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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for POU5F1_POU2F3
Z-value: 1.31
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Transcription factors associated with POU5F1_POU2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU5F1 | hg19_v2_chr6_-_31138439_31138475 | 0.33 | 1.1e-01 | Click! |
| POU2F3 | hg19_v2_chr11_+_120107344_120107351 | 0.15 | 4.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_61542922 Show fit | 8.39 |
ENST00000407417.3
|
nuclear factor I/A |
|
| chr1_+_61547405 Show fit | 7.95 |
ENST00000371189.4
|
nuclear factor I/A |
|
| chr4_-_186733363 Show fit | 6.36 |
ENST00000393523.2
ENST00000393528.3 ENST00000449407.2 |
sorbin and SH3 domain containing 2 |
|
| chr1_+_61547894 Show fit | 6.03 |
ENST00000403491.3
|
nuclear factor I/A |
|
| chr1_+_228645796 Show fit | 4.29 |
ENST00000369160.2
|
histone cluster 3, H2bb |
|
| chr12_-_58212487 Show fit | 3.46 |
ENST00000549994.1
|
advillin |
|
| chr1_+_164528866 Show fit | 3.31 |
ENST00000420696.2
|
pre-B-cell leukemia homeobox 1 |
|
| chr17_-_47841485 Show fit | 3.20 |
ENST00000506156.1
ENST00000240364.2 |
family with sequence similarity 117, member A |
|
| chr15_-_78526855 Show fit | 3.18 |
ENST00000541759.1
ENST00000558130.1 |
acyl-CoA synthetase bubblegum family member 1 |
|
| chr10_-_105452917 Show fit | 3.09 |
ENST00000427662.2
|
SH3 and PX domains 2A |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU5F1_POU2F3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 20.9 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 12.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 7.5 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.2 | 7.0 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 1.6 | 4.9 | GO:0070666 | positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668) |
| 0.1 | 4.8 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.1 | 4.8 | GO:0030835 | negative regulation of actin filament depolymerization(GO:0030835) |
| 1.2 | 4.7 | GO:2000691 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.3 | 3.7 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 3.5 | GO:0018149 | peptide cross-linking(GO:0018149) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.3 | GO:0030018 | Z disc(GO:0030018) |
| 1.0 | 4.9 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.0 | 4.8 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 4.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 3.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.4 | 3.7 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 3.3 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 2.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 2.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 2.5 | GO:0000786 | nucleosome(GO:0000786) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 13.2 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 6.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.6 | 4.6 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.1 | 4.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 4.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.3 | 3.8 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.2 | 3.1 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.2 | 3.1 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.2 | 2.7 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 24.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 7.5 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 4.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 3.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.2 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 2.1 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 1.6 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 1.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 4.9 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.2 | 2.9 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 2.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 2.4 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 2.3 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 2.1 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 1.9 | REACTOME REGULATORY RNA PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.1 | 1.7 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |