0 GO:0009249 protein lipoylation(GO:0009249)
0.1 0.4 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.8 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.1 0.3 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.1 0.5 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 1.3 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 0.3 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.3 GO:0002877 acute inflammatory response to non-antigenic stimulus(GO:0002525) regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
0.1 0.5 GO:0030242 pexophagy(GO:0030242)
0.1 0.3 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 0.2 GO:1904048 regulation of spontaneous neurotransmitter secretion(GO:1904048)
0.1 4.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 0.2 GO:0042214 terpene metabolic process(GO:0042214)
0.1 1.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 0.5 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 0.6 GO:0042908 xenobiotic transport(GO:0042908)
0.1 0.8 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.2 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.0 0.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.1 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860) pronephric nephron development(GO:0039019)
0.0 0.5 GO:0030091 protein repair(GO:0030091)
0.0 0.5 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.5 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.7 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 1.0 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.4 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.6 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.2 GO:0031394 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.1 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.2 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.1 GO:0010157 response to chlorate(GO:0010157)
0.0 0.3 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 1.7 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 0.5 GO:0043587 tongue morphogenesis(GO:0043587)
0.0 0.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.5 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.7 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.8 GO:0002385 mucosal immune response(GO:0002385)
0.0 1.9 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 0.6 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.3 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.0 0.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.4 GO:0001780 neutrophil homeostasis(GO:0001780)
0.0 0.1 GO:0061218 negative regulation of mesonephros development(GO:0061218) negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.1 GO:2000870 positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870)
0.0 0.5 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 1.7 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.2 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.9 GO:0010863 positive regulation of phospholipase C activity(GO:0010863)
0.0 0.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.3 GO:0090312 positive regulation of protein deacetylation(GO:0090312)
0.0 0.2 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.1 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 1.4 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.5 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.6 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.2 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 1.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.0 2.4 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.3 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.0 0.1 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.4 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.3 GO:0001502 cartilage condensation(GO:0001502)
0.0 1.7 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.2 1.3 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.2 1.7 GO:0071953 elastic fiber(GO:0071953)
0.2 0.5 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 1.0 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 4.3 GO:0000145 exocyst(GO:0000145)
0.1 1.8 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 1.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.4 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.1 0.3 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.3 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.1 10.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 4.0 GO:0099738 cell cortex region(GO:0099738)
0.1 6.9 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1 0.2 GO:0043291 RAVE complex(GO:0043291)
0.0 0.2 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.8 GO:0045120 pronucleus(GO:0045120)
0.0 0.6 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.7 GO:0005687 U4 snRNP(GO:0005687)
0.0 2.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0036128 CatSper complex(GO:0036128)
0.0 0.7 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 2.4 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.6 GO:0016459 myosin complex(GO:0016459)
0.0 0.3 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.3 1.0 GO:0005174 CD40 receptor binding(GO:0005174)
0.3 1.8 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.3 3.6 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.3 9.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.3 0.9 GO:0004756 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.2 0.7 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.2 0.7 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.2 2.3 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.2 2.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.2 0.5 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.2 2.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 0.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 0.6 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.2 0.5 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.2 0.5 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.1 0.8 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.1 0.4 GO:0043398 HLH domain binding(GO:0043398) calcium-induced calcium release activity(GO:0048763)
0.1 0.7 GO:0070573 metallodipeptidase activity(GO:0070573)
0.1 0.3 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.1 0.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.8 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.5 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 0.3 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.1 0.8 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 0.8 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.6 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 0.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.4 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 1.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.0 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.6 GO:0031013 troponin I binding(GO:0031013)
0.1 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 1.3 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.2 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 1.0 GO:0005112 Notch binding(GO:0005112)
0.0 0.4 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.9 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.5 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.1 GO:0031893 vasopressin receptor binding(GO:0031893)
0.0 0.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.3 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.4 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 2.1 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.1 GO:0031386 protein tag(GO:0031386)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.5 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.3 GO:0048156 tau protein binding(GO:0048156)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 1.3 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 1.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0070330 aromatase activity(GO:0070330)
0.0 1.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.4 GO:0035035 histone acetyltransferase binding(GO:0035035)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 7.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 2.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 4.1 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 2.2 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 1.8 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.5 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.0 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 3.4 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 4.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 2.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 1.0 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.3 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 2.2 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.7 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 2.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.7 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.0 0.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 2.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.3 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends