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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for REST

Z-value: 0.84

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.11 RE1 silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_577741140.262.0e-01Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_93897272 2.22 ENST00000393151.2
UNC79
unc-79 homolog (C. elegans)
chr11_-_72492878 2.12 ENST00000535054.1
ENST00000545082.1
STARD10
StAR-related lipid transfer (START) domain containing 10
chr9_+_135457530 2.11 ENST00000263610.2
BARHL1
BarH-like homeobox 1
chr14_+_93897199 1.57 ENST00000553484.1
UNC79
unc-79 homolog (C. elegans)
chr10_+_99609996 1.48 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr4_+_8582287 1.46 ENST00000382487.4
GPR78
G protein-coupled receptor 78
chr4_+_96012614 1.43 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr20_+_30555805 1.20 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr12_+_175930 1.09 ENST00000538872.1
ENST00000326261.4
IQSEC3
IQ motif and Sec7 domain 3
chr18_+_57567180 1.05 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr19_-_40724246 1.03 ENST00000311308.6
TTC9B
tetratricopeptide repeat domain 9B
chr12_+_113229543 0.97 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr12_+_113229452 0.96 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chr12_+_113229737 0.93 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr8_-_145559943 0.92 ENST00000332135.4
SCRT1
scratch family zinc finger 1
chr9_-_139096955 0.86 ENST00000371748.5
LHX3
LIM homeobox 3
chr5_+_33936491 0.79 ENST00000330120.3
RXFP3
relaxin/insulin-like family peptide receptor 3
chr6_+_25652432 0.77 ENST00000377961.2
SCGN
secretagogin, EF-hand calcium binding protein
chr6_+_43603552 0.74 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr1_+_212606219 0.73 ENST00000366988.3
NENF
neudesin neurotrophic factor
chr15_-_83378611 0.71 ENST00000542200.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr6_+_35773070 0.65 ENST00000373853.1
ENST00000360215.1
LHFPL5
lipoma HMGIC fusion partner-like 5
chr10_-_79398250 0.63 ENST00000286627.5
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr22_+_23054174 0.63 ENST00000390308.2
IGLV3-21
immunoglobulin lambda variable 3-21
chr6_+_154360616 0.62 ENST00000229768.5
ENST00000419506.2
ENST00000524163.1
ENST00000414028.2
ENST00000435918.2
ENST00000337049.4
OPRM1
opioid receptor, mu 1
chr3_+_75955817 0.62 ENST00000487694.3
ENST00000602589.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr12_-_12837423 0.61 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr20_-_44144249 0.60 ENST00000217428.6
SPINT3
serine peptidase inhibitor, Kunitz type, 3
chr3_-_8686479 0.59 ENST00000544814.1
ENST00000427408.1
SSUH2
ssu-2 homolog (C. elegans)
chr6_+_154360553 0.58 ENST00000452687.2
OPRM1
opioid receptor, mu 1
chrX_-_153237258 0.58 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr14_-_74892805 0.58 ENST00000331628.3
ENST00000554953.1
SYNDIG1L
synapse differentiation inducing 1-like
chr6_+_154360476 0.56 ENST00000428397.2
OPRM1
opioid receptor, mu 1
chr4_-_175750364 0.53 ENST00000340217.5
ENST00000274093.3
GLRA3
glycine receptor, alpha 3
chr18_-_40857493 0.52 ENST00000255224.3
SYT4
synaptotagmin IV
chr1_-_151689259 0.51 ENST00000420342.1
ENST00000290583.4
CELF3
CUGBP, Elav-like family member 3
chr3_-_131753830 0.50 ENST00000429747.1
CPNE4
copine IV
chr5_+_71014990 0.50 ENST00000296777.4
CARTPT
CART prepropeptide
chrX_-_49056635 0.50 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
SYP
synaptophysin
chr8_-_57358432 0.48 ENST00000517415.1
ENST00000314922.3
PENK
proenkephalin
chr5_-_151304337 0.46 ENST00000455880.2
ENST00000545569.1
ENST00000274576.4
GLRA1
glycine receptor, alpha 1
chr1_-_241520385 0.46 ENST00000366564.1
RGS7
regulator of G-protein signaling 7
chr9_-_74061751 0.45 ENST00000357533.2
ENST00000423814.3
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr2_-_30143525 0.44 ENST00000431873.1
ALK
anaplastic lymphoma receptor tyrosine kinase
chr20_+_62327996 0.44 ENST00000369996.1
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chrX_-_153141302 0.44 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1CAM
L1 cell adhesion molecule
chr20_+_44657845 0.43 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr3_+_62304648 0.42 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
C3orf14
chromosome 3 open reading frame 14
chr5_-_176037105 0.42 ENST00000303991.4
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr10_+_60936921 0.41 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr5_+_175298487 0.40 ENST00000393745.3
CPLX2
complexin 2
chr9_+_140033862 0.37 ENST00000350902.5
ENST00000371550.4
ENST00000371546.4
ENST00000371555.4
ENST00000371553.3
ENST00000371559.4
ENST00000371560.3
GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr20_-_62284766 0.37 ENST00000370053.1
STMN3
stathmin-like 3
chr6_+_110299501 0.36 ENST00000414000.2
GPR6
G protein-coupled receptor 6
chr3_+_62304712 0.35 ENST00000494481.1
C3orf14
chromosome 3 open reading frame 14
chr2_-_51259641 0.34 ENST00000406316.2
ENST00000405581.1
NRXN1
neurexin 1
chr11_-_125773085 0.33 ENST00000227474.3
ENST00000534158.1
ENST00000529801.1
PUS3
pseudouridylate synthase 3
chr3_+_9745510 0.33 ENST00000383831.3
CPNE9
copine family member IX
chrX_-_47479246 0.31 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr6_+_154360357 0.31 ENST00000330432.7
ENST00000360422.4
OPRM1
opioid receptor, mu 1
chr5_-_135701164 0.30 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr10_-_44880491 0.29 ENST00000374426.2
ENST00000395795.4
ENST00000395794.2
ENST00000374429.2
ENST00000395793.3
ENST00000343575.6
CXCL12
chemokine (C-X-C motif) ligand 12
chr12_-_99288536 0.29 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr13_-_111214015 0.29 ENST00000267328.3
RAB20
RAB20, member RAS oncogene family
chr14_-_94759595 0.28 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_-_51259528 0.28 ENST00000404971.1
NRXN1
neurexin 1
chr17_-_3301704 0.28 ENST00000322608.2
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr3_+_9745487 0.26 ENST00000383832.3
CPNE9
copine family member IX
chr14_-_94759408 0.26 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr4_+_158141899 0.25 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr12_-_57871853 0.24 ENST00000549602.1
ENST00000430041.2
ARHGAP9
Rho GTPase activating protein 9
chr14_-_94759361 0.24 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr4_+_158141806 0.23 ENST00000393815.2
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr10_+_89419370 0.23 ENST00000361175.4
ENST00000456849.1
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr4_+_158141843 0.23 ENST00000509417.1
ENST00000296526.7
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr3_-_48700310 0.23 ENST00000164024.4
ENST00000544264.1
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3
chr20_+_36012051 0.22 ENST00000373567.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr1_-_102462565 0.22 ENST00000370103.4
OLFM3
olfactomedin 3
chr9_-_104357277 0.21 ENST00000374806.1
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr14_+_93389425 0.20 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr7_+_145813453 0.20 ENST00000361727.3
CNTNAP2
contactin associated protein-like 2
chr20_-_60795296 0.20 ENST00000340177.5
HRH3
histamine receptor H3
chr15_-_72612470 0.20 ENST00000287202.5
CELF6
CUGBP, Elav-like family member 6
chr14_-_51561784 0.20 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr11_-_75141206 0.20 ENST00000376292.4
KLHL35
kelch-like family member 35
chr11_-_92931098 0.20 ENST00000326402.4
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr10_-_102790852 0.19 ENST00000470414.1
ENST00000370215.3
PDZD7
PDZ domain containing 7
chr17_+_42385927 0.19 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
RUNDC3A
RUN domain containing 3A
chr11_+_22359562 0.18 ENST00000263160.3
SLC17A6
solute carrier family 17 (vesicular glutamate transporter), member 6
chr2_-_47798044 0.18 ENST00000327876.4
KCNK12
potassium channel, subfamily K, member 12
chr10_+_26505662 0.18 ENST00000428517.2
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr5_+_63802109 0.17 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr17_-_7218403 0.17 ENST00000570780.1
GPS2
G protein pathway suppressor 2
chr1_+_154540246 0.17 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr2_+_131513864 0.17 ENST00000458606.1
ENST00000423981.1
AMER3
APC membrane recruitment protein 3
chr17_-_27332931 0.16 ENST00000442608.3
ENST00000335960.6
SEZ6
seizure related 6 homolog (mouse)
chr19_-_55691472 0.16 ENST00000537500.1
SYT5
synaptotagmin V
chr2_-_51259229 0.16 ENST00000405472.3
NRXN1
neurexin 1
chr9_-_123812542 0.15 ENST00000223642.1
C5
complement component 5
chr2_-_51259292 0.14 ENST00000401669.2
NRXN1
neurexin 1
chr14_+_96039882 0.14 ENST00000556346.1
ENST00000553785.1
RP11-1070N10.4
RP11-1070N10.4
chr12_+_71833550 0.14 ENST00000266674.5
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr11_+_45907177 0.13 ENST00000241014.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr8_-_91095099 0.12 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr3_-_42743006 0.12 ENST00000310417.5
HHATL
hedgehog acyltransferase-like
chr16_+_5008290 0.12 ENST00000251170.7
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr1_-_40105617 0.11 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr1_+_171750776 0.10 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
METTL13
methyltransferase like 13
chr2_+_226265364 0.10 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr7_+_150748288 0.10 ENST00000490540.1
ASIC3
acid-sensing (proton-gated) ion channel 3
chr22_+_22749343 0.08 ENST00000390298.2
IGLV7-43
immunoglobulin lambda variable 7-43
chr19_-_55691614 0.07 ENST00000592470.1
ENST00000354308.3
SYT5
synaptotagmin V
chr11_+_637246 0.06 ENST00000176183.5
DRD4
dopamine receptor D4
chr2_+_115199876 0.06 ENST00000436732.1
ENST00000410059.1
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr15_-_27018884 0.05 ENST00000299267.4
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr10_-_79398127 0.03 ENST00000372443.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr17_-_27333163 0.02 ENST00000360295.9
SEZ6
seizure related 6 homolog (mouse)
chr10_+_26505179 0.02 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr3_-_113897545 0.02 ENST00000467632.1
DRD3
dopamine receptor D3
chr15_-_22473353 0.02 ENST00000557788.2
IGHV4OR15-8
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr1_-_153517473 0.01 ENST00000368715.1
S100A4
S100 calcium binding protein A4
chr12_-_24737089 0.00 ENST00000483544.1
LINC00477
long intergenic non-protein coding RNA 477
chr19_-_51845378 0.00 ENST00000335624.4
VSIG10L
V-set and immunoglobulin domain containing 10 like

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
0.3 0.9 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.3 1.4 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.3 3.9 GO:0048149 behavioral response to ethanol(GO:0048149)
0.2 2.1 GO:0032782 bile acid secretion(GO:0032782)
0.2 0.5 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.2 0.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 1.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.6 GO:0019046 release from viral latency(GO:0019046)
0.1 0.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.4 GO:0043449 olfactory learning(GO:0008355) cellular alkene metabolic process(GO:0043449)
0.1 0.5 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 0.7 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 0.4 GO:0036269 swimming behavior(GO:0036269)
0.1 0.8 GO:0008218 bioluminescence(GO:0008218)
0.1 1.0 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 0.9 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 1.1 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.1 0.2 GO:2000705 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.1 0.2 GO:0071109 superior temporal gyrus development(GO:0071109)
0.1 0.7 GO:0034465 response to carbon monoxide(GO:0034465)
0.1 0.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.2 GO:0000103 sulfate assimilation(GO:0000103)
0.1 0.8 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) auditory receptor cell stereocilium organization(GO:0060088)
0.1 0.2 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.3 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.1 0.5 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.0 0.5 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 1.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.2 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.0 2.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.0 0.1 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.0 0.3 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.2 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.2 GO:0032099 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.0 0.5 GO:0030575 nuclear body organization(GO:0030575)
0.0 0.7 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.2 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.3 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.9 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.1 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.0 0.4 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.4 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.8 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.3 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 1.1 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 0.5 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.2 0.5 GO:0032127 dense core granule membrane(GO:0032127)
0.1 0.7 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 1.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.7 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.5 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.2 GO:0002139 stereocilia coupling link(GO:0002139)
0.1 0.7 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.2 GO:1990769 proximal neuron projection(GO:1990769)
0.0 1.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.6 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.4 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 3.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0042583 chromaffin granule(GO:0042583)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0004979 beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
0.3 2.9 GO:0008430 selenium binding(GO:0008430)
0.2 1.0 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2 1.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 0.8 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.7 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 0.5 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.2 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1 0.4 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.2 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.9 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.4 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.5 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.6 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.2 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.4 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID BMP PATHWAY BMP receptor signaling
0.0 2.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 1.1 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.1 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.0 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors