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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for RARG
Z-value: 1.03
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Transcription factors associated with RARG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RARG | hg19_v2_chr12_-_53625958_53626036 | -0.35 | 9.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_186696425 Show fit | 4.95 |
ENST00000430503.1
ENST00000319454.6 ENST00000450341.1 |
sorbin and SH3 domain containing 2 |
|
| chr6_+_142623063 Show fit | 4.67 |
ENST00000296932.8
ENST00000367609.3 |
G protein-coupled receptor 126 |
|
| chr13_+_32605437 Show fit | 3.67 |
ENST00000380250.3
|
furry homolog (Drosophila) |
|
| chr8_-_93115445 Show fit | 3.12 |
ENST00000523629.1
|
runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
|
| chr4_-_16900184 Show fit | 2.92 |
ENST00000515064.1
|
LIM domain binding 2 |
|
| chr7_+_30960915 Show fit | 2.91 |
ENST00000441328.2
ENST00000409899.1 ENST00000409611.1 |
aquaporin 1 (Colton blood group) |
|
| chr4_-_16900410 Show fit | 2.91 |
ENST00000304523.5
|
LIM domain binding 2 |
|
| chr4_-_16900217 Show fit | 2.89 |
ENST00000441778.2
|
LIM domain binding 2 |
|
| chr4_-_101439242 Show fit | 2.88 |
ENST00000296420.4
|
endomucin |
|
| chr4_-_16900242 Show fit | 2.87 |
ENST00000502640.1
ENST00000506732.1 |
LIM domain binding 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RARG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.2 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.1 | 5.7 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.2 | 4.8 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.2 | 4.7 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.3 | 4.3 | GO:1904776 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 1.3 | 3.8 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
| 0.5 | 3.8 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.0 | 3.7 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 1.0 | 2.9 | GO:0035378 | carbon dioxide transmembrane transport(GO:0035378) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229) |
| 0.8 | 2.5 | GO:0036146 | cellular response to mycotoxin(GO:0036146) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.8 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.0 | 7.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.2 | 5.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 5.3 | GO:0099738 | cell cortex region(GO:0099738) |
| 0.0 | 4.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 4.9 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 4.6 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 3.5 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 3.4 | GO:0005604 | basement membrane(GO:0005604) |
| 1.0 | 2.9 | GO:0020005 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 11.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 8.0 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 6.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 5.7 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 3.9 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.1 | 3.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 3.3 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 1.0 | 2.9 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.2 | 2.7 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.2 | 2.4 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.2 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 5.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 4.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 3.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 3.4 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 2.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 2.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 2.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 4.0 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.2 | 3.3 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 3.2 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 3.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 3.0 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 3.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 2.8 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.1 | 2.3 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 2.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |