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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for RFX7_RFX4_RFX1
Z-value: 0.89
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Transcription factors associated with RFX7_RFX4_RFX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX7 | hg19_v2_chr15_-_56535464_56535521 | -0.24 | 2.5e-01 | Click! |
| RFX4 | hg19_v2_chr12_+_106976678_106976708, hg19_v2_chr12_+_107078474_107078533 | 0.09 | 6.7e-01 | Click! |
| RFX1 | hg19_v2_chr19_-_14117074_14117141 | 0.07 | 7.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX7_RFX4_RFX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.0 | GO:0090299 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 0.5 | 2.4 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 0.1 | 2.0 | GO:0035646 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
| 0.2 | 1.8 | GO:0060154 | cellular process regulating host cell cycle in response to virus(GO:0060154) |
| 0.0 | 1.8 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.1 | 1.7 | GO:0048102 | autophagic cell death(GO:0048102) |
| 0.5 | 1.6 | GO:0050902 | leukocyte adhesive activation(GO:0050902) |
| 0.2 | 1.5 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.1 | 0.9 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.1 | 0.8 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 2.5 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 1.8 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 1.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.3 | 1.7 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 1.3 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 1.0 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.2 | 0.9 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 0.0 | 0.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 0.8 | GO:0033503 | HULC complex(GO:0033503) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 2.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 1.8 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 1.7 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 1.6 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.2 | 1.5 | GO:0005119 | smoothened binding(GO:0005119) |
| 0.1 | 0.9 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.0 | 0.9 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 0.9 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.8 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 1.8 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.5 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 0.5 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.3 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.2 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 2.0 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 1.8 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 1.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.8 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 0.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.7 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 0.7 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.4 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |