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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for POU4F2

Z-value: 0.35

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
POU4F2
ENSG00000151615.3 POU class 4 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU4F2hg19_v2_chr4_+_147560042_1475600460.019.7e-01Click!

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_79816965 0.69 ENST00000464233.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr1_-_182641367 0.53 ENST00000508450.1
RGS8
regulator of G-protein signaling 8
chr6_-_89927151 0.42 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr21_-_31859755 0.39 ENST00000334055.3
KRTAP19-2
keratin associated protein 19-2
chr12_-_52779433 0.38 ENST00000257951.3
KRT84
keratin 84
chr8_-_18541603 0.31 ENST00000428502.2
PSD3
pleckstrin and Sec7 domain containing 3
chr18_-_71959159 0.28 ENST00000494131.2
ENST00000397914.4
ENST00000340533.4
CYB5A
cytochrome b5 type A (microsomal)
chr14_+_22356029 0.27 ENST00000390437.2
TRAV12-2
T cell receptor alpha variable 12-2
chr4_+_169013666 0.27 ENST00000359299.3
ANXA10
annexin A10
chr5_-_58295712 0.23 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_-_47983519 0.19 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
CNGA1
cyclic nucleotide gated channel alpha 1
chr7_-_81399411 0.18 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr1_-_44482979 0.18 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr4_-_169401628 0.17 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr8_+_50824233 0.17 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr15_-_74421477 0.17 ENST00000514871.1
RP11-247C2.2
HCG2004779; Uncharacterized protein
chr6_+_39760129 0.16 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr3_+_121774202 0.15 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chr17_-_39623681 0.15 ENST00000225899.3
KRT32
keratin 32
chr20_+_11008408 0.15 ENST00000378252.1
C20orf187
chromosome 20 open reading frame 187
chr3_+_63428752 0.14 ENST00000295894.5
SYNPR
synaptoporin
chr7_-_81399329 0.14 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr19_-_35719609 0.14 ENST00000324675.3
FAM187B
family with sequence similarity 187, member B
chr4_-_123542224 0.13 ENST00000264497.3
IL21
interleukin 21
chr5_-_134914673 0.13 ENST00000512158.1
CXCL14
chemokine (C-X-C motif) ligand 14
chr17_-_64225508 0.13 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr3_-_58613323 0.12 ENST00000474531.1
ENST00000465970.1
FAM107A
family with sequence similarity 107, member A
chr5_-_140998481 0.12 ENST00000518047.1
DIAPH1
diaphanous-related formin 1
chr9_+_77230499 0.12 ENST00000396204.2
RORB
RAR-related orphan receptor B
chr4_+_159443090 0.11 ENST00000343542.5
ENST00000470033.1
RXFP1
relaxin/insulin-like family peptide receptor 1
chr7_-_81399355 0.11 ENST00000457544.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr18_+_74240610 0.11 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
LINC00908
long intergenic non-protein coding RNA 908
chr11_-_125550764 0.11 ENST00000527795.1
ACRV1
acrosomal vesicle protein 1
chr4_+_159443024 0.11 ENST00000448688.2
RXFP1
relaxin/insulin-like family peptide receptor 1
chr6_-_25874440 0.11 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr16_+_19421803 0.10 ENST00000541464.1
TMC5
transmembrane channel-like 5
chr10_-_73848086 0.10 ENST00000536168.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr10_-_73848531 0.10 ENST00000373109.2
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr17_-_7832753 0.10 ENST00000303790.2
KCNAB3
potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr17_-_79623597 0.10 ENST00000574024.1
ENST00000331056.5
PDE6G
phosphodiesterase 6G, cGMP-specific, rod, gamma
chrX_-_99987088 0.10 ENST00000372981.1
ENST00000263033.5
SYTL4
synaptotagmin-like 4
chr20_+_56136136 0.10 ENST00000319441.4
ENST00000543666.1
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr4_+_78432907 0.09 ENST00000286758.4
CXCL13
chemokine (C-X-C motif) ligand 13
chr20_+_48909240 0.09 ENST00000371639.3
RP11-290F20.1
RP11-290F20.1
chr21_-_31864275 0.09 ENST00000334063.4
KRTAP19-3
keratin associated protein 19-3
chr7_+_142982023 0.09 ENST00000359333.3
ENST00000409244.1
ENST00000409541.1
ENST00000410004.1
TMEM139
transmembrane protein 139
chr3_-_51909600 0.09 ENST00000446461.1
IQCF5
IQ motif containing F5
chr11_-_125550726 0.08 ENST00000315608.3
ENST00000530048.1
ACRV1
acrosomal vesicle protein 1
chr5_+_154393260 0.08 ENST00000435029.4
KIF4B
kinesin family member 4B
chr17_-_10372875 0.08 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr4_+_76481258 0.08 ENST00000311623.4
ENST00000435974.2
C4orf26
chromosome 4 open reading frame 26
chr1_+_50574585 0.08 ENST00000371824.1
ENST00000371823.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr2_-_70780572 0.07 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr18_+_32455201 0.07 ENST00000590831.2
DTNA
dystrobrevin, alpha
chrX_+_133930798 0.07 ENST00000414371.2
FAM122C
family with sequence similarity 122C
chr5_-_140998616 0.07 ENST00000389054.3
ENST00000398562.2
ENST00000389057.5
ENST00000398566.3
ENST00000398557.4
ENST00000253811.6
DIAPH1
diaphanous-related formin 1
chr21_-_32185570 0.07 ENST00000329621.4
KRTAP8-1
keratin associated protein 8-1
chr11_-_41481135 0.07 ENST00000528697.1
ENST00000530763.1
LRRC4C
leucine rich repeat containing 4C
chr12_-_118796910 0.07 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr11_+_118175132 0.07 ENST00000361763.4
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr20_-_50418947 0.06 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr16_-_20416053 0.06 ENST00000302451.4
PDILT
protein disulfide isomerase-like, testis expressed
chr20_-_50418972 0.06 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr1_+_198608146 0.06 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_-_204183071 0.06 ENST00000308302.3
GOLT1A
golgi transport 1A
chr6_-_109777128 0.06 ENST00000358807.3
ENST00000358577.3
MICAL1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr9_+_125132803 0.06 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr15_-_37393406 0.06 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr1_+_193028552 0.06 ENST00000400968.2
ENST00000432079.1
TROVE2
TROVE domain family, member 2
chr6_+_12717892 0.06 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr14_+_97925151 0.06 ENST00000554862.1
ENST00000554260.1
ENST00000499910.2
CTD-2506J14.1
CTD-2506J14.1
chr20_+_5987890 0.05 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr15_-_98417780 0.05 ENST00000503874.3
LINC00923
long intergenic non-protein coding RNA 923
chr2_+_54951679 0.05 ENST00000356458.6
EML6
echinoderm microtubule associated protein like 6
chr7_-_81399438 0.05 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr17_+_18086392 0.05 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr3_+_108541608 0.04 ENST00000426646.1
TRAT1
T cell receptor associated transmembrane adaptor 1
chr1_-_182641037 0.04 ENST00000483095.2
RGS8
regulator of G-protein signaling 8
chr10_+_18549645 0.04 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr17_+_68100989 0.04 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr1_-_182640988 0.04 ENST00000367556.1
RGS8
regulator of G-protein signaling 8
chr6_+_10521574 0.04 ENST00000495262.1
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr3_+_108541545 0.04 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr19_+_1269324 0.03 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
CIRBP
cold inducible RNA binding protein
chr17_-_33390667 0.03 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr8_-_131399110 0.03 ENST00000521426.1
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr19_-_7698599 0.03 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr14_+_23727694 0.03 ENST00000399905.1
ENST00000470456.1
C14orf164
chromosome 14 open reading frame 164
chrX_+_68835911 0.03 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
EDA
ectodysplasin A
chr19_-_10446449 0.03 ENST00000592439.1
ICAM3
intercellular adhesion molecule 3
chr6_+_151042224 0.02 ENST00000358517.2
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr16_+_19422035 0.02 ENST00000381414.4
ENST00000396229.2
TMC5
transmembrane channel-like 5
chr1_+_40506392 0.02 ENST00000414893.1
ENST00000414281.1
ENST00000420216.1
ENST00000372792.2
ENST00000372798.1
ENST00000340450.3
ENST00000372805.3
ENST00000435719.1
ENST00000427843.1
ENST00000417287.1
ENST00000424977.1
ENST00000446031.1
CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr10_+_95372289 0.02 ENST00000371447.3
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr7_-_25268104 0.02 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr4_+_169418195 0.02 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr2_-_158300556 0.02 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr1_-_193028426 0.02 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr20_-_50419055 0.02 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr1_-_47655686 0.02 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr1_-_193028621 0.02 ENST00000367455.4
ENST00000367454.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr12_-_7596735 0.02 ENST00000416109.2
ENST00000396630.1
ENST00000313599.3
CD163L1
CD163 molecule-like 1
chr8_-_49833978 0.02 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr6_+_118869452 0.02 ENST00000357525.5
PLN
phospholamban
chr4_-_10686475 0.02 ENST00000226951.6
CLNK
cytokine-dependent hematopoietic cell linker
chr1_-_193028632 0.01 ENST00000421683.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr15_-_43877062 0.01 ENST00000381885.1
ENST00000396923.3
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr14_+_32030582 0.01 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr2_+_101179152 0.01 ENST00000264254.6
PDCL3
phosducin-like 3
chr10_+_99205894 0.01 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chrX_+_139791917 0.01 ENST00000607004.1
ENST00000370535.3
LINC00632
long intergenic non-protein coding RNA 632
chr8_+_7682694 0.01 ENST00000335186.2
DEFB106A
defensin, beta 106A
chr10_+_99205959 0.01 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr16_+_28505955 0.01 ENST00000564831.1
ENST00000328423.5
ENST00000431282.1
APOBR
apolipoprotein B receptor
chr15_+_45544426 0.01 ENST00000347644.3
ENST00000560438.1
SLC28A2
solute carrier family 28 (concentrative nucleoside transporter), member 2
chr4_+_159442878 0.01 ENST00000307765.5
ENST00000423548.1
RXFP1
relaxin/insulin-like family peptide receptor 1
chr14_+_42077552 0.01 ENST00000554120.1
LRFN5
leucine rich repeat and fibronectin type III domain containing 5
chr12_+_56510368 0.00 ENST00000546591.1
ENST00000501597.3
RPL41
ribosomal protein L41
chr19_-_7697857 0.00 ENST00000598935.1
PCP2
Purkinje cell protein 2
chr6_-_139308777 0.00 ENST00000529597.1
ENST00000415951.2
ENST00000367663.4
ENST00000409812.2
REPS1
RALBP1 associated Eps domain containing 1
chr8_-_49834299 0.00 ENST00000396822.1
SNAI2
snail family zinc finger 2

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0021836 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.1 0.2 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.5 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.2 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0 0.6 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.4 GO:0035878 nail development(GO:0035878)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.1 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.1 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
0.0 0.1 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 0.0 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.1 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.0 0.1 GO:0043337 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.2 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.0 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling