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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for RFX3_RFX2
Z-value: 1.20
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Transcription factors associated with RFX3_RFX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX3 | hg19_v2_chr9_-_3525968_3526016 | -0.24 | 2.5e-01 | Click! |
| RFX2 | hg19_v2_chr19_-_6110474_6110551 | -0.02 | 9.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_149669192 Show fit | 4.69 |
ENST00000398376.3
|
calcium/calmodulin-dependent protein kinase II alpha |
|
| chr2_-_203736150 Show fit | 3.27 |
ENST00000457524.1
ENST00000421334.1 |
islet cell autoantigen 1,69kDa-like |
|
| chr16_-_75590114 Show fit | 2.40 |
ENST00000568377.1
ENST00000565067.1 ENST00000258173.6 |
transmembrane protein 231 |
|
| chr16_+_57406368 Show fit | 2.36 |
ENST00000006053.6
ENST00000563383.1 |
chemokine (C-X3-C motif) ligand 1 |
|
| chr13_-_44361025 Show fit | 2.02 |
ENST00000261488.6
|
ecto-NOX disulfide-thiol exchanger 1 |
|
| chr15_+_71184931 Show fit | 1.89 |
ENST00000560369.1
ENST00000260382.5 |
leucine rich repeat containing 49 |
|
| chr15_+_71185148 Show fit | 1.81 |
ENST00000443425.2
ENST00000560755.1 |
leucine rich repeat containing 49 |
|
| chr5_-_179780312 Show fit | 1.70 |
ENST00000253778.8
|
glutamine-fructose-6-phosphate transaminase 2 |
|
| chr6_+_109761898 Show fit | 1.61 |
ENST00000258052.3
|
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) |
|
| chr1_-_159869912 Show fit | 1.56 |
ENST00000368099.4
|
coiled-coil domain containing 19 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX3_RFX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.7 | GO:0010666 | positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) |
| 0.0 | 3.8 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.4 | 2.5 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.1 | 2.5 | GO:0007141 | male meiosis I(GO:0007141) |
| 0.8 | 2.4 | GO:0050902 | leukocyte adhesive activation(GO:0050902) |
| 0.1 | 2.2 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.0 | 2.2 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
| 0.1 | 1.9 | GO:2000304 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.1 | 1.9 | GO:0006002 | fructose 6-phosphate metabolic process(GO:0006002) |
| 0.0 | 1.8 | GO:0006298 | mismatch repair(GO:0006298) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 2.9 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 2.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 2.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.5 | 2.5 | GO:0097123 | cyclin A1-CDK2 complex(GO:0097123) |
| 0.1 | 2.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 2.0 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 1.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.2 | 1.8 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.0 | 1.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.8 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 3.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 2.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 2.2 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.2 | 2.1 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.1 | 1.9 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 1.9 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 1.8 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.1 | 1.7 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |
| 0.0 | 1.6 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 3.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 2.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 2.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.6 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 1.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.1 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.9 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.9 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 2.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 2.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 2.2 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 2.0 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 1.9 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 1.8 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 1.4 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.0 | 1.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |