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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for RELB
Z-value: 1.19
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Transcription factors associated with RELB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELB | hg19_v2_chr19_+_45504688_45504782 | 0.81 | 1.1e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_29527702 Show fit | 9.18 |
ENST00000377050.4
|
ubiquitin D |
|
| chr1_-_173020056 Show fit | 6.61 |
ENST00000239468.2
ENST00000404377.3 |
tumor necrosis factor (ligand) superfamily, member 18 |
|
| chr4_+_74702214 Show fit | 5.82 |
ENST00000226317.5
ENST00000515050.1 |
chemokine (C-X-C motif) ligand 6 |
|
| chr1_+_110453109 Show fit | 5.49 |
ENST00000525659.1
|
colony stimulating factor 1 (macrophage) |
|
| chr4_-_74864386 Show fit | 4.94 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
|
| chr14_+_103589789 Show fit | 4.92 |
ENST00000558056.1
ENST00000560869.1 |
tumor necrosis factor, alpha-induced protein 2 |
|
| chr19_+_45504688 Show fit | 4.39 |
ENST00000221452.8
ENST00000540120.1 ENST00000505236.1 |
v-rel avian reticuloendotheliosis viral oncogene homolog B |
|
| chr4_+_103423055 Show fit | 4.06 |
ENST00000505458.1
|
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
|
| chr1_-_8000872 Show fit | 3.95 |
ENST00000377507.3
|
tumor necrosis factor receptor superfamily, member 9 |
|
| chr8_+_90770008 Show fit | 3.85 |
ENST00000540020.1
|
receptor-interacting serine-threonine kinase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RELB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 14.9 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 2.7 | 13.5 | GO:1904141 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 1.9 | 11.4 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
| 1.8 | 9.2 | GO:0070842 | aggresome assembly(GO:0070842) |
| 1.8 | 7.3 | GO:0044501 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.8 | 7.1 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 1.7 | 6.6 | GO:2000329 | negative regulation of T-helper 17 cell lineage commitment(GO:2000329) |
| 1.5 | 6.1 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.8 | 5.8 | GO:2000630 | positive regulation of miRNA metabolic process(GO:2000630) |
| 0.7 | 5.5 | GO:0021564 | vagus nerve development(GO:0021564) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.3 | GO:0005615 | extracellular space(GO:0005615) |
| 2.3 | 13.5 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 1.0 | 12.0 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 8.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 5.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 4.9 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 3.9 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 3.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.5 | 3.7 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 3.7 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.3 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.9 | 13.9 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 1.7 | 13.5 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.4 | 9.2 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.2 | 7.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.6 | 7.1 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 6.0 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 1.2 | 5.8 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.0 | 5.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 5.4 | GO:0008201 | heparin binding(GO:0008201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 18.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 14.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.5 | 13.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 12.4 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 7.6 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 5.2 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 4.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 3.2 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 3.0 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 2.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 12.7 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.4 | 8.8 | REACTOME P75NTR SIGNALS VIA NFKB | Genes involved in p75NTR signals via NF-kB |
| 0.4 | 7.6 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.3 | 4.7 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.2 | 4.7 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.1 | 4.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.2 | 4.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 4.2 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.2 | 3.8 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |