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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for PRDM1
Z-value: 1.78
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Transcription factors associated with PRDM1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
PRDM1
|
ENSG00000057657.10 | PR/SET domain 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRDM1 | hg19_v2_chr6_+_106546808_106546833 | 0.59 | 1.8e-03 | Click! |
Activity profile of PRDM1 motif
Sorted Z-values of PRDM1 motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_29527702 | 17.91 |
ENST00000377050.4
|
UBD
|
ubiquitin D |
| chr22_-_36556821 | 10.04 |
ENST00000531095.1
ENST00000397293.2 ENST00000349314.2 |
APOL3
|
apolipoprotein L, 3 |
| chr4_+_142557717 | 10.04 |
ENST00000320650.4
ENST00000296545.7 |
IL15
|
interleukin 15 |
| chr4_+_142558078 | 9.38 |
ENST00000529613.1
|
IL15
|
interleukin 15 |
| chr4_+_142557771 | 9.18 |
ENST00000514653.1
|
IL15
|
interleukin 15 |
| chr6_+_32821924 | 8.87 |
ENST00000374859.2
ENST00000453265.2 |
PSMB9
|
proteasome (prosome, macropain) subunit, beta type, 9 |
| chr16_+_50776021 | 7.82 |
ENST00000566679.2
ENST00000564634.1 ENST00000398568.2 |
CYLD
|
cylindromatosis (turban tumor syndrome) |
| chr1_+_110453109 | 7.81 |
ENST00000525659.1
|
CSF1
|
colony stimulating factor 1 (macrophage) |
| chr17_+_41158742 | 7.57 |
ENST00000415816.2
ENST00000438323.2 |
IFI35
|
interferon-induced protein 35 |
| chr16_-_67970990 | 6.74 |
ENST00000358514.4
|
PSMB10
|
proteasome (prosome, macropain) subunit, beta type, 10 |
| chr6_+_127439749 | 6.35 |
ENST00000356698.4
|
RSPO3
|
R-spondin 3 |
| chr16_+_50775971 | 6.26 |
ENST00000311559.9
ENST00000564326.1 ENST00000566206.1 |
CYLD
|
cylindromatosis (turban tumor syndrome) |
| chr16_+_50775948 | 6.24 |
ENST00000569681.1
ENST00000569418.1 ENST00000540145.1 |
CYLD
|
cylindromatosis (turban tumor syndrome) |
| chr1_+_110453608 | 6.18 |
ENST00000369801.1
|
CSF1
|
colony stimulating factor 1 (macrophage) |
| chr1_+_110453203 | 6.00 |
ENST00000357302.4
ENST00000344188.5 ENST00000329608.6 |
CSF1
|
colony stimulating factor 1 (macrophage) |
| chr1_+_110453462 | 5.28 |
ENST00000488198.1
|
CSF1
|
colony stimulating factor 1 (macrophage) |
| chr1_+_212782012 | 5.10 |
ENST00000341491.4
ENST00000366985.1 |
ATF3
|
activating transcription factor 3 |
| chr6_-_32806506 | 4.85 |
ENST00000374897.2
ENST00000452392.2 |
TAP2
TAP2
|
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Uncharacterized protein |
| chr8_-_23540402 | 4.77 |
ENST00000523261.1
ENST00000380871.4 |
NKX3-1
|
NK3 homeobox 1 |
| chr12_-_57505121 | 4.59 |
ENST00000538913.2
ENST00000537215.2 ENST00000454075.3 ENST00000554825.1 ENST00000553275.1 ENST00000300134.3 |
STAT6
|
signal transducer and activator of transcription 6, interleukin-4 induced |
| chr11_+_93861993 | 4.57 |
ENST00000227638.3
ENST00000436171.2 |
PANX1
|
pannexin 1 |
| chr6_-_154831779 | 4.33 |
ENST00000607772.1
|
CNKSR3
|
CNKSR family member 3 |
| chr22_+_41697520 | 4.26 |
ENST00000352645.4
|
ZC3H7B
|
zinc finger CCCH-type containing 7B |
| chr17_+_74372662 | 4.24 |
ENST00000591651.1
ENST00000545180.1 |
SPHK1
|
sphingosine kinase 1 |
| chr21_+_43933946 | 4.04 |
ENST00000352133.2
|
SLC37A1
|
solute carrier family 37 (glucose-6-phosphate transporter), member 1 |
| chr6_-_137113604 | 4.01 |
ENST00000359015.4
|
MAP3K5
|
mitogen-activated protein kinase kinase kinase 5 |
| chr14_-_24615523 | 3.90 |
ENST00000559056.1
|
PSME2
|
proteasome (prosome, macropain) activator subunit 2 (PA28 beta) |
| chr14_-_24615805 | 3.80 |
ENST00000560410.1
|
PSME2
|
proteasome (prosome, macropain) activator subunit 2 (PA28 beta) |
| chr11_+_71710973 | 3.53 |
ENST00000393707.4
|
IL18BP
|
interleukin 18 binding protein |
| chr1_-_111746966 | 3.43 |
ENST00000369752.5
|
DENND2D
|
DENN/MADD domain containing 2D |
| chr5_-_94417314 | 3.27 |
ENST00000505208.1
|
MCTP1
|
multiple C2 domains, transmembrane 1 |
| chr15_+_71185148 | 3.21 |
ENST00000443425.2
ENST00000560755.1 |
LRRC49
|
leucine rich repeat containing 49 |
| chr6_+_32811885 | 3.21 |
ENST00000458296.1
ENST00000413039.1 ENST00000429600.1 ENST00000412095.1 ENST00000415067.1 ENST00000395330.1 |
TAPSAR1
PSMB9
|
TAP1 and PSMB8 antisense RNA 1 proteasome (prosome, macropain) subunit, beta type, 9 |
| chr11_+_71710648 | 3.20 |
ENST00000260049.5
|
IL18BP
|
interleukin 18 binding protein |
| chr11_+_71709938 | 3.19 |
ENST00000393705.4
ENST00000337131.5 ENST00000531053.1 ENST00000404792.1 |
IL18BP
|
interleukin 18 binding protein |
| chr15_+_71184931 | 3.01 |
ENST00000560369.1
ENST00000260382.5 |
LRRC49
|
leucine rich repeat containing 49 |
| chr5_+_96211643 | 3.00 |
ENST00000437043.3
ENST00000510373.1 |
ERAP2
|
endoplasmic reticulum aminopeptidase 2 |
| chrX_-_154563889 | 2.96 |
ENST00000369449.2
ENST00000321926.4 |
CLIC2
|
chloride intracellular channel 2 |
| chr22_-_36635684 | 2.94 |
ENST00000358502.5
|
APOL2
|
apolipoprotein L, 2 |
| chr20_+_6748311 | 2.86 |
ENST00000378827.4
|
BMP2
|
bone morphogenetic protein 2 |
| chr5_+_96212185 | 2.73 |
ENST00000379904.4
|
ERAP2
|
endoplasmic reticulum aminopeptidase 2 |
| chr1_-_205325850 | 2.71 |
ENST00000537168.1
|
KLHDC8A
|
kelch domain containing 8A |
| chr5_+_49962495 | 2.57 |
ENST00000515175.1
|
PARP8
|
poly (ADP-ribose) polymerase family, member 8 |
| chr2_-_231084820 | 2.57 |
ENST00000258382.5
ENST00000338556.3 |
SP110
|
SP110 nuclear body protein |
| chr17_+_6659153 | 2.48 |
ENST00000441631.1
ENST00000438512.1 ENST00000346752.4 ENST00000361842.3 |
XAF1
|
XIAP associated factor 1 |
| chr6_-_33282163 | 2.39 |
ENST00000434618.2
ENST00000456592.2 |
TAPBP
|
TAP binding protein (tapasin) |
| chr2_-_231084617 | 2.36 |
ENST00000409815.2
|
SP110
|
SP110 nuclear body protein |
| chr3_-_4793274 | 2.29 |
ENST00000414938.1
|
EGOT
|
eosinophil granule ontogeny transcript (non-protein coding) |
| chr5_+_112227311 | 2.22 |
ENST00000391338.1
|
ZRSR1
|
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1 |
| chr6_-_33282024 | 2.17 |
ENST00000475304.1
ENST00000489157.1 |
TAPBP
|
TAP binding protein (tapasin) |
| chr11_-_72432950 | 2.14 |
ENST00000426523.1
ENST00000429686.1 |
ARAP1
|
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 |
| chr6_-_33281979 | 2.10 |
ENST00000426633.2
ENST00000467025.1 |
TAPBP
|
TAP binding protein (tapasin) |
| chr9_-_117568365 | 2.04 |
ENST00000374045.4
|
TNFSF15
|
tumor necrosis factor (ligand) superfamily, member 15 |
| chr6_-_10412600 | 2.03 |
ENST00000379608.3
|
TFAP2A
|
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| chr14_+_24605361 | 2.01 |
ENST00000206451.6
ENST00000559123.1 |
PSME1
|
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) |
| chr14_+_24605389 | 1.98 |
ENST00000382708.3
ENST00000561435.1 |
PSME1
|
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) |
| chr6_+_32811861 | 1.88 |
ENST00000453426.1
|
TAPSAR1
|
TAP1 and PSMB8 antisense RNA 1 |
| chr11_+_64323098 | 1.86 |
ENST00000301891.4
|
SLC22A11
|
solute carrier family 22 (organic anion/urate transporter), member 11 |
| chr22_-_30642782 | 1.85 |
ENST00000249075.3
|
LIF
|
leukemia inhibitory factor |
| chr11_+_64008525 | 1.83 |
ENST00000449942.2
|
FKBP2
|
FK506 binding protein 2, 13kDa |
| chr11_+_64323428 | 1.80 |
ENST00000377581.3
|
SLC22A11
|
solute carrier family 22 (organic anion/urate transporter), member 11 |
| chr16_+_84801852 | 1.79 |
ENST00000569925.1
ENST00000567526.1 |
USP10
|
ubiquitin specific peptidase 10 |
| chr2_+_231191875 | 1.78 |
ENST00000444636.1
ENST00000415673.2 ENST00000243810.6 ENST00000396563.4 |
SP140L
|
SP140 nuclear body protein-like |
| chr19_+_34287174 | 1.76 |
ENST00000587559.1
ENST00000588637.1 |
KCTD15
|
potassium channel tetramerization domain containing 15 |
| chr11_+_64323156 | 1.74 |
ENST00000377585.3
|
SLC22A11
|
solute carrier family 22 (organic anion/urate transporter), member 11 |
| chr2_+_231280908 | 1.71 |
ENST00000427101.2
ENST00000432979.1 |
SP100
|
SP100 nuclear antigen |
| chr6_-_32811771 | 1.71 |
ENST00000395339.3
ENST00000374882.3 |
PSMB8
|
proteasome (prosome, macropain) subunit, beta type, 8 |
| chr11_+_64008443 | 1.69 |
ENST00000309366.4
|
FKBP2
|
FK506 binding protein 2, 13kDa |
| chr3_+_119013185 | 1.67 |
ENST00000264245.4
|
ARHGAP31
|
Rho GTPase activating protein 31 |
| chr2_-_202508169 | 1.63 |
ENST00000409883.2
|
TMEM237
|
transmembrane protein 237 |
| chr6_-_167276033 | 1.59 |
ENST00000503859.1
ENST00000506565.1 |
RPS6KA2
|
ribosomal protein S6 kinase, 90kDa, polypeptide 2 |
| chr6_-_167275991 | 1.57 |
ENST00000510118.1
|
RPS6KA2
|
ribosomal protein S6 kinase, 90kDa, polypeptide 2 |
| chr22_+_39436862 | 1.56 |
ENST00000381565.2
ENST00000452957.2 |
APOBEC3F
APOBEC3G
|
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G |
| chr1_+_110453514 | 1.45 |
ENST00000369802.3
ENST00000420111.2 |
CSF1
|
colony stimulating factor 1 (macrophage) |
| chr20_+_388679 | 1.41 |
ENST00000356286.5
ENST00000475269.1 |
RBCK1
|
RanBP-type and C3HC4-type zinc finger containing 1 |
| chr9_+_135457530 | 1.39 |
ENST00000263610.2
|
BARHL1
|
BarH-like homeobox 1 |
| chr21_-_35899113 | 1.39 |
ENST00000492600.1
ENST00000481448.1 ENST00000381132.2 |
RCAN1
|
regulator of calcineurin 1 |
| chr16_+_31085714 | 1.36 |
ENST00000300850.5
ENST00000564189.1 ENST00000428260.1 |
ZNF646
|
zinc finger protein 646 |
| chr17_+_7465216 | 1.34 |
ENST00000321337.7
|
SENP3
|
SUMO1/sentrin/SMT3 specific peptidase 3 |
| chr12_-_95941987 | 1.33 |
ENST00000537435.2
|
USP44
|
ubiquitin specific peptidase 44 |
| chr12_-_86650045 | 1.30 |
ENST00000604798.1
|
MGAT4C
|
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative) |
| chr3_-_167452262 | 1.29 |
ENST00000487947.2
|
PDCD10
|
programmed cell death 10 |
| chr4_+_146403912 | 1.28 |
ENST00000507367.1
ENST00000394092.2 ENST00000515385.1 |
SMAD1
|
SMAD family member 1 |
| chr1_+_17906970 | 1.26 |
ENST00000375415.1
|
ARHGEF10L
|
Rho guanine nucleotide exchange factor (GEF) 10-like |
| chr22_-_31688381 | 1.24 |
ENST00000487265.2
|
PIK3IP1
|
phosphoinositide-3-kinase interacting protein 1 |
| chr5_-_96143602 | 1.23 |
ENST00000443439.2
ENST00000503921.1 ENST00000508227.1 ENST00000507154.1 |
ERAP1
|
endoplasmic reticulum aminopeptidase 1 |
| chr2_+_145780725 | 1.19 |
ENST00000451478.1
|
TEX41
|
testis expressed 41 (non-protein coding) |
| chr13_-_95364389 | 1.19 |
ENST00000376945.2
|
SOX21
|
SRY (sex determining region Y)-box 21 |
| chr8_+_134203273 | 1.18 |
ENST00000250160.6
|
WISP1
|
WNT1 inducible signaling pathway protein 1 |
| chr7_+_134464376 | 1.18 |
ENST00000454108.1
ENST00000361675.2 |
CALD1
|
caldesmon 1 |
| chr4_-_146859787 | 1.18 |
ENST00000508784.1
|
ZNF827
|
zinc finger protein 827 |
| chr8_+_134203303 | 1.15 |
ENST00000519433.1
ENST00000517423.1 ENST00000377863.2 ENST00000220856.6 |
WISP1
|
WNT1 inducible signaling pathway protein 1 |
| chr2_+_231280954 | 1.15 |
ENST00000409824.1
ENST00000409341.1 ENST00000409112.1 ENST00000340126.4 ENST00000341950.4 |
SP100
|
SP100 nuclear antigen |
| chr12_+_6561190 | 1.14 |
ENST00000544021.1
ENST00000266556.7 |
TAPBPL
|
TAP binding protein-like |
| chr2_-_231084659 | 1.12 |
ENST00000258381.6
ENST00000358662.4 ENST00000455674.1 ENST00000392048.3 |
SP110
|
SP110 nuclear body protein |
| chr1_-_244006528 | 1.05 |
ENST00000336199.5
ENST00000263826.5 |
AKT3
|
v-akt murine thymoma viral oncogene homolog 3 |
| chr5_-_94417339 | 1.05 |
ENST00000429576.2
ENST00000508509.1 ENST00000510732.1 |
MCTP1
|
multiple C2 domains, transmembrane 1 |
| chr20_+_388935 | 1.04 |
ENST00000382181.2
ENST00000400247.3 |
RBCK1
|
RanBP-type and C3HC4-type zinc finger containing 1 |
| chr20_+_30946106 | 1.03 |
ENST00000375687.4
ENST00000542461.1 |
ASXL1
|
additional sex combs like 1 (Drosophila) |
| chr15_-_56209306 | 0.98 |
ENST00000506154.1
ENST00000338963.2 ENST00000508342.1 |
NEDD4
|
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase |
| chr6_-_9933500 | 0.98 |
ENST00000492169.1
|
OFCC1
|
orofacial cleft 1 candidate 1 |
| chr16_-_88851618 | 0.96 |
ENST00000301015.9
|
PIEZO1
|
piezo-type mechanosensitive ion channel component 1 |
| chr8_+_9009202 | 0.91 |
ENST00000518496.1
|
RP11-10A14.4
|
Uncharacterized protein |
| chr5_-_59481406 | 0.89 |
ENST00000546160.1
|
PDE4D
|
phosphodiesterase 4D, cAMP-specific |
| chr15_+_75491213 | 0.87 |
ENST00000360639.2
|
C15orf39
|
chromosome 15 open reading frame 39 |
| chr6_-_138820624 | 0.85 |
ENST00000343505.5
|
NHSL1
|
NHS-like 1 |
| chr5_-_96143796 | 0.84 |
ENST00000296754.3
|
ERAP1
|
endoplasmic reticulum aminopeptidase 1 |
| chr11_+_128563652 | 0.82 |
ENST00000527786.2
|
FLI1
|
Fli-1 proto-oncogene, ETS transcription factor |
| chr9_+_18474098 | 0.78 |
ENST00000327883.7
ENST00000431052.2 ENST00000380570.4 |
ADAMTSL1
|
ADAMTS-like 1 |
| chr11_-_85338311 | 0.78 |
ENST00000376104.2
|
DLG2
|
discs, large homolog 2 (Drosophila) |
| chr19_+_17186577 | 0.75 |
ENST00000595618.1
ENST00000594824.1 |
MYO9B
|
myosin IXB |
| chr9_+_84304628 | 0.74 |
ENST00000437181.1
|
RP11-154D17.1
|
RP11-154D17.1 |
| chr2_+_145780767 | 0.74 |
ENST00000599358.1
ENST00000596278.1 ENST00000596747.1 ENST00000608652.1 ENST00000609705.1 ENST00000608432.1 ENST00000596970.1 ENST00000602041.1 ENST00000601578.1 ENST00000596034.1 ENST00000414195.2 ENST00000594837.1 |
TEX41
|
testis expressed 41 (non-protein coding) |
| chr12_-_106641728 | 0.73 |
ENST00000378026.4
|
CKAP4
|
cytoskeleton-associated protein 4 |
| chr22_-_31688431 | 0.73 |
ENST00000402249.3
ENST00000443175.1 ENST00000215912.5 ENST00000441972.1 |
PIK3IP1
|
phosphoinositide-3-kinase interacting protein 1 |
| chr3_-_44552094 | 0.73 |
ENST00000436261.1
|
ZNF852
|
zinc finger protein 852 |
| chr11_+_60609537 | 0.72 |
ENST00000227520.5
|
CCDC86
|
coiled-coil domain containing 86 |
| chr2_+_145780739 | 0.71 |
ENST00000597173.1
ENST00000602108.1 ENST00000420472.1 |
TEX41
|
testis expressed 41 (non-protein coding) |
| chr7_+_134464414 | 0.70 |
ENST00000361901.2
|
CALD1
|
caldesmon 1 |
| chr10_-_112678692 | 0.70 |
ENST00000605742.1
|
BBIP1
|
BBSome interacting protein 1 |
| chr8_+_120079478 | 0.69 |
ENST00000332843.2
|
COLEC10
|
collectin sub-family member 10 (C-type lectin) |
| chr16_+_30675654 | 0.68 |
ENST00000287468.5
ENST00000395073.2 |
FBRS
|
fibrosin |
| chrX_-_118826784 | 0.65 |
ENST00000394616.4
|
SEPT6
|
septin 6 |
| chr3_-_167452298 | 0.65 |
ENST00000475915.2
ENST00000462725.2 ENST00000461494.1 |
PDCD10
|
programmed cell death 10 |
| chr4_-_111558135 | 0.64 |
ENST00000394598.2
ENST00000394595.3 |
PITX2
|
paired-like homeodomain 2 |
| chr8_+_77593448 | 0.63 |
ENST00000521891.2
|
ZFHX4
|
zinc finger homeobox 4 |
| chr4_-_140544386 | 0.62 |
ENST00000561977.1
|
RP11-308D13.3
|
RP11-308D13.3 |
| chr11_+_128634589 | 0.59 |
ENST00000281428.8
|
FLI1
|
Fli-1 proto-oncogene, ETS transcription factor |
| chr10_-_73976884 | 0.58 |
ENST00000317126.4
ENST00000545550.1 |
ASCC1
|
activating signal cointegrator 1 complex subunit 1 |
| chr6_-_105584560 | 0.58 |
ENST00000336775.5
|
BVES
|
blood vessel epicardial substance |
| chrX_-_118827113 | 0.57 |
ENST00000394617.2
|
SEPT6
|
septin 6 |
| chr7_-_31380502 | 0.56 |
ENST00000297142.3
|
NEUROD6
|
neuronal differentiation 6 |
| chr16_-_31085514 | 0.56 |
ENST00000300849.4
|
ZNF668
|
zinc finger protein 668 |
| chr12_-_50561075 | 0.55 |
ENST00000422340.2
ENST00000317551.6 |
CERS5
|
ceramide synthase 5 |
| chr11_+_128563948 | 0.55 |
ENST00000534087.2
|
FLI1
|
Fli-1 proto-oncogene, ETS transcription factor |
| chr2_-_175260368 | 0.55 |
ENST00000342016.3
ENST00000362053.5 |
CIR1
|
corepressor interacting with RBPJ, 1 |
| chr6_+_105404899 | 0.52 |
ENST00000345080.4
|
LIN28B
|
lin-28 homolog B (C. elegans) |
| chr1_-_182360918 | 0.51 |
ENST00000339526.4
|
GLUL
|
glutamate-ammonia ligase |
| chr16_-_72206034 | 0.49 |
ENST00000537465.1
ENST00000237353.10 |
PMFBP1
|
polyamine modulated factor 1 binding protein 1 |
| chr2_-_209010874 | 0.49 |
ENST00000260988.4
|
CRYGB
|
crystallin, gamma B |
| chr20_-_57089934 | 0.49 |
ENST00000439429.1
ENST00000371149.3 |
APCDD1L
|
adenomatosis polyposis coli down-regulated 1-like |
| chr6_+_31540056 | 0.48 |
ENST00000418386.2
|
LTA
|
lymphotoxin alpha |
| chr1_-_217250231 | 0.47 |
ENST00000493748.1
ENST00000463665.1 |
ESRRG
|
estrogen-related receptor gamma |
| chr2_-_145275228 | 0.47 |
ENST00000427902.1
ENST00000409487.3 ENST00000470879.1 ENST00000435831.1 |
ZEB2
|
zinc finger E-box binding homeobox 2 |
| chr8_+_77593474 | 0.46 |
ENST00000455469.2
ENST00000050961.6 |
ZFHX4
|
zinc finger homeobox 4 |
| chr1_+_28099683 | 0.45 |
ENST00000373943.4
|
STX12
|
syntaxin 12 |
| chr4_-_100242549 | 0.45 |
ENST00000305046.8
ENST00000394887.3 |
ADH1B
|
alcohol dehydrogenase 1B (class I), beta polypeptide |
| chr2_+_175260514 | 0.45 |
ENST00000424069.1
ENST00000427038.1 |
SCRN3
|
secernin 3 |
| chr7_+_128355439 | 0.43 |
ENST00000315184.5
|
FAM71F1
|
family with sequence similarity 71, member F1 |
| chr3_+_35682913 | 0.43 |
ENST00000449196.1
|
ARPP21
|
cAMP-regulated phosphoprotein, 21kDa |
| chr2_+_166150541 | 0.43 |
ENST00000283256.6
|
SCN2A
|
sodium channel, voltage-gated, type II, alpha subunit |
| chr11_-_40315640 | 0.42 |
ENST00000278198.2
|
LRRC4C
|
leucine rich repeat containing 4C |
| chr7_-_86849025 | 0.42 |
ENST00000257637.3
|
TMEM243
|
transmembrane protein 243, mitochondrial |
| chr8_+_77318769 | 0.41 |
ENST00000518732.1
|
RP11-706J10.1
|
long intergenic non-protein coding RNA 1111 |
| chr17_-_79818354 | 0.40 |
ENST00000576541.1
ENST00000576380.1 ENST00000571617.1 ENST00000576052.1 ENST00000576390.1 ENST00000573778.2 ENST00000439918.2 ENST00000574914.1 ENST00000331483.4 |
P4HB
|
prolyl 4-hydroxylase, beta polypeptide |
| chr5_+_140430979 | 0.39 |
ENST00000306549.3
|
PCDHB1
|
protocadherin beta 1 |
| chr20_+_388791 | 0.37 |
ENST00000441733.1
ENST00000353660.3 |
RBCK1
|
RanBP-type and C3HC4-type zinc finger containing 1 |
| chr1_+_156737292 | 0.37 |
ENST00000271526.4
ENST00000353233.3 |
PRCC
|
papillary renal cell carcinoma (translocation-associated) |
| chr1_-_205326022 | 0.36 |
ENST00000367155.3
|
KLHDC8A
|
kelch domain containing 8A |
| chr2_+_29336855 | 0.36 |
ENST00000404424.1
|
CLIP4
|
CAP-GLY domain containing linker protein family, member 4 |
| chr6_+_146348782 | 0.35 |
ENST00000361719.2
ENST00000392299.2 |
GRM1
|
glutamate receptor, metabotropic 1 |
| chr1_+_181003067 | 0.35 |
ENST00000434571.2
ENST00000367579.3 ENST00000282990.6 ENST00000367580.5 |
MR1
|
major histocompatibility complex, class I-related |
| chr6_+_26156551 | 0.35 |
ENST00000304218.3
|
HIST1H1E
|
histone cluster 1, H1e |
| chr18_+_34124507 | 0.32 |
ENST00000591635.1
|
FHOD3
|
formin homology 2 domain containing 3 |
| chr2_+_12246664 | 0.32 |
ENST00000449986.1
|
AC096559.1
|
AC096559.1 |
| chr13_+_102104980 | 0.31 |
ENST00000545560.2
|
ITGBL1
|
integrin, beta-like 1 (with EGF-like repeat domains) |
| chr18_-_19994830 | 0.29 |
ENST00000525417.1
|
CTAGE1
|
cutaneous T-cell lymphoma-associated antigen 1 |
| chr7_-_143059845 | 0.28 |
ENST00000443739.2
|
FAM131B
|
family with sequence similarity 131, member B |
| chr17_-_56606639 | 0.27 |
ENST00000579371.1
|
SEPT4
|
septin 4 |
| chr17_-_56606664 | 0.27 |
ENST00000580844.1
|
SEPT4
|
septin 4 |
| chr17_-_56606705 | 0.27 |
ENST00000317268.3
|
SEPT4
|
septin 4 |
| chr1_-_205326161 | 0.27 |
ENST00000367156.3
ENST00000606887.1 ENST00000607173.1 |
KLHDC8A
|
kelch domain containing 8A |
| chr1_+_2985760 | 0.25 |
ENST00000378391.2
ENST00000514189.1 ENST00000270722.5 |
PRDM16
|
PR domain containing 16 |
| chr6_+_146348810 | 0.24 |
ENST00000492807.2
|
GRM1
|
glutamate receptor, metabotropic 1 |
| chr7_-_143059780 | 0.24 |
ENST00000409578.1
ENST00000409346.1 |
FAM131B
|
family with sequence similarity 131, member B |
| chr19_-_43032532 | 0.23 |
ENST00000403461.1
ENST00000352591.5 ENST00000358394.3 ENST00000403444.3 ENST00000308072.4 ENST00000599389.1 ENST00000351134.3 ENST00000161559.6 |
CEACAM1
|
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) |
| chr19_+_49977818 | 0.23 |
ENST00000594009.1
ENST00000595510.1 |
FLT3LG
|
fms-related tyrosine kinase 3 ligand |
| chr2_-_70475586 | 0.21 |
ENST00000416149.2
|
TIA1
|
TIA1 cytotoxic granule-associated RNA binding protein |
| chr12_-_86650077 | 0.21 |
ENST00000552808.2
ENST00000547225.1 |
MGAT4C
|
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative) |
| chr3_+_159706537 | 0.21 |
ENST00000305579.2
ENST00000480787.1 ENST00000466512.1 |
IL12A
|
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) |
| chr5_+_76506706 | 0.18 |
ENST00000340978.3
ENST00000346042.3 ENST00000264917.5 ENST00000342343.4 ENST00000333194.4 |
PDE8B
|
phosphodiesterase 8B |
| chr6_+_108616243 | 0.16 |
ENST00000421954.1
|
LACE1
|
lactation elevated 1 |
| chr5_-_149380698 | 0.12 |
ENST00000296736.3
|
TIGD6
|
tigger transposable element derived 6 |
| chr4_+_186990298 | 0.12 |
ENST00000296795.3
ENST00000513189.1 |
TLR3
|
toll-like receptor 3 |
| chr4_+_15376165 | 0.12 |
ENST00000382383.3
ENST00000429690.1 |
C1QTNF7
|
C1q and tumor necrosis factor related protein 7 |
| chr2_-_64246206 | 0.12 |
ENST00000409558.4
ENST00000272322.4 |
VPS54
|
vacuolar protein sorting 54 homolog (S. cerevisiae) |
| chr12_+_10163231 | 0.11 |
ENST00000396502.1
ENST00000338896.5 |
CLEC12B
|
C-type lectin domain family 12, member B |
| chr21_+_22370608 | 0.11 |
ENST00000400546.1
|
NCAM2
|
neural cell adhesion molecule 2 |
| chr10_+_62538089 | 0.10 |
ENST00000519078.2
ENST00000395284.3 ENST00000316629.4 |
CDK1
|
cyclin-dependent kinase 1 |
| chr13_+_24144509 | 0.09 |
ENST00000248484.4
|
TNFRSF19
|
tumor necrosis factor receptor superfamily, member 19 |
| chr18_+_18943554 | 0.09 |
ENST00000580732.2
|
GREB1L
|
growth regulation by estrogen in breast cancer-like |
| chr5_-_64064508 | 0.08 |
ENST00000513458.4
|
SREK1IP1
|
SREK1-interacting protein 1 |
| chr10_-_82049424 | 0.07 |
ENST00000372213.3
|
MAT1A
|
methionine adenosyltransferase I, alpha |
| chr4_-_153303658 | 0.06 |
ENST00000296555.5
|
FBXW7
|
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
| chr2_+_69240415 | 0.06 |
ENST00000409829.3
|
ANTXR1
|
anthrax toxin receptor 1 |
| chr1_+_215747118 | 0.04 |
ENST00000448333.1
|
KCTD3
|
potassium channel tetramerization domain containing 3 |
| chr9_+_137533615 | 0.04 |
ENST00000371817.3
|
COL5A1
|
collagen, type V, alpha 1 |
| chr1_-_182361327 | 0.02 |
ENST00000331872.6
ENST00000311223.5 |
GLUL
|
glutamate-ammonia ligase |
| chr17_-_43339453 | 0.00 |
ENST00000543122.1
|
SPATA32
|
spermatogenesis associated 32 |
| chr17_+_57232690 | 0.00 |
ENST00000262293.4
|
PRR11
|
proline rich 11 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PRDM1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.5 | 28.6 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 6.8 | 20.3 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 5.3 | 26.7 | GO:0060611 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 3.6 | 17.9 | GO:0070842 | aggresome assembly(GO:0070842) |
| 2.2 | 6.7 | GO:0050822 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 1.7 | 5.1 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 1.4 | 4.2 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 1.2 | 3.6 | GO:0002476 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476) |
| 1.1 | 4.6 | GO:0002296 | T-helper 1 cell lineage commitment(GO:0002296) |
| 1.1 | 1.1 | GO:0002589 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) |
| 1.1 | 4.6 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 1.0 | 2.9 | GO:0060129 | thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) |
| 0.9 | 7.8 | GO:0002483 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.8 | 4.8 | GO:2000836 | androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836) |
| 0.7 | 2.9 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) |
| 0.5 | 2.1 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.5 | 2.0 | GO:0003409 | optic cup structural organization(GO:0003409) |
| 0.5 | 1.8 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.5 | 6.3 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.4 | 4.0 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.4 | 2.0 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.4 | 5.4 | GO:0015747 | urate transport(GO:0015747) |
| 0.4 | 9.9 | GO:1900115 | extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116) |
| 0.4 | 2.8 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.3 | 1.0 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.3 | 1.9 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.3 | 31.0 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.2 | 1.0 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 0.2 | 1.0 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 0.2 | 0.6 | GO:0060578 | subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578) |
| 0.2 | 1.6 | GO:0006216 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.2 | 3.5 | GO:0010666 | positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) |
| 0.2 | 3.0 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
| 0.2 | 0.8 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.2 | 0.5 | GO:0002874 | regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) |
| 0.1 | 0.5 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.1 | 1.3 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.1 | 4.3 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity(GO:2000651) |
| 0.1 | 1.3 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.1 | 0.9 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.1 | 2.2 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 10.1 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.1 | 0.5 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.1 | 2.0 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 0.2 | GO:0002856 | negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859) regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318) insulin catabolic process(GO:1901143) |
| 0.1 | 0.2 | GO:0090290 | positive regulation of osteoclast proliferation(GO:0090290) |
| 0.1 | 1.0 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.1 | 0.6 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 0.1 | 0.5 | GO:0070309 | lens fiber cell morphogenesis(GO:0070309) |
| 0.1 | 0.7 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.1 | 3.5 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 0.5 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.1 | 0.8 | GO:0035385 | Roundabout signaling pathway(GO:0035385) |
| 0.1 | 1.3 | GO:0090266 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.1 | 0.9 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.1 | 0.7 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.4 | GO:0034378 | chylomicron assembly(GO:0034378) |
| 0.0 | 13.0 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 0.0 | 0.6 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.0 | 0.3 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.0 | 0.4 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 0.0 | 0.2 | GO:0002855 | natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) |
| 0.0 | 0.3 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.0 | 0.3 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.8 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.0 | 0.2 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
| 0.0 | 0.1 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.0 | 0.1 | GO:2000639 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.0 | 0.1 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.0 | 0.0 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.0 | 0.4 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 0.1 | GO:0002767 | immune response-inhibiting cell surface receptor signaling pathway(GO:0002767) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 26.7 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 2.3 | 20.5 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 1.9 | 11.7 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 1.7 | 5.1 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 1.5 | 10.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.8 | 4.0 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.6 | 2.8 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.5 | 1.6 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.3 | 20.3 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.3 | 2.9 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.3 | 2.2 | GO:0089701 | U2AF(GO:0089701) |
| 0.3 | 17.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 4.6 | GO:0032059 | bleb(GO:0032059) |
| 0.2 | 0.5 | GO:0032173 | septin ring(GO:0005940) septin collar(GO:0032173) |
| 0.1 | 0.6 | GO:0038038 | G-protein coupled receptor homodimeric complex(GO:0038038) |
| 0.1 | 1.9 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 0.4 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.1 | 0.8 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.1 | 0.7 | GO:0034464 | BBSome(GO:0034464) |
| 0.1 | 1.3 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.0 | 1.6 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 24.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 3.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.2 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.0 | 0.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 1.3 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 1.0 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 2.7 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.5 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.0 | 0.3 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.8 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.1 | GO:0000938 | GARP complex(GO:0000938) |
| 0.0 | 0.4 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 4.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 2.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 7.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.5 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 0.2 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 6.5 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 1.0 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 0.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 3.5 | GO:0045121 | membrane raft(GO:0045121) |
| 0.0 | 2.6 | GO:0098802 | plasma membrane receptor complex(GO:0098802) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 26.7 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 3.3 | 9.9 | GO:0042007 | interleukin-18 binding(GO:0042007) |
| 2.0 | 10.2 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 1.6 | 20.3 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 1.5 | 11.7 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.9 | 4.6 | GO:0055077 | gap junction hemi-channel activity(GO:0055077) |
| 0.9 | 17.9 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.8 | 4.8 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.7 | 4.2 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.7 | 2.0 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.6 | 19.3 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.6 | 4.0 | GO:0015315 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.5 | 2.1 | GO:0005151 | interleukin-1, Type II receptor binding(GO:0005151) |
| 0.4 | 5.4 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.4 | 2.9 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.3 | 1.6 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
| 0.3 | 2.9 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.3 | 2.2 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.3 | 5.7 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.2 | 1.4 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.2 | 1.5 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.2 | 2.9 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.2 | 1.8 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 6.3 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 0.5 | GO:0016880 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.1 | 1.0 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.1 | 1.3 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.1 | 3.5 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 2.1 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.1 | 3.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 25.8 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 1.3 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.1 | 0.8 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.1 | 0.6 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
| 0.1 | 2.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 1.0 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 0.5 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.1 | 2.6 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 1.0 | GO:0008381 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.1 | 2.3 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.1 | 1.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 6.6 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 0.3 | GO:0032564 | adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564) |
| 0.1 | 0.4 | GO:0019798 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 0.1 | 0.9 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.1 | 4.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.6 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.0 | 7.7 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.0 | 3.2 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 0.7 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 3.1 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.4 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.0 | 1.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 2.8 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 0.4 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 0.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.8 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 1.3 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 0.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.6 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 2.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 26.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.5 | 20.3 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 4.2 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 5.6 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.1 | 4.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 3.2 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.1 | 1.3 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 29.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 4.3 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 2.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.6 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 1.0 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 2.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 31.0 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.4 | 20.3 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.3 | 4.6 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 5.4 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.2 | 1.6 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.2 | 3.6 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 5.1 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 10.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 4.8 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 4.1 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 2.1 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 3.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 1.0 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 1.5 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 2.6 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 4.6 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 0.6 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.5 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.3 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.1 | REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.0 | 0.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |