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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for POU6F2

Z-value: 0.45

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Transcription factors associated with POU6F2

Gene Symbol Gene ID Gene Info
ENSG00000106536.15 POU class 6 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F2hg19_v2_chr7_+_39017504_39017598,
hg19_v2_chr7_+_39125365_39125489
-0.096.5e-01Click!

Activity profile of POU6F2 motif

Sorted Z-values of POU6F2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_58206655 1.20 ENST00000377918.3
protocadherin 17
chr12_-_30887948 1.10 ENST00000433722.2
caprin family member 2
chr20_+_58515417 1.00 ENST00000360816.3
family with sequence similarity 217, member B
chr16_+_53133070 0.67 ENST00000565832.1
chromodomain helicase DNA binding protein 9
chr18_-_24129367 0.49 ENST00000408011.3
potassium channel tetramerization domain containing 1
chr15_+_96869165 0.47 ENST00000421109.2
nuclear receptor subfamily 2, group F, member 2
chr6_+_130339710 0.43 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr1_-_182641367 0.43 ENST00000508450.1
regulator of G-protein signaling 8
chr6_-_8064567 0.42 ENST00000543936.1
ENST00000397457.2
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr15_-_74421477 0.40 ENST00000514871.1
HCG2004779; Uncharacterized protein
chr20_-_58515344 0.39 ENST00000370996.3
protein phosphatase 1, regulatory subunit 3D
chr13_-_110438914 0.38 ENST00000375856.3
insulin receptor substrate 2
chr17_+_18086392 0.37 ENST00000541285.1
alkB, alkylation repair homolog 5 (E. coli)
chr6_-_111804905 0.36 ENST00000358835.3
ENST00000435970.1
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr14_-_36989336 0.36 ENST00000522719.2
NK2 homeobox 1
chr6_-_32157947 0.36 ENST00000375050.4
pre-B-cell leukemia homeobox 2
chr12_+_15699286 0.35 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
protein tyrosine phosphatase, receptor type, O
chr3_+_159557637 0.35 ENST00000445224.2
schwannomin interacting protein 1
chr2_-_70780572 0.33 ENST00000450929.1
transforming growth factor, alpha
chr4_+_175204818 0.33 ENST00000503780.1
centrosomal protein 44kDa
chr3_-_18466787 0.33 ENST00000338745.6
ENST00000450898.1
SATB homeobox 1
chrX_-_19988382 0.30 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
chromosome X open reading frame 23
chr7_+_141478242 0.29 ENST00000247881.2
taste receptor, type 2, member 4
chr13_+_78315466 0.28 ENST00000314070.5
ENST00000462234.1
SLAIN motif family, member 1
chr14_+_32798547 0.28 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr12_-_86230315 0.28 ENST00000361228.3
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr2_-_217559517 0.28 ENST00000449583.1
insulin-like growth factor binding protein 5
chr7_-_80141328 0.28 ENST00000398291.3
guanine nucleotide binding protein, alpha transducing 3
chr1_-_153123345 0.27 ENST00000368748.4
small proline-rich protein 2G
chr14_-_27066960 0.27 ENST00000539517.2
neuro-oncological ventral antigen 1
chr6_-_111136513 0.27 ENST00000368911.3
cyclin-dependent kinase 19
chr11_-_27494309 0.26 ENST00000389858.4
leucine-rich repeat containing G protein-coupled receptor 4
chr11_-_31531121 0.25 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr21_-_31869451 0.24 ENST00000334058.2
keratin associated protein 19-4
chr11_-_27494279 0.24 ENST00000379214.4
leucine-rich repeat containing G protein-coupled receptor 4
chr3_-_33686743 0.24 ENST00000333778.6
ENST00000539981.1
cytoplasmic linker associated protein 2
chr9_-_3469181 0.24 ENST00000366116.2
Uncharacterized protein
chr9_+_130853715 0.24 ENST00000373066.5
ENST00000432073.2
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr10_-_48416849 0.23 ENST00000249598.1
growth differentiation factor 2
chr9_+_109625378 0.23 ENST00000277225.5
ENST00000457913.1
ENST00000472574.1
zinc finger protein 462
chr4_+_40198527 0.23 ENST00000381799.5
ras homolog family member H
chr1_+_61869748 0.22 ENST00000357977.5
nuclear factor I/A
chr18_-_13915530 0.21 ENST00000327606.3
melanocortin 2 receptor (adrenocorticotropic hormone)
chr3_+_111718173 0.21 ENST00000494932.1
transgelin 3
chr14_+_32798462 0.20 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr1_-_234667504 0.20 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
chr21_+_17443521 0.19 ENST00000456342.1
long intergenic non-protein coding RNA 478
chr7_+_6655225 0.19 ENST00000457543.3
zinc finger protein 853
chr19_-_7968427 0.19 ENST00000539278.1
Uncharacterized protein
chrX_+_86772707 0.19 ENST00000373119.4
kelch-like family member 4
chr5_+_67586465 0.18 ENST00000336483.5
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr7_-_14028488 0.18 ENST00000405358.4
ets variant 1
chrX_-_110655306 0.18 ENST00000371993.2
doublecortin
chr8_+_26150628 0.17 ENST00000523925.1
ENST00000315985.7
protein phosphatase 2, regulatory subunit B, alpha
chr7_-_14029283 0.17 ENST00000433547.1
ENST00000405192.2
ets variant 1
chr21_+_17443434 0.17 ENST00000400178.2
long intergenic non-protein coding RNA 478
chr15_+_80351910 0.17 ENST00000261749.6
ENST00000561060.1
zinc finger, AN1-type domain 6
chr15_+_58702742 0.16 ENST00000356113.6
ENST00000414170.3
lipase, hepatic
chrX_+_10031499 0.16 ENST00000454666.1
WWC family member 3
chr17_-_39471947 0.15 ENST00000334202.3
keratin associated protein 17-1
chr1_-_193028426 0.15 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
ubiquitin carboxyl-terminal hydrolase L5
chr15_+_80351977 0.15 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
zinc finger, AN1-type domain 6
chr14_+_39583427 0.14 ENST00000308317.6
ENST00000396249.2
ENST00000250379.8
ENST00000534684.2
ENST00000527381.1
gem (nuclear organelle) associated protein 2
chr10_-_128210005 0.14 ENST00000284694.7
ENST00000454341.1
ENST00000432642.1
ENST00000392694.1
chromosome 10 open reading frame 90
chr21_+_17792672 0.14 ENST00000602620.1
long intergenic non-protein coding RNA 478
chr1_-_193028632 0.14 ENST00000421683.1
ubiquitin carboxyl-terminal hydrolase L5
chr21_-_31864275 0.13 ENST00000334063.4
keratin associated protein 19-3
chr3_+_189507460 0.13 ENST00000434928.1
tumor protein p63
chr4_-_175204765 0.13 ENST00000513696.1
ENST00000503293.1
F-box protein 8
chr7_+_116660246 0.13 ENST00000434836.1
ENST00000393443.1
ENST00000465133.1
ENST00000477742.1
ENST00000393447.4
ENST00000393444.3
suppression of tumorigenicity 7
chr2_+_138721850 0.12 ENST00000329366.4
ENST00000280097.3
histamine N-methyltransferase
chr15_-_54025300 0.12 ENST00000559418.1
WD repeat domain 72
chr8_-_42234745 0.12 ENST00000220812.2
dickkopf WNT signaling pathway inhibitor 4
chr9_-_13165457 0.12 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
multiple PDZ domain protein
chr2_+_128403720 0.11 ENST00000272644.3
G protein-coupled receptor 17
chr1_-_193028621 0.11 ENST00000367455.4
ENST00000367454.1
ubiquitin carboxyl-terminal hydrolase L5
chr3_-_33686925 0.11 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
cytoplasmic linker associated protein 2
chr10_-_94257512 0.11 ENST00000371581.5
insulin-degrading enzyme
chr21_+_17442799 0.11 ENST00000602580.1
ENST00000458468.1
ENST00000602935.1
long intergenic non-protein coding RNA 478
chrX_+_86772787 0.10 ENST00000373114.4
kelch-like family member 4
chr10_-_23633720 0.10 ENST00000323327.4
chromosome 10 open reading frame 67
chr15_-_37393406 0.10 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
Meis homeobox 2
chr6_-_74231444 0.10 ENST00000331523.2
ENST00000356303.2
eukaryotic translation elongation factor 1 alpha 1
chr2_+_128403439 0.10 ENST00000544369.1
G protein-coupled receptor 17
chr6_-_33160231 0.09 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
collagen, type XI, alpha 2
chr12_+_121131970 0.08 ENST00000535656.1
malectin
chrX_-_122756660 0.08 ENST00000441692.1
THO complex 2
chr1_+_107683436 0.08 ENST00000370068.1
netrin G1
chrX_+_43515467 0.08 ENST00000338702.3
ENST00000542639.1
monoamine oxidase A
chr2_-_158300556 0.08 ENST00000264192.3
cytohesin 1 interacting protein
chr7_+_129007964 0.08 ENST00000460109.1
ENST00000474594.1
ENST00000446212.1
adenosylhomocysteinase-like 2
chr17_-_10372875 0.07 ENST00000255381.2
myosin, heavy chain 4, skeletal muscle
chr11_-_129062093 0.07 ENST00000310343.9
Rho GTPase activating protein 32
chr7_+_148287657 0.07 ENST00000307003.2
chromosome 7 open reading frame 33
chr14_-_36988882 0.07 ENST00000498187.2
NK2 homeobox 1
chrX_+_107288239 0.07 ENST00000217957.5
V-set and immunoglobulin domain containing 1
chr8_+_119294456 0.07 ENST00000366457.2
Uncharacterized protein
chr7_+_115862858 0.06 ENST00000393481.2
testis derived transcript (3 LIM domains)
chr8_+_42396274 0.06 ENST00000438528.3
small integral membrane protein 19
chr6_+_25754927 0.06 ENST00000377905.4
ENST00000439485.2
solute carrier family 17, member 4
chr1_+_107683644 0.06 ENST00000370067.1
netrin G1
chr8_+_77593474 0.06 ENST00000455469.2
ENST00000050961.6
zinc finger homeobox 4
chr11_+_31531291 0.06 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
elongator acetyltransferase complex subunit 4
chr13_-_44735393 0.05 ENST00000400419.1
small integral membrane protein 2
chr9_-_79520989 0.05 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
prune homolog 2 (Drosophila)
chr17_-_48133054 0.05 ENST00000499842.1
RP11-1094H24.4
chr19_-_47137942 0.05 ENST00000300873.4
guanine nucleotide binding protein (G protein), gamma 8
chr12_+_54348618 0.05 ENST00000243103.3
homeobox C12
chr7_-_16840820 0.05 ENST00000450569.1
anterior gradient 2
chr5_-_111093167 0.05 ENST00000446294.2
ENST00000419114.2
neuronal regeneration related protein
chr6_+_151646800 0.05 ENST00000354675.6
A kinase (PRKA) anchor protein 12
chr4_-_66536057 0.04 ENST00000273854.3
EPH receptor A5
chr19_-_7697857 0.04 ENST00000598935.1
Purkinje cell protein 2
chr4_+_78829479 0.04 ENST00000504901.1
mitochondrial ribosomal protein L1
chr12_-_52946923 0.04 ENST00000267119.5
keratin 71
chr11_+_125034586 0.04 ENST00000298282.9
PBX/knotted 1 homeobox 2
chr16_-_4852915 0.04 ENST00000322048.7
rogdi homolog (Drosophila)
chr9_+_131062367 0.04 ENST00000601297.1
CDNA: FLJ21673 fis, clone COL09042; HCG2036511; Uncharacterized protein
chr4_-_74486217 0.04 ENST00000335049.5
ENST00000307439.5
Ras association (RalGDS/AF-6) domain family member 6
chr4_-_66536196 0.04 ENST00000511294.1
EPH receptor A5
chr2_+_44502597 0.04 ENST00000260649.6
ENST00000409387.1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr2_+_169757750 0.04 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
glucose-6-phosphatase, catalytic, 2
chr13_+_46039037 0.03 ENST00000349995.5
component of oligomeric golgi complex 3
chr10_+_94352956 0.03 ENST00000260731.3
kinesin family member 11
chr17_-_40337470 0.03 ENST00000293330.1
hypocretin (orexin) neuropeptide precursor
chr5_-_111093081 0.03 ENST00000453526.2
ENST00000509427.1
neuronal regeneration related protein
chrX_+_107288197 0.03 ENST00000415430.3
V-set and immunoglobulin domain containing 1
chr1_+_175036966 0.03 ENST00000239462.4
tenascin N
chr1_+_31883048 0.03 ENST00000536859.1
serine incorporator 2
chr9_-_34729457 0.03 ENST00000378788.3
family with sequence similarity 205, member A
chr13_-_95131923 0.03 ENST00000377028.5
ENST00000446125.1
dopachrome tautomerase
chr3_+_189507432 0.03 ENST00000354600.5
tumor protein p63
chr21_+_33671160 0.02 ENST00000303645.5
melanocortin 2 receptor accessory protein
chr2_-_216003127 0.02 ENST00000412081.1
ENST00000272895.7
ATP-binding cassette, sub-family A (ABC1), member 12
chr17_-_46716647 0.02 ENST00000608940.1
RP11-357H14.17
chr19_-_7698599 0.02 ENST00000311069.5
Purkinje cell protein 2
chr11_-_26593649 0.02 ENST00000455601.2
mucin 15, cell surface associated
chrX_-_151619746 0.02 ENST00000370314.4
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr17_-_33390667 0.02 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr8_+_39792474 0.02 ENST00000502986.2
indoleamine 2,3-dioxygenase 2
chr1_-_47655686 0.02 ENST00000294338.2
PDZK1 interacting protein 1
chr8_-_10512569 0.02 ENST00000382483.3
retinitis pigmentosa 1-like 1
chr6_+_29274403 0.02 ENST00000377160.2
olfactory receptor, family 14, subfamily J, member 1
chr4_-_74486109 0.02 ENST00000395777.2
Ras association (RalGDS/AF-6) domain family member 6
chr1_-_201140673 0.01 ENST00000367333.2
transmembrane protein 9
chr4_-_74486347 0.01 ENST00000342081.3
Ras association (RalGDS/AF-6) domain family member 6
chr3_-_101039402 0.01 ENST00000193391.7
interphotoreceptor matrix proteoglycan 2
chrX_-_106243451 0.01 ENST00000355610.4
ENST00000535534.1
MORC family CW-type zinc finger 4
chr11_+_71544246 0.01 ENST00000328698.1
defensin, beta 108B
chr17_+_4613776 0.01 ENST00000269260.2
arrestin, beta 2
chr12_-_71031220 0.01 ENST00000334414.6
protein tyrosine phosphatase, receptor type, B
chr8_+_77593448 0.00 ENST00000521891.2
zinc finger homeobox 4
chr4_-_109541539 0.00 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34 antisense RNA 1 (head to head)
chr5_-_140998481 0.00 ENST00000518047.1
diaphanous-related formin 1
chr5_+_126984710 0.00 ENST00000379445.3
cortexin 3
chr10_+_18549645 0.00 ENST00000396576.2
calcium channel, voltage-dependent, beta 2 subunit
chr5_+_115177178 0.00 ENST00000316788.7
adaptor-related protein complex 3, sigma 1 subunit
chr20_+_42187608 0.00 ENST00000373100.1
serum/glucocorticoid regulated kinase 2
chr3_-_45838011 0.00 ENST00000358525.4
ENST00000413781.1
solute carrier family 6 (proline IMINO transporter), member 20
chr3_+_111718036 0.00 ENST00000455401.2
transgelin 3

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.1 0.5 GO:0060995 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.5 GO:0009956 radial pattern formation(GO:0009956)
0.1 0.4 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.4 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.2 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 0.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.4 GO:0010748 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.1 0.3 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.4 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 1.1 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.4 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.4 GO:0050942 positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.1 GO:0001692 histamine metabolic process(GO:0001692)
0.0 0.1 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.4 GO:0048853 lateral ventricle development(GO:0021670) forebrain morphogenesis(GO:0048853)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.3 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.2 GO:0015866 ADP transport(GO:0015866)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.4 GO:0048935 mechanosensory behavior(GO:0007638) peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.3 GO:0006625 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.4 GO:0042276 error-prone translesion synthesis(GO:0042276)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.4 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.4 GO:0042587 glycogen granule(GO:0042587)
0.0 0.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.5 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.4 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.3 GO:0043559 insulin binding(GO:0043559)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.4 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.4 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.5 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.4 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.2 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors