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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PRDM4

Z-value: 0.28

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Transcription factors associated with PRDM4

Gene Symbol Gene ID Gene Info
PRDM4
ENSG00000110851.7 PR/SET domain 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM4hg19_v2_chr12_-_108154925_1081549450.281.7e-01Click!

Activity profile of PRDM4 motif

Sorted Z-values of PRDM4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_127263265 0.86 ENST00000373587.3
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr22_-_50050986 0.49 ENST00000405854.1
C22orf34
chromosome 22 open reading frame 34
chr11_-_85393886 0.41 ENST00000534224.1
CREBZF
CREB/ATF bZIP transcription factor
chr17_+_42634844 0.33 ENST00000315323.3
FZD2
frizzled family receptor 2
chr10_-_105212141 0.31 ENST00000369788.3
CALHM2
calcium homeostasis modulator 2
chr14_+_32030582 0.27 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr1_+_27114418 0.26 ENST00000078527.4
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr7_+_90893783 0.25 ENST00000287934.2
FZD1
frizzled family receptor 1
chr19_+_41117770 0.21 ENST00000601032.1
LTBP4
latent transforming growth factor beta binding protein 4
chr1_+_27114589 0.20 ENST00000431541.1
ENST00000449950.2
ENST00000374145.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr9_+_139560197 0.19 ENST00000371698.3
EGFL7
EGF-like-domain, multiple 7
chr1_+_43232913 0.19 ENST00000372525.5
ENST00000536543.1
C1orf50
chromosome 1 open reading frame 50
chr3_+_16926441 0.19 ENST00000418129.2
ENST00000396755.2
PLCL2
phospholipase C-like 2
chr7_-_38398721 0.18 ENST00000390346.2
TRGV3
T cell receptor gamma variable 3
chr6_-_8064567 0.16 ENST00000543936.1
ENST00000397457.2
BLOC1S5
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr2_+_219264466 0.16 ENST00000273062.2
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr5_-_78281603 0.16 ENST00000264914.4
ARSB
arylsulfatase B
chr10_+_88728189 0.16 ENST00000416348.1
ADIRF
adipogenesis regulatory factor
chr2_-_8723918 0.15 ENST00000454224.1
AC011747.4
AC011747.4
chr8_+_94712732 0.14 ENST00000518322.1
FAM92A1
family with sequence similarity 92, member A1
chr1_-_161168834 0.14 ENST00000367995.3
ENST00000367996.5
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chrX_-_73072534 0.14 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr16_+_29823427 0.14 ENST00000358758.7
ENST00000567659.1
ENST00000572820.1
PRRT2
proline-rich transmembrane protein 2
chr11_+_47279504 0.13 ENST00000441012.2
ENST00000437276.1
ENST00000436029.1
ENST00000467728.1
ENST00000405853.3
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr11_-_40314652 0.13 ENST00000527150.1
LRRC4C
leucine rich repeat containing 4C
chr9_-_70488865 0.13 ENST00000377392.5
CBWD5
COBW domain containing 5
chr8_+_94712752 0.12 ENST00000522324.1
ENST00000522803.1
ENST00000423990.2
FAM92A1
family with sequence similarity 92, member A1
chr19_-_11639910 0.12 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr20_-_49639631 0.11 ENST00000424171.1
ENST00000439216.1
ENST00000371571.4
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr1_+_171750776 0.11 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
METTL13
methyltransferase like 13
chr5_-_102455801 0.11 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr6_+_26045603 0.10 ENST00000540144.1
HIST1H3C
histone cluster 1, H3c
chr16_+_29823552 0.10 ENST00000300797.6
PRRT2
proline-rich transmembrane protein 2
chr6_-_24721054 0.10 ENST00000378119.4
C6orf62
chromosome 6 open reading frame 62
chr19_-_11639931 0.09 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT
ECSIT signalling integrator
chr1_+_55107449 0.09 ENST00000421030.2
ENST00000545244.1
ENST00000339553.5
ENST00000409996.1
ENST00000454855.2
MROH7
maestro heat-like repeat family member 7
chr1_+_6511651 0.08 ENST00000434576.1
ESPN
espin
chr15_+_45315302 0.08 ENST00000267814.9
SORD
sorbitol dehydrogenase
chr2_-_179343226 0.08 ENST00000434643.2
FKBP7
FK506 binding protein 7
chr5_-_78281775 0.08 ENST00000396151.3
ENST00000565165.1
ARSB
arylsulfatase B
chr5_-_180688105 0.07 ENST00000327767.4
TRIM52
tripartite motif containing 52
chr12_+_15475462 0.07 ENST00000543886.1
ENST00000348962.2
PTPRO
protein tyrosine phosphatase, receptor type, O
chr19_-_35264089 0.06 ENST00000588760.1
ENST00000329285.8
ENST00000587354.2
ZNF599
zinc finger protein 599
chrX_+_115567767 0.06 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr13_+_52436111 0.06 ENST00000242819.4
CCDC70
coiled-coil domain containing 70
chr1_-_68516393 0.06 ENST00000395201.1
DIRAS3
DIRAS family, GTP-binding RAS-like 3
chrX_+_15808569 0.06 ENST00000380308.3
ENST00000307771.7
ZRSR2
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
chr5_+_102455968 0.06 ENST00000358359.3
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr16_+_29674540 0.06 ENST00000436527.1
ENST00000360121.3
ENST00000449759.1
SPN
QPRT
sialophorin
quinolinate phosphoribosyltransferase
chr2_-_179343268 0.05 ENST00000424785.2
FKBP7
FK506 binding protein 7
chr5_+_159343688 0.05 ENST00000306675.3
ADRA1B
adrenoceptor alpha 1B
chr5_+_140261703 0.05 ENST00000409494.1
ENST00000289272.2
PCDHA13
protocadherin alpha 13
chr15_-_66797172 0.05 ENST00000569438.1
ENST00000569696.1
ENST00000307961.6
RPL4
ribosomal protein L4
chr12_+_15475331 0.04 ENST00000281171.4
PTPRO
protein tyrosine phosphatase, receptor type, O
chr11_+_55578854 0.04 ENST00000333973.2
OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr9_+_96338647 0.04 ENST00000359246.4
PHF2
PHD finger protein 2
chr7_-_23571586 0.04 ENST00000538367.1
ENST00000392502.4
ENST00000297071.4
TRA2A
transformer 2 alpha homolog (Drosophila)
chr1_+_172502336 0.04 ENST00000263688.3
SUCO
SUN domain containing ossification factor
chr3_+_148709128 0.04 ENST00000345003.4
ENST00000296048.6
ENST00000483267.1
GYG1
glycogenin 1
chr19_+_42724423 0.03 ENST00000301215.3
ENST00000597945.1
ZNF526
zinc finger protein 526
chr5_+_102455853 0.03 ENST00000515845.1
ENST00000321521.9
ENST00000507921.1
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr4_-_83295103 0.03 ENST00000313899.7
ENST00000352301.4
ENST00000509107.1
ENST00000353341.4
ENST00000541060.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr3_+_148709310 0.03 ENST00000484197.1
ENST00000492285.2
ENST00000461191.1
GYG1
glycogenin 1
chr20_+_30555805 0.03 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr16_+_15068955 0.02 ENST00000396410.4
ENST00000569715.1
ENST00000450288.2
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr11_+_19138670 0.02 ENST00000446113.2
ENST00000399351.3
ZDHHC13
zinc finger, DHHC-type containing 13
chr1_+_151043070 0.01 ENST00000368918.3
ENST00000368917.1
GABPB2
GA binding protein transcription factor, beta subunit 2
chr9_-_16727978 0.01 ENST00000418777.1
ENST00000468187.2
BNC2
basonuclin 2
chr20_+_62697564 0.01 ENST00000458442.1
TCEA2
transcription elongation factor A (SII), 2
chr22_+_38864041 0.00 ENST00000216014.4
ENST00000409006.3
KDELR3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr20_-_61569227 0.00 ENST00000266070.4
ENST00000395335.2
ENST00000266071.5
DIDO1
death inducer-obliterator 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0007538 primary sex determination(GO:0007538)
0.1 0.2 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.1 0.6 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.1 0.2 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.0 0.1 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.0 0.1 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.2 GO:0072719 cellular response to cisplatin(GO:0072719)
0.0 0.1 GO:0006059 hexitol metabolic process(GO:0006059)
0.0 0.5 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.0 0.0 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.1 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.2 GO:0050884 neuromuscular process controlling posture(GO:0050884)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.2 GO:1990909 Wnt signalosome(GO:1990909)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 0.2 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.0 0.1 GO:0032810 sterol response element binding(GO:0032810)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway