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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for RARB
Z-value: 0.87
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Transcription factors associated with RARB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RARB | hg19_v2_chr3_+_25469724_25469773 | 0.63 | 8.2e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_93963590 Show fit | 2.04 |
ENST00000340600.2
|
suppressor of cytokine signaling 2 |
|
| chr10_-_33625154 Show fit | 1.91 |
ENST00000265371.4
|
neuropilin 1 |
|
| chr1_+_221051699 Show fit | 1.89 |
ENST00000366903.6
|
H2.0-like homeobox |
|
| chr8_+_84824920 Show fit | 1.82 |
ENST00000523678.1
|
RP11-120I21.2 |
|
| chr17_+_58677539 Show fit | 1.73 |
ENST00000305921.3
|
protein phosphatase, Mg2+/Mn2+ dependent, 1D |
|
| chr14_+_22964877 Show fit | 1.61 |
ENST00000390494.1
|
T cell receptor alpha joining 43 |
|
| chrX_-_119709637 Show fit | 1.36 |
ENST00000404115.3
|
cullin 4B |
|
| chr5_-_55412774 Show fit | 1.28 |
ENST00000434982.2
|
ankyrin repeat domain 55 |
|
| chr12_+_20522179 Show fit | 1.23 |
ENST00000359062.3
|
phosphodiesterase 3A, cGMP-inhibited |
|
| chr11_+_121447469 Show fit | 1.21 |
ENST00000532694.1
ENST00000534286.1 |
sortilin-related receptor, L(DLR class) A repeats containing |
Network of associatons between targets according to the STRING database.
First level regulatory network of RARB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.1 | 2.0 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.4 | 1.9 | GO:0021649 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 0.3 | 1.9 | GO:0009450 | acetate metabolic process(GO:0006083) gamma-aminobutyric acid catabolic process(GO:0009450) |
| 0.2 | 1.9 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.1 | 1.9 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.4 | 1.2 | GO:1902955 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.3 | 1.2 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.2 | 1.2 | GO:0071321 | cellular response to cGMP(GO:0071321) |
| 0.2 | 1.1 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.9 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 1.6 | GO:0044439 | microbody part(GO:0044438) peroxisomal part(GO:0044439) |
| 0.2 | 1.4 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.2 | 1.2 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.1 | 1.2 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 1.2 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.2 | 1.1 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.2 | 1.0 | GO:0031436 | BRCA1-BARD1 complex(GO:0031436) |
| 0.1 | 1.0 | GO:0034464 | BBSome(GO:0034464) |
| 0.0 | 1.0 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.3 | 2.0 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.2 | 1.9 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.0 | 1.9 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) |
| 0.0 | 1.7 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 1.4 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 1.3 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.4 | 1.2 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.1 | 1.2 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 1.2 | GO:0019003 | GDP binding(GO:0019003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 1.9 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 1.9 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 1.7 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 1.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.0 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.7 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.7 | PID INSULIN PATHWAY | Insulin Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 1.9 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.7 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 1.2 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 1.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 1.1 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.1 | 1.1 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 1.0 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 0.8 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |