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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PROX1

Z-value: 0.81

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Transcription factors associated with PROX1

Gene Symbol Gene ID Gene Info
PROX1
ENSG00000117707.11 prospero homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PROX1hg19_v2_chr1_+_214161272_2141613220.154.7e-01Click!

Activity profile of PROX1 motif

Sorted Z-values of PROX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_54074033 1.77 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr1_-_76398077 1.59 ENST00000284142.6
ASB17
ankyrin repeat and SOCS box containing 17
chr3_-_64211112 1.22 ENST00000295902.6
PRICKLE2
prickle homolog 2 (Drosophila)
chr9_+_75136717 1.09 ENST00000297784.5
TMC1
transmembrane channel-like 1
chr19_+_49535169 1.03 ENST00000474913.1
ENST00000359342.6
CGB2
chorionic gonadotropin, beta polypeptide 2
chr3_-_48723268 0.97 ENST00000439518.1
ENST00000416649.2
ENST00000341520.4
ENST00000294129.2
NCKIPSD
NCK interacting protein with SH3 domain
chr5_+_131892603 0.94 ENST00000378823.3
ENST00000265335.6
RAD50
RAD50 homolog (S. cerevisiae)
chr19_-_45909585 0.91 ENST00000593226.1
ENST00000418234.2
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr1_+_82266053 0.89 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr12_+_52668394 0.87 ENST00000423955.2
KRT86
keratin 86
chr14_-_105420241 0.85 ENST00000557457.1
AHNAK2
AHNAK nucleoprotein 2
chr12_-_46766577 0.84 ENST00000256689.5
SLC38A2
solute carrier family 38, member 2
chr17_+_42081914 0.81 ENST00000293404.3
ENST00000589767.1
NAGS
N-acetylglutamate synthase
chrX_+_69454505 0.79 ENST00000374521.3
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr9_-_80437915 0.78 ENST00000397476.3
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
chr2_-_89247338 0.77 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr6_+_37321748 0.71 ENST00000373479.4
ENST00000394443.4
RNF8
ring finger protein 8, E3 ubiquitin protein ligase
chr6_+_168196210 0.71 ENST00000597278.1
AL009178.1
Uncharacterized protein; cDNA FLJ43200 fis, clone FEBRA2007793
chr14_+_45605157 0.70 ENST00000542564.2
FANCM
Fanconi anemia, complementation group M
chr18_-_2571437 0.59 ENST00000574676.1
ENST00000574538.1
ENST00000319888.6
METTL4
methyltransferase like 4
chr9_+_131267052 0.59 ENST00000539582.1
GLE1
GLE1 RNA export mediator
chr7_+_64254766 0.57 ENST00000307355.7
ENST00000359735.3
ZNF138
zinc finger protein 138
chr4_+_26862431 0.57 ENST00000465503.1
STIM2
stromal interaction molecule 2
chr3_+_138066539 0.57 ENST00000289104.4
MRAS
muscle RAS oncogene homolog
chr3_+_12525931 0.56 ENST00000446004.1
ENST00000314571.7
ENST00000454502.2
ENST00000383797.5
ENST00000402228.3
ENST00000284995.6
ENST00000444864.1
TSEN2
TSEN2 tRNA splicing endonuclease subunit
chr9_+_131266963 0.55 ENST00000309971.4
ENST00000372770.4
GLE1
GLE1 RNA export mediator
chr6_+_158957431 0.54 ENST00000367090.3
TMEM181
transmembrane protein 181
chr3_+_126113734 0.54 ENST00000352312.1
ENST00000393425.1
CCDC37
coiled-coil domain containing 37
chr11_+_28131821 0.53 ENST00000379199.2
ENST00000303459.6
METTL15
methyltransferase like 15
chr1_-_202311088 0.52 ENST00000367274.4
UBE2T
ubiquitin-conjugating enzyme E2T (putative)
chr17_+_66243715 0.52 ENST00000359904.3
AMZ2
archaelysin family metallopeptidase 2
chr5_+_156693159 0.51 ENST00000347377.6
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr1_+_70876891 0.51 ENST00000411986.2
CTH
cystathionase (cystathionine gamma-lyase)
chr4_+_26862400 0.51 ENST00000467011.1
ENST00000412829.2
STIM2
stromal interaction molecule 2
chr2_+_89999259 0.50 ENST00000558026.1
IGKV2D-28
immunoglobulin kappa variable 2D-28
chr7_+_64254793 0.50 ENST00000494380.1
ENST00000440155.2
ENST00000440598.1
ENST00000437743.1
ZNF138
zinc finger protein 138
chr7_-_138348969 0.50 ENST00000436657.1
SVOPL
SVOP-like
chr1_+_70876926 0.50 ENST00000370938.3
ENST00000346806.2
CTH
cystathionase (cystathionine gamma-lyase)
chr6_-_8102279 0.49 ENST00000488226.2
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr20_+_17949724 0.48 ENST00000377704.4
MGME1
mitochondrial genome maintenance exonuclease 1
chr4_+_128886532 0.48 ENST00000444616.1
ENST00000388795.5
C4orf29
chromosome 4 open reading frame 29
chr11_+_86106208 0.47 ENST00000528728.1
CCDC81
coiled-coil domain containing 81
chr19_+_35773242 0.47 ENST00000222304.3
HAMP
hepcidin antimicrobial peptide
chr1_-_182369751 0.47 ENST00000367565.1
TEDDM1
transmembrane epididymal protein 1
chr4_-_38666430 0.47 ENST00000436901.1
AC021860.1
Uncharacterized protein
chr12_+_72079842 0.46 ENST00000266673.5
ENST00000550524.1
TMEM19
transmembrane protein 19
chr17_+_41994576 0.45 ENST00000588043.2
FAM215A
family with sequence similarity 215, member A (non-protein coding)
chr5_+_154320623 0.45 ENST00000523037.1
ENST00000265229.8
ENST00000439747.3
ENST00000522038.1
MRPL22
mitochondrial ribosomal protein L22
chr4_-_69215467 0.45 ENST00000579690.1
YTHDC1
YTH domain containing 1
chr18_+_60190226 0.44 ENST00000269499.5
ZCCHC2
zinc finger, CCHC domain containing 2
chr10_+_16478942 0.44 ENST00000535784.2
ENST00000423462.2
ENST00000378000.1
PTER
phosphotriesterase related
chr2_+_163175394 0.44 ENST00000446271.1
ENST00000429691.2
GCA
grancalcin, EF-hand calcium binding protein
chr12_+_20522179 0.44 ENST00000359062.3
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr13_+_27131887 0.42 ENST00000335327.5
WASF3
WAS protein family, member 3
chr1_-_159046617 0.42 ENST00000368130.4
AIM2
absent in melanoma 2
chr1_-_44497118 0.42 ENST00000537678.1
ENST00000466926.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr9_+_125132803 0.41 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_-_27410847 0.41 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
NEK10
NIMA-related kinase 10
chr19_-_40732594 0.41 ENST00000430325.2
ENST00000433940.1
CNTD2
cyclin N-terminal domain containing 2
chr2_-_54087066 0.40 ENST00000394705.2
ENST00000352846.3
ENST00000406625.2
GPR75
GPR75-ASB3
ASB3
G protein-coupled receptor 75
GPR75-ASB3 readthrough
Ankyrin repeat and SOCS box protein 3
chr12_-_52946923 0.40 ENST00000267119.5
KRT71
keratin 71
chr4_-_69215699 0.40 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr13_+_27131798 0.40 ENST00000361042.4
WASF3
WAS protein family, member 3
chrX_-_152486108 0.39 ENST00000356661.5
MAGEA1
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
chr3_-_196065248 0.38 ENST00000446879.1
ENST00000273695.3
TM4SF19
transmembrane 4 L six family member 19
chr21_-_40033618 0.37 ENST00000417133.2
ENST00000398910.1
ENST00000442448.1
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chr6_-_35992270 0.37 ENST00000394602.2
ENST00000355574.2
SLC26A8
solute carrier family 26 (anion exchanger), member 8
chr4_+_26862313 0.37 ENST00000467087.1
ENST00000382009.3
ENST00000237364.5
STIM2
stromal interaction molecule 2
chr1_-_225616515 0.36 ENST00000338179.2
ENST00000425080.1
LBR
lamin B receptor
chr1_-_44497024 0.36 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_+_57308979 0.35 ENST00000457912.1
SMTNL1
smoothelin-like 1
chr4_-_169931393 0.35 ENST00000504480.1
ENST00000306193.3
CBR4
carbonyl reductase 4
chr11_+_93394805 0.35 ENST00000325212.6
ENST00000411936.1
ENST00000344196.4
KIAA1731
KIAA1731
chr9_+_132096166 0.35 ENST00000436710.1
RP11-65J3.1
RP11-65J3.1
chr1_+_246729724 0.34 ENST00000366513.4
ENST00000366512.3
CNST
consortin, connexin sorting protein
chr17_-_40273348 0.34 ENST00000225916.5
KAT2A
K(lysine) acetyltransferase 2A
chr19_-_16582815 0.34 ENST00000455140.2
ENST00000248070.6
ENST00000594975.1
EPS15L1
epidermal growth factor receptor pathway substrate 15-like 1
chr8_-_13134045 0.33 ENST00000512044.2
DLC1
deleted in liver cancer 1
chr1_+_154966058 0.33 ENST00000392487.1
LENEP
lens epithelial protein
chr5_+_64859066 0.33 ENST00000261308.5
ENST00000535264.1
ENST00000538977.1
PPWD1
peptidylprolyl isomerase domain and WD repeat containing 1
chr1_-_15850676 0.32 ENST00000440484.1
ENST00000333868.5
CASP9
caspase 9, apoptosis-related cysteine peptidase
chr10_+_30722866 0.32 ENST00000263056.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr17_+_16593539 0.32 ENST00000340621.5
ENST00000399273.1
ENST00000443444.2
ENST00000360524.8
ENST00000456009.1
CCDC144A
coiled-coil domain containing 144A
chr6_+_170151887 0.32 ENST00000588451.1
ERMARD
ER membrane-associated RNA degradation
chrY_+_22918021 0.32 ENST00000288666.5
RPS4Y2
ribosomal protein S4, Y-linked 2
chr12_-_43945724 0.32 ENST00000389420.3
ENST00000553158.1
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr1_+_104068562 0.31 ENST00000423855.2
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr14_-_23426322 0.31 ENST00000555367.1
HAUS4
HAUS augmin-like complex, subunit 4
chr14_-_23426270 0.31 ENST00000557591.1
ENST00000397409.4
ENST00000490506.1
ENST00000554406.1
HAUS4
HAUS augmin-like complex, subunit 4
chr18_+_2571510 0.31 ENST00000261597.4
ENST00000575515.1
NDC80
NDC80 kinetochore complex component
chr16_+_50300427 0.31 ENST00000394697.2
ENST00000566433.2
ENST00000538642.1
ADCY7
adenylate cyclase 7
chr6_+_37321823 0.30 ENST00000487950.1
ENST00000469731.1
RNF8
ring finger protein 8, E3 ubiquitin protein ligase
chr6_+_132455118 0.30 ENST00000458028.1
LINC01013
long intergenic non-protein coding RNA 1013
chr6_+_170151708 0.28 ENST00000592367.1
ENST00000590711.1
ENST00000366772.2
ENST00000592745.1
ENST00000392095.4
ENST00000366773.3
ENST00000586341.1
ENST00000418781.3
ENST00000588437.1
ERMARD
ER membrane-associated RNA degradation
chr19_-_9546227 0.27 ENST00000361451.2
ENST00000361151.1
ZNF266
zinc finger protein 266
chr14_-_23426337 0.27 ENST00000342454.8
ENST00000555986.1
ENST00000541587.1
ENST00000554516.1
ENST00000347758.2
ENST00000206474.7
ENST00000555040.1
HAUS4
HAUS augmin-like complex, subunit 4
chr4_+_2819883 0.27 ENST00000511747.1
ENST00000503393.2
SH3BP2
SH3-domain binding protein 2
chr9_-_86571628 0.27 ENST00000376344.3
C9orf64
chromosome 9 open reading frame 64
chr18_+_29769978 0.27 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr10_-_52008313 0.27 ENST00000329428.6
ENST00000395526.4
ENST00000447815.1
ASAH2
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
chr14_+_24563262 0.26 ENST00000559250.1
ENST00000216780.4
ENST00000560736.1
ENST00000396973.4
ENST00000559837.1
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr11_-_82997013 0.26 ENST00000529073.1
ENST00000529611.1
CCDC90B
coiled-coil domain containing 90B
chr16_+_31724552 0.26 ENST00000539915.1
ENST00000316491.9
ENST00000399681.3
ENST00000398696.3
ENST00000534369.1
ZNF720
zinc finger protein 720
chr1_+_222817629 0.26 ENST00000340535.7
MIA3
melanoma inhibitory activity family, member 3
chr1_+_150980989 0.26 ENST00000368935.1
PRUNE
prune exopolyphosphatase
chr16_+_12070567 0.25 ENST00000566228.1
SNX29
sorting nexin 29
chr9_+_125133315 0.25 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr14_+_23842018 0.25 ENST00000397242.2
ENST00000329715.2
IL25
interleukin 25
chr1_+_179050512 0.25 ENST00000367627.3
TOR3A
torsin family 3, member A
chr18_+_33767473 0.25 ENST00000261326.5
MOCOS
molybdenum cofactor sulfurase
chr14_+_45605127 0.25 ENST00000556036.1
ENST00000267430.5
FANCM
Fanconi anemia, complementation group M
chr11_-_82997371 0.25 ENST00000525503.1
CCDC90B
coiled-coil domain containing 90B
chr1_-_238054094 0.24 ENST00000366570.4
ZP4
zona pellucida glycoprotein 4
chr16_-_790982 0.24 ENST00000301694.5
ENST00000251588.2
NARFL
nuclear prelamin A recognition factor-like
chrX_+_16668278 0.24 ENST00000380200.3
S100G
S100 calcium binding protein G
chr11_-_61062762 0.24 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr1_+_104068312 0.24 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr20_-_61885826 0.24 ENST00000370316.3
NKAIN4
Na+/K+ transporting ATPase interacting 4
chr9_-_130497565 0.23 ENST00000336067.6
ENST00000373281.5
ENST00000373284.5
ENST00000458505.3
TOR2A
torsin family 2, member A
chr17_+_55183261 0.23 ENST00000576295.1
AKAP1
A kinase (PRKA) anchor protein 1
chr6_-_90529418 0.23 ENST00000439638.1
ENST00000369393.3
ENST00000428876.1
MDN1
MDN1, midasin homolog (yeast)
chr2_+_28718921 0.23 ENST00000327757.5
ENST00000422425.2
ENST00000404858.1
PLB1
phospholipase B1
chr11_+_111749650 0.22 ENST00000528125.1
C11orf1
chromosome 11 open reading frame 1
chr6_-_86303833 0.22 ENST00000505648.1
SNX14
sorting nexin 14
chr1_+_241695424 0.22 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr11_+_92085262 0.22 ENST00000298047.6
ENST00000409404.2
ENST00000541502.1
FAT3
FAT atypical cadherin 3
chr14_-_35183755 0.22 ENST00000555765.1
CFL2
cofilin 2 (muscle)
chr14_+_78266408 0.22 ENST00000238561.5
ADCK1
aarF domain containing kinase 1
chr1_-_28241024 0.22 ENST00000313433.7
ENST00000444045.1
RPA2
replication protein A2, 32kDa
chr2_+_17935383 0.21 ENST00000524465.1
ENST00000381254.2
ENST00000532257.1
GEN1
GEN1 Holliday junction 5' flap endonuclease
chr17_+_73629500 0.20 ENST00000375215.3
SMIM5
small integral membrane protein 5
chr1_-_15850839 0.20 ENST00000348549.5
ENST00000546424.1
CASP9
caspase 9, apoptosis-related cysteine peptidase
chr3_+_138067314 0.20 ENST00000423968.2
MRAS
muscle RAS oncogene homolog
chr17_+_72209653 0.20 ENST00000269346.4
TTYH2
tweety family member 2
chr2_-_136288113 0.20 ENST00000401392.1
ZRANB3
zinc finger, RAN-binding domain containing 3
chr6_-_134495992 0.19 ENST00000475719.2
ENST00000367857.5
ENST00000237305.7
SGK1
serum/glucocorticoid regulated kinase 1
chr17_-_38074859 0.19 ENST00000520542.1
ENST00000418519.1
ENST00000394179.1
GSDMB
gasdermin B
chr13_+_37581115 0.19 ENST00000481013.1
EXOSC8
exosome component 8
chr5_+_145583156 0.19 ENST00000265271.5
RBM27
RNA binding motif protein 27
chr3_-_11888246 0.18 ENST00000455809.1
ENST00000444133.2
ENST00000273037.5
TAMM41
TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae)
chr2_-_233877912 0.18 ENST00000264051.3
NGEF
neuronal guanine nucleotide exchange factor
chr12_-_11091862 0.18 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chr15_-_78913628 0.18 ENST00000348639.3
CHRNA3
cholinergic receptor, nicotinic, alpha 3 (neuronal)
chr2_+_28618532 0.18 ENST00000545753.1
FOSL2
FOS-like antigen 2
chr6_-_42690312 0.18 ENST00000230381.5
PRPH2
peripherin 2 (retinal degeneration, slow)
chr1_+_35544968 0.17 ENST00000359858.4
ENST00000373330.1
ZMYM1
zinc finger, MYM-type 1
chr10_+_134258649 0.17 ENST00000392630.3
ENST00000321248.2
C10orf91
chromosome 10 open reading frame 91
chr5_-_132113063 0.17 ENST00000378719.2
SEPT8
septin 8
chr1_-_211307404 0.17 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr12_+_54402790 0.16 ENST00000040584.4
HOXC8
homeobox C8
chr10_+_14920843 0.16 ENST00000433779.1
ENST00000378325.3
ENST00000354919.6
ENST00000313519.5
ENST00000420416.1
SUV39H2
suppressor of variegation 3-9 homolog 2 (Drosophila)
chr17_-_36904437 0.16 ENST00000585100.1
ENST00000360797.2
ENST00000578109.1
ENST00000579882.1
PCGF2
polycomb group ring finger 2
chr1_+_241695670 0.16 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr19_-_19754354 0.16 ENST00000587238.1
GMIP
GEM interacting protein
chr20_+_30028322 0.15 ENST00000376309.3
DEFB123
defensin, beta 123
chr9_+_131218698 0.15 ENST00000434106.3
ENST00000546203.1
ENST00000446274.1
ENST00000421776.2
ENST00000432065.2
ODF2
outer dense fiber of sperm tails 2
chr19_-_19754404 0.15 ENST00000587205.1
ENST00000445806.2
ENST00000203556.4
GMIP
GEM interacting protein
chr16_-_790887 0.15 ENST00000540986.1
NARFL
nuclear prelamin A recognition factor-like
chr4_+_48807155 0.15 ENST00000504654.1
OCIAD1
OCIA domain containing 1
chr7_-_156433195 0.14 ENST00000333319.6
C7orf13
chromosome 7 open reading frame 13
chr8_-_146176199 0.14 ENST00000532351.1
ENST00000276816.4
ENST00000394909.2
ZNF16
zinc finger protein 16
chr11_+_61522844 0.14 ENST00000265460.5
MYRF
myelin regulatory factor
chrX_+_118602363 0.14 ENST00000317881.8
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr19_+_53073526 0.14 ENST00000596514.1
ENST00000391785.3
ENST00000301093.2
ZNF701
zinc finger protein 701
chr17_+_66539369 0.14 ENST00000600820.1
AC079210.1
Uncharacterized protein; cDNA FLJ45097 fis, clone BRAWH3031054
chr1_+_95975672 0.14 ENST00000440116.2
ENST00000456933.1
RP11-286B14.1
RP11-286B14.1
chr1_-_111061797 0.14 ENST00000369771.2
KCNA10
potassium voltage-gated channel, shaker-related subfamily, member 10
chr5_+_180415839 0.14 ENST00000342868.6
BTNL3
butyrophilin-like 3
chr10_-_92681033 0.14 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr8_-_33457453 0.14 ENST00000523956.1
ENST00000256261.4
DUSP26
dual specificity phosphatase 26 (putative)
chr2_+_232826394 0.13 ENST00000409401.3
ENST00000441279.1
DIS3L2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
chr5_-_22853429 0.13 ENST00000504376.2
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr2_+_128403720 0.12 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr3_-_19975665 0.12 ENST00000295824.9
ENST00000389256.4
EFHB
EF-hand domain family, member B
chr15_-_78913521 0.12 ENST00000326828.5
CHRNA3
cholinergic receptor, nicotinic, alpha 3 (neuronal)
chr10_+_112327425 0.12 ENST00000361804.4
SMC3
structural maintenance of chromosomes 3
chr5_-_127418573 0.12 ENST00000508353.1
ENST00000508878.1
ENST00000501652.1
ENST00000514409.1
CTC-228N24.3
CTC-228N24.3
chr13_-_36788718 0.12 ENST00000317764.6
ENST00000379881.3
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr17_-_7307358 0.12 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr1_+_203830703 0.12 ENST00000414487.2
SNRPE
small nuclear ribonucleoprotein polypeptide E
chr4_+_164265035 0.12 ENST00000338566.3
NPY5R
neuropeptide Y receptor Y5
chr4_+_128886424 0.12 ENST00000398965.1
C4orf29
chromosome 4 open reading frame 29
chr19_+_15752088 0.12 ENST00000585846.1
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr22_-_29075853 0.11 ENST00000397906.2
TTC28
tetratricopeptide repeat domain 28
chr7_+_128864848 0.11 ENST00000325006.3
ENST00000446544.2
AHCYL2
adenosylhomocysteinase-like 2
chr4_-_128887069 0.11 ENST00000541133.1
ENST00000296468.3
ENST00000513559.1
MFSD8
major facilitator superfamily domain containing 8
chr6_+_132455526 0.11 ENST00000443303.1
LINC01013
long intergenic non-protein coding RNA 1013
chr2_+_101869262 0.11 ENST00000289382.3
CNOT11
CCR4-NOT transcription complex, subunit 11
chr1_+_93297582 0.11 ENST00000370321.3
RPL5
ribosomal protein L5
chr8_+_91013577 0.10 ENST00000220764.2
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial
chr9_+_93564191 0.10 ENST00000375747.1
SYK
spleen tyrosine kinase
chr19_+_6361754 0.10 ENST00000597326.1
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr19_+_45754505 0.10 ENST00000262891.4
ENST00000300843.4
MARK4
MAP/microtubule affinity-regulating kinase 4
chr8_+_110552046 0.10 ENST00000529931.1
EBAG9
estrogen receptor binding site associated, antigen, 9
chr7_+_100209979 0.09 ENST00000493970.1
ENST00000379527.2
MOSPD3
motile sperm domain containing 3
chr5_+_145826867 0.09 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr2_+_128403439 0.09 ENST00000544369.1
GPR17
G protein-coupled receptor 17
chr1_+_93297622 0.09 ENST00000315741.5
RPL5
ribosomal protein L5
chr6_-_28226984 0.09 ENST00000423974.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr19_+_6361440 0.09 ENST00000245816.4
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of PROX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.3 0.8 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 1.0 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.2 0.9 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.2 1.4 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.2 0.5 GO:0009405 pathogenesis(GO:0009405)
0.2 1.1 GO:0060005 vestibular reflex(GO:0060005)
0.2 0.5 GO:1990641 cellular response to bile acid(GO:1903413) response to iron ion starvation(GO:1990641)
0.1 0.6 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.1 0.8 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 0.5 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.1 1.0 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.5 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.1 0.8 GO:0032328 alanine transport(GO:0032328)
0.1 0.8 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.3 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) histone H4-K12 acetylation(GO:0043983)
0.1 1.1 GO:0006449 regulation of translational termination(GO:0006449)
0.1 0.3 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.1 0.4 GO:0071321 cellular response to cGMP(GO:0071321)
0.1 0.8 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 0.2 GO:0071140 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.1 0.5 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.4 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.1 0.9 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.2 GO:2000360 negative regulation of binding of sperm to zona pellucida(GO:2000360)
0.1 0.9 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 0.4 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.2 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.2 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.2 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.1 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0 0.3 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 0.4 GO:0070269 pyroptosis(GO:0070269)
0.0 0.5 GO:0032025 response to cobalt ion(GO:0032025)
0.0 0.9 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.2 GO:0030222 eosinophil differentiation(GO:0030222)
0.0 0.3 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 1.0 GO:0031643 positive regulation of myelination(GO:0031643)
0.0 0.3 GO:0006116 NADH oxidation(GO:0006116)
0.0 0.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.4 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 1.0 GO:0030728 ovulation(GO:0030728)
0.0 0.3 GO:0044597 polyketide metabolic process(GO:0030638) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.4 GO:0019532 oxalate transport(GO:0019532)
0.0 0.5 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.1 GO:0042223 response to molecule of fungal origin(GO:0002238) positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) cellular response to molecule of fungal origin(GO:0071226)
0.0 0.1 GO:0015853 adenine transport(GO:0015853)
0.0 1.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.0 0.3 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.2 GO:0003096 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.0 0.3 GO:0045634 regulation of melanocyte differentiation(GO:0045634)
0.0 0.3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.2 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604)
0.0 0.1 GO:1901569 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.0 0.2 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.1 GO:0044789 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0 0.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.2 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.1 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.3 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.4 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.1 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.4 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.1 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:2001300 lipoxin metabolic process(GO:2001300)
0.0 0.1 GO:0000050 urea cycle(GO:0000050)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0071821 FANCM-MHF complex(GO:0071821)
0.2 1.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.5 GO:0043293 apoptosome(GO:0043293)
0.1 0.6 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.1 0.9 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.1 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.9 GO:0070652 HAUS complex(GO:0070652)
0.1 0.1 GO:0071817 MMXD complex(GO:0071817)
0.1 0.4 GO:0097361 CIA complex(GO:0097361)
0.1 0.3 GO:0031262 condensed nuclear chromosome outer kinetochore(GO:0000942) Ndc80 complex(GO:0031262)
0.0 0.4 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.2 GO:0009368 endopeptidase Clp complex(GO:0009368)
0.0 0.5 GO:0045179 apical cortex(GO:0045179)
0.0 1.2 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.1 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.0 0.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.3 GO:0030914 STAGA complex(GO:0030914)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)
0.0 1.0 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.4 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)
0.0 2.0 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 0.8 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 0.6 GO:0030626 U12 snRNA binding(GO:0030626)
0.2 0.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 0.8 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.4 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 1.8 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.8 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 0.4 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 0.3 GO:0047025 NAD(P)H dehydrogenase (quinone) activity(GO:0003955) 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1 1.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.6 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.1 0.5 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.1 0.3 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1 1.2 GO:0043047 single-stranded telomeric DNA binding(GO:0043047)
0.1 1.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.6 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.1 1.1 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.8 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.3 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.1 0.3 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.3 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.1 0.3 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.2 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.2 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.2 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0097259 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.0 0.5 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.0 0.1 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.5 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0036033 mediator complex binding(GO:0036033)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.2 GO:1904047 S-adenosyl-L-methionine binding(GO:1904047)
0.0 0.4 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
0.0 0.2 GO:0032190 acrosin binding(GO:0032190)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.2 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.1 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.8 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.2 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.5 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.1 GO:0031208 POZ domain binding(GO:0031208)
0.0 0.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 1.5 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 2.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.1 PID ATM PATHWAY ATM pathway
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.9 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.5 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.8 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.2 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors