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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for RAD21_SMC3

Z-value: 0.70

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Transcription factors associated with RAD21_SMC3

Gene Symbol Gene ID Gene Info
ENSG00000164754.8 RAD21 cohesin complex component
ENSG00000108055.9 structural maintenance of chromosomes 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMC3hg19_v2_chr10_+_112327425_112327516-0.368.0e-02Click!
RAD21hg19_v2_chr8_-_117886955_117887105-0.262.1e-01Click!

Activity profile of RAD21_SMC3 motif

Sorted Z-values of RAD21_SMC3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_114737472 6.88 ENST00000420161.1
AC110769.3
chr9_+_116917807 3.19 ENST00000356083.3
collagen, type XXVII, alpha 1
chr2_+_114737146 3.14 ENST00000412690.1
AC010982.1
chr8_-_90996459 2.20 ENST00000517337.1
ENST00000409330.1
nibrin
chr10_-_6019984 2.11 ENST00000525219.2
interleukin 15 receptor, alpha
chr8_-_90996837 2.07 ENST00000519426.1
ENST00000265433.3
nibrin
chr14_+_24630465 1.76 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
interferon regulatory factor 9
chr10_-_49732281 1.72 ENST00000374170.1
Rho GTPase activating protein 22
chr10_+_104154229 1.70 ENST00000428099.1
ENST00000369966.3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr6_+_138188551 1.49 ENST00000237289.4
ENST00000433680.1
tumor necrosis factor, alpha-induced protein 3
chr16_+_66638685 1.48 ENST00000565003.1
CKLF-like MARVEL transmembrane domain containing 3
chr9_-_134615443 1.48 ENST00000372195.1
Rap guanine nucleotide exchange factor (GEF) 1
chr11_-_72504681 1.48 ENST00000538536.1
ENST00000543304.1
ENST00000540587.1
ENST00000334805.6
StAR-related lipid transfer (START) domain containing 10
chr15_-_64338521 1.46 ENST00000457488.1
ENST00000558069.1
death-associated protein kinase 2
chr2_+_102972363 1.09 ENST00000409599.1
interleukin 18 receptor 1
chr3_-_190040223 1.09 ENST00000295522.3
claudin 1
chrX_+_49969405 1.07 ENST00000376042.1
cyclin B3
chr5_-_146833222 1.05 ENST00000534907.1
dihydropyrimidinase-like 3
chr9_-_38069208 1.01 ENST00000377707.3
ENST00000377700.4
Src homology 2 domain containing adaptor protein B
chr9_+_103189536 0.97 ENST00000374885.1
Myb/SANT-like DNA-binding domain containing 3
chr19_-_49496557 0.97 ENST00000323798.3
ENST00000541188.1
ENST00000544287.1
ENST00000540532.1
ENST00000263276.6
glycogen synthase 1 (muscle)
chr19_+_12949251 0.94 ENST00000251472.4
microtubule associated serine/threonine kinase 1
chr10_+_81107216 0.91 ENST00000394579.3
ENST00000225174.3
peptidylprolyl isomerase F
chr9_+_103189405 0.87 ENST00000395067.2
Myb/SANT-like DNA-binding domain containing 3
chr2_+_234263120 0.87 ENST00000264057.2
ENST00000427930.1
diacylglycerol kinase, delta 130kDa
chr2_+_228678550 0.86 ENST00000409189.3
ENST00000358813.4
chemokine (C-C motif) ligand 20
chr15_+_71185148 0.84 ENST00000443425.2
ENST00000560755.1
leucine rich repeat containing 49
chr5_+_6583380 0.83 ENST00000507582.1
long intergenic non-protein coding RNA 1018
chr15_+_75074410 0.82 ENST00000439220.2
c-src tyrosine kinase
chr15_+_75074385 0.79 ENST00000220003.9
c-src tyrosine kinase
chr19_-_55652290 0.77 ENST00000589745.1
troponin T type 1 (skeletal, slow)
chr12_-_7245125 0.77 ENST00000542285.1
ENST00000540610.1
complement component 1, r subcomponent
chr16_+_4674814 0.76 ENST00000415496.1
ENST00000587747.1
ENST00000399577.5
ENST00000588994.1
ENST00000586183.1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr16_+_4674787 0.75 ENST00000262370.7
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr15_-_58358607 0.74 ENST00000249750.4
aldehyde dehydrogenase 1 family, member A2
chr19_-_55653259 0.72 ENST00000593194.1
troponin T type 1 (skeletal, slow)
chr17_-_79827808 0.71 ENST00000580685.1
Rho GDP dissociation inhibitor (GDI) alpha
chr19_-_6481776 0.69 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENN/MADD domain containing 1C
chr11_+_2421718 0.65 ENST00000380996.5
ENST00000333256.6
ENST00000380992.1
ENST00000437110.1
ENST00000435795.1
tumor suppressing subtransferable candidate 4
chr5_-_146833485 0.64 ENST00000398514.3
dihydropyrimidinase-like 3
chr14_+_52118576 0.63 ENST00000395718.2
ENST00000344768.5
FERM domain containing 6
chr11_+_64216546 0.62 ENST00000316124.2
HCG1652096, isoform CRA_a; Uncharacterized protein; cDNA FLJ37045 fis, clone BRACE2012185
chr9_+_130965677 0.61 ENST00000393594.3
ENST00000486160.1
dynamin 1
chr9_+_130965651 0.60 ENST00000475805.1
ENST00000341179.7
ENST00000372923.3
dynamin 1
chr18_+_596982 0.60 ENST00000579912.1
ENST00000400606.2
ENST00000540035.1
clusterin-like 1 (retinal)
chr6_-_32806506 0.58 ENST00000374897.2
ENST00000452392.2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr20_-_30311703 0.58 ENST00000450273.1
ENST00000456404.1
ENST00000420488.1
ENST00000439267.1
BCL2-like 1
chr9_+_71650645 0.58 ENST00000396366.2
frataxin
chr4_+_75858290 0.57 ENST00000513238.1
prostate androgen-regulated mucin-like protein 1
chr19_+_45842445 0.57 ENST00000598357.1
Uncharacterized protein
chr12_-_113574028 0.56 ENST00000546530.1
ENST00000261729.5
RAS protein activator like 1 (GAP1 like)
chr4_-_41884620 0.55 ENST00000504870.1
long intergenic non-protein coding RNA 682
chr1_+_16767167 0.55 ENST00000337132.5
NECAP endocytosis associated 2
chr17_-_1090599 0.55 ENST00000544583.2
active BCR-related
chr8_+_54764346 0.54 ENST00000297313.3
ENST00000344277.6
regulator of G-protein signaling 20
chr17_+_45810594 0.53 ENST00000177694.1
T-box 21
chr4_+_75858318 0.53 ENST00000307428.7
prostate androgen-regulated mucin-like protein 1
chr11_+_118826999 0.52 ENST00000264031.2
uroplakin 2
chr6_-_11044509 0.51 ENST00000354666.3
ELOVL fatty acid elongase 2
chr5_+_172571445 0.49 ENST00000231668.9
ENST00000351486.5
ENST00000352523.6
ENST00000393770.4
BCL2/adenovirus E1B 19kDa interacting protein 1
chrX_+_23801280 0.49 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
spermidine/spermine N1-acetyltransferase 1
chr18_-_47721447 0.49 ENST00000285039.7
myosin VB
chr1_-_40367530 0.48 ENST00000372816.2
ENST00000372815.1
v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
chr17_-_33469299 0.48 ENST00000586869.1
ENST00000360831.5
ENST00000442241.4
notchless homolog 1 (Drosophila)
chr4_-_171011323 0.48 ENST00000509167.1
ENST00000353187.2
ENST00000507375.1
ENST00000515480.1
aminoadipate aminotransferase
chr10_-_79789291 0.47 ENST00000372371.3
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr1_+_16767195 0.47 ENST00000504551.2
ENST00000457722.2
ENST00000406746.1
ENST00000443980.2
NECAP endocytosis associated 2
chr21_+_45725050 0.47 ENST00000403390.1
phosphofructokinase, liver
chr5_-_118324200 0.47 ENST00000515439.3
ENST00000510708.1
DTW domain containing 2
chr4_+_56814968 0.46 ENST00000422247.2
centrosomal protein 135kDa
chr17_+_7621045 0.46 ENST00000570791.1
dynein, axonemal, heavy chain 2
chr19_-_1848451 0.45 ENST00000170168.4
REX1, RNA exonuclease 1 homolog (S. cerevisiae)
chr17_+_38137050 0.45 ENST00000264639.4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr4_-_120548779 0.45 ENST00000264805.5
phosphodiesterase 5A, cGMP-specific
chr17_+_1958388 0.45 ENST00000399849.3
hypermethylated in cancer 1
chr16_+_1203194 0.45 ENST00000348261.5
ENST00000358590.4
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr21_-_36262032 0.45 ENST00000325074.5
ENST00000399237.2
runt-related transcription factor 1
chr8_-_48651648 0.44 ENST00000408965.3
CCAAT/enhancer binding protein (C/EBP), delta
chr1_+_205225319 0.44 ENST00000329800.7
transmembrane and coiled-coil domain family 2
chr1_-_6761855 0.44 ENST00000426784.1
ENST00000377573.5
ENST00000377577.5
ENST00000294401.7
DnaJ (Hsp40) homolog, subfamily C, member 11
chr14_+_22356029 0.44 ENST00000390437.2
T cell receptor alpha variable 12-2
chr10_-_96122682 0.43 ENST00000371361.3
nucleolar complex associated 3 homolog (S. cerevisiae)
chr15_-_40212363 0.42 ENST00000299092.3
G protein-coupled receptor 176
chr10_-_15413035 0.42 ENST00000378116.4
ENST00000455654.1
family with sequence similarity 171, member A1
chr20_+_48807351 0.42 ENST00000303004.3
CCAAT/enhancer binding protein (C/EBP), beta
chr9_+_103189660 0.42 ENST00000374886.3
Myb/SANT-like DNA-binding domain containing 3
chr17_+_38137073 0.41 ENST00000541736.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr14_+_23305760 0.41 ENST00000311852.6
matrix metallopeptidase 14 (membrane-inserted)
chr7_+_6144514 0.40 ENST00000306177.5
ENST00000465073.2
ubiquitin specific peptidase 42
chr2_+_186603545 0.40 ENST00000424728.1
fibrous sheath interacting protein 2
chr5_+_176514413 0.40 ENST00000513166.1
fibroblast growth factor receptor 4
chr2_+_171785824 0.40 ENST00000452526.2
golgi reassembly stacking protein 2, 55kDa
chr6_+_126277842 0.40 ENST00000229633.5
histidine triad nucleotide binding protein 3
chr19_-_19754354 0.40 ENST00000587238.1
GEM interacting protein
chr1_-_170043709 0.40 ENST00000367767.1
ENST00000361580.2
ENST00000538366.1
kinesin-associated protein 3
chr1_+_37940153 0.39 ENST00000373087.6
zinc finger CCCH-type containing 12A
chr22_-_50050986 0.39 ENST00000405854.1
chromosome 22 open reading frame 34
chr15_+_45722727 0.39 ENST00000396650.2
ENST00000558435.1
ENST00000344300.3
chromosome 15 open reading frame 48
chr4_-_171011084 0.39 ENST00000337664.4
aminoadipate aminotransferase
chr3_+_48507210 0.39 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
three prime repair exonuclease 1
chr7_-_5569588 0.38 ENST00000417101.1
actin, beta
chr1_+_151129103 0.38 ENST00000368910.3
tumor necrosis factor, alpha-induced protein 8-like 2
chr5_-_76788317 0.38 ENST00000296679.4
WD repeat domain 41
chr17_-_73901494 0.38 ENST00000309352.3
mitochondrial ribosomal protein L38
chr17_-_42441204 0.38 ENST00000293443.7
family with sequence similarity 171, member A2
chr9_-_139258235 0.38 ENST00000371738.3
DNL-type zinc finger
chr17_-_40833858 0.38 ENST00000332438.4
chemokine (C-C motif) receptor 10
chr1_+_18081804 0.38 ENST00000375406.1
actin-like 8
chr2_+_228337079 0.37 ENST00000409315.1
ENST00000373671.3
ENST00000409171.1
ArfGAP with FG repeats 1
chr16_-_88851618 0.36 ENST00000301015.9
piezo-type mechanosensitive ion channel component 1
chr12_-_8549301 0.36 ENST00000544461.1
long intergenic non-protein coding RNA 937
chr16_+_2255447 0.36 ENST00000562352.1
ENST00000562479.1
ENST00000301724.10
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr9_+_100174232 0.36 ENST00000355295.4
tudor domain containing 7
chr19_-_4791219 0.36 ENST00000598782.1
AC005523.3
chr10_-_90342947 0.36 ENST00000437752.1
ENST00000331772.4
renalase, FAD-dependent amine oxidase
chrX_-_153279697 0.36 ENST00000444254.1
interleukin-1 receptor-associated kinase 1
chrX_+_47053208 0.35 ENST00000442035.1
ENST00000457753.1
ENST00000335972.6
ubiquitin-like modifier activating enzyme 1
chr12_-_50101003 0.35 ENST00000550488.1
formin-like 3
chr9_-_22009241 0.35 ENST00000380142.4
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr9_+_100174344 0.35 ENST00000422139.2
tudor domain containing 7
chr17_-_7518145 0.35 ENST00000250113.7
ENST00000571597.1
fragile X mental retardation, autosomal homolog 2
chr18_+_60382672 0.35 ENST00000400316.4
ENST00000262719.5
PH domain and leucine rich repeat protein phosphatase 1
chr15_+_74165945 0.35 ENST00000535547.2
ENST00000300504.2
ENST00000562056.1
TBC1 domain family, member 21
chr12_-_102224457 0.35 ENST00000549165.1
ENST00000549940.1
ENST00000392919.4
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chr19_+_47852538 0.35 ENST00000328771.4
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr16_+_2255841 0.34 ENST00000301725.7
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr19_+_18043810 0.34 ENST00000445755.2
coiled-coil domain containing 124
chr3_+_172468472 0.34 ENST00000232458.5
ENST00000392692.3
epithelial cell transforming sequence 2 oncogene
chr2_+_186603355 0.34 ENST00000343098.5
fibrous sheath interacting protein 2
chr19_-_58400148 0.33 ENST00000595048.1
ENST00000600634.1
ENST00000595295.1
ENST00000596604.1
ENST00000597342.1
ENST00000597807.1
zinc finger protein 814
chr19_+_49977466 0.33 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
fms-related tyrosine kinase 3 ligand
chr10_-_47151341 0.33 ENST00000422732.2
long intergenic non-protein coding RNA 842
chr19_+_56165480 0.32 ENST00000450554.2
U2 small nuclear RNA auxiliary factor 2
chr16_+_2255710 0.32 ENST00000397124.1
ENST00000565250.1
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr3_-_128369643 0.32 ENST00000296255.3
ribophorin I
chr18_-_19180681 0.32 ENST00000269214.5
establishment of sister chromatid cohesion N-acetyltransferase 1
chr10_+_99332198 0.32 ENST00000307518.5
ENST00000298808.5
ENST00000370655.1
ankyrin repeat domain 2 (stretch responsive muscle)
chr5_-_76788024 0.32 ENST00000515253.1
ENST00000414719.2
ENST00000507654.1
ENST00000514559.1
ENST00000511791.1
WD repeat domain 41
chr17_-_37308824 0.32 ENST00000415163.1
ENST00000441877.1
ENST00000444911.2
plexin domain containing 1
chr1_+_109642799 0.31 ENST00000602755.1
small Cajal body-specific RNA 2
chr5_-_76788134 0.31 ENST00000507029.1
WD repeat domain 41
chr19_+_16222439 0.31 ENST00000300935.3
RAB8A, member RAS oncogene family
chr19_-_19754404 0.31 ENST00000587205.1
ENST00000445806.2
ENST00000203556.4
GEM interacting protein
chr11_+_73675873 0.30 ENST00000537753.1
ENST00000542350.1
DnaJ (Hsp40) homolog, subfamily B, member 13
chr15_+_63340553 0.30 ENST00000334895.5
tropomyosin 1 (alpha)
chr14_+_22265444 0.30 ENST00000390430.2
T cell receptor alpha variable 8-1
chr20_+_60878005 0.29 ENST00000253003.2
adhesion regulating molecule 1
chr12_-_113573495 0.29 ENST00000446861.3
RAS protein activator like 1 (GAP1 like)
chr18_-_21166841 0.29 ENST00000269228.5
Niemann-Pick disease, type C1
chr19_+_10982336 0.29 ENST00000344150.4
coactivator-associated arginine methyltransferase 1
chr10_+_103892787 0.29 ENST00000278070.2
ENST00000413464.2
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr2_-_166060571 0.29 ENST00000360093.3
sodium channel, voltage-gated, type III, alpha subunit
chr5_-_140998616 0.28 ENST00000389054.3
ENST00000398562.2
ENST00000389057.5
ENST00000398566.3
ENST00000398557.4
ENST00000253811.6
diaphanous-related formin 1
chr15_+_92396920 0.28 ENST00000318445.6
solute carrier organic anion transporter family, member 3A1
chr19_+_4791722 0.28 ENST00000269856.3
fem-1 homolog a (C. elegans)
chr15_-_38856836 0.28 ENST00000450598.2
ENST00000559830.1
ENST00000558164.1
ENST00000310803.5
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
chr3_+_23244511 0.28 ENST00000425792.1
ubiquitin-conjugating enzyme E2E 2
chr14_+_22465771 0.28 ENST00000390445.2
T cell receptor alpha variable 17
chr9_+_36136700 0.28 ENST00000396613.3
ENST00000377959.1
ENST00000377960.4
GLI pathogenesis-related 2
chr10_+_116581503 0.27 ENST00000369248.4
ENST00000369250.3
ENST00000369246.1
family with sequence similarity 160, member B1
chr1_-_172413195 0.27 ENST00000344529.4
phosphatidylinositol glycan anchor biosynthesis, class C
chr11_-_72504637 0.27 ENST00000536377.1
ENST00000359373.5
StAR-related lipid transfer (START) domain containing 10
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr2_-_154335300 0.27 ENST00000325926.3
reprimo, TP53 dependent G2 arrest mediator candidate
chr11_-_65150103 0.27 ENST00000294187.6
ENST00000398802.1
ENST00000360662.3
ENST00000377152.2
ENST00000530936.1
solute carrier family 25, member 45
chr1_-_172413226 0.27 ENST00000367728.1
ENST00000258324.1
phosphatidylinositol glycan anchor biosynthesis, class C
chr15_+_63340734 0.27 ENST00000560959.1
tropomyosin 1 (alpha)
chr12_-_95510743 0.27 ENST00000551521.1
FYVE, RhoGEF and PH domain containing 6
chr5_-_140998481 0.27 ENST00000518047.1
diaphanous-related formin 1
chr11_-_36531774 0.27 ENST00000348124.5
ENST00000526995.1
TNF receptor-associated factor 6, E3 ubiquitin protein ligase
chr10_+_72194585 0.26 ENST00000420338.2
Uncharacterized protein
chr2_+_90108504 0.26 ENST00000390271.2
immunoglobulin kappa variable 6D-41 (non-functional)
chr17_-_48474828 0.26 ENST00000576448.1
ENST00000225972.7
leucine rich repeat containing 59
chr12_-_89918522 0.26 ENST00000529983.2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
chr1_+_109632425 0.26 ENST00000338272.8
transmembrane protein 167B
chr10_-_27149792 0.26 ENST00000376140.3
ENST00000376170.4
abl-interactor 1
chr16_-_69788816 0.26 ENST00000268802.5
NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
chr1_+_114447763 0.26 ENST00000369563.3
DNA cross-link repair 1B
chr6_+_146864829 0.25 ENST00000367495.3
RAB32, member RAS oncogene family
chr16_+_30662360 0.25 ENST00000542965.2
proline rich 14
chr17_-_37309480 0.25 ENST00000539608.1
plexin domain containing 1
chr5_+_137688285 0.25 ENST00000314358.5
lysine (K)-specific demethylase 3B
chr5_-_45696253 0.25 ENST00000303230.4
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr22_-_19132154 0.25 ENST00000252137.6
DiGeorge syndrome critical region gene 14
chr10_+_12391481 0.25 ENST00000378847.3
calcium/calmodulin-dependent protein kinase ID
chr2_-_166060552 0.25 ENST00000283254.7
ENST00000453007.1
sodium channel, voltage-gated, type III, alpha subunit
chr2_+_171785012 0.25 ENST00000234160.4
golgi reassembly stacking protein 2, 55kDa
chr3_+_5163905 0.24 ENST00000256496.3
ENST00000419534.2
ADP-ribosylation factor-like 8B
chr11_+_61447845 0.24 ENST00000257215.5
diacylglycerol lipase, alpha
chrX_+_11776410 0.24 ENST00000361672.2
male-specific lethal 3 homolog (Drosophila)
chr12_+_51818586 0.24 ENST00000394856.1
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr3_+_172468505 0.24 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
epithelial cell transforming sequence 2 oncogene
chr16_+_69345243 0.24 ENST00000254950.11
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr4_+_7194247 0.24 ENST00000507866.2
sortilin-related VPS10 domain containing receptor 2
chr19_+_49496705 0.23 ENST00000595090.1
RuvB-like AAA ATPase 2
chr5_+_175875349 0.23 ENST00000261942.6
Fas associated factor family member 2
chr5_-_139726181 0.23 ENST00000507104.1
ENST00000230990.6
heparin-binding EGF-like growth factor
chr12_+_51818555 0.23 ENST00000453097.2
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr10_-_27149904 0.23 ENST00000376166.1
ENST00000376138.3
ENST00000355394.4
ENST00000346832.5
ENST00000376134.3
ENST00000376137.4
ENST00000536334.1
ENST00000490841.2
abl-interactor 1
chr14_+_22386325 0.23 ENST00000390439.2
T cell receptor alpha variable 13-2
chr15_+_63340775 0.23 ENST00000559281.1
ENST00000317516.7
tropomyosin 1 (alpha)

Network of associatons between targets according to the STRING database.

First level regulatory network of RAD21_SMC3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.5 1.5 GO:0090291 B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) negative regulation of osteoclast proliferation(GO:0090291)
0.5 3.2 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.4 1.7 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.4 1.2 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.4 1.1 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.3 0.9 GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.3 0.9 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.3 1.0 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.2 1.5 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.2 0.9 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.2 1.6 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.2 1.5 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.2 0.6 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.2 0.5 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 1.7 GO:0032782 bile acid secretion(GO:0032782)
0.1 0.6 GO:0018283 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
0.1 0.4 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.1 0.4 GO:0032203 telomere formation via telomerase(GO:0032203)
0.1 0.4 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.1 0.4 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294)
0.1 0.4 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.1 1.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.5 GO:0009447 putrescine catabolic process(GO:0009447)
0.1 1.0 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.3 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.1 1.2 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.1 1.5 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 0.4 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.6 GO:0003383 apical constriction(GO:0003383)
0.1 1.1 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655)
0.1 0.7 GO:0035799 ureter maturation(GO:0035799)
0.1 0.4 GO:1990834 response to odorant(GO:1990834)
0.1 0.5 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 0.5 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 0.2 GO:0002325 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.1 0.6 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.1 0.4 GO:0071733 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 1.7 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.3 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
0.1 0.3 GO:2000569 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.1 0.5 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.3 GO:1903412 response to bile acid(GO:1903412)
0.1 0.5 GO:0032439 endosome localization(GO:0032439)
0.1 0.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.2 GO:0098917 retrograde trans-synaptic signaling(GO:0098917)
0.1 0.2 GO:0009946 proximal/distal axis specification(GO:0009946) bronchiole development(GO:0060435) submandibular salivary gland formation(GO:0060661) positive regulation of white fat cell proliferation(GO:0070352) Harderian gland development(GO:0070384) hair follicle cell proliferation(GO:0071335) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.1 0.5 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.2 GO:1904387 cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387)
0.1 0.3 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.1 0.4 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.1 0.2 GO:0033241 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204) negative regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901205) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.1 0.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.2 GO:1905229 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.0 0.4 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.2 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.2 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0 0.3 GO:0032252 secretory granule localization(GO:0032252)
0.0 0.6 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 1.2 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.8 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.2 GO:0035106 angiotensin-mediated drinking behavior(GO:0003051) operant conditioning(GO:0035106)
0.0 0.4 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 0.1 GO:1903028 positive regulation of opsonization(GO:1903028)
0.0 0.3 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.2 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.1 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.0 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.3 GO:0002870 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 0.5 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.5 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.3 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.1 GO:1904647 response to rotenone(GO:1904647)
0.0 0.2 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 0.1 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.0 0.3 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.0 0.5 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.0 0.1 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.0 0.2 GO:1901490 regulation of lymphangiogenesis(GO:1901490)
0.0 0.4 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.4 GO:1902074 response to salt(GO:1902074)
0.0 0.5 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.3 GO:0072718 response to cisplatin(GO:0072718)
0.0 0.7 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.3 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.2 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.7 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 1.2 GO:0038202 TORC1 signaling(GO:0038202)
0.0 0.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.8 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.5 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.0 0.1 GO:0009227 UDP-glucose catabolic process(GO:0006258) nucleotide-sugar catabolic process(GO:0009227)
0.0 0.1 GO:0060168 positive regulation of adenosine receptor signaling pathway(GO:0060168) regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 0.2 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.2 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.5 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 1.1 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.1 GO:0044026 DNA hypermethylation(GO:0044026)
0.0 0.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.2 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0 0.1 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 0.1 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0 0.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.4 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.0 0.2 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 1.8 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:1903540 neurotransmitter receptor transport to postsynaptic membrane(GO:0098969) establishment of protein localization to postsynaptic membrane(GO:1903540)
0.0 0.3 GO:0015732 prostaglandin transport(GO:0015732)
0.0 0.1 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.0 0.5 GO:0000469 cleavage involved in rRNA processing(GO:0000469)
0.0 0.2 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway(GO:0035791)
0.0 0.2 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0 0.1 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.0 0.0 GO:1900019 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0 0.8 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 0.0 GO:0071301 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.0 0.1 GO:0071504 cellular response to heparin(GO:0071504)
0.0 0.1 GO:0046108 uridine metabolic process(GO:0046108)
0.0 0.1 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.0 0.0 GO:0071529 cementum mineralization(GO:0071529)
0.0 1.2 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.0 0.0 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220)
0.0 0.4 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.2 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) histone H2B ubiquitination(GO:0033523)
0.0 0.9 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.3 GO:0030870 Mre11 complex(GO:0030870)
0.4 1.7 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.2 3.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 1.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.6 GO:0097149 centralspindlin complex(GO:0097149)
0.1 1.0 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.4 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.1 0.4 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.1 0.5 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 1.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.2 GO:0098855 HCN channel complex(GO:0098855)
0.1 1.5 GO:0005861 troponin complex(GO:0005861)
0.1 0.4 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.1 0.4 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.5 GO:0072487 MSL complex(GO:0072487)
0.1 0.4 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.2 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 1.0 GO:0032059 muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059)
0.1 0.3 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.3 GO:0042825 TAP complex(GO:0042825)
0.0 0.3 GO:0089701 U2AF(GO:0089701)
0.0 0.7 GO:0031209 SCAR complex(GO:0031209)
0.0 0.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.3 GO:0001940 male pronucleus(GO:0001940)
0.0 0.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0016938 kinesin I complex(GO:0016938)
0.0 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.4 GO:0097433 dense body(GO:0097433)
0.0 0.7 GO:0033391 chromatoid body(GO:0033391)
0.0 0.2 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.0 0.4 GO:0097255 R2TP complex(GO:0097255)
0.0 1.7 GO:0031941 filamentous actin(GO:0031941)
0.0 0.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.8 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 0.9 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.1 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.8 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.5 GO:0000791 euchromatin(GO:0000791)
0.0 1.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.5 GO:0005776 autophagosome(GO:0005776)
0.0 0.3 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.1 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.2 GO:0005858 axonemal dynein complex(GO:0005858)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.3 0.9 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 0.5 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.4 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 1.7 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.5 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 1.5 GO:0031014 troponin T binding(GO:0031014)
0.1 1.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.3 GO:0031862 prostanoid receptor binding(GO:0031862)
0.1 1.5 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 4.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.8 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 1.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 1.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.6 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 0.3 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.1 0.4 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 0.6 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.3 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.1 0.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.7 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 0.9 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.5 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.2 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.1 0.2 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.1 0.4 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 0.2 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.0 0.6 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.3 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.3 GO:0035473 lipase binding(GO:0035473)
0.0 0.3 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.4 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.7 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.2 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.1 GO:0098625 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.0 0.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 3.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.3 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.4 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.1 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.2 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.4 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.7 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 2.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.5 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.5 GO:0030553 cGMP binding(GO:0030553)
0.0 0.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.3 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0051731 polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.0 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.0 1.3 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.2 GO:0001164 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.1 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.0 0.7 GO:0019894 kinesin binding(GO:0019894)
0.0 0.1 GO:0048256 flap endonuclease activity(GO:0048256)
0.0 0.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 4.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 4.2 PID BARD1 PATHWAY BARD1 signaling events
0.1 3.8 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 2.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 3.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.6 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.8 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.4 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.6 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.2 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 1.9 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.5 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.5 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.8 PID AURORA A PATHWAY Aurora A signaling
0.0 0.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.1 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 1.6 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 1.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.2 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 1.2 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 1.0 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.5 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 3.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 2.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.4 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 4.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.4 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.1 REACTOME PHOSPHOLIPASE C MEDIATED CASCADE Genes involved in Phospholipase C-mediated cascade
0.0 0.6 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 1.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.4 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.0 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling