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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for RFX3_RFX2

Z-value: 1.20

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Transcription factors associated with RFX3_RFX2

Gene Symbol Gene ID Gene Info
RFX3
ENSG00000080298.11 regulatory factor X3
RFX2
ENSG00000087903.8 regulatory factor X2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX3hg19_v2_chr9_-_3525968_3526016-0.242.5e-01Click!
RFX2hg19_v2_chr19_-_6110474_6110551-0.029.3e-01Click!

Activity profile of RFX3_RFX2 motif

Sorted Z-values of RFX3_RFX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_149669192 4.69 ENST00000398376.3
CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr2_-_203736150 3.27 ENST00000457524.1
ENST00000421334.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr16_-_75590114 2.40 ENST00000568377.1
ENST00000565067.1
ENST00000258173.6
TMEM231
transmembrane protein 231
chr16_+_57406368 2.36 ENST00000006053.6
ENST00000563383.1
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr13_-_44361025 2.02 ENST00000261488.6
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr15_+_71184931 1.89 ENST00000560369.1
ENST00000260382.5
LRRC49
leucine rich repeat containing 49
chr15_+_71185148 1.81 ENST00000443425.2
ENST00000560755.1
LRRC49
leucine rich repeat containing 49
chr5_-_179780312 1.70 ENST00000253778.8
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr6_+_109761898 1.61 ENST00000258052.3
SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr1_-_159869912 1.56 ENST00000368099.4
CCDC19
coiled-coil domain containing 19
chr22_+_23487513 1.54 ENST00000263116.2
ENST00000341989.4
RAB36
RAB36, member RAS oncogene family
chr1_-_36916066 1.53 ENST00000315643.9
OSCP1
organic solute carrier partner 1
chr19_-_7553852 1.48 ENST00000593547.1
PEX11G
peroxisomal biogenesis factor 11 gamma
chr7_-_140624499 1.44 ENST00000288602.6
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr22_-_38240412 1.35 ENST00000215941.4
ANKRD54
ankyrin repeat domain 54
chr8_+_13424352 1.35 ENST00000297324.4
C8orf48
chromosome 8 open reading frame 48
chr19_-_7553889 1.28 ENST00000221480.1
PEX11G
peroxisomal biogenesis factor 11 gamma
chr1_+_144339738 1.25 ENST00000538264.1
AL592284.1
Protein LOC642441
chr3_-_58563094 1.24 ENST00000464064.1
FAM107A
family with sequence similarity 107, member A
chr13_+_37005967 1.17 ENST00000440264.1
ENST00000449823.1
CCNA1
cyclin A1
chr2_+_232063260 1.13 ENST00000349938.4
ARMC9
armadillo repeat containing 9
chr20_-_44540686 1.11 ENST00000477313.1
ENST00000542937.1
ENST00000372431.3
ENST00000354050.4
ENST00000420868.2
PLTP
phospholipid transfer protein
chr20_-_48532046 1.10 ENST00000543716.1
SPATA2
spermatogenesis associated 2
chr17_-_60885659 1.09 ENST00000311269.5
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr17_-_60885700 1.09 ENST00000583600.1
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr11_+_134201768 1.08 ENST00000535456.2
ENST00000339772.7
GLB1L2
galactosidase, beta 1-like 2
chr17_+_41132564 1.07 ENST00000361677.1
ENST00000589705.1
RUNDC1
RUN domain containing 1
chr19_-_51017881 1.05 ENST00000601207.1
ENST00000598657.1
ENST00000376916.3
ASPDH
aspartate dehydrogenase domain containing
chr10_-_25305011 1.03 ENST00000331161.4
ENST00000376363.1
ENKUR
enkurin, TRPC channel interacting protein
chr16_+_57662419 1.01 ENST00000388812.4
ENST00000538815.1
ENST00000456916.1
ENST00000567154.1
ENST00000388813.5
ENST00000562558.1
ENST00000566271.2
GPR56
G protein-coupled receptor 56
chr11_+_134201911 1.01 ENST00000389881.3
GLB1L2
galactosidase, beta 1-like 2
chr1_-_36916011 1.01 ENST00000356637.5
ENST00000354267.3
ENST00000235532.5
OSCP1
organic solute carrier partner 1
chr11_-_8832182 1.01 ENST00000527510.1
ENST00000528527.1
ENST00000528523.1
ENST00000313726.6
ST5
suppression of tumorigenicity 5
chr22_-_50746027 1.00 ENST00000425954.1
ENST00000449103.1
PLXNB2
plexin B2
chr16_+_57662138 1.00 ENST00000562414.1
ENST00000561969.1
ENST00000562631.1
ENST00000563445.1
ENST00000565338.1
ENST00000567702.1
GPR56
G protein-coupled receptor 56
chr7_-_102715263 1.00 ENST00000379305.3
FBXL13
F-box and leucine-rich repeat protein 13
chr19_-_633576 0.98 ENST00000588649.2
POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr7_-_102715172 0.97 ENST00000456695.1
ENST00000455112.2
ENST00000440067.1
FBXL13
F-box and leucine-rich repeat protein 13
chr1_-_38325256 0.93 ENST00000373036.4
MTF1
metal-regulatory transcription factor 1
chr9_+_96846740 0.92 ENST00000288976.3
PTPDC1
protein tyrosine phosphatase domain containing 1
chr15_-_82555000 0.89 ENST00000557844.1
ENST00000359445.3
ENST00000268206.7
EFTUD1
elongation factor Tu GTP binding domain containing 1
chr9_+_35829208 0.86 ENST00000439587.2
ENST00000377991.4
TMEM8B
transmembrane protein 8B
chr2_+_27071045 0.86 ENST00000401478.1
DPYSL5
dihydropyrimidinase-like 5
chr2_-_175869936 0.85 ENST00000409900.3
CHN1
chimerin 1
chr1_+_155178481 0.83 ENST00000368376.3
MTX1
metaxin 1
chrX_-_71351678 0.83 ENST00000609883.1
ENST00000545866.1
RGAG4
retrotransposon gag domain containing 4
chr4_+_154073469 0.81 ENST00000441616.1
TRIM2
tripartite motif containing 2
chr2_-_26864228 0.81 ENST00000288861.4
CIB4
calcium and integrin binding family member 4
chr11_-_57089671 0.81 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr15_+_90728145 0.81 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr22_+_37447771 0.81 ENST00000402077.3
ENST00000403888.3
ENST00000456470.1
KCTD17
potassium channel tetramerization domain containing 17
chr1_+_155178518 0.81 ENST00000316721.4
MTX1
metaxin 1
chr8_+_22462532 0.80 ENST00000389279.3
CCAR2
cell cycle and apoptosis regulator 2
chr17_+_7621045 0.80 ENST00000570791.1
DNAH2
dynein, axonemal, heavy chain 2
chr8_+_22462145 0.80 ENST00000308511.4
ENST00000523801.1
ENST00000521301.1
CCAR2
cell cycle and apoptosis regulator 2
chr3_+_48507210 0.80 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
TREX1
three prime repair exonuclease 1
chr6_-_112408661 0.78 ENST00000368662.5
TUBE1
tubulin, epsilon 1
chr8_+_42010464 0.77 ENST00000518421.1
ENST00000174653.3
ENST00000396926.3
ENST00000521280.1
ENST00000522288.1
AP3M2
adaptor-related protein complex 3, mu 2 subunit
chr14_-_77279153 0.77 ENST00000251089.2
ANGEL1
angel homolog 1 (Drosophila)
chr14_+_32798462 0.77 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr1_+_109656579 0.76 ENST00000526264.1
ENST00000369939.3
KIAA1324
KIAA1324
chr1_-_156571254 0.76 ENST00000438976.2
ENST00000334588.7
ENST00000368232.4
ENST00000415314.2
GPATCH4
G patch domain containing 4
chr11_+_75526212 0.76 ENST00000356136.3
UVRAG
UV radiation resistance associated
chr4_-_177116772 0.75 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chr8_+_120428546 0.75 ENST00000259526.3
NOV
nephroblastoma overexpressed
chr1_-_52499443 0.74 ENST00000371614.1
KTI12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr1_+_151682909 0.74 ENST00000326413.3
ENST00000442233.2
RIIAD1
AL589765.1
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
Uncharacterized protein; cDNA FLJ36032 fis, clone TESTI2017069
chr16_+_30773636 0.74 ENST00000402121.3
ENST00000565995.1
ENST00000563683.1
ENST00000357890.5
ENST00000565931.1
RNF40
ring finger protein 40, E3 ubiquitin protein ligase
chr6_-_32145861 0.74 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr3_+_48507621 0.74 ENST00000456089.1
TREX1
three prime repair exonuclease 1
chr7_-_140340576 0.73 ENST00000275884.6
ENST00000475837.1
DENND2A
DENN/MADD domain containing 2A
chr1_+_161068179 0.72 ENST00000368011.4
ENST00000392192.2
KLHDC9
kelch domain containing 9
chr11_-_64885111 0.72 ENST00000528598.1
ENST00000310597.4
ZNHIT2
zinc finger, HIT-type containing 2
chr14_-_74417096 0.72 ENST00000286544.3
FAM161B
family with sequence similarity 161, member B
chr21_+_43919710 0.71 ENST00000398341.3
SLC37A1
solute carrier family 37 (glucose-6-phosphate transporter), member 1
chr4_-_119759795 0.71 ENST00000419654.2
SEC24D
SEC24 family member D
chr19_+_58978418 0.70 ENST00000536459.2
ZNF324
zinc finger protein 324
chr12_+_48577366 0.70 ENST00000316554.3
C12orf68
chromosome 12 open reading frame 68
chr14_+_78227105 0.70 ENST00000439131.2
ENST00000355883.3
ENST00000557011.1
ENST00000556047.1
C14orf178
chromosome 14 open reading frame 178
chr17_+_7258442 0.70 ENST00000389982.4
ENST00000576060.1
ENST00000330767.4
TMEM95
transmembrane protein 95
chr13_+_24553933 0.70 ENST00000424834.2
ENST00000439928.2
SPATA13
RP11-309I15.1
spermatogenesis associated 13
RP11-309I15.1
chr11_-_72492878 0.69 ENST00000535054.1
ENST00000545082.1
STARD10
StAR-related lipid transfer (START) domain containing 10
chr19_-_47249679 0.68 ENST00000263280.6
STRN4
striatin, calmodulin binding protein 4
chr11_-_72492903 0.68 ENST00000537947.1
STARD10
StAR-related lipid transfer (START) domain containing 10
chr19_+_58978463 0.67 ENST00000196482.3
ZNF324
zinc finger protein 324
chr19_+_35630022 0.67 ENST00000589209.1
FXYD1
FXYD domain containing ion transport regulator 1
chr13_+_37006398 0.67 ENST00000418263.1
CCNA1
cyclin A1
chr19_+_35630344 0.67 ENST00000455515.2
FXYD1
FXYD domain containing ion transport regulator 1
chr13_+_37006421 0.67 ENST00000255465.4
CCNA1
cyclin A1
chr16_+_30671223 0.66 ENST00000568722.1
FBRS
fibrosin
chr2_-_175870085 0.66 ENST00000409156.3
CHN1
chimerin 1
chr12_+_6930964 0.66 ENST00000382315.3
GPR162
G protein-coupled receptor 162
chr16_-_34740829 0.65 ENST00000562591.1
RP11-80F22.15
RP11-80F22.15
chr1_+_15736359 0.64 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr20_+_61904137 0.64 ENST00000370283.4
ENST00000523114.1
ENST00000547204.1
ENST00000549047.1
ENST00000523460.1
ENST00000519604.1
ENST00000519273.2
ENST00000370275.4
ARFGAP1
ADP-ribosylation factor GTPase activating protein 1
chr17_-_78428487 0.64 ENST00000562672.2
CTD-2526A2.2
CTD-2526A2.2
chr16_-_67840442 0.64 ENST00000536251.1
ENST00000448631.2
ENST00000602677.1
ENST00000411657.2
ENST00000425512.2
ENST00000317506.3
RANBP10
RAN binding protein 10
chr7_+_6144514 0.63 ENST00000306177.5
ENST00000465073.2
USP42
ubiquitin specific peptidase 42
chr19_-_4535233 0.63 ENST00000381848.3
ENST00000588887.1
ENST00000586133.1
PLIN5
perilipin 5
chr1_-_222763214 0.62 ENST00000350027.4
TAF1A
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
chr19_-_51017127 0.61 ENST00000389208.4
ASPDH
aspartate dehydrogenase domain containing
chr15_-_67546963 0.60 ENST00000561452.1
ENST00000261880.5
AAGAB
alpha- and gamma-adaptin binding protein
chr2_-_10588630 0.60 ENST00000234111.4
ODC1
ornithine decarboxylase 1
chr19_+_35630628 0.59 ENST00000588715.1
ENST00000588607.1
FXYD1
FXYD domain containing ion transport regulator 1
chr22_+_38453207 0.59 ENST00000404072.3
ENST00000424694.1
PICK1
protein interacting with PRKCA 1
chr1_-_222763101 0.59 ENST00000391883.2
ENST00000366890.1
TAF1A
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
chr17_+_26662730 0.59 ENST00000226225.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr11_-_64546202 0.59 ENST00000377390.3
ENST00000227503.9
ENST00000377394.3
ENST00000422298.2
ENST00000334944.5
SF1
splicing factor 1
chr1_-_222763240 0.59 ENST00000352967.4
ENST00000391882.1
ENST00000543857.1
TAF1A
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
chr21_-_37432540 0.59 ENST00000443703.1
ENST00000399207.1
ENST00000399215.1
ENST00000442559.1
ENST00000399205.1
ENST00000429161.1
ENST00000424303.1
ENST00000399208.2
SETD4
SET domain containing 4
chr16_+_84178874 0.59 ENST00000378553.5
DNAAF1
dynein, axonemal, assembly factor 1
chr5_-_147162078 0.59 ENST00000507386.1
JAKMIP2
janus kinase and microtubule interacting protein 2
chr8_+_38243821 0.58 ENST00000519476.2
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr2_+_202937972 0.58 ENST00000541917.1
ENST00000295844.3
AC079354.1
uncharacterized protein KIAA2012
chr22_+_38453378 0.58 ENST00000437453.1
ENST00000356976.3
PICK1
protein interacting with PRKCA 1
chr4_+_128703295 0.57 ENST00000296464.4
ENST00000508549.1
HSPA4L
heat shock 70kDa protein 4-like
chr11_-_66112555 0.57 ENST00000425825.2
ENST00000359957.3
BRMS1
breast cancer metastasis suppressor 1
chr1_+_203444887 0.56 ENST00000343110.2
PRELP
proline/arginine-rich end leucine-rich repeat protein
chr19_+_10217270 0.56 ENST00000446223.1
PPAN
peter pan homolog (Drosophila)
chr14_-_59932044 0.56 ENST00000395116.1
GPR135
G protein-coupled receptor 135
chr16_+_53738053 0.56 ENST00000394647.3
FTO
fat mass and obesity associated
chr6_+_116575329 0.56 ENST00000430252.2
ENST00000540275.1
ENST00000448740.2
DSE
RP3-486I3.7
dermatan sulfate epimerase
RP3-486I3.7
chr19_+_10217364 0.55 ENST00000430370.1
PPAN
peter pan homolog (Drosophila)
chr1_-_74663825 0.55 ENST00000370911.3
ENST00000370909.2
ENST00000354431.4
LRRIQ3
leucine-rich repeats and IQ motif containing 3
chr11_-_66103867 0.55 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chr16_-_57836321 0.55 ENST00000569112.1
ENST00000562311.1
ENST00000445690.2
ENST00000379655.4
KIFC3
kinesin family member C3
chr11_-_64646086 0.55 ENST00000320631.3
EHD1
EH-domain containing 1
chr19_+_35630926 0.54 ENST00000588081.1
ENST00000589121.1
FXYD1
FXYD domain containing ion transport regulator 1
chr15_+_98503922 0.54 ENST00000268042.6
ARRDC4
arrestin domain containing 4
chr3_-_49761337 0.53 ENST00000535833.1
ENST00000308388.6
ENST00000480687.1
ENST00000308375.6
AMIGO3
GMPPB
adhesion molecule with Ig-like domain 3
GDP-mannose pyrophosphorylase B
chr14_-_24658053 0.53 ENST00000354464.6
IPO4
importin 4
chr15_+_42066632 0.53 ENST00000457542.2
ENST00000221214.6
ENST00000260357.7
ENST00000456763.2
MAPKBP1
mitogen-activated protein kinase binding protein 1
chr2_+_159651821 0.52 ENST00000309950.3
ENST00000409042.1
DAPL1
death associated protein-like 1
chr3_-_118753716 0.52 ENST00000393775.2
IGSF11
immunoglobulin superfamily, member 11
chr10_+_25305524 0.52 ENST00000524413.1
ENST00000376356.4
THNSL1
threonine synthase-like 1 (S. cerevisiae)
chrX_+_153146127 0.52 ENST00000452593.1
ENST00000357566.1
LCA10
Putative lung carcinoma-associated protein 10
chrX_-_48693955 0.51 ENST00000218230.5
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr22_-_18507279 0.51 ENST00000441493.2
ENST00000444520.1
ENST00000207726.7
ENST00000429452.1
MICAL3
microtubule associated monooxygenase, calponin and LIM domain containing 3
chr2_+_220144052 0.51 ENST00000425450.1
ENST00000392086.4
ENST00000421532.1
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chrX_+_48455866 0.51 ENST00000376729.5
ENST00000218056.5
WDR13
WD repeat domain 13
chr15_-_85197501 0.51 ENST00000434634.2
WDR73
WD repeat domain 73
chr7_-_100965011 0.51 ENST00000498704.2
ENST00000517481.1
ENST00000437644.2
ENST00000315322.4
RABL5
RAB, member RAS oncogene family-like 5
chr16_+_70680439 0.51 ENST00000288098.2
IL34
interleukin 34
chr12_+_70132458 0.50 ENST00000247833.7
RAB3IP
RAB3A interacting protein
chr1_+_156119798 0.50 ENST00000355014.2
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr2_-_203736452 0.50 ENST00000419460.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr20_+_3869423 0.50 ENST00000497424.1
PANK2
pantothenate kinase 2
chr4_-_76555657 0.50 ENST00000307465.4
CDKL2
cyclin-dependent kinase-like 2 (CDC2-related kinase)
chr19_-_50370799 0.50 ENST00000600910.1
ENST00000322344.3
ENST00000600573.1
PNKP
polynucleotide kinase 3'-phosphatase
chr4_+_128702969 0.49 ENST00000508776.1
ENST00000439123.2
HSPA4L
heat shock 70kDa protein 4-like
chr19_-_50370509 0.49 ENST00000596014.1
PNKP
polynucleotide kinase 3'-phosphatase
chr19_+_1941117 0.49 ENST00000255641.8
CSNK1G2
casein kinase 1, gamma 2
chr11_-_75379479 0.49 ENST00000434603.2
MAP6
microtubule-associated protein 6
chr22_-_50746001 0.49 ENST00000359337.4
PLXNB2
plexin B2
chr3_-_118753626 0.49 ENST00000489689.1
IGSF11
immunoglobulin superfamily, member 11
chr12_+_32655110 0.48 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr22_+_27053422 0.48 ENST00000413665.1
ENST00000421151.1
ENST00000456129.1
ENST00000430080.1
MIAT
myocardial infarction associated transcript (non-protein coding)
chr19_+_55851221 0.47 ENST00000255613.3
ENST00000539076.1
SUV420H2
AC020922.1
suppressor of variegation 4-20 homolog 2 (Drosophila)
Uncharacterized protein
chr21_-_37432832 0.47 ENST00000332131.4
SETD4
SET domain containing 4
chr2_-_9771075 0.47 ENST00000446619.1
ENST00000238081.3
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
chr7_+_99699179 0.47 ENST00000438383.1
ENST00000429084.1
ENST00000359593.4
ENST00000439416.1
AP4M1
adaptor-related protein complex 4, mu 1 subunit
chr11_-_64545941 0.47 ENST00000377387.1
SF1
splicing factor 1
chr12_-_58329819 0.46 ENST00000551421.1
RP11-620J15.3
RP11-620J15.3
chr1_-_183622442 0.46 ENST00000308641.4
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr20_+_44420570 0.46 ENST00000372622.3
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr20_+_44420617 0.46 ENST00000449078.1
ENST00000456939.1
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr19_+_58919992 0.46 ENST00000306910.4
ENST00000598901.1
ENST00000593920.1
ENST00000596281.1
ZNF584
zinc finger protein 584
chr22_+_27053190 0.46 ENST00000439738.1
ENST00000422403.1
ENST00000436238.1
ENST00000425476.1
ENST00000455640.1
ENST00000451141.1
ENST00000452429.1
ENST00000423278.1
MIAT
myocardial infarction associated transcript (non-protein coding)
chrX_-_106449656 0.46 ENST00000372466.4
ENST00000421752.1
ENST00000372461.3
NUP62CL
nucleoporin 62kDa C-terminal like
chr14_-_70546897 0.45 ENST00000394330.2
ENST00000533541.1
ENST00000216568.7
SLC8A3
solute carrier family 8 (sodium/calcium exchanger), member 3
chr16_+_67840668 0.45 ENST00000415766.3
TSNAXIP1
translin-associated factor X interacting protein 1
chr7_-_4923259 0.45 ENST00000536091.1
RADIL
Ras association and DIL domains
chr7_-_4923315 0.45 ENST00000399583.3
RADIL
Ras association and DIL domains
chr19_+_10216899 0.45 ENST00000428358.1
ENST00000393796.4
ENST00000253107.7
ENST00000556468.1
ENST00000393793.1
PPAN-P2RY11
PPAN
PPAN-P2RY11 readthrough
peter pan homolog (Drosophila)
chr12_-_113909877 0.44 ENST00000261731.3
LHX5
LIM homeobox 5
chr5_-_147162263 0.44 ENST00000333010.6
ENST00000265272.5
JAKMIP2
janus kinase and microtubule interacting protein 2
chr1_+_209859510 0.44 ENST00000367028.2
ENST00000261465.1
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr8_+_38243967 0.44 ENST00000524874.1
ENST00000379957.4
ENST00000523983.2
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr12_+_121124599 0.43 ENST00000228506.3
MLEC
malectin
chr17_-_41132410 0.43 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr2_+_45168875 0.43 ENST00000260653.3
SIX3
SIX homeobox 3
chr6_-_30640811 0.43 ENST00000376442.3
DHX16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr8_+_59465728 0.43 ENST00000260130.4
ENST00000422546.2
ENST00000447182.2
ENST00000413219.2
ENST00000424270.2
ENST00000523483.1
ENST00000520168.1
SDCBP
syndecan binding protein (syntenin)
chr1_-_231376836 0.43 ENST00000451322.1
C1orf131
chromosome 1 open reading frame 131
chr17_-_17184605 0.43 ENST00000268717.5
COPS3
COP9 signalosome subunit 3
chr19_+_56652556 0.42 ENST00000337080.3
ZNF444
zinc finger protein 444
chr3_-_107941230 0.42 ENST00000264538.3
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr3_-_27410847 0.41 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
NEK10
NIMA-related kinase 10
chr11_+_31391381 0.41 ENST00000465995.1
ENST00000536040.1
DNAJC24
DnaJ (Hsp40) homolog, subfamily C, member 24
chr22_-_30987837 0.41 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr21_-_37432764 0.41 ENST00000399212.1
ENST00000446166.1
SETD4
SET domain containing 4
chr19_+_2785458 0.41 ENST00000307741.6
ENST00000585338.1
THOP1
thimet oligopeptidase 1
chr19_-_55791431 0.40 ENST00000593263.1
ENST00000376343.3
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr14_+_32798547 0.40 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr5_+_140430979 0.40 ENST00000306549.3
PCDHB1
protocadherin beta 1
chr15_+_81426588 0.40 ENST00000286732.4
C15orf26
chromosome 15 open reading frame 26
chr16_+_30064444 0.40 ENST00000395248.1
ENST00000566897.1
ENST00000568435.1
ALDOA
aldolase A, fructose-bisphosphate
chr18_+_32290218 0.40 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha
chr16_+_67840986 0.39 ENST00000561639.1
ENST00000567852.1
ENST00000565148.1
ENST00000388833.3
ENST00000561654.1
ENST00000431934.2
TSNAXIP1
translin-associated factor X interacting protein 1
chr16_+_30064411 0.39 ENST00000338110.5
ALDOA
aldolase A, fructose-bisphosphate

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.6 1.7 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.4 2.5 GO:0010732 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.3 1.4 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.3 1.1 GO:0042360 vitamin E metabolic process(GO:0042360)
0.3 4.7 GO:0010666 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.2 1.7 GO:0044375 regulation of peroxisome size(GO:0044375)
0.2 1.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.2 0.2 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.2 0.6 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.2 1.0 GO:0098502 DNA dephosphorylation(GO:0098502)
0.2 1.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 0.8 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.2 0.6 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552)
0.2 0.7 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.2 1.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.2 0.5 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.2 1.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.1 0.6 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 0.7 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.1 1.9 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.1 0.4 GO:0009946 proximal/distal axis specification(GO:0009946) neuroblast differentiation(GO:0014016)
0.1 1.9 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.1 0.7 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.4 GO:1902490 regulation of sperm capacitation(GO:1902490)
0.1 0.5 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.8 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.6 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 0.4 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.1 1.6 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 1.4 GO:0032782 bile acid secretion(GO:0032782)
0.1 0.6 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.1 0.3 GO:0080154 regulation of fertilization(GO:0080154)
0.1 0.4 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.1 1.5 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.3 GO:0070637 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.1 0.8 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.4 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.1 0.3 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.1 0.3 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.1 0.4 GO:0098917 retrograde trans-synaptic signaling(GO:0098917)
0.1 0.4 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.5 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.3 GO:0018874 benzoate metabolic process(GO:0018874)
0.1 1.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.5 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.1 0.3 GO:0006850 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.1 2.5 GO:0007141 male meiosis I(GO:0007141)
0.1 0.5 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 0.2 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.1 0.2 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.1 0.6 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.3 GO:0035026 leading edge cell differentiation(GO:0035026)
0.1 0.4 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1 0.2 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.1 0.3 GO:1904398 positive regulation of neuromuscular junction development(GO:1904398)
0.1 0.7 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.7 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.4 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1 0.4 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1 0.5 GO:1990034 calcium ion export from cell(GO:1990034)
0.1 0.2 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.1 0.2 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.1 0.4 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 0.6 GO:0007000 nucleolus organization(GO:0007000)
0.1 0.3 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.4 GO:2001279 regulation of prostaglandin biosynthetic process(GO:0031392) regulation of unsaturated fatty acid biosynthetic process(GO:2001279)
0.1 0.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.3 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.1 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.5 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 2.2 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.1 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.0 0.2 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.5 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.1 GO:0060166 olfactory pit development(GO:0060166)
0.0 0.3 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.1 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.0 1.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.0 0.1 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.4 GO:0032264 IMP salvage(GO:0032264)
0.0 0.1 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232) myeloid dendritic cell activation involved in immune response(GO:0002277)
0.0 0.1 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.0 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.0 0.3 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.5 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.8 GO:0021670 lateral ventricle development(GO:0021670)
0.0 1.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.3 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 1.7 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.6 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.0 0.6 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.1 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.0 1.3 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 0.1 GO:1901355 response to rapamycin(GO:1901355)
0.0 3.8 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 1.8 GO:0006298 mismatch repair(GO:0006298)
0.0 0.3 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.8 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.9 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.6 GO:0090312 positive regulation of protein deacetylation(GO:0090312)
0.0 0.3 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.0 1.2 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.5 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.3 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 2.2 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 0.5 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.2 GO:0001757 somite specification(GO:0001757)
0.0 0.5 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.2 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.1 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.1 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.1 GO:0019060 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.3 GO:0051014 actin filament severing(GO:0051014)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.4 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.5 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.1 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.4 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.3 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.6 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.1 GO:0061009 common bile duct development(GO:0061009)
0.0 0.4 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.5 GO:0002021 response to dietary excess(GO:0002021)
0.0 0.7 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.6 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.2 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.0 GO:1900222 negative regulation of beta-amyloid clearance(GO:1900222)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.4 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.3 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.6 GO:0018146 keratan sulfate biosynthetic process(GO:0018146)
0.0 0.2 GO:0001302 replicative cell aging(GO:0001302)
0.0 0.3 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.3 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 1.1 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 0.6 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.1 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.6 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.0 0.2 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.6 GO:0021795 cerebral cortex cell migration(GO:0021795)
0.0 0.3 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0 0.1 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0044609 DBIRD complex(GO:0044609)
0.5 2.5 GO:0097123 cyclin A1-CDK2 complex(GO:0097123)
0.2 0.7 GO:1990716 axonemal central apparatus(GO:1990716)
0.2 1.8 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.2 3.0 GO:0036038 MKS complex(GO:0036038)
0.1 0.4 GO:1902636 kinociliary basal body(GO:1902636)
0.1 1.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.9 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.5 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 2.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.7 GO:0033503 HULC complex(GO:0033503)
0.1 0.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 1.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.6 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.4 GO:0097149 centralspindlin complex(GO:0097149)
0.1 0.9 GO:0044292 dendrite terminus(GO:0044292)
0.1 2.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.2 GO:1990032 parallel fiber(GO:1990032)
0.1 1.7 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.2 GO:0016939 kinesin II complex(GO:0016939)
0.1 0.2 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 2.9 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.5 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.4 GO:0043196 varicosity(GO:0043196)
0.0 0.9 GO:0005858 axonemal dynein complex(GO:0005858)
0.0 0.2 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.8 GO:0030897 HOPS complex(GO:0030897)
0.0 0.3 GO:0034448 EGO complex(GO:0034448)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.5 GO:0005915 zonula adherens(GO:0005915)
0.0 0.4 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.0 0.3 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.4 GO:0034709 methylosome(GO:0034709)
0.0 0.1 GO:1990031 pinceau fiber(GO:1990031)
0.0 0.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.3 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.2 GO:0036128 CatSper complex(GO:0036128)
0.0 0.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.5 GO:0036020 AP-2 adaptor complex(GO:0030122) endolysosome membrane(GO:0036020)
0.0 0.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.5 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 2.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 1.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0001741 XY body(GO:0001741)
0.0 0.8 GO:0005921 gap junction(GO:0005921)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.3 GO:0032059 bleb(GO:0032059)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.2 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.6 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.8 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.3 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.8 GO:0031430 M band(GO:0031430)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)
0.0 0.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.6 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.4 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 2.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.2 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0035686 sperm fibrous sheath(GO:0035686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 1.0 GO:0098518 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) polynucleotide phosphatase activity(GO:0098518)
0.2 4.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 2.1 GO:0004565 beta-galactosidase activity(GO:0004565)
0.2 0.6 GO:0035514 DNA demethylase activity(GO:0035514)
0.2 0.5 GO:0031862 prostanoid receptor binding(GO:0031862)
0.1 0.4 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 1.9 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.4 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.1 0.4 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 0.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.6 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 1.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.7 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1 0.5 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.1 0.5 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.7 GO:0035473 lipase binding(GO:0035473)
0.1 1.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.8 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.1 0.4 GO:0002046 opsin binding(GO:0002046)
0.1 0.2 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.6 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 1.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.3 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.5 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 0.5 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 1.7 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 0.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.8 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 2.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 3.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.1 GO:0070984 SET domain binding(GO:0070984)
0.0 0.4 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0001026 TFIIIB-type transcription factor activity(GO:0001026)
0.0 0.2 GO:0070568 guanylyltransferase activity(GO:0070568)
0.0 1.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.9 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 1.5 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.1 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.0 1.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.1 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.0 0.4 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.7 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.8 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.8 GO:0005112 Notch binding(GO:0005112)
0.0 0.3 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.5 GO:0005522 profilin binding(GO:0005522)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.5 GO:0070513 death domain binding(GO:0070513)
0.0 0.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.5 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.3 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.4 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.3 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.2 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 1.6 GO:0043022 ribosome binding(GO:0043022)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.6 GO:0019843 rRNA binding(GO:0019843)
0.0 0.1 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.0 0.6 GO:0071949 FAD binding(GO:0071949)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 1.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 1.0 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.9 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.3 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0004673 phosphorelay sensor kinase activity(GO:0000155) protein histidine kinase activity(GO:0004673)
0.0 0.1 GO:0032408 purine-specific mismatch base pair DNA N-glycosylase activity(GO:0000701) MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 2.2 GO:0000149 SNARE binding(GO:0000149)
0.0 0.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.9 GO:0016279 protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.3 GO:0008483 transaminase activity(GO:0008483)
0.0 0.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.5 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 4.7 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.1 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.9 PID ARF 3PATHWAY Arf1 pathway
0.0 2.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.4 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.0 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.6 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.3 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.2 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.9 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 0.8 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 1.4 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 2.0 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 1.8 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.1 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.6 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX Genes involved in Formation of RNA Pol II elongation complex
0.0 1.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 2.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME INFLUENZA LIFE CYCLE Genes involved in Influenza Life Cycle
0.0 0.5 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 2.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.9 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.9 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.0 0.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.9 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.0 0.7 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.2 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.0 0.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects