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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PTF1A

Z-value: 0.77

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Transcription factors associated with PTF1A

Gene Symbol Gene ID Gene Info
PTF1A
ENSG00000168267.5 pancreas associated transcription factor 1a

Activity profile of PTF1A motif

Sorted Z-values of PTF1A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_71238313 3.11 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr4_+_156587853 2.19 ENST00000506455.1
ENST00000511108.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr4_+_156588115 2.14 ENST00000455639.2
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr21_-_46012386 2.07 ENST00000400368.1
KRTAP10-6
keratin associated protein 10-6
chr4_+_156587979 2.01 ENST00000511507.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr7_+_150688166 1.96 ENST00000461406.1
NOS3
nitric oxide synthase 3 (endothelial cell)
chr20_+_42544782 1.70 ENST00000423191.2
ENST00000372999.1
TOX2
TOX high mobility group box family member 2
chr4_-_123843597 1.66 ENST00000510735.1
ENST00000304430.5
NUDT6
nudix (nucleoside diphosphate linked moiety X)-type motif 6
chr11_+_7597639 1.54 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_-_1629693 1.37 ENST00000399685.1
KRTAP5-3
keratin associated protein 5-3
chr2_-_241622278 1.10 ENST00000407834.3
AQP12B
aquaporin 12B
chr1_+_231114795 1.01 ENST00000310256.2
ENST00000366658.2
ENST00000450711.1
ENST00000435927.1
ARV1
ARV1 homolog (S. cerevisiae)
chr2_+_241631262 1.00 ENST00000337801.4
ENST00000429564.1
AQP12A
aquaporin 12A
chr4_-_89744457 0.98 ENST00000395002.2
FAM13A
family with sequence similarity 13, member A
chr12_+_109826524 0.96 ENST00000431443.2
MYO1H
myosin IH
chr4_+_40198527 0.96 ENST00000381799.5
RHOH
ras homolog family member H
chr1_-_231114542 0.95 ENST00000522821.1
ENST00000366661.4
ENST00000366662.4
ENST00000414259.1
ENST00000522399.1
TTC13
tetratricopeptide repeat domain 13
chr5_-_39425222 0.90 ENST00000320816.6
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr5_-_39425290 0.89 ENST00000545653.1
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr19_-_10491130 0.87 ENST00000530829.1
ENST00000529370.1
TYK2
tyrosine kinase 2
chr1_-_33647267 0.87 ENST00000291416.5
TRIM62
tripartite motif containing 62
chr17_-_73892992 0.85 ENST00000540128.1
ENST00000269383.3
TRIM65
tripartite motif containing 65
chr17_+_67498538 0.83 ENST00000589647.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr5_-_39425068 0.83 ENST00000515700.1
ENST00000339788.6
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr1_-_76076793 0.81 ENST00000370859.3
SLC44A5
solute carrier family 44, member 5
chr5_+_78532003 0.75 ENST00000396137.4
JMY
junction mediating and regulatory protein, p53 cofactor
chr4_-_83719983 0.75 ENST00000319540.4
SCD5
stearoyl-CoA desaturase 5
chr1_-_205649580 0.73 ENST00000367145.3
SLC45A3
solute carrier family 45, member 3
chr11_-_1643368 0.70 ENST00000399682.1
KRTAP5-4
keratin associated protein 5-4
chr19_-_46526304 0.69 ENST00000008938.4
PGLYRP1
peptidoglycan recognition protein 1
chr4_+_81951957 0.69 ENST00000282701.2
BMP3
bone morphogenetic protein 3
chr6_-_2962331 0.67 ENST00000380524.1
SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr8_-_99306564 0.67 ENST00000430223.2
NIPAL2
NIPA-like domain containing 2
chr18_-_53177984 0.66 ENST00000543082.1
TCF4
transcription factor 4
chr1_-_9129598 0.66 ENST00000535586.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr13_-_79979952 0.63 ENST00000438724.1
RBM26
RNA binding motif protein 26
chr13_-_79979919 0.59 ENST00000267229.7
RBM26
RNA binding motif protein 26
chr17_-_34313685 0.59 ENST00000435911.2
ENST00000586216.1
ENST00000394509.4
CCL14
chemokine (C-C motif) ligand 14
chr2_+_202122703 0.58 ENST00000447616.1
ENST00000358485.4
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr5_-_162887071 0.58 ENST00000302764.4
NUDCD2
NudC domain containing 2
chr5_-_162887054 0.57 ENST00000517501.1
NUDCD2
NudC domain containing 2
chr1_+_178694300 0.56 ENST00000367635.3
RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr3_-_169587621 0.52 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31
leucine rich repeat containing 31
chr11_+_64107663 0.51 ENST00000356786.5
CCDC88B
coiled-coil domain containing 88B
chr1_-_78149041 0.51 ENST00000414381.1
ENST00000370798.1
ZZZ3
zinc finger, ZZ-type containing 3
chr1_-_9129895 0.51 ENST00000473209.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr8_-_99306611 0.50 ENST00000341166.3
NIPAL2
NIPA-like domain containing 2
chrX_-_107019181 0.50 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family, member 3
chr1_+_26856236 0.48 ENST00000374168.2
ENST00000374166.4
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr20_+_18125727 0.47 ENST00000489634.2
CSRP2BP
CSRP2 binding protein
chr3_+_49027308 0.47 ENST00000383729.4
ENST00000343546.4
P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr12_+_50451331 0.45 ENST00000228468.4
ASIC1
acid-sensing (proton-gated) ion channel 1
chr5_-_75013193 0.44 ENST00000514838.2
ENST00000506164.1
ENST00000502826.1
ENST00000503835.1
ENST00000428202.2
ENST00000380475.2
POC5
POC5 centriolar protein
chr1_-_114447620 0.44 ENST00000369569.1
ENST00000432415.1
ENST00000369571.2
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr1_-_45956822 0.43 ENST00000372086.3
ENST00000341771.6
TESK2
testis-specific kinase 2
chr15_+_41099788 0.43 ENST00000299173.10
ENST00000566407.1
ZFYVE19
zinc finger, FYVE domain containing 19
chr8_-_38126635 0.42 ENST00000529359.1
PPAPDC1B
phosphatidic acid phosphatase type 2 domain containing 1B
chr9_+_138235095 0.42 ENST00000320778.2
C9orf62
chromosome 9 open reading frame 62
chr19_+_6464502 0.42 ENST00000308243.7
CRB3
crumbs homolog 3 (Drosophila)
chr6_-_159466042 0.41 ENST00000338313.5
TAGAP
T-cell activation RhoGTPase activating protein
chr1_-_76076759 0.41 ENST00000370855.5
SLC44A5
solute carrier family 44, member 5
chr20_+_54823788 0.40 ENST00000243911.2
MC3R
melanocortin 3 receptor
chr12_-_90102594 0.40 ENST00000428670.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr9_-_116061145 0.39 ENST00000416588.2
RNF183
ring finger protein 183
chr1_-_114447683 0.38 ENST00000256658.4
ENST00000369564.1
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr7_-_142207004 0.38 ENST00000426318.2
TRBV10-2
T cell receptor beta variable 10-2
chr4_-_83719884 0.36 ENST00000282709.4
ENST00000273908.4
SCD5
stearoyl-CoA desaturase 5
chr19_-_39694894 0.35 ENST00000318438.6
SYCN
syncollin
chr19_+_54495542 0.34 ENST00000252729.2
ENST00000352529.1
CACNG6
calcium channel, voltage-dependent, gamma subunit 6
chr2_-_89278535 0.34 ENST00000390247.2
IGKV3-7
immunoglobulin kappa variable 3-7 (non-functional)
chr4_-_14889791 0.34 ENST00000509654.1
ENST00000515031.1
ENST00000505089.2
LINC00504
long intergenic non-protein coding RNA 504
chr12_-_48398104 0.33 ENST00000337299.6
ENST00000380518.3
COL2A1
collagen, type II, alpha 1
chr6_+_57182400 0.33 ENST00000607273.1
PRIM2
primase, DNA, polypeptide 2 (58kDa)
chr13_-_31736027 0.32 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
HSPH1
heat shock 105kDa/110kDa protein 1
chr10_+_124739964 0.32 ENST00000406217.2
PSTK
phosphoseryl-tRNA kinase
chr12_+_75784850 0.31 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr1_-_114447412 0.29 ENST00000369567.1
ENST00000369566.3
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr12_+_112451120 0.29 ENST00000261735.3
ENST00000455836.1
ERP29
endoplasmic reticulum protein 29
chr1_+_150480576 0.29 ENST00000346569.6
ECM1
extracellular matrix protein 1
chr8_+_11351494 0.29 ENST00000259089.4
BLK
B lymphoid tyrosine kinase
chr7_+_141811539 0.28 ENST00000550469.2
ENST00000477922.3
RP11-1220K2.2
Putative inactive maltase-glucoamylase-like protein LOC93432
chr20_-_44259893 0.28 ENST00000326000.1
WFDC9
WAP four-disulfide core domain 9
chr9_+_125281420 0.27 ENST00000340750.1
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chr10_+_124739911 0.26 ENST00000405485.1
PSTK
phosphoseryl-tRNA kinase
chr17_-_3461092 0.26 ENST00000301365.4
ENST00000572519.1
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr6_-_41715128 0.26 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
PGC
progastricsin (pepsinogen C)
chrX_-_48216101 0.25 ENST00000298396.2
ENST00000376893.3
SSX3
synovial sarcoma, X breakpoint 3
chr1_+_150480551 0.25 ENST00000369049.4
ENST00000369047.4
ECM1
extracellular matrix protein 1
chr11_-_111794446 0.24 ENST00000527950.1
CRYAB
crystallin, alpha B
chr6_-_56258892 0.24 ENST00000370819.1
COL21A1
collagen, type XXI, alpha 1
chr20_+_44637526 0.24 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr1_+_12185949 0.23 ENST00000413146.2
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr17_+_27895609 0.23 ENST00000581411.2
ENST00000301057.7
TP53I13
tumor protein p53 inducible protein 13
chrX_-_44402231 0.23 ENST00000378045.4
FUNDC1
FUN14 domain containing 1
chr1_+_151682909 0.22 ENST00000326413.3
ENST00000442233.2
RIIAD1
AL589765.1
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
Uncharacterized protein; cDNA FLJ36032 fis, clone TESTI2017069
chr4_-_89744314 0.22 ENST00000508369.1
FAM13A
family with sequence similarity 13, member A
chr13_+_113633620 0.22 ENST00000421756.1
ENST00000375601.3
MCF2L
MCF.2 cell line derived transforming sequence-like
chr7_-_152373216 0.21 ENST00000359321.1
XRCC2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr3_-_88108192 0.21 ENST00000309534.6
CGGBP1
CGG triplet repeat binding protein 1
chr22_-_17640110 0.20 ENST00000399852.3
ENST00000336737.4
CECR5
cat eye syndrome chromosome region, candidate 5
chr2_-_27435125 0.20 ENST00000414408.1
ENST00000310574.3
SLC5A6
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chrX_+_154299690 0.20 ENST00000340647.4
ENST00000330045.7
BRCC3
BRCA1/BRCA2-containing complex, subunit 3
chr2_+_173600514 0.20 ENST00000264111.6
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr12_+_53689309 0.19 ENST00000351500.3
ENST00000550846.1
ENST00000334478.4
ENST00000549759.1
PFDN5
prefoldin subunit 5
chr14_-_50154921 0.19 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit
chr14_+_77292715 0.19 ENST00000393774.3
ENST00000555189.1
ENST00000450042.2
C14orf166B
chromosome 14 open reading frame 166B
chr2_+_173600565 0.19 ENST00000397081.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_+_32084794 0.18 ENST00000373705.1
HCRTR1
hypocretin (orexin) receptor 1
chr10_+_76871454 0.18 ENST00000372687.4
SAMD8
sterile alpha motif domain containing 8
chr14_-_77737543 0.18 ENST00000298352.4
NGB
neuroglobin
chr8_+_11351876 0.18 ENST00000529894.1
BLK
B lymphoid tyrosine kinase
chr4_-_89744365 0.17 ENST00000513837.1
ENST00000503556.1
FAM13A
family with sequence similarity 13, member A
chr3_+_40518599 0.17 ENST00000314686.5
ENST00000447116.2
ENST00000429348.2
ENST00000456778.1
ZNF619
zinc finger protein 619
chr2_+_120187465 0.17 ENST00000409826.1
ENST00000417645.1
TMEM37
transmembrane protein 37
chrX_-_13956497 0.17 ENST00000398361.3
GPM6B
glycoprotein M6B
chr16_+_71392616 0.16 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2
calbindin 2
chr1_+_100503643 0.16 ENST00000370152.3
HIAT1
hippocampus abundant transcript 1
chr12_-_56223394 0.15 ENST00000317269.3
DNAJC14
DnaJ (Hsp40) homolog, subfamily C, member 14
chr13_+_113812956 0.14 ENST00000375547.2
ENST00000342783.4
PROZ
protein Z, vitamin K-dependent plasma glycoprotein
chr2_+_27435179 0.14 ENST00000606999.1
ENST00000405489.3
ATRAID
all-trans retinoic acid-induced differentiation factor
chr20_+_29956369 0.13 ENST00000253381.2
DEFB118
defensin, beta 118
chr17_+_53342311 0.13 ENST00000226067.5
HLF
hepatic leukemia factor
chr17_+_12692774 0.13 ENST00000379672.5
ENST00000340825.3
ARHGAP44
Rho GTPase activating protein 44
chrX_-_13956737 0.13 ENST00000454189.2
GPM6B
glycoprotein M6B
chrX_+_154299753 0.13 ENST00000369459.2
ENST00000369462.1
ENST00000411985.1
ENST00000399042.1
BRCC3
BRCA1/BRCA2-containing complex, subunit 3
chr22_-_39190116 0.13 ENST00000406622.1
ENST00000216068.4
ENST00000406199.3
SUN2
DNAL4
Sad1 and UNC84 domain containing 2
dynein, axonemal, light chain 4
chr16_+_89696692 0.13 ENST00000261615.4
DPEP1
dipeptidase 1 (renal)
chr6_-_24877490 0.13 ENST00000540914.1
ENST00000378023.4
FAM65B
family with sequence similarity 65, member B
chr14_-_35099377 0.13 ENST00000362031.4
SNX6
sorting nexin 6
chr15_+_68924327 0.12 ENST00000543950.1
CORO2B
coronin, actin binding protein, 2B
chr13_+_107028897 0.11 ENST00000439790.1
ENST00000435024.1
LINC00460
long intergenic non-protein coding RNA 460
chr11_+_64058758 0.10 ENST00000538767.1
KCNK4
potassium channel, subfamily K, member 4
chr16_-_15950868 0.10 ENST00000396324.3
ENST00000452625.2
ENST00000576790.2
ENST00000300036.5
MYH11
myosin, heavy chain 11, smooth muscle
chr16_+_2802316 0.10 ENST00000301740.8
SRRM2
serine/arginine repetitive matrix 2
chr18_+_5238055 0.09 ENST00000582363.1
ENST00000582008.1
ENST00000580082.1
LINC00667
long intergenic non-protein coding RNA 667
chr8_-_38126675 0.09 ENST00000531823.1
ENST00000534339.1
ENST00000524616.1
ENST00000422581.2
ENST00000424479.2
ENST00000419686.2
PPAPDC1B
phosphatidic acid phosphatase type 2 domain containing 1B
chr1_-_45956800 0.09 ENST00000538496.1
TESK2
testis-specific kinase 2
chr16_-_2004683 0.09 ENST00000268661.7
RPL3L
ribosomal protein L3-like
chr10_+_120116527 0.08 ENST00000445161.1
LINC00867
long intergenic non-protein coding RNA 867
chr19_+_11670245 0.08 ENST00000585493.1
ZNF627
zinc finger protein 627
chr12_-_50677255 0.08 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1
LIM domain and actin binding 1
chr13_-_31736132 0.08 ENST00000429785.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr3_-_12883026 0.08 ENST00000396953.2
ENST00000457131.1
ENST00000435983.1
ENST00000273223.6
ENST00000396957.1
ENST00000429711.2
RPL32
ribosomal protein L32
chr2_-_136288113 0.08 ENST00000401392.1
ZRANB3
zinc finger, RAN-binding domain containing 3
chr2_-_89417335 0.07 ENST00000490686.1
IGKV1-17
immunoglobulin kappa variable 1-17
chr6_-_159466136 0.07 ENST00000367066.3
ENST00000326965.6
TAGAP
T-cell activation RhoGTPase activating protein
chr19_+_6464243 0.07 ENST00000600229.1
ENST00000356762.3
CRB3
crumbs homolog 3 (Drosophila)
chr10_+_43572475 0.07 ENST00000355710.3
ENST00000498820.1
ENST00000340058.5
RET
ret proto-oncogene
chr11_-_130298888 0.06 ENST00000257359.6
ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chrX_+_155110956 0.06 ENST00000286448.6
ENST00000262640.6
ENST00000460621.1
VAMP7
vesicle-associated membrane protein 7
chr9_-_104145795 0.06 ENST00000259407.2
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr14_-_35099315 0.06 ENST00000396526.3
ENST00000396534.3
ENST00000355110.5
ENST00000557265.1
SNX6
sorting nexin 6
chr3_-_193272874 0.06 ENST00000342695.4
ATP13A4
ATPase type 13A4
chr1_+_40204538 0.06 ENST00000324379.5
ENST00000356511.2
ENST00000497370.1
ENST00000470213.1
ENST00000372835.5
ENST00000372830.1
PPIE
peptidylprolyl isomerase E (cyclophilin E)
chr12_+_1929421 0.06 ENST00000543818.1
LRTM2
leucine-rich repeats and transmembrane domains 2
chr22_+_24999114 0.05 ENST00000412658.1
ENST00000445029.1
ENST00000419133.1
ENST00000400382.1
ENST00000438643.2
ENST00000452551.1
ENST00000400383.1
ENST00000412898.1
ENST00000400380.1
ENST00000455483.1
ENST00000430289.1
GGT1
gamma-glutamyltransferase 1
chr4_+_20702059 0.05 ENST00000444671.2
ENST00000510700.1
ENST00000506745.1
ENST00000514663.1
ENST00000509469.1
ENST00000515339.1
ENST00000513861.1
ENST00000502374.1
ENST00000538990.1
ENST00000511160.1
ENST00000504630.1
ENST00000513590.1
ENST00000514292.1
ENST00000502938.1
ENST00000509625.1
ENST00000505160.1
ENST00000507634.1
ENST00000513459.1
ENST00000511089.1
PACRGL
PARK2 co-regulated-like
chr7_+_142458507 0.05 ENST00000492062.1
PRSS1
protease, serine, 1 (trypsin 1)
chr22_+_23101182 0.05 ENST00000390312.2
IGLV2-14
immunoglobulin lambda variable 2-14
chr6_-_46620522 0.05 ENST00000275016.2
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr12_-_120884175 0.05 ENST00000546954.1
TRIAP1
TP53 regulated inhibitor of apoptosis 1
chr9_-_138853156 0.05 ENST00000371756.3
UBAC1
UBA domain containing 1
chr7_+_30323923 0.04 ENST00000323037.4
ZNRF2
zinc and ring finger 2
chr9_-_19033185 0.04 ENST00000380534.4
FAM154A
family with sequence similarity 154, member A
chr1_+_228337553 0.04 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chr9_-_19033237 0.04 ENST00000380530.1
ENST00000542071.1
FAM154A
family with sequence similarity 154, member A
chr11_+_56949221 0.04 ENST00000497933.1
LRRC55
leucine rich repeat containing 55
chr8_-_135725205 0.03 ENST00000523399.1
ENST00000377838.3
ZFAT
zinc finger and AT hook domain containing
chr17_+_40996590 0.03 ENST00000253799.3
ENST00000452774.2
AOC2
amine oxidase, copper containing 2 (retina-specific)
chr20_-_48732472 0.03 ENST00000340309.3
ENST00000415862.2
ENST00000371677.3
ENST00000420027.2
UBE2V1
ubiquitin-conjugating enzyme E2 variant 1
chr1_-_158300747 0.03 ENST00000451207.1
CD1B
CD1b molecule
chr6_-_24489842 0.03 ENST00000230036.1
GPLD1
glycosylphosphatidylinositol specific phospholipase D1
chr11_+_8704748 0.03 ENST00000526562.1
ENST00000525981.1
RPL27A
ribosomal protein L27a
chr18_+_33877654 0.02 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3
formin homology 2 domain containing 3
chr1_+_32084641 0.02 ENST00000373706.5
HCRTR1
hypocretin (orexin) receptor 1
chr1_-_9129735 0.02 ENST00000377424.4
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr19_+_42300548 0.02 ENST00000344550.4
CEACAM3
carcinoembryonic antigen-related cell adhesion molecule 3
chr2_+_183943464 0.02 ENST00000354221.4
DUSP19
dual specificity phosphatase 19
chr17_+_31318886 0.01 ENST00000269053.3
ENST00000394638.1
SPACA3
sperm acrosome associated 3
chr12_+_1929644 0.01 ENST00000299194.1
LRTM2
leucine-rich repeats and transmembrane domains 2
chr11_-_63933504 0.01 ENST00000255681.6
MACROD1
MACRO domain containing 1
chr8_-_145641864 0.01 ENST00000276833.5
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr19_+_19779686 0.00 ENST00000415784.2
ZNF101
zinc finger protein 101

Network of associatons between targets according to the STRING database.

First level regulatory network of PTF1A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.3 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.7 2.6 GO:0035026 leading edge cell differentiation(GO:0035026)
0.7 2.0 GO:0014806 negative regulation of muscle hyperplasia(GO:0014740) smooth muscle hyperplasia(GO:0014806)
0.4 1.1 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.3 0.8 GO:0072709 cellular response to sorbitol(GO:0072709)
0.2 0.7 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.2 0.7 GO:0002325 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.2 1.0 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.2 0.8 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.6 GO:0052056 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.1 1.0 GO:0098704 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.1 0.6 GO:0032484 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.1 0.6 GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process(GO:0097056)
0.1 1.2 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.2 GO:0032679 TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759)
0.1 0.3 GO:0043335 protein unfolding(GO:0043335)
0.1 1.2 GO:0015871 choline transport(GO:0015871)
0.1 0.4 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.1 0.5 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 0.5 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.3 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.5 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.3 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.1 0.3 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.1 0.4 GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0 0.4 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.0 0.3 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.0 0.1 GO:0016999 antibiotic metabolic process(GO:0016999)
0.0 0.2 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0 6.8 GO:0031424 keratinization(GO:0031424)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.2 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.0 0.3 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0071469 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.0 0.3 GO:0060174 limb bud formation(GO:0060174)
0.0 0.2 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.4 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.9 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.1 GO:0007497 posterior midgut development(GO:0007497)
0.0 0.5 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.1 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0051673 membrane disruption in other organism(GO:0051673)
0.0 0.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 1.0 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 1.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.7 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 6.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.0 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.6 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.1 6.8 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.3 GO:0070552 BRISC complex(GO:0070552)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.5 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.6 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.4 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 1.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.4 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 1.0 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 0.7 GO:0015154 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 6.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 1.1 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.2 0.7 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.1 1.0 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.1 1.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 2.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.4 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.6 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 0.3 GO:0003896 DNA primase activity(GO:0003896)
0.1 0.5 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 0.8 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.2 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 1.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.5 GO:0043426 MRF binding(GO:0043426)
0.1 0.7 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.2 GO:0016499 orexin receptor activity(GO:0016499)
0.1 0.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.0 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.1 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 1.0 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.0 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.1 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 0.0 GO:0052595 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 2.0 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 2.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.5 PID EPHA FWDPATHWAY EPHA forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 6.2 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 1.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.8 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.2 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.3 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 2.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions