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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for PLAGL1
Z-value: 1.36
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Transcription factors associated with PLAGL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAGL1 | hg19_v2_chr6_-_144385698_144385742 | -0.18 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_123691047 Show fit | 2.75 |
ENST00000373887.3
|
TNF receptor-associated factor 1 |
|
| chr9_-_123691439 Show fit | 2.60 |
ENST00000540010.1
|
TNF receptor-associated factor 1 |
|
| chr1_+_33207381 Show fit | 2.22 |
ENST00000401073.2
|
KIAA1522 |
|
| chr19_+_676385 Show fit | 2.19 |
ENST00000166139.4
|
follistatin-like 3 (secreted glycoprotein) |
|
| chr10_+_104155450 Show fit | 1.92 |
ENST00000471698.1
ENST00000189444.6 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
|
| chr6_-_29595779 Show fit | 1.85 |
ENST00000355973.3
ENST00000377012.4 |
gamma-aminobutyric acid (GABA) B receptor, 1 |
|
| chr4_+_156588350 Show fit | 1.83 |
ENST00000296518.7
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr15_-_64338521 Show fit | 1.67 |
ENST00000457488.1
ENST00000558069.1 |
death-associated protein kinase 2 |
|
| chr7_+_6144514 Show fit | 1.67 |
ENST00000306177.5
ENST00000465073.2 |
ubiquitin specific peptidase 42 |
|
| chr17_-_61777090 Show fit | 1.59 |
ENST00000578061.1
|
LIM domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAGL1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 0.1 | 4.0 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.6 | 3.9 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.1 | 3.8 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 0.9 | 3.7 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.1 | 3.3 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.1 | 3.3 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.0 | 3.3 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.7 | 3.0 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.1 | 2.7 | GO:0033198 | response to ATP(GO:0033198) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 5.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.2 | 5.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 4.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.5 | 4.1 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.0 | 4.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.9 | 3.7 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 3.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 3.0 | GO:0015030 | Cajal body(GO:0015030) |
| 0.3 | 2.8 | GO:0035976 | AP1 complex(GO:0035976) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 6.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 5.9 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 5.9 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.2 | 5.3 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.3 | 4.2 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 4.1 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.3 | 3.8 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 3.6 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 3.5 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 9.7 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 7.9 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 6.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 5.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 5.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 4.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 3.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 3.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 2.9 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 7.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 6.8 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 5.6 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.3 | 5.2 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.1 | 4.5 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 4.3 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 4.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 3.6 | REACTOME GAB1 SIGNALOSOME | Genes involved in GAB1 signalosome |
| 0.2 | 3.4 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |