Project

Inflammatory response time course, HUVEC (Wada et al., 2009)

Navigation
Downloads

Results for PRDM14

Z-value: 0.36

Motif logo

logo of

Transcription factors associated with PRDM14

Gene Symbol Gene ID Gene Info
PRDM14
ENSG00000147596.3 PR/SET domain 14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM14hg19_v2_chr8_-_70983506_70983562-0.106.2e-01Click!

Activity profile of PRDM14 motif

Sorted Z-values of PRDM14 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_26934165 1.49 ENST00000456917.1
MIR155HG
MIR155 host gene (non-protein coding)
chr18_+_57567180 1.00 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr5_-_16936340 0.81 ENST00000507288.1
ENST00000513610.1
MYO10
myosin X
chr7_-_139763521 0.80 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr2_-_145278475 0.66 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr12_+_121647962 0.61 ENST00000542067.1
P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr12_+_121647868 0.58 ENST00000359949.7
ENST00000541532.1
ENST00000543171.1
ENST00000538701.1
P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr2_-_208030647 0.57 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr2_-_145277882 0.39 ENST00000465070.1
ENST00000444559.1
ZEB2
zinc finger E-box binding homeobox 2
chr11_-_105892937 0.36 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr12_-_49351148 0.30 ENST00000398092.4
ENST00000539611.1
RP11-302B13.5
ARF3
ADP-ribosylation factor 3
ADP-ribosylation factor 3
chr1_+_156052354 0.29 ENST00000368301.2
LMNA
lamin A/C
chr2_-_69098566 0.28 ENST00000295379.1
BMP10
bone morphogenetic protein 10
chr4_+_81187753 0.28 ENST00000312465.7
ENST00000456523.3
FGF5
fibroblast growth factor 5
chrX_+_119292467 0.27 ENST00000371388.3
RHOXF2
Rhox homeobox family, member 2
chr3_-_155394152 0.25 ENST00000494598.1
PLCH1
phospholipase C, eta 1
chr12_-_49351303 0.25 ENST00000256682.4
ARF3
ADP-ribosylation factor 3
chr12_-_49351228 0.23 ENST00000541959.1
ENST00000447318.2
ARF3
ADP-ribosylation factor 3
chr1_+_36621529 0.23 ENST00000316156.4
MAP7D1
MAP7 domain containing 1
chr12_+_49760639 0.22 ENST00000549538.1
ENST00000548654.1
ENST00000550643.1
ENST00000548710.1
ENST00000549179.1
ENST00000548377.1
SPATS2
spermatogenesis associated, serine-rich 2
chr17_-_17485731 0.22 ENST00000395783.1
PEMT
phosphatidylethanolamine N-methyltransferase
chr5_-_24645078 0.21 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chrX_+_15525426 0.21 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr3_+_10289707 0.20 ENST00000287652.4
TATDN2
TatD DNase domain containing 2
chr1_-_182642017 0.18 ENST00000367557.4
ENST00000258302.4
RGS8
regulator of G-protein signaling 8
chr5_-_135528822 0.17 ENST00000607574.1
AC009014.3
AC009014.3
chr1_+_155006300 0.16 ENST00000295542.1
ENST00000392480.1
ENST00000423025.2
ENST00000368419.2
DCST1
DC-STAMP domain containing 1
chr11_-_65624415 0.16 ENST00000524553.1
ENST00000527344.1
CFL1
cofilin 1 (non-muscle)
chr1_-_42384343 0.16 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr5_+_32711419 0.15 ENST00000265074.8
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr1_+_50571949 0.15 ENST00000357083.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr6_-_109777128 0.15 ENST00000358807.3
ENST00000358577.3
MICAL1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr4_+_4861385 0.15 ENST00000382723.4
MSX1
msh homeobox 1
chrX_+_41193407 0.14 ENST00000457138.2
ENST00000441189.2
DDX3X
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr2_-_228244013 0.14 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr12_+_3600356 0.14 ENST00000382622.3
PRMT8
protein arginine methyltransferase 8
chr5_-_108063949 0.13 ENST00000606054.1
LINC01023
long intergenic non-protein coding RNA 1023
chr15_+_45694523 0.13 ENST00000305560.6
SPATA5L1
spermatogenesis associated 5-like 1
chr11_-_46615498 0.12 ENST00000533727.1
ENST00000534300.1
ENST00000528950.1
ENST00000526606.1
AMBRA1
autophagy/beclin-1 regulator 1
chr7_+_39989611 0.12 ENST00000181839.4
CDK13
cyclin-dependent kinase 13
chr9_+_87283430 0.11 ENST00000376214.1
ENST00000376213.1
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr14_-_21492113 0.11 ENST00000554094.1
NDRG2
NDRG family member 2
chr8_+_110346546 0.10 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
ENY2
enhancer of yellow 2 homolog (Drosophila)
chr11_+_62475130 0.10 ENST00000294117.5
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr1_-_155006224 0.09 ENST00000368424.3
DCST2
DC-STAMP domain containing 2
chr17_+_39994032 0.09 ENST00000293303.4
ENST00000438813.1
KLHL10
kelch-like family member 10
chr1_-_116383322 0.09 ENST00000429731.1
NHLH2
nescient helix loop helix 2
chr17_-_19651654 0.08 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr14_-_21492251 0.07 ENST00000554398.1
NDRG2
NDRG family member 2
chr20_-_3154162 0.07 ENST00000360342.3
LZTS3
Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA.
chr19_+_49838653 0.07 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37
CD37 molecule
chr11_-_65625014 0.07 ENST00000534784.1
CFL1
cofilin 1 (non-muscle)
chr17_+_36873677 0.06 ENST00000471200.1
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr22_-_29457832 0.06 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr2_-_37193606 0.06 ENST00000379213.2
ENST00000263918.4
STRN
striatin, calmodulin binding protein
chr17_-_19651668 0.06 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr4_-_103266626 0.05 ENST00000356736.4
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr11_+_85566422 0.05 ENST00000342404.3
CCDC83
coiled-coil domain containing 83
chr7_-_30066233 0.04 ENST00000222803.5
FKBP14
FK506 binding protein 14, 22 kDa
chr11_+_15136462 0.04 ENST00000379556.3
ENST00000424273.1
INSC
inscuteable homolog (Drosophila)
chr6_-_46048116 0.04 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr3_+_155838337 0.03 ENST00000490337.1
ENST00000389636.5
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr2_-_192711968 0.03 ENST00000304141.4
SDPR
serum deprivation response
chr15_+_63188009 0.02 ENST00000557900.1
RP11-1069G10.2
RP11-1069G10.2
chr16_-_55866997 0.02 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr5_+_32710736 0.01 ENST00000415685.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr3_-_155394099 0.01 ENST00000414191.1
PLCH1
phospholipase C, eta 1
chr7_-_124405681 0.00 ENST00000303921.2
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr7_-_44580861 0.00 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 1.2 GO:0032306 regulation of prostaglandin secretion(GO:0032306) positive regulation of prostaglandin secretion(GO:0032308)
0.1 1.0 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.1 0.3 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.1 GO:0090427 activation of meiosis(GO:0090427)
0.0 0.3 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.2 GO:2000784 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.1 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.1 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.0 0.2 GO:0050747 sphingomyelin biosynthetic process(GO:0006686) positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 0.2 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.1 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0 0.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.2 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.3 GO:0023019 signal transduction involved in regulation of gene expression(GO:0023019)
0.0 0.8 GO:0051489 regulation of filopodium assembly(GO:0051489)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.8 GO:0032433 filopodium tip(GO:0032433)
0.0 0.1 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.8 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.3 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
0.1 0.2 GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.1 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.0 0.3 GO:0031433 telethonin binding(GO:0031433)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.0 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.1 GO:0033592 RNA strand annealing activity(GO:0033592)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling