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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for POU3F2
Z-value: 1.13
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Transcription factors associated with POU3F2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F2 | hg19_v2_chr6_+_99282570_99282591 | -0.13 | 5.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_76957214 Show fit | 5.90 |
ENST00000306621.3
|
chemokine (C-X-C motif) ligand 11 |
|
| chr3_-_127455200 Show fit | 5.22 |
ENST00000398101.3
|
monoglyceride lipase |
|
| chr2_+_152214098 Show fit | 4.15 |
ENST00000243347.3
|
tumor necrosis factor, alpha-induced protein 6 |
|
| chr11_+_5710919 Show fit | 3.20 |
ENST00000379965.3
ENST00000425490.1 |
tripartite motif containing 22 |
|
| chr10_+_91087651 Show fit | 3.01 |
ENST00000371818.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr11_-_102668879 Show fit | 2.92 |
ENST00000315274.6
|
matrix metallopeptidase 1 (interstitial collagenase) |
|
| chr1_-_173020056 Show fit | 2.87 |
ENST00000239468.2
ENST00000404377.3 |
tumor necrosis factor (ligand) superfamily, member 18 |
|
| chr10_-_49860525 Show fit | 2.85 |
ENST00000435790.2
|
Rho GTPase activating protein 22 |
|
| chr4_-_76944621 Show fit | 2.81 |
ENST00000306602.1
|
chemokine (C-X-C motif) ligand 10 |
|
| chr11_+_20044600 Show fit | 2.77 |
ENST00000311043.8
|
neuron navigator 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU3F2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 8.7 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.7 | 5.2 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.5 | 4.6 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.6 | 4.5 | GO:0021564 | vagus nerve development(GO:0021564) |
| 0.1 | 4.4 | GO:0030728 | ovulation(GO:0030728) |
| 0.7 | 3.6 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 0.0 | 3.5 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.0 | 3.3 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.2 | 3.2 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.5 | 3.1 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | GO:0015030 | Cajal body(GO:0015030) |
| 0.4 | 3.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 3.2 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 3.2 | GO:0031256 | leading edge membrane(GO:0031256) |
| 0.2 | 3.1 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 3.0 | GO:0030684 | preribosome(GO:0030684) |
| 0.0 | 2.7 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.3 | 2.3 | GO:1990393 | 3M complex(GO:1990393) |
| 0.0 | 2.3 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 2.2 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 8.7 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.2 | 5.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 4.9 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 4.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 4.2 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 3.8 | GO:0032813 | tumor necrosis factor receptor superfamily binding(GO:0032813) |
| 0.0 | 3.8 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.3 | 3.1 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.1 | 3.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.4 | 3.0 | GO:0032554 | purine deoxyribonucleotide binding(GO:0032554) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 5.3 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 3.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 3.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 2.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.4 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 2.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 2.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 6.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 5.0 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 4.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 4.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 4.0 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 3.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 3.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 3.2 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 3.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |