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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for RFX5
Z-value: 0.64
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Transcription factors associated with RFX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX5 | hg19_v2_chr1_-_151319283_151319314 | 0.46 | 2.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.1 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 1.0 | 3.8 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.2 | 3.0 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.0 | 1.2 | GO:0006305 | DNA alkylation(GO:0006305) DNA methylation(GO:0006306) |
| 0.3 | 1.0 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.0 | 0.8 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.2 | 0.7 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.0 | 0.7 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.2 | 0.5 | GO:0002581 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) |
| 0.0 | 0.5 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 9.9 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.5 | 3.8 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 1.3 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 1.2 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 1.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.8 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 0.4 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.0 | 0.4 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.0 | 0.4 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 0.2 | GO:0070545 | PeBoW complex(GO:0070545) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.9 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.5 | 3.8 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.0 | 1.2 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.1 | 0.8 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
| 0.0 | 0.7 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 0.6 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 0.4 | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 0.1 | 0.4 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.0 | 0.4 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.1 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.0 | 0.4 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |