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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for RCOR1_MTA3
Z-value: 1.44
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Transcription factors associated with RCOR1_MTA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MTA3 | hg19_v2_chr2_+_42795745_42795824, hg19_v2_chr2_+_42795651_42795676, hg19_v2_chr2_+_42795839_42795887 | 0.46 | 2.0e-02 | Click! |
| RCOR1 | hg19_v2_chr14_+_103058948_103059005 | 0.08 | 7.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_-_46012386 Show fit | 4.17 |
ENST00000400368.1
|
keratin associated protein 10-6 |
|
| chr14_-_105420241 Show fit | 3.86 |
ENST00000557457.1
|
AHNAK nucleoprotein 2 |
|
| chr9_+_71320557 Show fit | 2.96 |
ENST00000541509.1
|
phosphatidylinositol-4-phosphate 5-kinase, type I, beta |
|
| chr13_-_44453826 Show fit | 2.95 |
ENST00000444614.3
|
coiled-coil domain containing 122 |
|
| chr2_+_48757278 Show fit | 2.92 |
ENST00000404752.1
ENST00000406226.1 |
stonin 1 |
|
| chr19_-_7936344 Show fit | 2.89 |
ENST00000599142.1
|
Protein FLJ22184 |
|
| chr2_+_112656176 Show fit | 2.82 |
ENST00000421804.2
ENST00000409780.1 |
c-mer proto-oncogene tyrosine kinase |
|
| chr12_-_47473425 Show fit | 2.72 |
ENST00000550413.1
|
adhesion molecule with Ig-like domain 2 |
|
| chr16_-_88772670 Show fit | 2.71 |
ENST00000562544.1
|
ring finger protein 166 |
|
| chr3_+_37903432 Show fit | 2.61 |
ENST00000443503.2
|
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of RCOR1_MTA3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.1 | 18.5 | GO:0031424 | keratinization(GO:0031424) |
| 0.2 | 13.4 | GO:0033108 | mitochondrial respiratory chain complex assembly(GO:0033108) |
| 0.4 | 8.9 | GO:1901663 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.8 | 8.5 | GO:0097350 | neutrophil clearance(GO:0097350) |
| 0.2 | 8.3 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.1 | 7.3 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.2 | 6.8 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 0.3 | 6.5 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.2 | 6.5 | GO:0042407 | cristae formation(GO:0042407) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 48.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 32.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 17.3 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 16.9 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 14.5 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 12.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 11.0 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.2 | 10.0 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 9.1 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.1 | 8.7 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 9.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.2 | 8.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 8.5 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.0 | 7.7 | GO:0019787 | ubiquitin-like protein transferase activity(GO:0019787) |
| 0.2 | 7.2 | GO:0016505 | peptidase activator activity involved in apoptotic process(GO:0016505) |
| 0.0 | 7.2 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.1 | 6.8 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.3 | 6.3 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.0 | 6.3 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 9.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 8.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 7.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 6.0 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 5.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 5.3 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 5.1 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 4.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 4.0 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 12.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 12.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 12.3 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.1 | 11.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 11.0 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.3 | 10.8 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.3 | 10.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.3 | 9.5 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.3 | 8.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |