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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for REL
Z-value: 2.66
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Transcription factors associated with REL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| REL | hg19_v2_chr2_+_61108650_61108687 | -0.16 | 4.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_29527702 Show fit | 28.30 |
ENST00000377050.4
|
ubiquitin D |
|
| chr6_-_31550192 Show fit | 21.69 |
ENST00000429299.2
ENST00000446745.2 |
lymphotoxin beta (TNF superfamily, member 3) |
|
| chr4_+_74702214 Show fit | 19.95 |
ENST00000226317.5
ENST00000515050.1 |
chemokine (C-X-C motif) ligand 6 |
|
| chr6_+_138188551 Show fit | 18.48 |
ENST00000237289.4
ENST00000433680.1 |
tumor necrosis factor, alpha-induced protein 3 |
|
| chr4_-_76957214 Show fit | 17.31 |
ENST00000306621.3
|
chemokine (C-X-C motif) ligand 11 |
|
| chr19_+_4229495 Show fit | 15.93 |
ENST00000221847.5
|
Epstein-Barr virus induced 3 |
|
| chr5_-_150460914 Show fit | 15.22 |
ENST00000389378.2
|
TNFAIP3 interacting protein 1 |
|
| chr11_+_102188224 Show fit | 15.07 |
ENST00000263464.3
|
baculoviral IAP repeat containing 3 |
|
| chr10_+_104155450 Show fit | 14.80 |
ENST00000471698.1
ENST00000189444.6 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
|
| chr2_+_228678550 Show fit | 14.53 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
Network of associatons between targets according to the STRING database.
First level regulatory network of REL
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 41.9 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 3.3 | 29.4 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 5.8 | 29.1 | GO:1903974 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 7.1 | 28.6 | GO:0052027 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 5.7 | 28.3 | GO:0070842 | aggresome assembly(GO:0070842) |
| 3.5 | 27.8 | GO:0021564 | vagus nerve development(GO:0021564) |
| 5.9 | 23.5 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 3.6 | 21.7 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 6.2 | 18.5 | GO:0001922 | B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
| 3.5 | 17.6 | GO:0033590 | response to cobalamin(GO:0033590) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 99.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 37.5 | GO:0045121 | membrane raft(GO:0045121) |
| 4.8 | 29.1 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 1.2 | 28.7 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.4 | 28.3 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 25.4 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 5.9 | 23.5 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 19.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 18.2 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 2.2 | 17.6 | GO:0043196 | varicosity(GO:0043196) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 60.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 1.1 | 36.9 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.7 | 36.7 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 31.0 | GO:0004386 | helicase activity(GO:0004386) |
| 0.7 | 29.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 3.6 | 29.1 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 1.3 | 28.3 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 23.1 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 1.2 | 18.5 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 3.4 | 16.9 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 88.8 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.2 | 68.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.7 | 30.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 1.0 | 30.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 24.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.3 | 23.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.2 | 13.1 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 10.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.3 | 9.7 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.5 | 9.5 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 75.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.0 | 53.0 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 1.4 | 31.0 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.5 | 19.1 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.2 | 18.9 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.2 | 17.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.6 | 13.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.4 | 13.3 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.3 | 10.3 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.3 | 8.8 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |