Project

Inflammatory response time course, HUVEC (Wada et al., 2009)

Navigation
Downloads

Results for RELA

Z-value: 3.69

Motif logo

Transcription factors associated with RELA

Gene Symbol Gene ID Gene Info
ENSG00000173039.14 RELA proto-oncogene, NF-kB subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RELAhg19_v2_chr11_-_65430251_654303990.945.1e-12Click!

Activity profile of RELA motif

Sorted Z-values of RELA motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_76944621 64.70 ENST00000306602.1
chemokine (C-X-C motif) ligand 10
chr6_-_31550192 45.65 ENST00000429299.2
ENST00000446745.2
lymphotoxin beta (TNF superfamily, member 3)
chr6_-_29527702 38.52 ENST00000377050.4
ubiquitin D
chr19_+_45504688 35.86 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr11_+_102188224 33.63 ENST00000263464.3
baculoviral IAP repeat containing 3
chr6_+_138188551 32.02 ENST00000237289.4
ENST00000433680.1
tumor necrosis factor, alpha-induced protein 3
chr11_+_102188272 31.75 ENST00000532808.1
baculoviral IAP repeat containing 3
chr10_+_104154229 30.96 ENST00000428099.1
ENST00000369966.3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr4_+_74702214 30.75 ENST00000226317.5
ENST00000515050.1
chemokine (C-X-C motif) ligand 6
chr2_+_228678550 29.39 ENST00000409189.3
ENST00000358813.4
chemokine (C-C motif) ligand 20
chr5_-_150460914 27.29 ENST00000389378.2
TNFAIP3 interacting protein 1
chr19_+_10381769 25.48 ENST00000423829.2
ENST00000588645.1
intercellular adhesion molecule 1
chr4_-_76957214 24.75 ENST00000306621.3
chemokine (C-X-C motif) ligand 11
chr4_+_103422471 24.46 ENST00000226574.4
ENST00000394820.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr1_+_101185290 23.98 ENST00000370119.4
ENST00000347652.2
ENST00000294728.2
ENST00000370115.1
vascular cell adhesion molecule 1
chr1_+_110453109 21.86 ENST00000525659.1
colony stimulating factor 1 (macrophage)
chr4_-_74864386 21.60 ENST00000296027.4
chemokine (C-X-C motif) ligand 5
chr4_-_74904398 20.44 ENST00000296026.4
chemokine (C-X-C motif) ligand 3
chr1_-_8000872 19.27 ENST00000377507.3
tumor necrosis factor receptor superfamily, member 9
chr5_-_150460539 19.23 ENST00000520931.1
ENST00000520695.1
ENST00000521591.1
ENST00000518977.1
TNFAIP3 interacting protein 1
chr14_+_103589789 19.18 ENST00000558056.1
ENST00000560869.1
tumor necrosis factor, alpha-induced protein 2
chr11_+_19798964 19.08 ENST00000527559.2
neuron navigator 2
chr1_+_110453203 19.00 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
colony stimulating factor 1 (macrophage)
chr4_-_74964904 18.68 ENST00000508487.2
chemokine (C-X-C motif) ligand 2
chr4_+_74735102 18.52 ENST00000395761.3
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr19_+_4229495 18.18 ENST00000221847.5
Epstein-Barr virus induced 3
chr12_-_49259643 17.76 ENST00000309739.5
Rho family GTPase 1
chr11_+_19799327 17.72 ENST00000540292.1
neuron navigator 2
chr12_-_9913489 17.33 ENST00000228434.3
ENST00000536709.1
CD69 molecule
chr14_-_35873856 17.26 ENST00000553342.1
ENST00000216797.5
ENST00000557140.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr5_-_150466692 17.09 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNFAIP3 interacting protein 1
chr12_-_57504069 16.74 ENST00000543873.2
ENST00000554663.1
ENST00000557635.1
signal transducer and activator of transcription 6, interleukin-4 induced
chr10_+_104155450 15.78 ENST00000471698.1
ENST00000189444.6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr16_+_50776021 15.65 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
cylindromatosis (turban tumor syndrome)
chr1_+_110453462 14.82 ENST00000488198.1
colony stimulating factor 1 (macrophage)
chr3_+_53195136 13.90 ENST00000394729.2
ENST00000330452.3
protein kinase C, delta
chr17_+_40440481 13.35 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
signal transducer and activator of transcription 5A
chr1_-_209825674 12.66 ENST00000367030.3
ENST00000356082.4
laminin, beta 3
chr16_+_50775948 12.57 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
cylindromatosis (turban tumor syndrome)
chr16_+_50775971 12.45 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
cylindromatosis (turban tumor syndrome)
chr4_-_120550146 11.62 ENST00000354960.3
phosphodiesterase 5A, cGMP-specific
chr20_+_44746885 11.51 ENST00000372285.3
CD40 molecule, TNF receptor superfamily member 5
chr11_-_8832182 11.50 ENST00000527510.1
ENST00000528527.1
ENST00000528523.1
ENST00000313726.6
suppression of tumorigenicity 5
chr2_+_161993465 11.21 ENST00000457476.1
TRAF family member-associated NFKB activator
chr9_-_136344197 11.00 ENST00000414172.1
ENST00000371897.4
solute carrier family 2 (facilitated glucose transporter), member 6
chr19_-_47734448 9.72 ENST00000439096.2
BCL2 binding component 3
chr19_-_4338783 9.45 ENST00000601482.1
ENST00000600324.1
signal transducing adaptor family member 2
chr19_-_4338838 9.40 ENST00000594605.1
signal transducing adaptor family member 2
chr17_-_34207295 9.29 ENST00000463941.1
ENST00000293272.3
chemokine (C-C motif) ligand 5
chr11_-_128392085 9.28 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr5_+_159895275 9.25 ENST00000517927.1
microRNA 146a
chr21_+_34775698 9.06 ENST00000381995.1
interferon gamma receptor 2 (interferon gamma transducer 1)
chr18_-_71959159 9.02 ENST00000494131.2
ENST00000397914.4
ENST00000340533.4
cytochrome b5 type A (microsomal)
chr21_+_34775772 8.82 ENST00000405436.1
interferon gamma receptor 2 (interferon gamma transducer 1)
chr21_+_34775181 8.69 ENST00000290219.6
interferon gamma receptor 2 (interferon gamma transducer 1)
chr19_+_45251804 8.66 ENST00000164227.5
B-cell CLL/lymphoma 3
chr7_-_47579188 8.55 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
tensin 3
chr17_-_61777090 8.49 ENST00000578061.1
LIM domain containing 2
chr2_-_163175133 8.44 ENST00000421365.2
ENST00000263642.2
interferon induced with helicase C domain 1
chr14_+_103243813 8.43 ENST00000560371.1
ENST00000347662.4
ENST00000392745.2
ENST00000539721.1
ENST00000560463.1
TNF receptor-associated factor 3
chr22_-_19512893 8.17 ENST00000403084.1
ENST00000413119.2
claudin 5
chr8_+_86157699 8.13 ENST00000321764.3
carbonic anhydrase XIII
chr7_-_22396533 8.02 ENST00000344041.6
Rap guanine nucleotide exchange factor (GEF) 5
chr9_-_117568365 7.88 ENST00000374045.4
tumor necrosis factor (ligand) superfamily, member 15
chr2_+_161993412 7.86 ENST00000259075.2
ENST00000432002.1
TRAF family member-associated NFKB activator
chr11_-_72492903 7.81 ENST00000537947.1
StAR-related lipid transfer (START) domain containing 10
chr16_+_50730910 7.62 ENST00000300589.2
nucleotide-binding oligomerization domain containing 2
chr17_+_21191341 7.51 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
mitogen-activated protein kinase kinase 3
chr20_-_43977055 7.46 ENST00000372733.3
ENST00000537976.1
syndecan 4
chr3_+_101546827 7.36 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr4_-_185395672 7.33 ENST00000393593.3
interferon regulatory factor 2
chr9_-_32526184 7.27 ENST00000545044.1
ENST00000379868.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr19_-_17958832 7.24 ENST00000458235.1
Janus kinase 3
chr10_+_30722866 7.16 ENST00000263056.1
mitogen-activated protein kinase kinase kinase 8
chr14_+_73704201 7.16 ENST00000340738.5
ENST00000427855.1
ENST00000381166.3
papilin, proteoglycan-like sulfated glycoprotein
chr11_-_72492878 6.88 ENST00000535054.1
ENST00000545082.1
StAR-related lipid transfer (START) domain containing 10
chr10_+_13142075 6.70 ENST00000378757.2
ENST00000430081.1
ENST00000378752.3
ENST00000378748.3
optineurin
chr10_+_13142225 6.53 ENST00000378747.3
optineurin
chr4_-_122085469 6.50 ENST00000057513.3
TNFAIP3 interacting protein 3
chr1_+_169077172 6.48 ENST00000499679.3
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr13_+_97874574 6.19 ENST00000343600.4
ENST00000345429.6
ENST00000376673.3
muscleblind-like splicing regulator 2
chr14_+_22984601 6.14 ENST00000390509.1
T cell receptor alpha joining 28
chr10_+_13141585 6.06 ENST00000378764.2
optineurin
chr3_-_4793274 5.81 ENST00000414938.1
eosinophil granule ontogeny transcript (non-protein coding)
chr6_+_29691198 5.60 ENST00000440587.2
ENST00000434407.2
major histocompatibility complex, class I, F
chr1_+_100818156 5.59 ENST00000336454.3
cell division cycle 14A
chr15_+_52311398 5.55 ENST00000261845.5
mitogen-activated protein kinase 6
chr14_-_24616426 5.52 ENST00000216802.5
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_-_209824643 5.43 ENST00000391911.1
ENST00000415782.1
laminin, beta 3
chr14_+_93897272 5.30 ENST00000393151.2
unc-79 homolog (C. elegans)
chr1_-_65432171 5.28 ENST00000342505.4
Janus kinase 1
chr2_+_97202480 5.26 ENST00000357485.3
AT rich interactive domain 5A (MRF1-like)
chr2_+_97203082 5.11 ENST00000454558.2
AT rich interactive domain 5A (MRF1-like)
chr19_+_39390320 5.07 ENST00000576510.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr7_+_143078652 5.06 ENST00000354434.4
ENST00000449423.2
zyxin
chr6_+_29691056 5.05 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
major histocompatibility complex, class I, F
chr16_+_53738053 4.85 ENST00000394647.3
fat mass and obesity associated
chr11_-_75062829 4.82 ENST00000393505.4
arrestin, beta 1
chr6_+_135502466 4.78 ENST00000367814.4
v-myb avian myeloblastosis viral oncogene homolog
chr11_-_3862206 4.70 ENST00000351018.4
ras homolog family member G
chr1_+_6845384 4.53 ENST00000303635.7
calmodulin binding transcription activator 1
chr2_+_162016916 4.53 ENST00000405852.1
TRAF family member-associated NFKB activator
chr10_+_12391481 4.51 ENST00000378847.3
calcium/calmodulin-dependent protein kinase ID
chr5_+_14143728 4.51 ENST00000344204.4
ENST00000537187.1
trio Rho guanine nucleotide exchange factor
chr7_-_98741642 4.40 ENST00000361368.2
SMAD specific E3 ubiquitin protein ligase 1
chr19_+_39390587 4.35 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr12_-_323689 4.23 ENST00000428720.1
solute carrier family 6 (neurotransmitter transporter), member 12
chr7_-_98741714 4.23 ENST00000361125.1
SMAD specific E3 ubiquitin protein ligase 1
chr4_+_4861385 4.22 ENST00000382723.4
msh homeobox 1
chr11_-_75062730 4.16 ENST00000420843.2
ENST00000360025.3
arrestin, beta 1
chr1_+_100818009 4.15 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
cell division cycle 14A
chr3_-_58563094 4.09 ENST00000464064.1
family with sequence similarity 107, member A
chr14_+_93897199 3.89 ENST00000553484.1
unc-79 homolog (C. elegans)
chr6_+_144471643 3.88 ENST00000367568.4
syntaxin 11
chr15_+_44719970 3.86 ENST00000558966.1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr1_+_110453514 3.81 ENST00000369802.3
ENST00000420111.2
colony stimulating factor 1 (macrophage)
chr5_+_133984462 3.78 ENST00000398844.2
ENST00000322887.4
SEC24 family member A
chr14_-_53417732 3.73 ENST00000399304.3
ENST00000395631.2
ENST00000341590.3
ENST00000343279.4
fermitin family member 2
chr3_+_9691117 3.62 ENST00000353332.5
ENST00000420925.1
ENST00000296003.4
ENST00000351233.5
myotubularin related protein 14
chr6_+_106534192 3.52 ENST00000369091.2
ENST00000369096.4
PR domain containing 1, with ZNF domain
chr19_+_41725140 3.42 ENST00000359092.3
AXL receptor tyrosine kinase
chr20_+_18488528 3.36 ENST00000377465.1
Sec23 homolog B (S. cerevisiae)
chr2_-_209028300 3.34 ENST00000304502.4
crystallin, gamma A
chr4_-_103749205 3.31 ENST00000508249.1
ubiquitin-conjugating enzyme E2D 3
chr2_-_136743039 3.28 ENST00000537273.1
aspartyl-tRNA synthetase
chr17_-_7590745 3.26 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
tumor protein p53
chr9_+_132934835 3.22 ENST00000372398.3
neuronal calcium sensor 1
chr2_+_208394455 3.22 ENST00000430624.1
cAMP responsive element binding protein 1
chr4_-_76928641 3.15 ENST00000264888.5
chemokine (C-X-C motif) ligand 9
chr20_+_18488137 3.11 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
Sec23 homolog B (S. cerevisiae)
chr2_+_208394794 3.07 ENST00000536726.1
ENST00000374397.4
ENST00000452474.1
cAMP responsive element binding protein 1
chr11_+_118478313 3.07 ENST00000356063.5
pleckstrin homology-like domain, family B, member 1
chr2_-_136743169 3.06 ENST00000264161.4
aspartyl-tRNA synthetase
chr6_+_29910301 3.06 ENST00000376809.5
ENST00000376802.2
major histocompatibility complex, class I, A
chr1_+_44870866 3.01 ENST00000355387.2
ENST00000361799.2
ring finger protein 220
chr1_+_100818484 2.96 ENST00000544534.1
cell division cycle 14A
chr22_-_38380543 2.96 ENST00000396884.2
SRY (sex determining region Y)-box 10
chr12_+_49761147 2.90 ENST00000549298.1
spermatogenesis associated, serine-rich 2
chr21_-_43373999 2.87 ENST00000380486.3
C2 calcium-dependent domain containing 2
chr4_+_146560245 2.74 ENST00000541599.1
methylmalonic aciduria (cobalamin deficiency) cblA type
chr12_+_53662073 2.69 ENST00000553219.1
ENST00000257934.4
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr2_+_208394658 2.67 ENST00000421139.1
cAMP responsive element binding protein 1
chr5_-_132113036 2.66 ENST00000378706.1
septin 8
chr9_-_32526299 2.64 ENST00000379882.1
ENST00000379883.2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_+_6625046 2.63 ENST00000396751.2
integrin-linked kinase
chrX_-_48901012 2.59 ENST00000315869.7
transcription factor binding to IGHM enhancer 3
chr16_-_66959429 2.57 ENST00000420652.1
ENST00000299759.6
Ras-related associated with diabetes
chr11_+_6624955 2.57 ENST00000299421.4
ENST00000537806.1
integrin-linked kinase
chr20_-_62203808 2.55 ENST00000467148.1
helicase with zinc finger 2, transcriptional coactivator
chr1_-_155947951 2.54 ENST00000313695.7
ENST00000497907.1
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr5_-_132112907 2.52 ENST00000458488.2
septin 8
chr12_+_53662110 2.51 ENST00000552462.1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr13_-_38443860 2.50 ENST00000426868.2
ENST00000379681.3
ENST00000338947.5
ENST00000355779.2
ENST00000358477.2
ENST00000379673.2
transient receptor potential cation channel, subfamily C, member 4
chr5_-_132112921 2.49 ENST00000378721.4
ENST00000378701.1
septin 8
chr1_-_1822495 2.46 ENST00000378609.4
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr2_+_64681641 2.45 ENST00000409537.2
lectin, galactoside-binding-like
chr22_-_28315115 2.43 ENST00000455418.3
ENST00000436663.1
ENST00000320996.10
ENST00000335272.5
phosphatidylinositol transfer protein, beta
chr15_+_85923797 2.40 ENST00000559362.1
A kinase (PRKA) anchor protein 13
chr5_-_58652788 2.35 ENST00000405755.2
phosphodiesterase 4D, cAMP-specific
chr20_+_34359905 2.30 ENST00000374012.3
ENST00000439301.1
ENST00000339089.6
ENST00000374000.4
PHD finger protein 20
chr2_+_124782857 2.27 ENST00000431078.1
contactin associated protein-like 5
chr4_+_140222609 2.23 ENST00000296543.5
ENST00000398947.1
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr19_+_51728316 2.19 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33 molecule
chr20_-_4795747 2.19 ENST00000379376.2
Ras association (RalGDS/AF-6) domain family member 2
chr5_-_58335281 2.17 ENST00000358923.6
phosphodiesterase 4D, cAMP-specific
chr19_+_496454 2.16 ENST00000346144.4
ENST00000215637.3
ENST00000382683.4
mucosal vascular addressin cell adhesion molecule 1
chrX_-_131352152 2.12 ENST00000342983.2
RAP2C, member of RAS oncogene family
chr18_-_12884259 2.11 ENST00000353319.4
ENST00000327283.3
protein tyrosine phosphatase, non-receptor type 2
chr5_-_132113083 2.10 ENST00000296873.7
septin 8
chr9_+_36572851 2.10 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
maternal embryonic leucine zipper kinase
chr17_+_16318850 2.09 ENST00000338560.7
transient receptor potential cation channel, subfamily V, member 2
chr17_+_16318909 2.07 ENST00000577397.1
transient receptor potential cation channel, subfamily V, member 2
chr3_+_157154578 2.06 ENST00000295927.3
pentraxin 3, long
chr11_+_94501497 2.05 ENST00000317829.8
ENST00000317837.9
ENST00000433060.2
angiomotin like 1
chr7_+_134464376 2.05 ENST00000454108.1
ENST00000361675.2
caldesmon 1
chr6_-_136847099 2.01 ENST00000438100.2
microtubule-associated protein 7
chr1_+_107683436 2.01 ENST00000370068.1
netrin G1
chr10_-_43904235 1.98 ENST00000356053.3
heterogeneous nuclear ribonucleoprotein F
chr12_+_49761224 1.98 ENST00000553127.1
ENST00000321898.6
spermatogenesis associated, serine-rich 2
chr1_+_151171012 1.96 ENST00000349792.5
ENST00000409426.1
ENST00000441902.2
ENST00000368890.4
ENST00000424999.1
ENST00000368888.4
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
chr11_+_65292884 1.96 ENST00000527009.1
SCY1-like 1 (S. cerevisiae)
chr1_+_107683644 1.92 ENST00000370067.1
netrin G1
chr10_+_86088381 1.91 ENST00000224756.8
ENST00000372088.2
coiled-coil serine-rich protein 2
chr12_-_48499591 1.90 ENST00000551330.1
ENST00000004980.5
ENST00000339976.6
ENST00000448372.1
SUMO1/sentrin specific peptidase 1
chr16_+_67571351 1.90 ENST00000428437.2
ENST00000569253.1
family with sequence similarity 65, member A
chr3_+_184032919 1.87 ENST00000427845.1
ENST00000342981.4
ENST00000319274.6
eukaryotic translation initiation factor 4 gamma, 1
chr20_+_1115821 1.82 ENST00000435720.1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr22_-_37640456 1.80 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr4_-_103749105 1.76 ENST00000394801.4
ENST00000394804.2
ubiquitin-conjugating enzyme E2D 3
chr3_+_184033135 1.74 ENST00000424196.1
eukaryotic translation initiation factor 4 gamma, 1
chr1_-_46664074 1.74 ENST00000371986.3
ENST00000371984.3
protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
chr20_-_2451395 1.72 ENST00000339610.6
ENST00000381342.2
ENST00000438552.2
small nuclear ribonucleoprotein polypeptides B and B1
chr15_+_26360970 1.71 ENST00000556159.1
ENST00000557523.1
long intergenic non-protein coding RNA 929
chr19_+_41281060 1.70 ENST00000594436.1
ENST00000597784.1
melanoma inhibitory activity
chr12_-_6716569 1.66 ENST00000544040.1
ENST00000545942.1
chromodomain helicase DNA binding protein 4
chr1_-_39395165 1.65 ENST00000372985.3
rhomboid, veinlet-like 2 (Drosophila)
chr12_-_6716534 1.61 ENST00000544484.1
ENST00000309577.6
ENST00000357008.2
chromodomain helicase DNA binding protein 4
chr14_+_24616588 1.61 ENST00000324103.6
ENST00000559260.1
ring finger protein 31
chr18_+_63418068 1.61 ENST00000397968.2
cadherin 7, type 2
chr19_-_4831701 1.59 ENST00000248244.5
toll-like receptor adaptor molecule 1

Network of associatons between targets according to the STRING database.

First level regulatory network of RELA

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.9 63.6 GO:0085032 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
13.9 55.4 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
13.6 40.7 GO:1990108 protein linear deubiquitination(GO:1990108)
11.9 59.5 GO:1903974 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
10.7 32.0 GO:0034146 B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
9.8 29.4 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
9.3 92.6 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
7.8 70.1 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
7.7 38.5 GO:0070842 aggresome assembly(GO:0070842)
7.6 7.6 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
7.3 65.4 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
7.1 49.5 GO:0022614 membrane to membrane docking(GO:0022614)
5.8 17.3 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
4.6 36.8 GO:0021564 vagus nerve development(GO:0021564)
4.6 18.3 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
4.2 16.7 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
3.9 114.1 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
3.9 23.6 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
3.5 13.9 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
3.3 13.3 GO:0000255 allantoin metabolic process(GO:0000255)
3.2 19.3 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
3.1 27.9 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
2.3 9.3 GO:2000110 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) negative regulation of macrophage apoptotic process(GO:2000110)
2.3 11.5 GO:0033590 response to cobalamin(GO:0033590)
2.3 6.9 GO:0002730 regulation of dendritic cell cytokine production(GO:0002730) negative regulation of dendritic cell cytokine production(GO:0002731)
2.2 28.7 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
2.1 6.3 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
1.7 18.2 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
1.6 3.3 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
1.6 4.8 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552)
1.6 4.8 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
1.6 9.3 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
1.5 3.1 GO:2000669 negative regulation of dendritic cell apoptotic process(GO:2000669)
1.5 7.5 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
1.5 10.2 GO:0060282 positive regulation of oocyte development(GO:0060282)
1.4 4.2 GO:0090427 activation of meiosis(GO:0090427)
1.4 8.4 GO:0008063 Toll signaling pathway(GO:0008063)
1.4 13.7 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
1.3 6.5 GO:1903281 protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288)
1.2 14.7 GO:0032782 bile acid secretion(GO:0032782)
1.2 9.3 GO:0030578 PML body organization(GO:0030578)
1.1 17.8 GO:0016322 neuron remodeling(GO:0016322)
1.1 19.2 GO:0051601 exocyst localization(GO:0051601)
1.1 3.2 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
1.0 8.2 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.9 7.5 GO:0035897 proteolysis in other organism(GO:0035897)
0.9 3.7 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.9 9.0 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.8 1.6 GO:0045350 interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.8 12.7 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.8 3.8 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.8 27.1 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.8 4.5 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.7 3.0 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.7 3.5 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.7 2.7 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.6 2.6 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.6 3.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.6 18.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.5 9.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.5 4.5 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.4 1.3 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.4 9.0 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.4 3.3 GO:0072553 terminal button organization(GO:0072553)
0.4 8.9 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.4 1.4 GO:0000103 sulfate assimilation(GO:0000103)
0.3 2.1 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.3 11.0 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.3 1.0 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.3 6.7 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.3 2.0 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.3 1.0 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.3 1.6 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.3 2.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.3 13.9 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.3 3.6 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.3 0.8 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 1.9 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 0.7 GO:1904529 regulation of actin filament binding(GO:1904529) negative regulation of actin filament binding(GO:1904530) regulation of actin binding(GO:1904616) negative regulation of actin binding(GO:1904617)
0.2 9.7 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.2 2.2 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.2 1.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.2 0.6 GO:0051685 maintenance of ER location(GO:0051685)
0.2 0.6 GO:0031938 regulation of chromatin silencing at telomere(GO:0031938)
0.2 5.2 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.2 3.9 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.2 2.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.2 12.3 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.2 1.0 GO:0007296 vitellogenesis(GO:0007296)
0.2 5.9 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.2 3.7 GO:0033622 integrin activation(GO:0033622)
0.2 2.5 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.2 0.5 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 4.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 8.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 1.2 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.1 12.5 GO:0035690 cellular response to drug(GO:0035690)
0.1 1.5 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 2.3 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1 2.0 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 2.5 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 2.0 GO:0097178 ruffle assembly(GO:0097178)
0.1 1.3 GO:0030091 protein repair(GO:0030091)
0.1 2.5 GO:0003334 keratinocyte development(GO:0003334)
0.1 7.5 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) response to interleukin-12(GO:0070671) cellular response to interleukin-12(GO:0071349)
0.1 0.3 GO:1902218 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 0.5 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 6.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.4 GO:1900194 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.1 2.2 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.8 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 5.5 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 5.7 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 4.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 1.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 1.4 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.1 0.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.9 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 1.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 7.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 3.0 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.6 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 1.1 GO:0070365 hepatocyte differentiation(GO:0070365)
0.1 0.3 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.3 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.1 2.1 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 0.4 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.0 5.1 GO:0030038 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 7.4 GO:0071222 cellular response to lipopolysaccharide(GO:0071222)
0.0 0.3 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 1.7 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.0 1.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 3.9 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.5 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 3.1 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.0 4.2 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 0.1 GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
0.0 0.5 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716)
0.0 1.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 1.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 1.8 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.0 2.0 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.3 GO:0038171 cannabinoid signaling pathway(GO:0038171)
0.0 1.4 GO:0032418 lysosome localization(GO:0032418)
0.0 0.2 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.3 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 1.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.6 GO:0036297 interstrand cross-link repair(GO:0036297)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
13.9 55.4 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
9.9 59.5 GO:1990682 CSF1-CSF1R complex(GO:1990682)
9.0 72.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
8.0 24.0 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
2.3 18.1 GO:0005610 laminin-5 complex(GO:0005610)
1.5 36.8 GO:0005614 interstitial matrix(GO:0005614)
1.4 11.5 GO:0043196 varicosity(GO:0043196)
1.3 14.7 GO:0046581 intercellular canaliculus(GO:0046581)
1.3 9.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
1.2 13.7 GO:0042612 MHC class I protein complex(GO:0042612)
1.2 14.7 GO:0060091 kinocilium(GO:0060091)
0.9 5.5 GO:0008537 proteasome activator complex(GO:0008537)
0.8 4.8 GO:0032584 growth cone membrane(GO:0032584)
0.7 40.7 GO:0097542 ciliary tip(GO:0097542)
0.7 8.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.6 38.5 GO:0016235 aggresome(GO:0016235)
0.5 19.2 GO:0000145 exocyst(GO:0000145)
0.4 10.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.4 25.5 GO:0001772 immunological synapse(GO:0001772)
0.3 6.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.3 21.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 6.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 8.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 2.2 GO:0031415 NatA complex(GO:0031415)
0.3 1.4 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.3 8.0 GO:0031143 pseudopodium(GO:0031143)
0.3 5.5 GO:0032156 septin cytoskeleton(GO:0032156)
0.3 3.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 12.5 GO:0043034 costamere(GO:0043034)
0.2 3.2 GO:0031045 dense core granule(GO:0031045)
0.2 3.1 GO:0033643 host cell part(GO:0033643)
0.2 82.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 78.5 GO:0045121 membrane raft(GO:0045121)
0.2 0.6 GO:0016938 kinesin I complex(GO:0016938)
0.2 0.6 GO:0031933 telomeric heterochromatin(GO:0031933)
0.2 0.6 GO:0070939 Dsl1p complex(GO:0070939)
0.2 1.7 GO:0071204 U7 snRNP(GO:0005683) histone pre-mRNA 3'end processing complex(GO:0071204)
0.2 3.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 3.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.5 GO:0045180 basal cortex(GO:0045180)
0.1 1.6 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 6.7 GO:0008180 COP9 signalosome(GO:0008180)
0.1 2.1 GO:0030478 actin cap(GO:0030478)
0.1 2.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 11.6 GO:0035580 specific granule lumen(GO:0035580) tertiary granule lumen(GO:1904724)
0.1 1.1 GO:0000125 PCAF complex(GO:0000125)
0.1 3.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 2.0 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 6.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 4.7 GO:0002102 podosome(GO:0002102)
0.1 1.5 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 176.9 GO:0005615 extracellular space(GO:0005615)
0.1 9.0 GO:0005923 bicellular tight junction(GO:0005923)
0.1 3.0 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.1 4.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 5.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 49.3 GO:0005912 adherens junction(GO:0005912)
0.1 3.9 GO:0031201 SNARE complex(GO:0031201)
0.1 3.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 2.3 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 1.8 GO:0005839 proteasome core complex(GO:0005839)
0.1 2.0 GO:0032420 stereocilium(GO:0032420)
0.0 6.7 GO:0043209 myelin sheath(GO:0043209)
0.0 28.0 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 9.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.4 GO:0031594 neuromuscular junction(GO:0031594)
0.0 5.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.7 GO:0072686 mitotic spindle(GO:0072686)
0.0 25.0 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 0.9 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 2.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)
0.0 1.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 2.2 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.6 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
18.5 92.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
10.0 110.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
9.8 29.4 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
7.4 59.5 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
5.3 26.6 GO:0004906 interferon-gamma receptor activity(GO:0004906)
4.5 72.7 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
3.9 23.6 GO:0035800 deubiquitinase activator activity(GO:0035800)
3.0 24.0 GO:0008131 primary amine oxidase activity(GO:0008131)
3.0 9.0 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
1.9 40.3 GO:0070628 proteasome binding(GO:0070628)
1.7 89.4 GO:0031593 polyubiquitin binding(GO:0031593)
1.6 4.8 GO:0035514 DNA demethylase activity(GO:0035514)
1.5 10.6 GO:0046979 TAP2 binding(GO:0046979)
1.5 14.6 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.4 62.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
1.3 6.3 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
1.2 5.9 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
1.2 9.3 GO:1990763 arrestin family protein binding(GO:1990763)
0.9 46.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.8 30.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.8 5.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.7 7.5 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.7 11.0 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.7 2.2 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.7 4.2 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.7 2.0 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.6 8.0 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.6 2.5 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.6 1.7 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.5 2.1 GO:0097677 STAT family protein binding(GO:0097677)
0.5 8.6 GO:0048185 activin binding(GO:0048185)
0.5 1.4 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.5 5.5 GO:0004707 MAP kinase activity(GO:0004707)
0.5 8.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.4 17.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.4 4.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.4 11.6 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.4 6.2 GO:0042834 peptidoglycan binding(GO:0042834)
0.3 18.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 10.4 GO:0046965 retinoid X receptor binding(GO:0046965)
0.3 6.5 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.3 1.9 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.3 3.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.3 1.7 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.3 3.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 9.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 2.1 GO:0046790 virion binding(GO:0046790)
0.3 28.6 GO:0001618 virus receptor activity(GO:0001618)
0.3 7.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 55.9 GO:0004386 helicase activity(GO:0004386)
0.2 7.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 4.5 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.2 1.3 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 3.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 7.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 6.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 3.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 16.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 2.3 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.2 1.5 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.2 1.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.2 3.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.2 9.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 0.5 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 26.9 GO:0001047 core promoter binding(GO:0001047)
0.2 2.5 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.2 10.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 2.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.0 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.1 3.0 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 50.1 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 23.3 GO:0000149 SNARE binding(GO:0000149)
0.1 5.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 3.3 GO:0005523 tropomyosin binding(GO:0005523)
0.1 3.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 10.2 GO:0051117 ATPase binding(GO:0051117)
0.1 9.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 6.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 3.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 2.0 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 1.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 5.2 GO:0035326 enhancer binding(GO:0035326)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.6 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 29.1 GO:0003924 GTPase activity(GO:0003924)
0.1 3.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.6 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 0.4 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 2.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.3 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.1 19.3 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 4.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 5.2 GO:0005178 integrin binding(GO:0005178)
0.0 5.4 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 5.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.5 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.7 GO:0031005 filamin binding(GO:0031005)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 1.6 GO:0043130 ubiquitin binding(GO:0043130)
0.0 18.1 GO:0005198 structural molecule activity(GO:0005198)
0.0 4.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.6 GO:0017022 myosin binding(GO:0017022)
0.0 0.5 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.6 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 195.3 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
2.1 59.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.7 55.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
1.4 111.6 PID CXCR3 PATHWAY CXCR3-mediated signaling events
1.3 24.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
1.2 40.2 PID CD40 PATHWAY CD40/CD40L signaling
0.8 28.0 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.8 18.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.7 6.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.7 22.0 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.6 25.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.5 5.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5 29.6 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.4 171.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.3 19.0 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.3 0.6 PID TRAIL PATHWAY TRAIL signaling pathway
0.3 7.0 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.2 9.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 2.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.2 4.8 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 3.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 3.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 9.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 8.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 5.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 10.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 2.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 5.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.1 ST ADRENERGIC Adrenergic Pathway
0.1 3.2 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 2.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 4.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 1.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 4.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.3 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 3.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.3 PID E2F PATHWAY E2F transcription factor network
0.0 1.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 0.3 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.8 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 8.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
3.6 239.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
3.4 73.9 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
2.7 144.1 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
2.0 18.3 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
1.4 13.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
1.3 7.5 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
1.2 25.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.9 18.0 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.8 26.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.8 18.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.7 49.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.5 8.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.5 11.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.5 13.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.4 9.3 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.4 17.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.4 12.7 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.3 7.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 27.2 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.3 7.5 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 7.2 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.2 10.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.2 1.6 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.2 9.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 11.4 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.2 3.6 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.2 6.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 4.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 2.5 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 3.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.2 6.5 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 3.9 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 4.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 13.9 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 11.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 9.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 7.3 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 3.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.7 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 6.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 2.4 REACTOME PI METABOLISM Genes involved in PI Metabolism
0.1 2.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 3.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 0.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.5 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 5.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 2.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.1 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 2.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation