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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PPARD

Z-value: 0.38

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Transcription factors associated with PPARD

Gene Symbol Gene ID Gene Info
PPARD
ENSG00000112033.9 peroxisome proliferator activated receptor delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PPARDhg19_v2_chr6_+_35310391_35310410-0.164.4e-01Click!

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_10196981 0.51 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr19_+_10197463 0.49 ENST00000590378.1
ENST00000397881.3
C19orf66
chromosome 19 open reading frame 66
chr3_-_49314640 0.44 ENST00000436325.1
C3orf62
chromosome 3 open reading frame 62
chr16_+_81272287 0.31 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr2_+_219433588 0.30 ENST00000295701.5
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr17_+_4853442 0.25 ENST00000522301.1
ENO3
enolase 3 (beta, muscle)
chrX_-_108868390 0.24 ENST00000372101.2
KCNE1L
KCNE1-like
chr3_-_126236605 0.20 ENST00000290868.2
UROC1
urocanate hydratase 1
chr1_-_109968973 0.20 ENST00000271308.4
ENST00000538610.1
PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr11_-_45939374 0.19 ENST00000533151.1
ENST00000241041.3
PEX16
peroxisomal biogenesis factor 16
chr19_-_10687907 0.19 ENST00000589348.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr19_-_10687948 0.18 ENST00000592285.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr17_+_7483761 0.17 ENST00000584180.1
CD68
CD68 molecule
chrX_+_38211777 0.16 ENST00000039007.4
OTC
ornithine carbamoyltransferase
chr7_+_7222233 0.16 ENST00000436587.2
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr2_-_219433014 0.15 ENST00000418019.1
ENST00000454775.1
ENST00000338465.5
ENST00000415516.1
ENST00000258399.3
USP37
ubiquitin specific peptidase 37
chr15_-_82555000 0.15 ENST00000557844.1
ENST00000359445.3
ENST00000268206.7
EFTUD1
elongation factor Tu GTP binding domain containing 1
chr3_+_19189946 0.15 ENST00000328405.2
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr1_+_156123318 0.15 ENST00000368285.3
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr19_-_10687983 0.15 ENST00000587069.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chrX_+_2746818 0.15 ENST00000398806.3
GYG2
glycogenin 2
chr3_-_50605077 0.14 ENST00000426034.1
ENST00000441239.1
C3orf18
chromosome 3 open reading frame 18
chr17_-_34344991 0.14 ENST00000591423.1
CCL23
chemokine (C-C motif) ligand 23
chr14_+_32546274 0.14 ENST00000396582.2
ARHGAP5
Rho GTPase activating protein 5
chr1_+_165864800 0.13 ENST00000469256.2
UCK2
uridine-cytidine kinase 2
chr3_+_46538981 0.12 ENST00000296142.3
RTP3
receptor (chemosensory) transporter protein 3
chr11_+_111169976 0.12 ENST00000398035.2
COLCA2
colorectal cancer associated 2
chr1_+_9005917 0.12 ENST00000549778.1
ENST00000480186.3
ENST00000377443.2
ENST00000377436.3
ENST00000377442.2
CA6
carbonic anhydrase VI
chr7_+_112090483 0.12 ENST00000403825.3
ENST00000429071.1
IFRD1
interferon-related developmental regulator 1
chr17_-_34270697 0.12 ENST00000585556.1
LYZL6
lysozyme-like 6
chr14_-_25045446 0.12 ENST00000216336.2
CTSG
cathepsin G
chr17_-_34270668 0.12 ENST00000293274.4
LYZL6
lysozyme-like 6
chr1_+_165864821 0.12 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr17_-_34345002 0.12 ENST00000293280.2
CCL23
chemokine (C-C motif) ligand 23
chr6_+_31637944 0.12 ENST00000375864.4
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr1_+_244998602 0.11 ENST00000411948.2
COX20
COX20 cytochrome C oxidase assembly factor
chr17_+_48610074 0.11 ENST00000503690.1
ENST00000514874.1
ENST00000537145.1
ENST00000541226.1
EPN3
epsin 3
chr1_+_202317815 0.11 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr3_+_48507210 0.11 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
TREX1
three prime repair exonuclease 1
chr16_-_74808710 0.10 ENST00000219368.3
ENST00000544337.1
FA2H
fatty acid 2-hydroxylase
chr2_+_219283815 0.10 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1
villin 1
chr1_-_160832642 0.10 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr2_+_115919684 0.10 ENST00000310323.8
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr15_+_43885252 0.09 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr6_+_32006042 0.09 ENST00000418967.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr2_-_99871570 0.09 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr15_+_43985084 0.09 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr5_+_34757309 0.09 ENST00000397449.1
RAI14
retinoic acid induced 14
chr3_+_186383741 0.09 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr11_-_45939565 0.09 ENST00000525192.1
ENST00000378750.5
PEX16
peroxisomal biogenesis factor 16
chr6_+_32006159 0.09 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr6_+_30295036 0.09 ENST00000376659.5
ENST00000428555.1
TRIM39
tripartite motif containing 39
chr1_-_43855479 0.08 ENST00000290663.6
ENST00000372457.4
MED8
mediator complex subunit 8
chr2_+_159651821 0.08 ENST00000309950.3
ENST00000409042.1
DAPL1
death associated protein-like 1
chr6_+_33172407 0.08 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr2_-_28113217 0.08 ENST00000444339.2
RBKS
ribokinase
chr2_+_219433281 0.08 ENST00000273064.6
ENST00000509807.2
ENST00000542068.1
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr16_-_4401284 0.08 ENST00000318059.3
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr17_+_37894179 0.08 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7
growth factor receptor-bound protein 7
chr16_-_4401258 0.08 ENST00000577031.1
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr7_+_100663353 0.08 ENST00000306151.4
MUC17
mucin 17, cell surface associated
chr17_-_7123021 0.08 ENST00000399510.2
DLG4
discs, large homolog 4 (Drosophila)
chr6_-_33548006 0.08 ENST00000374467.3
BAK1
BCL2-antagonist/killer 1
chr1_-_43855444 0.08 ENST00000372455.4
MED8
mediator complex subunit 8
chr8_-_80942467 0.07 ENST00000518271.1
ENST00000276585.4
ENST00000521605.1
MRPS28
mitochondrial ribosomal protein S28
chr9_+_115142217 0.07 ENST00000398805.3
ENST00000398803.1
ENST00000262542.7
ENST00000539114.1
HSDL2
hydroxysteroid dehydrogenase like 2
chr6_-_33547975 0.07 ENST00000442998.2
ENST00000360661.5
BAK1
BCL2-antagonist/killer 1
chr5_-_156593273 0.07 ENST00000302938.4
FAM71B
family with sequence similarity 71, member B
chr15_+_82555125 0.07 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000566861.1
FAM154B
family with sequence similarity 154, member B
chr12_-_95467267 0.07 ENST00000330677.7
NR2C1
nuclear receptor subfamily 2, group C, member 1
chr20_+_39969519 0.07 ENST00000373257.3
LPIN3
lipin 3
chr1_+_43855545 0.06 ENST00000372450.4
ENST00000310739.4
SZT2
seizure threshold 2 homolog (mouse)
chr1_+_55107449 0.06 ENST00000421030.2
ENST00000545244.1
ENST00000339553.5
ENST00000409996.1
ENST00000454855.2
MROH7
maestro heat-like repeat family member 7
chr1_-_120311517 0.06 ENST00000369406.3
ENST00000544913.2
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
chr3_-_53878644 0.06 ENST00000481668.1
ENST00000467802.1
CHDH
choline dehydrogenase
chr19_+_4153598 0.06 ENST00000078445.2
ENST00000252587.3
ENST00000595923.1
ENST00000602257.1
ENST00000602147.1
CREB3L3
cAMP responsive element binding protein 3-like 3
chr22_-_51017084 0.06 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr1_+_159175201 0.06 ENST00000368121.2
DARC
Duffy blood group, atypical chemokine receptor
chr2_+_95940186 0.05 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
PROM2
prominin 2
chr14_+_32546145 0.05 ENST00000556611.1
ENST00000539826.2
ARHGAP5
Rho GTPase activating protein 5
chr10_-_74714533 0.05 ENST00000373032.3
PLA2G12B
phospholipase A2, group XIIB
chr1_-_161039456 0.05 ENST00000368016.3
ARHGAP30
Rho GTPase activating protein 30
chr20_-_44485835 0.05 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8
acyl-CoA thioesterase 8
chr1_+_43855560 0.05 ENST00000562955.1
SZT2
seizure threshold 2 homolog (mouse)
chr22_-_51016846 0.05 ENST00000312108.7
ENST00000395650.2
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr1_-_197036364 0.05 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr11_-_61659006 0.04 ENST00000278829.2
FADS3
fatty acid desaturase 3
chr2_+_120125245 0.04 ENST00000393103.2
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr10_+_94050913 0.04 ENST00000358935.2
MARCH5
membrane-associated ring finger (C3HC4) 5
chr15_+_75494214 0.04 ENST00000394987.4
C15orf39
chromosome 15 open reading frame 39
chr3_-_187009646 0.04 ENST00000296280.6
ENST00000392470.2
ENST00000169293.6
ENST00000439271.1
ENST00000392472.2
ENST00000392475.2
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr4_-_7069760 0.03 ENST00000264954.4
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr20_+_46130601 0.03 ENST00000341724.6
NCOA3
nuclear receptor coactivator 3
chr10_-_94050820 0.03 ENST00000265997.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr20_+_32077880 0.03 ENST00000342704.6
ENST00000375279.2
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr9_+_126773880 0.03 ENST00000373615.4
LHX2
LIM homeobox 2
chr4_+_159593271 0.03 ENST00000512251.1
ENST00000511912.1
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr1_-_11863171 0.03 ENST00000376592.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chrX_+_2746850 0.03 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
GYG2
glycogenin 2
chr5_+_14664762 0.02 ENST00000284274.4
FAM105B
family with sequence similarity 105, member B
chr17_-_4464081 0.02 ENST00000574154.1
GGT6
gamma-glutamyltransferase 6
chr2_-_159313214 0.02 ENST00000409889.1
ENST00000283233.5
ENST00000536771.1
CCDC148
coiled-coil domain containing 148
chr22_-_42526802 0.02 ENST00000359033.4
ENST00000389970.3
ENST00000360608.5
CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
chr3_-_125094093 0.02 ENST00000484491.1
ENST00000492394.1
ENST00000471196.1
ENST00000468369.1
ENST00000544464.1
ENST00000485866.1
ENST00000360647.4
ZNF148
zinc finger protein 148
chr19_+_17420340 0.02 ENST00000359866.4
DDA1
DET1 and DDB1 associated 1
chr12_+_96252706 0.02 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr6_+_142468361 0.02 ENST00000367630.4
VTA1
vesicle (multivesicular body) trafficking 1
chr11_+_64073699 0.01 ENST00000405666.1
ENST00000468670.1
ESRRA
estrogen-related receptor alpha
chr2_+_198365095 0.01 ENST00000409468.1
HSPE1
heat shock 10kDa protein 1
chr2_+_198365122 0.01 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr9_-_33402506 0.01 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr11_-_61658853 0.01 ENST00000525588.1
ENST00000540820.1
FADS3
fatty acid desaturase 3
chr20_+_42187608 0.01 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr2_+_73441350 0.01 ENST00000389501.4
SMYD5
SMYD family member 5
chr5_-_16509101 0.01 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr20_+_42187682 0.01 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr12_+_121163538 0.01 ENST00000242592.4
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr6_-_88299678 0.01 ENST00000369536.5
RARS2
arginyl-tRNA synthetase 2, mitochondrial
chr9_+_131037623 0.01 ENST00000495313.1
ENST00000372898.2
SWI5
SWI5 recombination repair homolog (yeast)
chr5_-_143550159 0.01 ENST00000448443.2
ENST00000513112.1
ENST00000519064.1
ENST00000274496.5
YIPF5
Yip1 domain family, member 5
chr7_+_75911902 0.01 ENST00000413003.1
SRRM3
serine/arginine repetitive matrix 3
chr12_+_131438443 0.01 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chr16_+_2255841 0.01 ENST00000301725.7
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr11_-_47470591 0.00 ENST00000524487.1
RAPSN
receptor-associated protein of the synapse
chr18_-_47340297 0.00 ENST00000586485.1
ENST00000587994.1
ENST00000586100.1
ENST00000285093.10
ACAA2
acetyl-CoA acyltransferase 2
chr11_+_66624527 0.00 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr21_-_27107198 0.00 ENST00000400094.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr21_-_27107344 0.00 ENST00000457143.2
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr21_-_27107881 0.00 ENST00000400090.3
ENST00000400087.3
ENST00000400093.3
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr11_-_47470682 0.00 ENST00000529341.1
ENST00000352508.3
RAPSN
receptor-associated protein of the synapse
chr1_-_161039647 0.00 ENST00000368013.3
ARHGAP30
Rho GTPase activating protein 30
chr21_-_27107283 0.00 ENST00000284971.3
ENST00000400099.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr16_+_2255710 0.00 ENST00000397124.1
ENST00000565250.1
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr11_-_119599794 0.00 ENST00000264025.3
PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C)
chr3_-_187009798 0.00 ENST00000337774.5
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr17_+_7123125 0.00 ENST00000356839.5
ENST00000583312.1
ENST00000350303.5
ACADVL
acyl-CoA dehydrogenase, very long chain

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 0.2 GO:0006238 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.1 0.2 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.1 0.2 GO:0002352 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0 0.1 GO:0007518 myoblast fate determination(GO:0007518)
0.0 0.2 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.1 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.1 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.1 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.1 GO:0019303 D-ribose catabolic process(GO:0019303)
0.0 0.1 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.0 0.1 GO:0070943 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) neutrophil mediated killing of bacterium(GO:0070944)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.2 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.2 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.0 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0044393 microspike(GO:0044393)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.3 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.1 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.0 0.1 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 0.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.2 GO:0042301 phosphate ion binding(GO:0042301)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D