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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for RFX5

Z-value: 0.64

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
RFX5
ENSG00000143390.13 regulatory factor X5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg19_v2_chr1_-_151319283_1513193140.462.0e-02Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_32821924 4.75 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32821599 3.85 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_+_32812568 3.56 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_+_26440700 1.79 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr6_-_32812420 1.58 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr6_+_26383404 1.53 ENST00000416795.2
ENST00000494184.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr6_+_26383318 1.49 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr6_+_26458152 1.21 ENST00000312541.5
BTN2A1
butyrophilin, subfamily 2, member A1
chr19_+_19496728 1.10 ENST00000537887.1
ENST00000417582.2
GATAD2A
GATA zinc finger domain containing 2A
chr6_+_26458171 0.88 ENST00000493173.1
ENST00000541522.1
ENST00000429381.1
ENST00000469185.1
BTN2A1
butyrophilin, subfamily 2, member A1
chr17_+_38137050 0.78 ENST00000264639.4
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr6_-_32908765 0.78 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr11_-_72433346 0.69 ENST00000334211.8
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr6_+_26365443 0.66 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr6_-_32784687 0.50 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr17_+_38137073 0.48 ENST00000541736.1
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr11_-_85430088 0.46 ENST00000533057.1
ENST00000533892.1
SYTL2
synaptotagmin-like 2
chr11_+_45868957 0.44 ENST00000443527.2
CRY2
cryptochrome 2 (photolyase-like)
chr6_-_30181133 0.44 ENST00000454678.2
ENST00000434785.1
TRIM26
tripartite motif containing 26
chrX_-_40594755 0.44 ENST00000324817.1
MED14
mediator complex subunit 14
chr6_-_30658745 0.43 ENST00000376420.5
ENST00000376421.5
NRM
nurim (nuclear envelope membrane protein)
chrX_+_19362011 0.42 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr6_-_30181156 0.40 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
TRIM26
tripartite motif containing 26
chr7_+_766320 0.39 ENST00000297440.6
ENST00000313147.5
HEATR2
HEAT repeat containing 2
chr2_-_105030466 0.36 ENST00000449772.1
AC068535.3
AC068535.3
chr16_+_67381263 0.35 ENST00000541146.1
ENST00000563189.1
ENST00000290940.7
LRRC36
leucine rich repeat containing 36
chr1_+_85527987 0.34 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WDR63
WD repeat domain 63
chr16_+_67381289 0.33 ENST00000435835.3
LRRC36
leucine rich repeat containing 36
chr20_+_42875935 0.32 ENST00000438466.1
ENST00000372952.3
ENST00000537864.1
ENST00000445952.1
GDAP1L1
ganglioside induced differentiation associated protein 1-like 1
chr17_-_19265982 0.28 ENST00000268841.6
ENST00000261499.4
ENST00000575478.1
B9D1
B9 protein domain 1
chr20_+_42875887 0.28 ENST00000342560.5
GDAP1L1
ganglioside induced differentiation associated protein 1-like 1
chr17_-_19265855 0.28 ENST00000440841.1
ENST00000395615.1
ENST00000461069.2
B9D1
B9 protein domain 1
chr6_-_32498046 0.26 ENST00000374975.3
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr6_-_32908792 0.25 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr4_-_143226979 0.24 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr5_-_149792295 0.24 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr17_-_19266045 0.22 ENST00000395616.3
B9D1
B9 protein domain 1
chr22_-_30987837 0.22 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr8_-_98290087 0.21 ENST00000322128.3
TSPYL5
TSPY-like 5
chr11_+_111385497 0.21 ENST00000375618.4
ENST00000529167.1
ENST00000332814.6
C11orf88
chromosome 11 open reading frame 88
chr12_-_110841462 0.20 ENST00000455511.3
ENST00000450008.2
ANAPC7
anaphase promoting complex subunit 7
chr3_+_66271410 0.19 ENST00000336733.6
SLC25A26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chrX_+_125953746 0.19 ENST00000371125.3
CXorf64
chromosome X open reading frame 64
chr19_+_45417921 0.19 ENST00000252491.4
ENST00000592885.1
ENST00000589781.1
APOC1
apolipoprotein C-I
chr3_+_66271489 0.18 ENST00000536651.1
SLC25A26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr19_+_45418067 0.18 ENST00000589078.1
ENST00000586638.1
APOC1
apolipoprotein C-I
chr1_+_181003067 0.17 ENST00000434571.2
ENST00000367579.3
ENST00000282990.6
ENST00000367580.5
MR1
major histocompatibility complex, class I-related
chr3_+_196466710 0.16 ENST00000327134.3
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr10_+_82116529 0.15 ENST00000411538.1
ENST00000256039.2
DYDC2
DPY30 domain containing 2
chr19_+_19496624 0.14 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATAD2A
GATA zinc finger domain containing 2A
chr3_-_27410847 0.12 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
NEK10
NIMA-related kinase 10
chr8_+_101170257 0.12 ENST00000251809.3
SPAG1
sperm associated antigen 1
chr19_+_3933579 0.11 ENST00000593949.1
NMRK2
nicotinamide riboside kinase 2
chr1_+_36549676 0.09 ENST00000207457.3
TEKT2
tektin 2 (testicular)
chr19_+_10563567 0.09 ENST00000344979.3
PDE4A
phosphodiesterase 4A, cAMP-specific
chr16_-_74808710 0.09 ENST00000219368.3
ENST00000544337.1
FA2H
fatty acid 2-hydroxylase
chr6_-_24666819 0.09 ENST00000341060.3
TDP2
tyrosyl-DNA phosphodiesterase 2
chr12_-_126467906 0.08 ENST00000507313.1
ENST00000545784.1
LINC00939
long intergenic non-protein coding RNA 939
chr1_+_249132462 0.07 ENST00000306562.3
ZNF672
zinc finger protein 672
chr1_-_53608249 0.07 ENST00000371494.4
SLC1A7
solute carrier family 1 (glutamate transporter), member 7
chr6_-_24667180 0.06 ENST00000545995.1
TDP2
tyrosyl-DNA phosphodiesterase 2
chr4_-_143227088 0.06 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr9_+_135937365 0.05 ENST00000372080.4
ENST00000351304.7
CEL
carboxyl ester lipase
chr1_-_53608289 0.03 ENST00000371491.4
SLC1A7
solute carrier family 1 (glutamate transporter), member 7
chr10_-_82116497 0.03 ENST00000372204.3
DYDC1
DPY30 domain containing 1
chr13_-_47012325 0.02 ENST00000409879.2
KIAA0226L
KIAA0226-like
chr5_+_119799927 0.02 ENST00000407149.2
ENST00000379551.2
PRR16
proline rich 16

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.8 GO:0046967 cytosol to ER transport(GO:0046967)
0.3 1.0 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.2 3.0 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.2 0.7 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.2 0.5 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.1 0.4 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.1 11.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 0.4 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.0 0.2 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0 0.4 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.4 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.5 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.7 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.2 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 1.2 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 9.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.5 3.8 GO:0042825 TAP complex(GO:0042825)
0.1 1.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.4 GO:0070847 core mediator complex(GO:0070847)
0.0 1.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.8 GO:0036038 MKS complex(GO:0036038)
0.0 1.2 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.4 GO:0042627 chylomicron(GO:0042627)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.8 GO:0046979 TAP2 binding(GO:0046979)
0.3 9.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.4 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.8 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 0.4 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.3 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.1 GO:0036317 tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260)
0.0 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 1.2 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.4 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.7 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.0 0.4 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.4 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.2 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.6 GO:0004364 glutathione transferase activity(GO:0004364)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 3.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 14.1 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane