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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for RELA
Z-value: 3.69
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Transcription factors associated with RELA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELA | hg19_v2_chr11_-_65430251_65430399 | 0.94 | 5.1e-12 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_76944621 Show fit | 64.70 |
ENST00000306602.1
|
chemokine (C-X-C motif) ligand 10 |
|
| chr6_-_31550192 Show fit | 45.65 |
ENST00000429299.2
ENST00000446745.2 |
lymphotoxin beta (TNF superfamily, member 3) |
|
| chr6_-_29527702 Show fit | 38.52 |
ENST00000377050.4
|
ubiquitin D |
|
| chr19_+_45504688 Show fit | 35.86 |
ENST00000221452.8
ENST00000540120.1 ENST00000505236.1 |
v-rel avian reticuloendotheliosis viral oncogene homolog B |
|
| chr11_+_102188224 Show fit | 33.63 |
ENST00000263464.3
|
baculoviral IAP repeat containing 3 |
|
| chr6_+_138188551 Show fit | 32.02 |
ENST00000237289.4
ENST00000433680.1 |
tumor necrosis factor, alpha-induced protein 3 |
|
| chr11_+_102188272 Show fit | 31.75 |
ENST00000532808.1
|
baculoviral IAP repeat containing 3 |
|
| chr10_+_104154229 Show fit | 30.96 |
ENST00000428099.1
ENST00000369966.3 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
|
| chr4_+_74702214 Show fit | 30.75 |
ENST00000226317.5
ENST00000515050.1 |
chemokine (C-X-C motif) ligand 6 |
|
| chr2_+_228678550 Show fit | 29.39 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RELA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 114.1 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 9.3 | 92.6 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 7.8 | 70.1 | GO:0042090 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 7.3 | 65.4 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 15.9 | 63.6 | GO:0085032 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 11.9 | 59.5 | GO:1903974 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 13.9 | 55.4 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 7.1 | 49.5 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 13.6 | 40.7 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 7.7 | 38.5 | GO:0070842 | aggresome assembly(GO:0070842) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 176.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 82.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 78.5 | GO:0045121 | membrane raft(GO:0045121) |
| 9.0 | 72.0 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 9.9 | 59.5 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 13.9 | 55.4 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.1 | 49.3 | GO:0005912 | adherens junction(GO:0005912) |
| 0.7 | 40.7 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.6 | 38.5 | GO:0016235 | aggresome(GO:0016235) |
| 1.5 | 36.8 | GO:0005614 | interstitial matrix(GO:0005614) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.0 | 110.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 18.5 | 92.6 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 1.7 | 89.4 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 4.5 | 72.7 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 1.4 | 62.8 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 7.4 | 59.5 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.2 | 55.9 | GO:0004386 | helicase activity(GO:0004386) |
| 0.1 | 50.1 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.9 | 46.9 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 1.9 | 40.3 | GO:0070628 | proteasome binding(GO:0070628) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 195.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.4 | 171.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.4 | 111.6 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 2.1 | 59.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 1.7 | 55.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 1.2 | 40.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.5 | 29.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.8 | 28.0 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.6 | 25.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.3 | 24.0 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 239.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 2.7 | 144.1 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 3.4 | 73.9 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.7 | 49.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.3 | 27.2 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.8 | 26.1 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 1.2 | 25.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 2.0 | 18.3 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.8 | 18.2 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.9 | 18.0 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |