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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for POU6F1

Z-value: 0.57

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
POU6F1
ENSG00000184271.11 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F1hg19_v2_chr12_-_51611477_51611612-0.242.4e-01Click!

Activity profile of POU6F1 motif

Sorted Z-values of POU6F1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_127541194 2.26 ENST00000453507.2
MGLL
monoglyceride lipase
chr2_-_202563414 1.54 ENST00000409474.3
ENST00000315506.7
ENST00000359962.5
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr2_-_202562716 1.54 ENST00000428900.2
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr2_-_202562774 1.52 ENST00000396886.3
ENST00000409143.1
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr20_+_58515417 1.26 ENST00000360816.3
FAM217B
family with sequence similarity 217, member B
chr1_+_171107241 1.05 ENST00000236166.3
FMO6P
flavin containing monooxygenase 6 pseudogene
chr18_+_61554932 0.87 ENST00000299502.4
ENST00000457692.1
ENST00000413956.1
SERPINB2
serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr7_-_83824169 0.81 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr20_-_58515344 0.66 ENST00000370996.3
PPP1R3D
protein phosphatase 1, regulatory subunit 3D
chr4_-_169401628 0.59 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr12_-_30887948 0.57 ENST00000433722.2
CAPRIN2
caprin family member 2
chr5_+_67586465 0.54 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr3_+_46395219 0.52 ENST00000445132.2
ENST00000292301.4
CCR2
chemokine (C-C motif) receptor 2
chr8_+_118147498 0.51 ENST00000519688.1
ENST00000456015.2
SLC30A8
solute carrier family 30 (zinc transporter), member 8
chr1_-_153538292 0.50 ENST00000497140.1
ENST00000368708.3
S100A2
S100 calcium binding protein A2
chr1_-_197115818 0.45 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr2_+_202937972 0.41 ENST00000541917.1
ENST00000295844.3
AC079354.1
uncharacterized protein KIAA2012
chr13_+_98612446 0.40 ENST00000496368.1
ENST00000421861.2
ENST00000357602.3
IPO5
importin 5
chr11_-_4414880 0.40 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr17_-_39165366 0.38 ENST00000391588.1
KRTAP3-1
keratin associated protein 3-1
chr19_+_52076425 0.38 ENST00000436511.2
ZNF175
zinc finger protein 175
chr1_-_161008697 0.36 ENST00000318289.10
ENST00000368023.3
ENST00000368024.1
ENST00000423014.2
TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr1_-_106161540 0.32 ENST00000420901.1
ENST00000610126.1
ENST00000435253.2
RP11-251P6.1
RP11-251P6.1
chr17_-_40337470 0.31 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr6_-_47010061 0.31 ENST00000371253.2
GPR110
G protein-coupled receptor 110
chr12_-_7596735 0.30 ENST00000416109.2
ENST00000396630.1
ENST00000313599.3
CD163L1
CD163 molecule-like 1
chr2_+_191045562 0.30 ENST00000340623.4
C2orf88
chromosome 2 open reading frame 88
chr1_-_89641680 0.30 ENST00000294671.2
GBP7
guanylate binding protein 7
chr1_-_153123345 0.27 ENST00000368748.4
SPRR2G
small proline-rich protein 2G
chr9_-_89562104 0.25 ENST00000298743.7
GAS1
growth arrest-specific 1
chr7_+_148287657 0.23 ENST00000307003.2
C7orf33
chromosome 7 open reading frame 33
chr2_-_99917639 0.23 ENST00000308528.4
LYG1
lysozyme G-like 1
chr16_+_19421803 0.22 ENST00000541464.1
TMC5
transmembrane channel-like 5
chr19_-_35719609 0.21 ENST00000324675.3
FAM187B
family with sequence similarity 187, member B
chr6_+_29274403 0.21 ENST00000377160.2
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr11_+_2323236 0.20 ENST00000182290.4
TSPAN32
tetraspanin 32
chr11_+_2323349 0.19 ENST00000381121.3
TSPAN32
tetraspanin 32
chr8_-_10512569 0.19 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr6_+_110501621 0.19 ENST00000368930.1
ENST00000307731.1
CDC40
cell division cycle 40
chr20_+_5987890 0.19 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr19_-_3786354 0.19 ENST00000395040.2
ENST00000310132.6
MATK
megakaryocyte-associated tyrosine kinase
chr19_-_3786253 0.18 ENST00000585778.1
MATK
megakaryocyte-associated tyrosine kinase
chr16_-_58718611 0.17 ENST00000564100.1
ENST00000570101.1
SLC38A7
solute carrier family 38, member 7
chr5_+_162864575 0.17 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
CCNG1
cyclin G1
chr6_+_110501344 0.17 ENST00000368932.1
CDC40
cell division cycle 40
chr12_+_49297887 0.16 ENST00000266984.5
CCDC65
coiled-coil domain containing 65
chr5_+_115177178 0.16 ENST00000316788.7
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr15_+_80351910 0.16 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr2_+_191045656 0.16 ENST00000443551.2
C2orf88
chromosome 2 open reading frame 88
chr4_-_76912070 0.15 ENST00000395711.4
ENST00000356260.5
SDAD1
SDA1 domain containing 1
chrX_-_122756660 0.15 ENST00000441692.1
THOC2
THO complex 2
chr9_+_103790991 0.15 ENST00000374874.3
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr16_+_19422035 0.15 ENST00000381414.4
ENST00000396229.2
TMC5
transmembrane channel-like 5
chr20_+_59654146 0.14 ENST00000441660.1
RP5-827L5.1
RP5-827L5.1
chr2_-_179516225 0.14 ENST00000446966.1
ENST00000426232.1
TTN
titin
chr6_+_151646800 0.14 ENST00000354675.6
AKAP12
A kinase (PRKA) anchor protein 12
chr1_+_225140372 0.13 ENST00000366848.1
ENST00000439375.2
DNAH14
dynein, axonemal, heavy chain 14
chr3_+_77088989 0.13 ENST00000461745.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr13_+_107029084 0.12 ENST00000444865.1
LINC00460
long intergenic non-protein coding RNA 460
chr4_+_78829479 0.12 ENST00000504901.1
MRPL1
mitochondrial ribosomal protein L1
chr6_+_25754927 0.12 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr1_+_225117350 0.12 ENST00000413949.2
ENST00000430092.1
ENST00000366850.3
ENST00000400952.3
ENST00000366849.1
DNAH14
dynein, axonemal, heavy chain 14
chr16_+_15744078 0.12 ENST00000396354.1
ENST00000570727.1
NDE1
nudE neurodevelopment protein 1
chr10_+_18041218 0.12 ENST00000480516.1
ENST00000457860.1
TMEM236
TMEM236
chr2_+_11679963 0.12 ENST00000263834.5
GREB1
growth regulation by estrogen in breast cancer 1
chr15_+_45028753 0.12 ENST00000338264.4
TRIM69
tripartite motif containing 69
chr19_-_58662139 0.12 ENST00000598312.1
ZNF329
zinc finger protein 329
chr9_+_128509624 0.11 ENST00000342287.5
ENST00000373487.4
PBX3
pre-B-cell leukemia homeobox 3
chr4_+_106631966 0.11 ENST00000360505.5
ENST00000510865.1
ENST00000509336.1
GSTCD
glutathione S-transferase, C-terminal domain containing
chr12_+_49297899 0.11 ENST00000552942.1
ENST00000320516.4
CCDC65
coiled-coil domain containing 65
chr15_-_31283618 0.11 ENST00000563714.1
MTMR10
myotubularin related protein 10
chr15_+_80351977 0.10 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
ZFAND6
zinc finger, AN1-type domain 6
chrX_-_100129128 0.10 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1
NADPH oxidase 1
chr15_+_45028520 0.09 ENST00000329464.4
TRIM69
tripartite motif containing 69
chr15_+_45028719 0.09 ENST00000560442.1
ENST00000558329.1
ENST00000561043.1
TRIM69
tripartite motif containing 69
chr1_+_50571949 0.09 ENST00000357083.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr4_+_113970772 0.08 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ANK2
ankyrin 2, neuronal
chr22_-_22307199 0.08 ENST00000397495.4
ENST00000263212.5
PPM1F
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr2_-_166060571 0.08 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr2_-_166060552 0.08 ENST00000283254.7
ENST00000453007.1
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr11_-_65149422 0.07 ENST00000526432.1
ENST00000527174.1
SLC25A45
solute carrier family 25, member 45
chr6_+_50786414 0.06 ENST00000344788.3
ENST00000393655.3
ENST00000263046.4
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr15_+_59279851 0.06 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr12_+_54892550 0.06 ENST00000545638.2
NCKAP1L
NCK-associated protein 1-like
chr1_-_47655686 0.06 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr9_-_113100088 0.06 ENST00000374510.4
ENST00000423740.2
ENST00000374511.3
ENST00000374507.4
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr6_+_42123141 0.06 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
GUCA1A
RP1-139D8.6
guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr12_+_102513950 0.06 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr17_-_30186328 0.06 ENST00000302362.6
COPRS
coordinator of PRMT5, differentiation stimulator
chr11_+_71544246 0.05 ENST00000328698.1
DEFB108B
defensin, beta 108B
chr1_+_113010056 0.05 ENST00000369686.5
WNT2B
wingless-type MMTV integration site family, member 2B
chr13_-_52027134 0.04 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr6_-_111804905 0.04 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chrX_-_100129320 0.04 ENST00000372966.3
NOX1
NADPH oxidase 1
chr1_-_243326612 0.04 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
CEP170
centrosomal protein 170kDa
chr13_+_30510003 0.03 ENST00000400540.1
LINC00544
long intergenic non-protein coding RNA 544
chr11_-_2323089 0.03 ENST00000456145.2
C11orf21
chromosome 11 open reading frame 21
chr16_-_87350970 0.02 ENST00000567970.1
C16orf95
chromosome 16 open reading frame 95
chr16_-_87351022 0.02 ENST00000253461.4
C16orf95
chromosome 16 open reading frame 95
chrX_+_102024075 0.01 ENST00000431616.1
ENST00000440496.1
ENST00000420471.1
ENST00000435966.1
LINC00630
long intergenic non-protein coding RNA 630
chr20_-_50418947 0.01 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr20_-_50418972 0.01 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr9_-_86955598 0.01 ENST00000376238.4
SLC28A3
solute carrier family 28 (concentrative nucleoside transporter), member 3
chrX_+_119737806 0.01 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr17_-_26972126 0.00 ENST00000528896.2
KIAA0100
KIAA0100
chr2_-_217560248 0.00 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 0.5 GO:2000439 negative regulation of eosinophil activation(GO:1902567) positive regulation of monocyte extravasation(GO:2000439)
0.2 0.8 GO:0048880 sensory system development(GO:0048880)
0.1 0.4 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.4 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.1 0.4 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.1 0.2 GO:0089709 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.1 0.3 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.5 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.7 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.2 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.1 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.5 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.2 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.9 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.2 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.7 GO:0042587 glycogen granule(GO:0042587)
0.0 0.4 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.1 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.1 GO:0071438 invadopodium membrane(GO:0071438)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 2.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.2 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.1 0.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0031433 telethonin binding(GO:0031433)
0.0 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.8 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME BETA DEFENSINS Genes involved in Beta defensins