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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for REL

Z-value: 2.66

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Transcription factors associated with REL

Gene Symbol Gene ID Gene Info
REL
ENSG00000162924.9 REL proto-oncogene, NF-kB subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RELhg19_v2_chr2_+_61108650_61108687-0.164.6e-01Click!

Activity profile of REL motif

Sorted Z-values of REL motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_29527702 28.30 ENST00000377050.4
UBD
ubiquitin D
chr6_-_31550192 21.69 ENST00000429299.2
ENST00000446745.2
LTB
lymphotoxin beta (TNF superfamily, member 3)
chr4_+_74702214 19.95 ENST00000226317.5
ENST00000515050.1
CXCL6
chemokine (C-X-C motif) ligand 6
chr6_+_138188551 18.48 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr4_-_76957214 17.31 ENST00000306621.3
CXCL11
chemokine (C-X-C motif) ligand 11
chr19_+_4229495 15.93 ENST00000221847.5
EBI3
Epstein-Barr virus induced 3
chr5_-_150460914 15.22 ENST00000389378.2
TNIP1
TNFAIP3 interacting protein 1
chr11_+_102188224 15.07 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chr10_+_104155450 14.80 ENST00000471698.1
ENST00000189444.6
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr2_+_228678550 14.53 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr11_+_19798964 14.44 ENST00000527559.2
NAV2
neuron navigator 2
chr11_+_102188272 14.33 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr14_+_103589789 13.77 ENST00000558056.1
ENST00000560869.1
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr5_-_150466692 13.38 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNIP1
TNFAIP3 interacting protein 1
chr11_+_19799327 13.36 ENST00000540292.1
NAV2
neuron navigator 2
chr4_-_74864386 13.19 ENST00000296027.4
CXCL5
chemokine (C-X-C motif) ligand 5
chr1_-_169703203 13.08 ENST00000333360.7
ENST00000367781.4
ENST00000367782.4
ENST00000367780.4
ENST00000367779.4
SELE
selectin E
chr1_-_8000872 12.43 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr15_+_67430339 11.17 ENST00000439724.3
SMAD3
SMAD family member 3
chr1_+_110453109 10.68 ENST00000525659.1
CSF1
colony stimulating factor 1 (macrophage)
chr6_-_44233361 10.00 ENST00000275015.5
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr12_+_102271129 9.36 ENST00000258534.8
DRAM1
DNA-damage regulated autophagy modulator 1
chr1_+_110453203 9.11 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1
colony stimulating factor 1 (macrophage)
chr20_+_44746885 8.96 ENST00000372285.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr20_+_44746939 8.68 ENST00000372276.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr10_+_104154229 8.68 ENST00000428099.1
ENST00000369966.3
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr2_-_204400113 8.38 ENST00000319170.5
RAPH1
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
chr12_-_57504069 8.36 ENST00000543873.2
ENST00000554663.1
ENST00000557635.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr6_-_32821599 8.29 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr8_+_123793633 8.23 ENST00000314393.4
ZHX2
zinc fingers and homeoboxes 2
chr6_+_32821924 8.03 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr9_-_136344197 7.78 ENST00000414172.1
ENST00000371897.4
SLC2A6
solute carrier family 2 (facilitated glucose transporter), member 6
chr11_-_72492903 7.45 ENST00000537947.1
STARD10
StAR-related lipid transfer (START) domain containing 10
chr1_+_110453462 7.33 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr11_-_72492878 7.23 ENST00000535054.1
ENST00000545082.1
STARD10
StAR-related lipid transfer (START) domain containing 10
chr4_+_74735102 7.18 ENST00000395761.3
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr8_-_119964434 6.78 ENST00000297350.4
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr9_+_72658490 6.57 ENST00000377182.4
MAMDC2
MAM domain containing 2
chr11_-_128392085 6.48 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr19_-_47734448 6.37 ENST00000439096.2
BBC3
BCL2 binding component 3
chr16_+_50730910 6.11 ENST00000300589.2
NOD2
nucleotide-binding oligomerization domain containing 2
chr22_-_19512893 6.11 ENST00000403084.1
ENST00000413119.2
CLDN5
claudin 5
chr7_-_47579188 6.08 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3
tensin 3
chr12_-_77272765 6.07 ENST00000547435.1
ENST00000552330.1
ENST00000546966.1
ENST00000311083.5
CSRP2
cysteine and glycine-rich protein 2
chr17_+_40440481 5.99 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
STAT5A
signal transducer and activator of transcription 5A
chr19_-_4338783 5.87 ENST00000601482.1
ENST00000600324.1
STAP2
signal transducing adaptor family member 2
chr21_+_34775772 5.85 ENST00000405436.1
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr19_-_4338838 5.84 ENST00000594605.1
STAP2
signal transducing adaptor family member 2
chr21_+_34775698 5.61 ENST00000381995.1
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr21_+_34775181 5.46 ENST00000290219.6
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr17_+_26662730 5.17 ENST00000226225.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr1_+_165796753 5.14 ENST00000367879.4
UCK2
uridine-cytidine kinase 2
chr2_-_163175133 5.13 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr2_+_162016827 5.10 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
TANK
TRAF family member-associated NFKB activator
chr10_+_90750378 4.96 ENST00000355740.2
ENST00000352159.4
FAS
Fas cell surface death receptor
chr1_+_144339738 4.92 ENST00000538264.1
AL592284.1
Protein LOC642441
chr14_-_24616426 4.88 ENST00000216802.5
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr15_-_51058005 4.88 ENST00000261854.5
SPPL2A
signal peptide peptidase like 2A
chr20_-_43977055 4.83 ENST00000372733.3
ENST00000537976.1
SDC4
syndecan 4
chr10_+_90750493 4.51 ENST00000357339.2
ENST00000355279.2
FAS
Fas cell surface death receptor
chr5_+_14143728 4.44 ENST00000344204.4
ENST00000537187.1
TRIO
trio Rho guanine nucleotide exchange factor
chr1_-_209824643 4.43 ENST00000391911.1
ENST00000415782.1
LAMB3
laminin, beta 3
chr14_+_103243813 4.38 ENST00000560371.1
ENST00000347662.4
ENST00000392745.2
ENST00000539721.1
ENST00000560463.1
TRAF3
TNF receptor-associated factor 3
chr12_-_9913489 4.38 ENST00000228434.3
ENST00000536709.1
CD69
CD69 molecule
chr2_+_102314161 4.35 ENST00000425019.1
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr2_+_162016916 4.35 ENST00000405852.1
TANK
TRAF family member-associated NFKB activator
chr10_-_96122682 4.34 ENST00000371361.3
NOC3L
nucleolar complex associated 3 homolog (S. cerevisiae)
chr16_+_31044812 4.00 ENST00000313843.3
STX4
syntaxin 4
chr7_-_98741714 3.95 ENST00000361125.1
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr7_-_98741642 3.93 ENST00000361368.2
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr4_-_185395672 3.88 ENST00000393593.3
IRF2
interferon regulatory factor 2
chr1_-_65432171 3.85 ENST00000342505.4
JAK1
Janus kinase 1
chr19_-_17958832 3.81 ENST00000458235.1
JAK3
Janus kinase 3
chr2_-_128145498 3.79 ENST00000409179.2
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr11_-_75062829 3.73 ENST00000393505.4
ARRB1
arrestin, beta 1
chr10_+_13142075 3.62 ENST00000378757.2
ENST00000430081.1
ENST00000378752.3
ENST00000378748.3
OPTN
optineurin
chr5_+_133984462 3.56 ENST00000398844.2
ENST00000322887.4
SEC24A
SEC24 family member A
chr8_-_105601134 3.52 ENST00000276654.5
ENST00000424843.2
LRP12
low density lipoprotein receptor-related protein 12
chr10_+_13142225 3.51 ENST00000378747.3
OPTN
optineurin
chr1_-_204380919 3.47 ENST00000367188.4
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr19_+_39390320 3.36 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr10_+_13141585 3.35 ENST00000378764.2
OPTN
optineurin
chr2_+_68694678 3.32 ENST00000303795.4
APLF
aprataxin and PNKP like factor
chr13_+_97928395 3.24 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr11_-_75062730 3.23 ENST00000420843.2
ENST00000360025.3
ARRB1
arrestin, beta 1
chr10_-_100027943 3.06 ENST00000260702.3
LOXL4
lysyl oxidase-like 4
chr15_+_71145578 3.03 ENST00000544974.2
ENST00000558546.1
LRRC49
leucine rich repeat containing 49
chr10_-_97050777 3.02 ENST00000329399.6
PDLIM1
PDZ and LIM domain 1
chr16_+_27325202 2.96 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
IL4R
interleukin 4 receptor
chr16_-_75498553 2.86 ENST00000569276.1
ENST00000357613.4
ENST00000561878.1
ENST00000566980.1
ENST00000567194.1
TMEM170A
RP11-77K12.1
transmembrane protein 170A
Uncharacterized protein
chr1_-_159894319 2.84 ENST00000320307.4
TAGLN2
transgelin 2
chr1_-_27816556 2.81 ENST00000536657.1
WASF2
WAS protein family, member 2
chr6_+_151042224 2.80 ENST00000358517.2
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr9_-_115095851 2.64 ENST00000343327.2
PTBP3
polypyrimidine tract binding protein 3
chr6_+_135502408 2.64 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr8_-_23712312 2.59 ENST00000290271.2
STC1
stanniocalcin 1
chr19_+_39390587 2.56 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr9_+_132934835 2.53 ENST00000372398.3
NCS1
neuronal calcium sensor 1
chr4_-_74904398 2.52 ENST00000296026.4
CXCL3
chemokine (C-X-C motif) ligand 3
chr19_+_41725140 2.50 ENST00000359092.3
AXL
AXL receptor tyrosine kinase
chr7_-_19184929 2.49 ENST00000275461.3
FERD3L
Fer3-like bHLH transcription factor
chr9_-_115095123 2.47 ENST00000458258.1
PTBP3
polypyrimidine tract binding protein 3
chr3_+_9691117 2.45 ENST00000353332.5
ENST00000420925.1
ENST00000296003.4
ENST00000351233.5
MTMR14
myotubularin related protein 14
chr15_+_52311398 2.43 ENST00000261845.5
MAPK6
mitogen-activated protein kinase 6
chr12_+_51632600 2.42 ENST00000549555.1
ENST00000439799.2
ENST00000425012.2
DAZAP2
DAZ associated protein 2
chr1_+_16767195 2.42 ENST00000504551.2
ENST00000457722.2
ENST00000406746.1
ENST00000443980.2
NECAP2
NECAP endocytosis associated 2
chr15_+_44719970 2.39 ENST00000558966.1
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr9_-_115095883 2.34 ENST00000450374.1
ENST00000374255.2
ENST00000334318.6
ENST00000374257.1
PTBP3
polypyrimidine tract binding protein 3
chr17_-_7590745 2.34 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
TP53
tumor protein p53
chr19_+_496454 2.31 ENST00000346144.4
ENST00000215637.3
ENST00000382683.4
MADCAM1
mucosal vascular addressin cell adhesion molecule 1
chr4_-_146101304 2.24 ENST00000447906.2
OTUD4
OTU domain containing 4
chr8_-_101321584 2.23 ENST00000523167.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr1_-_205912577 2.22 ENST00000367135.3
ENST00000367134.2
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr12_-_49504655 2.13 ENST00000551782.1
ENST00000267102.8
LMBR1L
limb development membrane protein 1-like
chr9_-_117880477 2.08 ENST00000534839.1
ENST00000340094.3
ENST00000535648.1
ENST00000346706.3
ENST00000345230.3
ENST00000350763.4
TNC
tenascin C
chr1_+_6845384 2.08 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr2_+_114647504 2.05 ENST00000263238.2
ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr6_+_29910301 2.04 ENST00000376809.5
ENST00000376802.2
HLA-A
major histocompatibility complex, class I, A
chr22_-_38380543 2.04 ENST00000396884.2
SOX10
SRY (sex determining region Y)-box 10
chr12_+_56211703 2.02 ENST00000243045.5
ENST00000552672.1
ENST00000550836.1
ORMDL2
ORM1-like 2 (S. cerevisiae)
chrX_-_48755030 1.99 ENST00000490755.2
ENST00000465150.2
ENST00000495490.2
TIMM17B
translocase of inner mitochondrial membrane 17 homolog B (yeast)
chr2_+_90153696 1.96 ENST00000417279.2
IGKV3D-15
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr2_+_208394794 1.96 ENST00000536726.1
ENST00000374397.4
ENST00000452474.1
CREB1
cAMP responsive element binding protein 1
chr1_+_110453514 1.95 ENST00000369802.3
ENST00000420111.2
CSF1
colony stimulating factor 1 (macrophage)
chr14_-_53417732 1.95 ENST00000399304.3
ENST00000395631.2
ENST00000341590.3
ENST00000343279.4
FERMT2
fermitin family member 2
chr1_-_113249948 1.94 ENST00000339083.7
ENST00000369642.3
RHOC
ras homolog family member C
chr6_-_30710265 1.92 ENST00000438162.1
ENST00000454845.1
FLOT1
flotillin 1
chr14_+_24616588 1.90 ENST00000324103.6
ENST00000559260.1
RNF31
ring finger protein 31
chr6_+_31683117 1.86 ENST00000375825.3
ENST00000375824.1
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr7_-_102715263 1.83 ENST00000379305.3
FBXL13
F-box and leucine-rich repeat protein 13
chr12_+_51632638 1.80 ENST00000549732.2
DAZAP2
DAZ associated protein 2
chr2_+_208394658 1.72 ENST00000421139.1
CREB1
cAMP responsive element binding protein 1
chrX_+_48755183 1.71 ENST00000376563.1
ENST00000376566.4
PQBP1
polyglutamine binding protein 1
chr2_+_208394455 1.68 ENST00000430624.1
CREB1
cAMP responsive element binding protein 1
chr15_-_89755034 1.64 ENST00000563254.1
RLBP1
retinaldehyde binding protein 1
chr10_+_89419370 1.62 ENST00000361175.4
ENST00000456849.1
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr14_-_24658053 1.59 ENST00000354464.6
IPO4
importin 4
chr4_-_103749205 1.59 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr14_-_35873856 1.58 ENST00000553342.1
ENST00000216797.5
ENST00000557140.1
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr3_+_101546827 1.56 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr16_+_84209738 1.53 ENST00000564928.1
DNAAF1
dynein, axonemal, assembly factor 1
chr1_-_27816641 1.52 ENST00000430629.2
WASF2
WAS protein family, member 2
chr3_+_183967409 1.50 ENST00000324557.4
ENST00000402825.3
ECE2
endothelin converting enzyme 2
chr16_-_2059748 1.50 ENST00000562103.1
ENST00000431526.1
ZNF598
zinc finger protein 598
chr6_+_15401075 1.49 ENST00000541660.1
JARID2
jumonji, AT rich interactive domain 2
chr17_-_37382105 1.48 ENST00000333461.5
STAC2
SH3 and cysteine rich domain 2
chr19_-_50370509 1.47 ENST00000596014.1
PNKP
polynucleotide kinase 3'-phosphatase
chr18_+_63418068 1.45 ENST00000397968.2
CDH7
cadherin 7, type 2
chr13_-_38443860 1.45 ENST00000426868.2
ENST00000379681.3
ENST00000338947.5
ENST00000355779.2
ENST00000358477.2
ENST00000379673.2
TRPC4
transient receptor potential cation channel, subfamily C, member 4
chr5_-_59064458 1.41 ENST00000502575.1
ENST00000507116.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_122985067 1.40 ENST00000540586.1
ENST00000543897.1
ZCCHC8
zinc finger, CCHC domain containing 8
chr11_+_65292884 1.40 ENST00000527009.1
SCYL1
SCY1-like 1 (S. cerevisiae)
chr2_-_27357479 1.36 ENST00000406567.3
ENST00000260643.2
PREB
prolactin regulatory element binding
chr9_-_136004782 1.28 ENST00000393157.3
RALGDS
ral guanine nucleotide dissociation stimulator
chr16_+_3014217 1.23 ENST00000572045.1
KREMEN2
kringle containing transmembrane protein 2
chr4_+_169418195 1.23 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr3_-_58572760 1.15 ENST00000447756.2
FAM107A
family with sequence similarity 107, member A
chr20_-_33872518 1.14 ENST00000374436.3
EIF6
eukaryotic translation initiation factor 6
chr3_+_42201653 1.14 ENST00000341421.3
ENST00000396175.1
TRAK1
trafficking protein, kinesin binding 1
chrX_-_40594755 1.13 ENST00000324817.1
MED14
mediator complex subunit 14
chr16_-_88717482 1.09 ENST00000261623.3
CYBA
cytochrome b-245, alpha polypeptide
chr18_+_33877654 1.08 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3
formin homology 2 domain containing 3
chr22_-_24951054 1.07 ENST00000447813.2
ENST00000402766.1
ENST00000407471.3
ENST00000435822.1
GUCD1
guanylyl cyclase domain containing 1
chr15_+_85923797 1.05 ENST00000559362.1
AKAP13
A kinase (PRKA) anchor protein 13
chr20_-_33872548 1.01 ENST00000374443.3
EIF6
eukaryotic translation initiation factor 6
chr3_-_179322436 1.00 ENST00000392659.2
ENST00000476781.1
MRPL47
mitochondrial ribosomal protein L47
chr1_+_95582881 0.97 ENST00000370203.4
ENST00000456991.1
TMEM56
transmembrane protein 56
chr2_-_18741882 0.95 ENST00000381249.3
RDH14
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
chr3_-_179322416 0.94 ENST00000259038.2
MRPL47
mitochondrial ribosomal protein L47
chr17_+_40985407 0.94 ENST00000586114.1
ENST00000590720.1
ENST00000585805.1
ENST00000541124.1
ENST00000441946.2
ENST00000591152.1
ENST00000589469.1
ENST00000293362.3
ENST00000592169.1
PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr11_+_65479462 0.92 ENST00000377046.3
ENST00000352980.4
ENST00000341318.4
KAT5
K(lysine) acetyltransferase 5
chr9_+_6328338 0.91 ENST00000344545.5
TPD52L3
tumor protein D52-like 3
chr1_-_93426998 0.89 ENST00000370310.4
FAM69A
family with sequence similarity 69, member A
chr2_-_113594279 0.88 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr20_+_44486246 0.88 ENST00000255152.2
ENST00000454862.2
ZSWIM3
zinc finger, SWIM-type containing 3
chr19_+_18794470 0.87 ENST00000321949.8
ENST00000338797.6
CRTC1
CREB regulated transcription coactivator 1
chr4_+_169418255 0.87 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr3_+_52719936 0.87 ENST00000418458.1
ENST00000394799.2
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr12_+_51633061 0.85 ENST00000551313.1
DAZAP2
DAZ associated protein 2
chr16_-_88717423 0.84 ENST00000568278.1
ENST00000569359.1
ENST00000567174.1
CYBA
cytochrome b-245, alpha polypeptide
chr12_-_122985494 0.84 ENST00000336229.4
ZCCHC8
zinc finger, CCHC domain containing 8
chr7_+_107384579 0.84 ENST00000222597.2
ENST00000415884.2
CBLL1
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
chr17_-_4643114 0.82 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr4_-_176733897 0.81 ENST00000393658.2
GPM6A
glycoprotein M6A
chr16_+_67571351 0.81 ENST00000428437.2
ENST00000569253.1
FAM65A
family with sequence similarity 65, member A
chr4_-_103749179 0.81 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr4_-_103749105 0.81 ENST00000394801.4
ENST00000394804.2
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr17_+_34640031 0.81 ENST00000339270.6
ENST00000482104.1
CCL4L2
chemokine (C-C motif) ligand 4-like 2
chr22_+_22676808 0.80 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr19_-_49250054 0.79 ENST00000602105.1
ENST00000332955.2
IZUMO1
izumo sperm-egg fusion 1
chr10_+_70587279 0.79 ENST00000298596.6
ENST00000399169.4
ENST00000399165.4
ENST00000399162.2
STOX1
storkhead box 1
chr15_+_26360970 0.78 ENST00000556159.1
ENST00000557523.1
LINC00929
long intergenic non-protein coding RNA 929
chr11_-_104893863 0.78 ENST00000260315.3
ENST00000526056.1
ENST00000531367.1
ENST00000456094.1
ENST00000444749.2
ENST00000393141.2
ENST00000418434.1
ENST00000393139.2
CASP5
caspase 5, apoptosis-related cysteine peptidase
chr6_+_160327974 0.77 ENST00000252660.4
MAS1
MAS1 oncogene
chr10_-_29923893 0.77 ENST00000355867.4
SVIL
supervillin
chr3_-_178789993 0.77 ENST00000432729.1
ZMAT3
zinc finger, matrin-type 3
chr4_-_54930790 0.76 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr17_-_4852332 0.75 ENST00000572383.1
PFN1
profilin 1
chr11_-_61734599 0.75 ENST00000532601.1
FTH1
ferritin, heavy polypeptide 1
chr14_-_61190754 0.73 ENST00000216513.4
SIX4
SIX homeobox 4

Network of associatons between targets according to the STRING database.

First level regulatory network of REL

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 28.6 GO:0052027 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
6.2 18.5 GO:0001922 B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
6.1 6.1 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
5.9 23.5 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
5.8 29.1 GO:1903974 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
5.7 28.3 GO:0070842 aggresome assembly(GO:0070842)
4.8 14.5 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
3.6 21.7 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
3.5 17.6 GO:0033590 response to cobalamin(GO:0033590)
3.5 27.8 GO:0021564 vagus nerve development(GO:0021564)
3.3 29.4 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
2.6 7.9 GO:1902534 single-organism membrane invagination(GO:1902534)
2.3 6.8 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
2.2 11.2 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
2.1 8.4 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
2.1 12.4 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
2.1 8.3 GO:0046967 cytosol to ER transport(GO:0046967)
1.7 17.3 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
1.7 5.1 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
1.6 9.5 GO:0036337 Fas signaling pathway(GO:0036337)
1.6 9.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
1.5 6.0 GO:0000255 allantoin metabolic process(GO:0000255)
1.5 10.5 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
1.4 41.9 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
1.3 4.0 GO:0043311 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
1.3 15.9 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
1.3 6.6 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626)
1.3 5.1 GO:0009224 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
1.2 14.7 GO:0032782 bile acid secretion(GO:0032782)
1.2 2.3 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
1.1 2.2 GO:2000669 negative regulation of dendritic cell apoptotic process(GO:2000669)
1.0 10.0 GO:0042940 D-amino acid transport(GO:0042940)
1.0 4.8 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.9 5.6 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.9 2.6 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.8 6.5 GO:0030578 PML body organization(GO:0030578)
0.8 13.8 GO:0051601 exocyst localization(GO:0051601)
0.8 6.1 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.7 4.4 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.7 4.4 GO:0008063 Toll signaling pathway(GO:0008063)
0.7 7.0 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.7 2.0 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.6 7.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.5 2.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.5 4.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.5 1.6 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.5 12.1 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.5 2.0 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.5 2.8 GO:0014805 smooth muscle adaptation(GO:0014805)
0.5 1.4 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.4 2.1 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.4 3.3 GO:0051106 positive regulation of DNA ligation(GO:0051106)
0.4 1.6 GO:0000103 sulfate assimilation(GO:0000103)
0.4 12.9 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.4 3.5 GO:1903898 negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.4 1.9 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.4 2.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.4 1.5 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.3 2.1 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.3 1.9 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.3 2.5 GO:0033504 floor plate development(GO:0033504)
0.3 1.5 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836) DNA dephosphorylation(GO:0098502)
0.3 0.9 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.2 0.7 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.2 1.9 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
0.2 4.9 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.2 7.8 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.2 0.7 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
0.2 2.0 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.2 0.6 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.2 2.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.2 5.8 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.2 0.7 GO:0010887 negative regulation of cholesterol storage(GO:0010887) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.2 4.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 1.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 1.4 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2 4.3 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.2 11.5 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 2.9 GO:0071786 nuclear pore complex assembly(GO:0051292) endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.7 GO:0071321 cellular response to cGMP(GO:0071321)
0.1 0.8 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.1 16.9 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.1 5.4 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 1.1 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.1 1.4 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.1 5.6 GO:0048286 lung alveolus development(GO:0048286)
0.1 1.6 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 2.1 GO:0003334 keratinocyte development(GO:0003334)
0.1 1.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 2.5 GO:0030033 microvillus assembly(GO:0030033)
0.1 0.5 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.1 0.7 GO:0032621 interleukin-18 production(GO:0032621)
0.1 2.0 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.7 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 2.3 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 2.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 0.4 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.1 0.6 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.1 1.9 GO:0033622 integrin activation(GO:0033622)
0.1 0.5 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.1 1.4 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.1 0.9 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.1 2.2 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 0.8 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 1.0 GO:0019532 oxalate transport(GO:0019532)
0.1 0.1 GO:0045080 positive regulation of chemokine biosynthetic process(GO:0045080)
0.1 1.0 GO:0010002 cardioblast differentiation(GO:0010002)
0.1 0.8 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 1.9 GO:1905145 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 8.4 GO:0048675 axon extension(GO:0048675)
0.1 0.8 GO:0010818 T cell chemotaxis(GO:0010818)
0.1 0.3 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 0.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 3.9 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.1 0.2 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 0.5 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 4.5 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 4.4 GO:0035690 cellular response to drug(GO:0035690)
0.0 2.4 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.9 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 1.1 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.3 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.1 GO:0070563 cell migration involved in endocardial cushion formation(GO:0003273) negative regulation of vitamin D receptor signaling pathway(GO:0070563) negative regulation of response to alcohol(GO:1901420)
0.0 0.8 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.4 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0036114 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.2 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.3 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.4 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.8 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.1 GO:0097155 fasciculation of sensory neuron axon(GO:0097155) fasciculation of motor neuron axon(GO:0097156)
0.0 0.2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 5.3 GO:0045665 negative regulation of neuron differentiation(GO:0045665)
0.0 1.0 GO:0042572 retinol metabolic process(GO:0042572)
0.0 2.5 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.0 0.3 GO:0010561 negative regulation of glycoprotein biosynthetic process(GO:0010561)
0.0 0.3 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.5 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.0 0.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 2.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.2 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 1.9 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 1.2 GO:0030279 negative regulation of ossification(GO:0030279)
0.0 1.4 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 1.1 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 0.0 GO:1904760 peptidyl-serine ADP-ribosylation(GO:0018312) myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760) negative regulation of ATP biosynthetic process(GO:2001170)
0.0 0.2 GO:0048820 hair follicle maturation(GO:0048820)
0.0 1.5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.8 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.2 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.0 1.2 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 3.0 GO:0001666 response to hypoxia(GO:0001666)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 23.5 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
4.8 29.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
2.2 17.6 GO:0043196 varicosity(GO:0043196)
1.4 11.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
1.3 14.7 GO:0046581 intercellular canaliculus(GO:0046581)
1.2 28.7 GO:0005614 interstitial matrix(GO:0005614)
1.2 8.3 GO:0042825 TAP complex(GO:0042825)
1.0 4.9 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
1.0 5.8 GO:0008537 proteasome activator complex(GO:0008537)
0.9 8.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.9 4.3 GO:0031209 SCAR complex(GO:0031209)
0.8 5.6 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.6 4.7 GO:0005610 laminin-5 complex(GO:0005610)
0.5 2.0 GO:0035339 SPOTS complex(GO:0035339)
0.4 5.3 GO:0035631 CD40 receptor complex(GO:0035631)
0.4 28.3 GO:0016235 aggresome(GO:0016235)
0.4 4.0 GO:0000322 storage vacuole(GO:0000322)
0.4 13.8 GO:0000145 exocyst(GO:0000145)
0.3 1.7 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.2 5.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.2 0.7 GO:0098855 HCN channel complex(GO:0098855)
0.2 6.2 GO:0031143 pseudopodium(GO:0031143)
0.2 3.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 0.7 GO:0008043 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.2 2.0 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 2.5 GO:0031045 dense core granule(GO:0031045)
0.2 1.1 GO:0070847 core mediator complex(GO:0070847)
0.2 2.0 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 18.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 3.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.9 GO:0016600 flotillin complex(GO:0016600)
0.1 10.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 2.2 GO:0033643 host cell part(GO:0033643)
0.1 2.0 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 0.9 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.7 GO:0044294 dendritic growth cone(GO:0044294)
0.1 0.8 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.1 3.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 2.4 GO:0032156 septin cytoskeleton(GO:0032156)
0.1 5.8 GO:0043034 costamere(GO:0043034)
0.1 1.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 2.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 37.5 GO:0045121 membrane raft(GO:0045121)
0.1 3.9 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.6 GO:0005827 polar microtubule(GO:0005827)
0.1 5.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.6 GO:0042382 paraspeckles(GO:0042382)
0.1 2.0 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.1 9.9 GO:0001650 fibrillar center(GO:0001650)
0.1 0.5 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 8.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 0.8 GO:0044295 axonal growth cone(GO:0044295)
0.1 99.9 GO:0005615 extracellular space(GO:0005615)
0.0 1.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.8 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 2.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 1.9 GO:0032420 stereocilium(GO:0032420)
0.0 3.5 GO:0030175 filopodium(GO:0030175)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.8 GO:0002080 acrosomal membrane(GO:0002080)
0.0 19.4 GO:0005925 focal adhesion(GO:0005925)
0.0 25.4 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 1.1 GO:1904115 axon cytoplasm(GO:1904115)
0.0 1.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 5.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 15.1 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 4.2 GO:0034399 nuclear periphery(GO:0034399)
0.0 1.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.0 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.1 GO:0097342 ripoptosome(GO:0097342)
0.0 2.4 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.1 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.2 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 6.2 GO:0044297 cell body(GO:0044297)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.5 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
3.8 60.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
3.6 29.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
3.4 16.9 GO:0004906 interferon-gamma receptor activity(GO:0004906)
2.3 7.0 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
2.2 11.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
1.9 9.5 GO:0043120 tumor necrosis factor binding(GO:0043120)
1.6 9.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
1.3 28.3 GO:0070628 proteasome binding(GO:0070628)
1.2 8.3 GO:0046979 TAP2 binding(GO:0046979)
1.2 18.5 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
1.1 36.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
1.0 4.0 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
1.0 3.0 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.9 13.1 GO:0033691 sialic acid binding(GO:0033691)
0.8 5.8 GO:0061133 endopeptidase activator activity(GO:0061133)
0.8 4.9 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.8 2.3 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.7 5.6 GO:1990763 arrestin family protein binding(GO:1990763)
0.7 36.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.7 29.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.6 1.9 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.5 4.4 GO:0004111 creatine kinase activity(GO:0004111)
0.5 1.6 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.5 7.8 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.5 4.8 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.5 5.1 GO:0004849 uridine kinase activity(GO:0004849)
0.4 7.9 GO:0048185 activin binding(GO:0048185)
0.4 3.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.4 6.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.4 1.5 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) polynucleotide phosphatase activity(GO:0098518)
0.3 16.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.3 8.0 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 1.6 GO:0005502 11-cis retinal binding(GO:0005502)
0.2 2.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 4.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.2 2.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 2.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.2 2.1 GO:0045545 syndecan binding(GO:0045545)
0.2 2.0 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.2 2.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 0.7 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 3.1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1 3.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1 5.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 31.0 GO:0004386 helicase activity(GO:0004386)
0.1 2.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 4.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.7 GO:0051525 NFAT protein binding(GO:0051525)
0.1 2.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 0.6 GO:0031208 POZ domain binding(GO:0031208)
0.1 0.8 GO:0004945 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.1 3.0 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 2.5 GO:0004707 MAP kinase activity(GO:0004707)
0.1 9.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 0.5 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 1.4 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 1.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 1.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 4.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.7 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 3.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 1.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 2.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 13.8 GO:0000149 SNARE binding(GO:0000149)
0.1 1.4 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 2.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 2.3 GO:0070840 dynein complex binding(GO:0070840)
0.1 1.1 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 0.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 0.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 23.1 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 8.6 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 0.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 2.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.5 GO:0032452 histone demethylase activity(GO:0032452)
0.1 5.5 GO:0051117 ATPase binding(GO:0051117)
0.0 0.8 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 2.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.2 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 3.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 5.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.9 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.3 GO:0042731 PH domain binding(GO:0042731)
0.0 1.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 3.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 1.5 GO:0043022 ribosome binding(GO:0043022)
0.0 2.6 GO:0005179 hormone activity(GO:0005179)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.6 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.0 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.9 GO:0002039 p53 binding(GO:0002039)
0.0 11.9 GO:0005198 structural molecule activity(GO:0005198)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:1990825 sequence-specific mRNA binding(GO:1990825)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 88.8 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
1.0 30.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.7 30.8 PID CD40 PATHWAY CD40/CD40L signaling
0.5 9.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.4 4.9 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.4 7.2 PID IL23 PATHWAY IL23-mediated signaling events
0.4 0.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 9.7 PID IL27 PATHWAY IL27-mediated signaling events
0.3 24.3 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.3 9.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.3 8.4 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.3 8.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3 23.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.2 4.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 7.4 PID BMP PATHWAY BMP receptor signaling
0.2 13.1 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 6.3 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.2 68.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.2 4.8 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 6.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 10.0 PID AP1 PATHWAY AP-1 transcription factor network
0.1 4.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 4.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 4.5 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 6.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 2.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 6.8 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.1 3.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 1.9 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 1.2 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 2.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.4 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 3.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 4.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
1.4 31.0 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
1.1 75.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.0 53.0 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.6 13.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.6 5.1 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.5 19.1 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.4 13.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.4 7.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 8.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.3 10.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 6.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.2 18.9 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.2 5.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 5.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 7.0 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 17.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 4.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 4.0 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 6.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 4.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.4 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 5.1 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 4.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 7.6 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 1.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 8.4 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 1.9 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.1 1.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.3 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.4 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 2.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 2.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.8 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.7 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 0.5 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.4 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.1 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI