ISMARA results: PRRX1_ALX4

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PRRX1_ALX4_PHOX2A

Z-value: 0.57

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Transcription factors associated with PRRX1_ALX4_PHOX2A

Gene Symbol	Gene ID	Gene Info
PRRX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000116132.7	paired related homeobox 1
ALX4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000052850.5	ALX homeobox 4
PHOX2A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000165462.5	paired like homeobox 2A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PRRX1	hg19_v2_chr1_+_170633047_170633084	0.49	1.4e-02	Click!
ALX4	hg19_v2_chr11_-_44331679_44331716	0.20	3.4e-01	Click!
PHOX2A	hg19_v2_chr11_-_71955210_71955227, hg19_v2_chr11_-_71952236_71952319	0.06	7.9e-01	Click!

Activity profile of PRRX1_ALX4_PHOX2A motif

Sorted Z-values of PRRX1_ALX4_PHOX2A motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_+_616672 Show fit	1.68	ENST00000338387.7	CLUL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin-like 1 (retinal)
chr2_+_152214098 Show fit	1.60	ENST00000243347.3	TNFAIP6 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor necrosis factor, alpha-induced protein 6
chr4_-_76957214 Show fit	1.44	ENST00000306621.3	CXCL11 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-X-C motif) ligand 11
chr2_-_145278475 Show fit	1.43	ENST00000558170.2	ZEB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger E-box binding homeobox 2
chr2_+_162272605 Show fit	1.41	ENST00000389554.3	TBR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	T-box, brain, 1
chr18_+_616711 Show fit	1.15	ENST00000579494.1	CLUL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin-like 1 (retinal)
chr6_-_27835357 Show fit	1.08	ENST00000331442.3	HIST1H1B Ensembl NCBI GeneCards UniProt NextProt Show fit	histone cluster 1, H1b
chr1_+_12976450 Show fit	0.96	ENST00000361079.2	PRAMEF7 Ensembl NCBI GeneCards UniProt NextProt Show fit	PRAME family member 7
chr2_+_228678550 Show fit	0.91	ENST00000409189.3 ENST00000358813.4	CCL20 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) ligand 20
chr6_-_134639180 Show fit	0.90	ENST00000367858.5	SGK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serum/glucocorticoid regulated kinase 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.3	1.6	GO:0021764	amygdala development(GO:0021764)
0.1	1.6	GO:0030728	ovulation(GO:0030728)
0.2	1.5	GO:1902748	positive regulation of lens fiber cell differentiation(GO:1902748)
0.1	1.3	GO:0043950	positive regulation of cAMP-mediated signaling(GO:0043950)
0.1	1.0	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	1.0	GO:0032528	microvillus organization(GO:0032528)
0.3	0.9	GO:0045360	regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1	0.9	GO:0070294	renal sodium ion absorption(GO:0070294)
0.1	0.9	GO:0071169	establishment of protein localization to chromatin(GO:0071169)

Showing 1 to 10 of 78 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	GO:0045095	keratin filament(GO:0045095)
0.0	1.1	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	0.9	GO:0000786	nucleosome(GO:0000786)
0.1	0.7	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.7	GO:0042613	MHC class II protein complex(GO:0042613)
0.1	0.4	GO:0044530	supraspliceosomal complex(GO:0044530)
0.0	0.4	GO:0036449	microtubule minus-end(GO:0036449)
0.0	0.4	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.4	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.4	GO:0097381	photoreceptor disc membrane(GO:0097381)

Showing 1 to 10 of 16 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.9	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	1.6	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	1.5	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.3	1.4	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.0	1.4	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	1.3	GO:0004984	olfactory receptor activity(GO:0004984)
0.3	0.9	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)
0.0	0.9	GO:0005549	odorant binding(GO:0005549)
0.0	0.9	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	0.7	GO:0023026	MHC class II protein complex binding(GO:0023026)

Showing 1 to 10 of 56 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.4	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.9	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.6	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.6	PID EPHB FWD PATHWAY	EPHB forward signaling
0.2	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	PID IL5 PATHWAY	IL5-mediated signaling events

Showing 1 to 7 of 7 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	2.2	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	1.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.1	1.0	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.6	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.6	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.5	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.4	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.4	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events

Showing 1 to 10 of 12 entries

Results for PRRX1_ALX4_PHOX2A

Z-value: 0.57

Motif logo

Transcription factors associated with PRRX1_ALX4_PHOX2A

Activity-expression correlation:

Activity profile of PRRX1_ALX4_PHOX2A motif

Sorted Z-values of PRRX1_ALX4_PHOX2A motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: