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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PRRX1_ALX4_PHOX2A

Z-value: 0.57

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Transcription factors associated with PRRX1_ALX4_PHOX2A

Gene Symbol Gene ID Gene Info
PRRX1
ENSG00000116132.7 paired related homeobox 1
ALX4
ENSG00000052850.5 ALX homeobox 4
PHOX2A
ENSG00000165462.5 paired like homeobox 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRRX1hg19_v2_chr1_+_170633047_1706330840.491.4e-02Click!
ALX4hg19_v2_chr11_-_44331679_443317160.203.4e-01Click!
PHOX2Ahg19_v2_chr11_-_71955210_71955227,
hg19_v2_chr11_-_71952236_71952319		0.067.9e-01Click!

Activity profile of PRRX1_ALX4_PHOX2A motif

Sorted Z-values of PRRX1_ALX4_PHOX2A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_616672 1.68 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr2_+_152214098 1.60 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr4_-_76957214 1.44 ENST00000306621.3
CXCL11
chemokine (C-X-C motif) ligand 11
chr2_-_145278475 1.43 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr2_+_162272605 1.41 ENST00000389554.3
TBR1
T-box, brain, 1
chr18_+_616711 1.15 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr6_-_27835357 1.08 ENST00000331442.3
HIST1H1B
histone cluster 1, H1b
chr1_+_12976450 0.96 ENST00000361079.2
PRAMEF7
PRAME family member 7
chr2_+_228678550 0.91 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr6_-_134639180 0.90 ENST00000367858.5
SGK1
serum/glucocorticoid regulated kinase 1
chr17_+_39261584 0.83 ENST00000391415.1
KRTAP4-9
keratin associated protein 4-9
chr3_-_164914640 0.80 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr12_-_10151773 0.80 ENST00000298527.6
ENST00000348658.4
CLEC1B
C-type lectin domain family 1, member B
chr12_-_43833515 0.78 ENST00000549670.1
ENST00000395541.2
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr6_-_66417107 0.78 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr6_-_32908765 0.76 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_-_154751629 0.75 ENST00000424998.1
CNKSR3
CNKSR family member 3
chr1_+_92632542 0.69 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chr7_+_143701022 0.67 ENST00000408922.2
OR6B1
olfactory receptor, family 6, subfamily B, member 1
chr4_+_155484155 0.66 ENST00000509493.1
FGB
fibrinogen beta chain
chr6_+_12007897 0.65 ENST00000437559.1
RP11-456H18.2
RP11-456H18.2
chr2_+_102413726 0.64 ENST00000350878.4
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr5_-_160279207 0.63 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr10_+_69865866 0.61 ENST00000354393.2
MYPN
myopalladin
chr21_+_43619796 0.59 ENST00000398457.2
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr3_-_157824292 0.57 ENST00000483851.2
SHOX2
short stature homeobox 2
chr14_-_38064198 0.56 ENST00000250448.2
FOXA1
forkhead box A1
chr4_+_74606223 0.56 ENST00000307407.3
ENST00000401931.1
IL8
interleukin 8
chr2_+_223725652 0.55 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr4_+_142558078 0.53 ENST00000529613.1
IL15
interleukin 15
chr17_+_3118915 0.52 ENST00000304094.1
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr1_+_50569575 0.47 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr11_+_49050504 0.47 ENST00000332682.7
TRIM49B
tripartite motif containing 49B
chr12_-_16761007 0.46 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chrX_-_68385354 0.45 ENST00000361478.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr11_-_40315640 0.44 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr5_-_142780280 0.43 ENST00000424646.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr1_-_154600421 0.42 ENST00000368471.3
ENST00000292205.5
ADAR
adenosine deaminase, RNA-specific
chr6_+_34204642 0.42 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr2_-_175711133 0.41 ENST00000409597.1
ENST00000413882.1
CHN1
chimerin 1
chr10_-_29923893 0.41 ENST00000355867.4
SVIL
supervillin
chr16_+_1728257 0.41 ENST00000248098.3
ENST00000562684.1
ENST00000561516.1
ENST00000382711.5
ENST00000566742.1
HN1L
hematological and neurological expressed 1-like
chr15_+_51669444 0.39 ENST00000396399.2
GLDN
gliomedin
chr3_-_11623804 0.38 ENST00000451674.2
VGLL4
vestigial like 4 (Drosophila)
chr11_+_55029628 0.37 ENST00000417545.2
TRIM48
tripartite motif containing 48
chr17_-_39254391 0.36 ENST00000333822.4
KRTAP4-8
keratin associated protein 4-8
chr11_-_7847519 0.35 ENST00000328375.1
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chrX_+_9431324 0.35 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr3_-_186262166 0.34 ENST00000307944.5
CRYGS
crystallin, gamma S
chr3_-_194188956 0.34 ENST00000256031.4
ENST00000446356.1
ATP13A3
ATPase type 13A3
chr14_-_95236551 0.34 ENST00000238558.3
GSC
goosecoid homeobox
chr2_-_161350305 0.34 ENST00000348849.3
RBMS1
RNA binding motif, single stranded interacting protein 1
chrX_-_11284095 0.33 ENST00000303025.6
ENST00000534860.1
ARHGAP6
Rho GTPase activating protein 6
chr6_-_137314371 0.32 ENST00000432330.1
ENST00000418699.1
RP11-55K22.5
RP11-55K22.5
chr6_+_132891461 0.32 ENST00000275198.1
TAAR6
trace amine associated receptor 6
chr14_+_95078714 0.32 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr8_+_11961898 0.31 ENST00000400085.3
ZNF705D
zinc finger protein 705D
chr1_-_13390765 0.31 ENST00000357367.2
PRAMEF8
PRAME family member 8
chr3_+_97868170 0.31 ENST00000437310.1
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr1_-_203055129 0.30 ENST00000241651.4
MYOG
myogenin (myogenic factor 4)
chr4_+_155484103 0.29 ENST00000302068.4
FGB
fibrinogen beta chain
chr1_+_109756523 0.29 ENST00000234677.2
ENST00000369923.4
SARS
seryl-tRNA synthetase
chr15_+_42066632 0.28 ENST00000457542.2
ENST00000221214.6
ENST00000260357.7
ENST00000456763.2
MAPKBP1
mitogen-activated protein kinase binding protein 1
chr2_+_196313239 0.28 ENST00000413290.1
AC064834.1
AC064834.1
chr12_+_122688090 0.28 ENST00000324189.4
ENST00000546192.1
B3GNT4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr17_-_9694614 0.28 ENST00000330255.5
ENST00000571134.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr12_+_20968608 0.28 ENST00000381541.3
ENST00000540229.1
ENST00000553473.1
ENST00000554957.1
LST3
SLCO1B3
SLCO1B7
Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein
solute carrier organic anion transporter family, member 1B3
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr19_-_44174330 0.28 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr3_+_111393501 0.27 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr6_+_12007963 0.27 ENST00000607445.1
RP11-456H18.2
RP11-456H18.2
chr5_+_140743859 0.27 ENST00000518069.1
PCDHGA5
protocadherin gamma subfamily A, 5
chrX_-_124097620 0.26 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr3_-_195310802 0.26 ENST00000421243.1
ENST00000453131.1
APOD
apolipoprotein D
chr19_+_7030589 0.25 ENST00000329753.5
MBD3L5
methyl-CpG binding domain protein 3-like 5
chr6_-_107235378 0.25 ENST00000606430.1
RP1-60O19.1
RP1-60O19.1
chr7_-_27169801 0.24 ENST00000511914.1
HOXA4
homeobox A4
chr10_+_13141441 0.24 ENST00000263036.5
OPTN
optineurin
chr2_-_172967621 0.24 ENST00000234198.4
ENST00000466293.2
DLX2
distal-less homeobox 2
chr17_-_60885700 0.23 ENST00000583600.1
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr17_-_60885659 0.23 ENST00000311269.5
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr6_+_45296391 0.23 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr7_-_25268104 0.23 ENST00000222674.2
NPVF
neuropeptide VF precursor
chrX_-_68385274 0.23 ENST00000374584.3
ENST00000590146.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr8_+_67039131 0.23 ENST00000315962.4
ENST00000353317.5
TRIM55
tripartite motif containing 55
chr15_-_75748115 0.22 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr4_-_119759795 0.21 ENST00000419654.2
SEC24D
SEC24 family member D
chr4_+_88571429 0.21 ENST00000339673.6
ENST00000282479.7
DMP1
dentin matrix acidic phosphoprotein 1
chr3_+_138340049 0.21 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr1_-_165414414 0.21 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr16_+_6533729 0.20 ENST00000551752.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chrX_-_15332665 0.20 ENST00000537676.1
ENST00000344384.4
ASB11
ankyrin repeat and SOCS box containing 11
chr14_-_81893734 0.20 ENST00000555447.1
STON2
stonin 2
chr19_+_7049332 0.20 ENST00000381393.3
MBD3L2
methyl-CpG binding domain protein 3-like 2
chr7_-_111032971 0.20 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr17_+_39240459 0.20 ENST00000391417.4
KRTAP4-7
keratin associated protein 4-7
chr3_-_9291063 0.20 ENST00000383836.3
SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr14_-_101036119 0.20 ENST00000355173.2
BEGAIN
brain-enriched guanylate kinase-associated
chr3_+_138340067 0.20 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr4_+_54927213 0.19 ENST00000595906.1
AC110792.1
HCG2027126; Uncharacterized protein
chr17_-_39023462 0.19 ENST00000251643.4
KRT12
keratin 12
chr10_+_13141585 0.18 ENST00000378764.2
OPTN
optineurin
chr21_-_43346790 0.18 ENST00000329623.7
C2CD2
C2 calcium-dependent domain containing 2
chr5_-_66492562 0.18 ENST00000256447.4
CD180
CD180 molecule
chr3_+_111393659 0.18 ENST00000477665.1
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr4_-_143226979 0.18 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr5_+_140762268 0.18 ENST00000518325.1
PCDHGA7
protocadherin gamma subfamily A, 7
chr7_+_148287657 0.18 ENST00000307003.2
C7orf33
chromosome 7 open reading frame 33
chr4_-_23735183 0.18 ENST00000507666.1
RP11-380P13.2
RP11-380P13.2
chr6_+_108487245 0.18 ENST00000368986.4
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr4_-_48082192 0.17 ENST00000507351.1
TXK
TXK tyrosine kinase
chr10_+_89420706 0.17 ENST00000427144.2
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr21_-_35899113 0.17 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr3_-_141747950 0.17 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_+_183774240 0.17 ENST00000360851.3
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr19_-_44174305 0.17 ENST00000601723.1
ENST00000339082.3
PLAUR
plasminogen activator, urokinase receptor
chr17_+_53342311 0.17 ENST00000226067.5
HLF
hepatic leukemia factor
chr10_+_13142225 0.16 ENST00000378747.3
OPTN
optineurin
chr7_+_93535866 0.16 ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr2_-_69180083 0.16 ENST00000328895.4
GKN2
gastrokine 2
chr10_-_75226166 0.16 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr12_+_54519842 0.16 ENST00000508564.1
RP11-834C11.4
RP11-834C11.4
chr5_-_59783882 0.16 ENST00000505507.2
ENST00000502484.2
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_+_36923933 0.16 ENST00000497382.1
ENST00000404084.1
ENST00000379241.3
ENST00000401530.1
VIT
vitrin
chr6_+_29274403 0.16 ENST00000377160.2
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr4_-_176733897 0.15 ENST00000393658.2
GPM6A
glycoprotein M6A
chr6_-_40555176 0.15 ENST00000338305.6
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr12_-_81992111 0.15 ENST00000443686.3
ENST00000407050.4
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr7_-_140482926 0.15 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr1_+_87012753 0.15 ENST00000370563.3
CLCA4
chloride channel accessory 4
chr16_-_74700737 0.15 ENST00000576652.1
ENST00000572337.1
ENST00000571750.1
ENST00000572990.1
ENST00000361070.4
RFWD3
ring finger and WD repeat domain 3
chr19_-_7040190 0.15 ENST00000381394.4
MBD3L4
methyl-CpG binding domain protein 3-like 4
chr6_-_107235331 0.15 ENST00000433965.1
ENST00000430094.1
RP1-60O19.1
RP1-60O19.1
chr10_+_71075552 0.15 ENST00000298649.3
HK1
hexokinase 1
chr2_+_74685413 0.15 ENST00000233615.2
WBP1
WW domain binding protein 1
chr2_-_69180012 0.15 ENST00000481498.1
GKN2
gastrokine 2
chr11_-_8964580 0.15 ENST00000325884.1
ASCL3
achaete-scute family bHLH transcription factor 3
chr16_+_21244986 0.15 ENST00000311620.5
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr3_-_3151664 0.15 ENST00000256452.3
ENST00000311981.8
ENST00000430514.2
ENST00000456302.1
IL5RA
interleukin 5 receptor, alpha
chr12_-_91573132 0.15 ENST00000550563.1
ENST00000546370.1
DCN
decorin
chrX_+_1710484 0.15 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr2_+_36923830 0.14 ENST00000379242.3
ENST00000389975.3
VIT
vitrin
chr2_+_185463093 0.14 ENST00000302277.6
ZNF804A
zinc finger protein 804A
chr10_-_50396425 0.14 ENST00000374148.1
C10orf128
chromosome 10 open reading frame 128
chr17_-_39306054 0.14 ENST00000343246.4
KRTAP4-5
keratin associated protein 4-5
chr15_+_44092784 0.13 ENST00000458412.1
HYPK
huntingtin interacting protein K
chr15_-_34331243 0.13 ENST00000306730.3
AVEN
apoptosis, caspase activation inhibitor
chrX_+_149887090 0.13 ENST00000538506.1
MTMR1
myotubularin related protein 1
chr8_+_39792474 0.13 ENST00000502986.2
IDO2
indoleamine 2,3-dioxygenase 2
chr19_+_6887571 0.13 ENST00000250572.8
ENST00000381407.5
ENST00000312053.4
ENST00000450315.3
ENST00000381404.4
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr5_+_142149932 0.13 ENST00000274498.4
ARHGAP26
Rho GTPase activating protein 26
chr8_+_77318769 0.13 ENST00000518732.1
RP11-706J10.1
long intergenic non-protein coding RNA 1111
chr1_+_158815588 0.13 ENST00000438394.1
MNDA
myeloid cell nuclear differentiation antigen
chr5_+_98109322 0.12 ENST00000513185.1
RGMB
repulsive guidance molecule family member b
chr6_+_15401075 0.12 ENST00000541660.1
JARID2
jumonji, AT rich interactive domain 2
chr15_-_38519066 0.12 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1
RP11-346D14.1
chr16_+_7382745 0.12 ENST00000436368.2
ENST00000311745.5
ENST00000355637.4
ENST00000340209.4
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr7_+_93535817 0.12 ENST00000248572.5
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr10_+_24755416 0.12 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr8_-_122653630 0.12 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr2_+_159651821 0.12 ENST00000309950.3
ENST00000409042.1
DAPL1
death associated protein-like 1
chr3_-_87325728 0.12 ENST00000350375.2
POU1F1
POU class 1 homeobox 1
chr3_+_159943362 0.12 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr5_+_101569696 0.12 ENST00000597120.1
AC008948.1
AC008948.1
chr4_-_83769996 0.12 ENST00000511338.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr1_-_151148442 0.12 ENST00000441701.1
ENST00000416280.2
TMOD4
tropomodulin 4 (muscle)
chr2_-_145277882 0.11 ENST00000465070.1
ENST00000444559.1
ZEB2
zinc finger E-box binding homeobox 2
chrX_+_11311533 0.11 ENST00000380714.3
ENST00000380712.3
ENST00000348912.4
AMELX
amelogenin, X-linked
chr12_-_125052010 0.11 ENST00000458234.1
NCOR2
nuclear receptor corepressor 2
chr5_-_87516448 0.11 ENST00000511218.1
TMEM161B
transmembrane protein 161B
chr10_+_134150835 0.11 ENST00000432555.2
LRRC27
leucine rich repeat containing 27
chr3_-_196242233 0.11 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr19_+_42580274 0.11 ENST00000359044.4
ZNF574
zinc finger protein 574
chr12_+_49621658 0.11 ENST00000541364.1
TUBA1C
tubulin, alpha 1c
chr11_+_24518723 0.11 ENST00000336930.6
ENST00000529015.1
ENST00000533227.1
LUZP2
leucine zipper protein 2
chr2_+_171571827 0.11 ENST00000375281.3
SP5
Sp5 transcription factor
chr17_-_39150385 0.11 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr14_+_52164820 0.10 ENST00000554167.1
FRMD6
FERM domain containing 6
chrX_+_36246735 0.10 ENST00000378653.3
CXorf30
chromosome X open reading frame 30
chr15_-_76304731 0.10 ENST00000394907.3
NRG4
neuregulin 4
chr10_-_102989551 0.10 ENST00000370193.2
LBX1
ladybird homeobox 1
chr3_+_149191723 0.10 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chr8_+_38677850 0.10 ENST00000518809.1
ENST00000520611.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr20_+_31823792 0.10 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
BPIFA1
BPI fold containing family A, member 1
chr6_+_88106840 0.10 ENST00000369570.4
C6orf164
chromosome 6 open reading frame 164
chr3_-_87325612 0.10 ENST00000561167.1
ENST00000560656.1
ENST00000344265.3
POU1F1
POU class 1 homeobox 1
chr5_-_54468974 0.10 ENST00000381375.2
ENST00000296733.1
ENST00000322374.6
ENST00000334206.5
ENST00000331730.3
CDC20B
cell division cycle 20B
chrX_+_18725758 0.10 ENST00000472826.1
ENST00000544635.1
ENST00000496075.2
PPEF1
protein phosphatase, EF-hand calcium binding domain 1
chr20_+_16729003 0.10 ENST00000246081.2
OTOR
otoraplin
chr2_-_136594740 0.10 ENST00000264162.2
LCT
lactase
chr7_+_129015484 0.09 ENST00000490911.1
AHCYL2
adenosylhomocysteinase-like 2
chr1_+_158323755 0.09 ENST00000368157.1
ENST00000368156.1
ENST00000368155.3
ENST00000368154.1
ENST00000368160.3
ENST00000368161.3
CD1E
CD1e molecule
chr12_+_26348246 0.09 ENST00000422622.2
SSPN
sarcospan
chr12_-_89746173 0.09 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr1_+_186265399 0.09 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr8_-_57472154 0.09 ENST00000499425.1
ENST00000523664.1
ENST00000518943.1
ENST00000524338.1
LINC00968
long intergenic non-protein coding RNA 968
chr12_-_91398796 0.09 ENST00000261172.3
ENST00000551767.1
EPYC
epiphycan
chr11_+_5372738 0.09 ENST00000380219.1
OR51B6
olfactory receptor, family 51, subfamily B, member 6
chr5_-_16738451 0.09 ENST00000274203.9
ENST00000515803.1
MYO10
myosin X
chr5_-_76935513 0.09 ENST00000306422.3
OTP
orthopedia homeobox
chr5_+_140079919 0.09 ENST00000274712.3
ZMAT2
zinc finger, matrin-type 2

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.3 1.6 GO:0021764 amygdala development(GO:0021764)
0.2 0.7 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.2 1.5 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 0.6 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.2 0.5 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.2 0.5 GO:0045062 extrathymic T cell selection(GO:0045062)
0.1 0.6 GO:0009726 detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099)
0.1 0.4 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.1 1.3 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.3 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 0.4 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.1 0.9 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 1.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.3 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.1 0.9 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.1 0.8 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636)
0.1 0.9 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 0.3 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.4 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.2 GO:1902868 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.1 0.5 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.7 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 0.2 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.3 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 0.2 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.2 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.2 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.1 1.6 GO:0030728 ovulation(GO:0030728)
0.1 0.4 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.1 GO:1904106 protein localization to microvillus(GO:1904106)
0.0 0.1 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.0 0.2 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.3 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.0 0.1 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.1 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.0 0.8 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.2 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.6 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.1 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0 0.2 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.2 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.2 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 1.0 GO:0032528 microvillus organization(GO:0032528)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.6 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.8 GO:0030220 platelet formation(GO:0030220)
0.0 0.1 GO:0042710 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.8 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.6 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.1 GO:1903973 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.0 2.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.0 GO:1900157 positive regulation of osteoclast proliferation(GO:0090290) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.2 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.1 GO:0003383 apical constriction(GO:0003383)
0.0 0.0 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.1 GO:0072364 regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter(GO:0072364)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.4 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.1 GO:0015827 tryptophan transport(GO:0015827)
0.0 0.1 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795) negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0 0.0 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.4 GO:0008045 motor neuron axon guidance(GO:0008045)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.7 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.4 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 1.6 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.9 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.4 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.3 1.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 0.6 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.1 0.4 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.1 0.3 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.1 0.4 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.4 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.6 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.3 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 0.2 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 0.2 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.2 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 1.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.0 0.9 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.1 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.0 1.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.9 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.2 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.7 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0 0.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.2 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.1 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.0 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 1.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.1 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 1.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.5 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.0 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.0 0.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.6 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.9 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.6 PID EPHB FWD PATHWAY EPHB forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 1.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.4 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 2.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 2.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.4 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism