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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for RFX7_RFX4_RFX1

Z-value: 0.89

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Transcription factors associated with RFX7_RFX4_RFX1

Gene Symbol Gene ID Gene Info
RFX7
ENSG00000181827.10 regulatory factor X7
RFX4
ENSG00000111783.8 regulatory factor X4
RFX1
ENSG00000132005.4 regulatory factor X1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX7hg19_v2_chr15_-_56535464_56535521-0.242.5e-01Click!
RFX4hg19_v2_chr12_+_106976678_106976708,
hg19_v2_chr12_+_107078474_107078533		0.096.7e-01Click!
RFX1hg19_v2_chr19_-_14117074_141171410.077.5e-01Click!

Activity profile of RFX7_RFX4_RFX1 motif

Sorted Z-values of RFX7_RFX4_RFX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_50316517 1.79 ENST00000313777.4
ENST00000445575.2
FUZ
fuzzy planar cell polarity protein
chr19_-_50316489 1.63 ENST00000533418.1
FUZ
fuzzy planar cell polarity protein
chr19_-_50316423 1.60 ENST00000528094.1
ENST00000526575.1
FUZ
fuzzy planar cell polarity protein
chr16_+_57406368 1.56 ENST00000006053.6
ENST00000563383.1
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr10_-_25305011 1.49 ENST00000331161.4
ENST00000376363.1
ENKUR
enkurin, TRPC channel interacting protein
chr1_-_45308616 1.47 ENST00000447098.2
ENST00000372192.3
PTCH2
patched 2
chr22_+_23487513 1.24 ENST00000263116.2
ENST00000341989.4
RAB36
RAB36, member RAS oncogene family
chr1_-_36916066 1.19 ENST00000315643.9
OSCP1
organic solute carrier partner 1
chr19_+_16308711 1.18 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr19_-_51014345 0.98 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
JOSD2
Josephin domain containing 2
chr20_-_30311703 0.97 ENST00000450273.1
ENST00000456404.1
ENST00000420488.1
ENST00000439267.1
BCL2L1
BCL2-like 1
chr19_+_55888186 0.91 ENST00000291934.3
TMEM190
transmembrane protein 190
chr20_-_30310797 0.88 ENST00000422920.1
BCL2L1
BCL2-like 1
chr19_-_10679697 0.86 ENST00000335766.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr19_+_16308659 0.86 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr17_-_60885659 0.85 ENST00000311269.5
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr17_-_60885700 0.85 ENST00000583600.1
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr19_-_10679644 0.84 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr1_+_206808918 0.83 ENST00000367108.3
DYRK3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
chr1_+_206808868 0.80 ENST00000367109.2
DYRK3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
chr1_+_206809113 0.77 ENST00000441486.1
ENST00000367106.1
DYRK3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
chr11_+_61248583 0.68 ENST00000432063.2
ENST00000338608.2
PPP1R32
protein phosphatase 1, regulatory subunit 32
chr11_-_113577052 0.65 ENST00000540540.1
ENST00000545579.1
ENST00000538955.1
ENST00000299882.5
TMPRSS5
transmembrane protease, serine 5
chr1_-_21044489 0.63 ENST00000247986.2
KIF17
kinesin family member 17
chr19_-_45953983 0.62 ENST00000592083.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr19_-_51014588 0.61 ENST00000598418.1
JOSD2
Josephin domain containing 2
chr19_+_50321528 0.61 ENST00000312865.6
ENST00000595185.1
ENST00000538643.1
MED25
mediator complex subunit 25
chrX_+_23925918 0.61 ENST00000379211.3
CXorf58
chromosome X open reading frame 58
chr19_-_55791058 0.60 ENST00000587959.1
ENST00000585927.1
ENST00000587922.1
ENST00000585698.1
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr10_+_25305524 0.59 ENST00000524413.1
ENST00000376356.4
THNSL1
threonine synthase-like 1 (S. cerevisiae)
chr16_+_30773636 0.59 ENST00000402121.3
ENST00000565995.1
ENST00000563683.1
ENST00000357890.5
ENST00000565931.1
RNF40
ring finger protein 40, E3 ubiquitin protein ligase
chr2_-_170550877 0.56 ENST00000447353.1
CCDC173
coiled-coil domain containing 173
chr19_-_41220957 0.53 ENST00000596357.1
ENST00000243583.6
ENST00000600080.1
ENST00000595254.1
ENST00000601967.1
ADCK4
aarF domain containing kinase 4
chr16_+_57673207 0.53 ENST00000564783.1
ENST00000564729.1
ENST00000565976.1
ENST00000566508.1
ENST00000544297.1
GPR56
G protein-coupled receptor 56
chr19_-_51014460 0.52 ENST00000595669.1
JOSD2
Josephin domain containing 2
chr20_+_814349 0.52 ENST00000381941.3
FAM110A
family with sequence similarity 110, member A
chr8_+_42010464 0.50 ENST00000518421.1
ENST00000174653.3
ENST00000396926.3
ENST00000521280.1
ENST00000522288.1
AP3M2
adaptor-related protein complex 3, mu 2 subunit
chr16_+_57673430 0.49 ENST00000540164.2
ENST00000568531.1
GPR56
G protein-coupled receptor 56
chr11_-_113577014 0.48 ENST00000544634.1
ENST00000539732.1
ENST00000538770.1
ENST00000536856.1
ENST00000544476.1
TMPRSS5
transmembrane protease, serine 5
chr11_+_102188224 0.48 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chrX_-_23926004 0.48 ENST00000379226.4
ENST00000379220.3
APOO
apolipoprotein O
chr1_+_161068179 0.47 ENST00000368011.4
ENST00000392192.2
KLHDC9
kelch domain containing 9
chr4_-_177116772 0.46 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chr12_-_76478686 0.46 ENST00000261182.8
NAP1L1
nucleosome assembly protein 1-like 1
chr19_-_40324767 0.44 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr5_+_68485433 0.44 ENST00000502689.1
CENPH
centromere protein H
chr19_-_3801789 0.44 ENST00000590849.1
ENST00000395045.2
MATK
megakaryocyte-associated tyrosine kinase
chr9_-_138391692 0.44 ENST00000429260.2
C9orf116
chromosome 9 open reading frame 116
chr1_+_36549676 0.43 ENST00000207457.3
TEKT2
tektin 2 (testicular)
chr15_+_67430339 0.43 ENST00000439724.3
SMAD3
SMAD family member 3
chr20_-_10654639 0.42 ENST00000254958.5
JAG1
jagged 1
chr11_+_69455855 0.42 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr7_-_62858860 0.41 ENST00000593633.1
AC073188.1
AC073188.1
chr10_+_23216944 0.40 ENST00000298032.5
ENST00000409983.3
ENST00000409049.3
ARMC3
armadillo repeat containing 3
chr22_+_38453207 0.40 ENST00000404072.3
ENST00000424694.1
PICK1
protein interacting with PRKCA 1
chr11_+_113185533 0.40 ENST00000393020.1
TTC12
tetratricopeptide repeat domain 12
chrX_-_64254587 0.40 ENST00000337990.2
ZC4H2
zinc finger, C4H2 domain containing
chr11_-_66103867 0.39 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chr22_+_38453378 0.39 ENST00000437453.1
ENST00000356976.3
PICK1
protein interacting with PRKCA 1
chr10_+_23217006 0.38 ENST00000376528.4
ENST00000447081.1
ARMC3
armadillo repeat containing 3
chr16_-_84538218 0.38 ENST00000562447.1
ENST00000565765.1
ENST00000535580.1
ENST00000343629.6
TLDC1
TBC/LysM-associated domain containing 1
chr22_-_50970919 0.37 ENST00000329363.4
ENST00000437588.1
ODF3B
outer dense fiber of sperm tails 3B
chr20_-_44540686 0.37 ENST00000477313.1
ENST00000542937.1
ENST00000372431.3
ENST00000354050.4
ENST00000420868.2
PLTP
phospholipid transfer protein
chr3_-_123339343 0.36 ENST00000578202.1
MYLK
myosin light chain kinase
chr18_-_45935663 0.36 ENST00000589194.1
ENST00000591279.1
ENST00000590855.1
ENST00000587107.1
ENST00000588970.1
ENST00000586525.1
ENST00000592387.1
ENST00000590800.1
ZBTB7C
zinc finger and BTB domain containing 7C
chr14_+_96343100 0.36 ENST00000503525.2
LINC00617
long intergenic non-protein coding RNA 617
chr12_+_113659234 0.36 ENST00000551096.1
ENST00000551099.1
ENST00000335509.6
ENST00000552897.1
ENST00000550785.1
ENST00000549279.1
TPCN1
two pore segment channel 1
chr1_+_15736359 0.36 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr11_+_86085778 0.36 ENST00000354755.1
ENST00000278487.3
ENST00000531271.1
ENST00000445632.2
CCDC81
coiled-coil domain containing 81
chr3_-_123339418 0.36 ENST00000583087.1
MYLK
myosin light chain kinase
chr1_-_118727781 0.35 ENST00000336338.5
SPAG17
sperm associated antigen 17
chr1_-_36916011 0.34 ENST00000356637.5
ENST00000354267.3
ENST00000235532.5
OSCP1
organic solute carrier partner 1
chr16_+_72127461 0.34 ENST00000268482.3
ENST00000566794.1
DHX38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr17_-_80231300 0.33 ENST00000398519.5
ENST00000580446.1
CSNK1D
casein kinase 1, delta
chr14_+_105452094 0.32 ENST00000551606.1
ENST00000547315.1
C14orf79
chromosome 14 open reading frame 79
chr5_-_149669192 0.32 ENST00000398376.3
CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr11_-_85397167 0.32 ENST00000316398.3
CCDC89
coiled-coil domain containing 89
chr16_+_72127670 0.32 ENST00000536867.1
DHX38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr17_-_55911970 0.31 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3
RP11-60A24.3
chr21_-_44846999 0.31 ENST00000270162.6
SIK1
salt-inducible kinase 1
chr17_-_15244894 0.31 ENST00000338696.2
ENST00000543896.1
ENST00000539245.1
ENST00000539316.1
ENST00000395930.1
TEKT3
tektin 3
chr8_-_27115931 0.30 ENST00000523048.1
STMN4
stathmin-like 4
chr7_-_102715263 0.30 ENST00000379305.3
FBXL13
F-box and leucine-rich repeat protein 13
chr1_-_72748417 0.30 ENST00000357731.5
NEGR1
neuronal growth regulator 1
chr12_+_111051832 0.29 ENST00000550703.2
ENST00000551590.1
TCTN1
tectonic family member 1
chr2_+_219537015 0.29 ENST00000440309.1
ENST00000424080.1
STK36
serine/threonine kinase 36
chr1_+_1447517 0.29 ENST00000378756.3
ENST00000378755.5
ATAD3A
ATPase family, AAA domain containing 3A
chr12_+_111051902 0.28 ENST00000397655.3
ENST00000471804.2
ENST00000377654.3
ENST00000397659.4
TCTN1
tectonic family member 1
chr4_-_156297949 0.28 ENST00000515654.1
MAP9
microtubule-associated protein 9
chr9_-_130635741 0.28 ENST00000223836.10
AK1
adenylate kinase 1
chr12_-_47473707 0.28 ENST00000429635.1
AMIGO2
adhesion molecule with Ig-like domain 2
chr7_+_86273218 0.28 ENST00000361669.2
GRM3
glutamate receptor, metabotropic 3
chr22_-_23484246 0.28 ENST00000216036.4
RTDR1
rhabdoid tumor deletion region gene 1
chr2_+_219536749 0.27 ENST00000295709.3
ENST00000392106.2
ENST00000392105.3
ENST00000455724.1
STK36
serine/threonine kinase 36
chr6_+_32407619 0.27 ENST00000395388.2
ENST00000374982.5
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr10_+_106113515 0.27 ENST00000369704.3
ENST00000312902.5
CCDC147
coiled-coil domain containing 147
chr19_+_46850320 0.27 ENST00000391919.1
PPP5C
protein phosphatase 5, catalytic subunit
chr7_+_23637118 0.27 ENST00000448353.1
CCDC126
coiled-coil domain containing 126
chr11_-_62521614 0.27 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr4_+_96012614 0.27 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr15_+_74610894 0.26 ENST00000558821.1
ENST00000268082.4
CCDC33
coiled-coil domain containing 33
chr22_-_30987837 0.26 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr19_-_40324255 0.26 ENST00000593685.1
ENST00000600611.1
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr19_+_46850251 0.26 ENST00000012443.4
PPP5C
protein phosphatase 5, catalytic subunit
chr11_-_64885111 0.25 ENST00000528598.1
ENST00000310597.4
ZNHIT2
zinc finger, HIT-type containing 2
chr1_-_74663825 0.25 ENST00000370911.3
ENST00000370909.2
ENST00000354431.4
LRRIQ3
leucine-rich repeats and IQ motif containing 3
chr2_+_106682135 0.25 ENST00000437659.1
C2orf40
chromosome 2 open reading frame 40
chr1_-_1051736 0.24 ENST00000448924.1
ENST00000294576.5
ENST00000437760.1
ENST00000462097.1
ENST00000475119.1
C1orf159
chromosome 1 open reading frame 159
chr19_+_507299 0.24 ENST00000359315.5
TPGS1
tubulin polyglutamylase complex subunit 1
chr19_+_19496728 0.24 ENST00000537887.1
ENST00000417582.2
GATAD2A
GATA zinc finger domain containing 2A
chr6_+_116601265 0.24 ENST00000452085.3
DSE
dermatan sulfate epimerase
chr1_+_24120143 0.24 ENST00000374501.1
LYPLA2
lysophospholipase II
chr11_+_60681346 0.24 ENST00000227525.3
TMEM109
transmembrane protein 109
chr2_-_190044480 0.23 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr2_+_219575543 0.23 ENST00000457313.1
ENST00000415717.1
ENST00000392102.1
TTLL4
tubulin tyrosine ligase-like family, member 4
chr10_+_50887683 0.23 ENST00000374113.3
ENST00000374111.3
ENST00000374112.3
ENST00000535836.1
C10orf53
chromosome 10 open reading frame 53
chr16_-_75590114 0.23 ENST00000568377.1
ENST00000565067.1
ENST00000258173.6
TMEM231
transmembrane protein 231
chr1_-_36915880 0.23 ENST00000445843.3
OSCP1
organic solute carrier partner 1
chr1_+_39456895 0.23 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chr9_+_138391805 0.23 ENST00000371785.1
MRPS2
mitochondrial ribosomal protein S2
chr11_+_71791803 0.22 ENST00000539271.1
LRTOMT
leucine rich transmembrane and O-methyltransferase domain containing
chr1_-_159893507 0.22 ENST00000368096.1
TAGLN2
transgelin 2
chr2_+_27193480 0.22 ENST00000233121.2
ENST00000405074.3
MAPRE3
microtubule-associated protein, RP/EB family, member 3
chr19_-_55791563 0.22 ENST00000588971.1
ENST00000255631.5
ENST00000587551.1
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr17_-_56296580 0.22 ENST00000313863.6
ENST00000546108.1
ENST00000337050.7
ENST00000393119.2
MKS1
Meckel syndrome, type 1
chr1_-_1051455 0.22 ENST00000379339.1
ENST00000480643.1
ENST00000434641.1
ENST00000421241.2
C1orf159
chromosome 1 open reading frame 159
chr11_+_71791359 0.22 ENST00000419228.1
ENST00000435085.1
ENST00000307198.7
ENST00000538413.1
LRTOMT
leucine rich transmembrane and O-methyltransferase domain containing
chr15_-_44969086 0.22 ENST00000434130.1
ENST00000560780.1
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr6_-_32908765 0.22 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr14_-_39417410 0.21 ENST00000557019.1
ENST00000556116.1
ENST00000554732.1
LINC00639
long intergenic non-protein coding RNA 639
chr20_+_814377 0.21 ENST00000304189.2
ENST00000381939.1
FAM110A
family with sequence similarity 110, member A
chr22_-_30987849 0.21 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chr22_-_43485381 0.21 ENST00000331018.7
ENST00000266254.7
ENST00000445824.1
TTLL1
tubulin tyrosine ligase-like family, member 1
chr1_-_11865982 0.21 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr11_-_119991589 0.21 ENST00000526881.1
TRIM29
tripartite motif containing 29
chr1_+_43637996 0.21 ENST00000528956.1
ENST00000529956.1
WDR65
WD repeat domain 65
chr17_-_80231557 0.21 ENST00000392334.2
ENST00000314028.6
CSNK1D
casein kinase 1, delta
chr8_+_13424352 0.21 ENST00000297324.4
C8orf48
chromosome 8 open reading frame 48
chr7_+_55177416 0.21 ENST00000450046.1
ENST00000454757.2
EGFR
epidermal growth factor receptor
chr17_-_45908875 0.21 ENST00000351111.2
ENST00000414011.1
MRPL10
mitochondrial ribosomal protein L10
chr20_-_44718538 0.21 ENST00000290231.6
ENST00000372291.3
NCOA5
nuclear receptor coactivator 5
chr2_+_54558004 0.20 ENST00000405749.1
ENST00000398634.2
ENST00000447328.1
C2orf73
chromosome 2 open reading frame 73
chr19_+_572543 0.20 ENST00000333511.3
ENST00000573216.1
ENST00000353555.4
BSG
basigin (Ok blood group)
chr2_+_242089046 0.20 ENST00000407025.1
ENST00000272983.8
PPP1R7
protein phosphatase 1, regulatory subunit 7
chr16_+_3550924 0.20 ENST00000576634.1
ENST00000574369.1
ENST00000341633.5
ENST00000417763.2
ENST00000571025.1
CLUAP1
clusterin associated protein 1
chr15_+_71185148 0.20 ENST00000443425.2
ENST00000560755.1
LRRC49
leucine rich repeat containing 49
chr12_+_49687425 0.20 ENST00000257860.4
PRPH
peripherin
chr6_+_52285131 0.20 ENST00000433625.2
EFHC1
EF-hand domain (C-terminal) containing 1
chr8_+_10530155 0.20 ENST00000521818.1
C8orf74
chromosome 8 open reading frame 74
chr20_+_62492566 0.20 ENST00000369916.3
ABHD16B
abhydrolase domain containing 16B
chr11_-_3078616 0.20 ENST00000401769.3
ENST00000278224.9
ENST00000397114.3
ENST00000380525.4
CARS
cysteinyl-tRNA synthetase
chr17_+_4736627 0.20 ENST00000355280.6
ENST00000347992.7
MINK1
misshapen-like kinase 1
chr2_+_219187871 0.20 ENST00000258362.3
PNKD
paroxysmal nonkinesigenic dyskinesia
chr1_+_64669294 0.19 ENST00000371077.5
UBE2U
ubiquitin-conjugating enzyme E2U (putative)
chr20_+_44420570 0.19 ENST00000372622.3
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr4_+_123653807 0.19 ENST00000314218.3
ENST00000542236.1
BBS12
Bardet-Biedl syndrome 12
chr4_+_15004165 0.19 ENST00000538197.1
ENST00000541112.1
ENST00000442003.2
CPEB2
cytoplasmic polyadenylation element binding protein 2
chr2_+_219575653 0.19 ENST00000442769.1
ENST00000424644.1
TTLL4
tubulin tyrosine ligase-like family, member 4
chr17_+_73642486 0.19 ENST00000579469.1
SMIM6
small integral membrane protein 6
chr19_-_55791540 0.19 ENST00000433386.2
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr17_+_73642315 0.19 ENST00000556126.2
SMIM6
small integral membrane protein 6
chr3_+_111805182 0.19 ENST00000430855.1
ENST00000431717.2
ENST00000264848.5
C3orf52
chromosome 3 open reading frame 52
chr1_+_150480551 0.18 ENST00000369049.4
ENST00000369047.4
ECM1
extracellular matrix protein 1
chr22_+_18834324 0.18 ENST00000342005.4
AC008132.13
Uncharacterized protein
chr3_+_184056614 0.18 ENST00000453072.1
FAM131A
family with sequence similarity 131, member A
chr14_-_24658053 0.18 ENST00000354464.6
IPO4
importin 4
chr15_+_71184931 0.18 ENST00000560369.1
ENST00000260382.5
LRRC49
leucine rich repeat containing 49
chr2_-_217236750 0.18 ENST00000273067.4
MARCH4
membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
chr10_+_15001430 0.18 ENST00000407572.1
MEIG1
meiosis/spermiogenesis associated 1
chr6_+_109761898 0.18 ENST00000258052.3
SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr1_+_40627038 0.18 ENST00000372771.4
RLF
rearranged L-myc fusion
chr3_+_51705222 0.18 ENST00000457573.1
ENST00000341333.5
ENST00000412249.1
ENST00000425781.1
ENST00000415259.1
ENST00000395057.1
ENST00000416589.1
TEX264
testis expressed 264
chr19_-_40971667 0.18 ENST00000263368.4
BLVRB
biliverdin reductase B (flavin reductase (NADPH))
chr1_-_228603694 0.18 ENST00000366697.2
TRIM17
tripartite motif containing 17
chr12_-_57472522 0.18 ENST00000379391.3
ENST00000300128.4
TMEM194A
transmembrane protein 194A
chr15_+_91473403 0.18 ENST00000394275.2
UNC45A
unc-45 homolog A (C. elegans)
chr12_+_119772502 0.18 ENST00000536742.1
ENST00000327554.2
CCDC60
coiled-coil domain containing 60
chr22_+_31477296 0.17 ENST00000426927.1
ENST00000440425.1
ENST00000358743.1
ENST00000347557.2
ENST00000333137.7
SMTN
smoothelin
chr16_+_699319 0.17 ENST00000549091.1
ENST00000293879.4
WDR90
WD repeat domain 90
chr20_+_44420617 0.17 ENST00000449078.1
ENST00000456939.1
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr12_-_76478386 0.17 ENST00000535020.2
NAP1L1
nucleosome assembly protein 1-like 1
chr21_-_35883541 0.17 ENST00000399284.1
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr11_-_108422926 0.17 ENST00000428840.1
ENST00000526312.1
EXPH5
exophilin 5
chr17_-_72709050 0.17 ENST00000583937.1
ENST00000301573.9
ENST00000326165.6
ENST00000469092.1
CD300LF
CD300 molecule-like family member f
chr12_-_76478446 0.17 ENST00000393263.3
ENST00000548044.1
ENST00000547704.1
ENST00000431879.3
ENST00000549596.1
ENST00000550934.1
ENST00000551600.1
ENST00000547479.1
ENST00000547773.1
ENST00000544816.1
ENST00000542344.1
ENST00000548273.1
NAP1L1
nucleosome assembly protein 1-like 1
chr9_-_34458531 0.17 ENST00000379089.1
ENST00000379087.1
ENST00000379084.1
ENST00000379081.1
ENST00000379080.1
ENST00000422409.1
ENST00000379078.1
ENST00000445726.1
ENST00000297620.4
FAM219A
family with sequence similarity 219, member A
chr7_+_149535455 0.17 ENST00000223210.4
ENST00000460379.1
ZNF862
zinc finger protein 862
chr17_+_46985731 0.17 ENST00000360943.5
UBE2Z
ubiquitin-conjugating enzyme E2Z
chr17_-_8648105 0.17 ENST00000539522.2
ENST00000293845.3
CCDC42
coiled-coil domain containing 42
chr5_+_68530697 0.17 ENST00000256443.3
ENST00000514676.1
CDK7
cyclin-dependent kinase 7
chr7_+_99006550 0.17 ENST00000222969.5
BUD31
BUD31 homolog (S. cerevisiae)
chr12_+_48577366 0.17 ENST00000316554.3
C12orf68
chromosome 12 open reading frame 68
chr19_-_11545920 0.17 ENST00000356392.4
ENST00000591179.1
CCDC151
coiled-coil domain containing 151
chr3_-_107941209 0.17 ENST00000492106.1
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr19_+_2096868 0.17 ENST00000395296.1
ENST00000395301.3
IZUMO4
IZUMO family member 4
chr22_-_50970506 0.17 ENST00000428989.2
ENST00000403326.1
ODF3B
outer dense fiber of sperm tails 3B
chr19_-_10514184 0.17 ENST00000589629.1
ENST00000222005.2
CDC37
cell division cycle 37
chr9_-_130477912 0.16 ENST00000543175.1
PTRH1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr14_+_93357749 0.16 ENST00000557689.1
RP11-862G15.1
RP11-862G15.1
chrX_+_139791917 0.16 ENST00000607004.1
ENST00000370535.3
LINC00632
long intergenic non-protein coding RNA 632

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX7_RFX4_RFX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.0 GO:0090299 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.5 1.6 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.5 2.4 GO:0035617 stress granule disassembly(GO:0035617)
0.2 1.8 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.2 0.6 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.2 1.5 GO:0009957 epidermal cell fate specification(GO:0009957)
0.2 0.6 GO:0036034 mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
0.1 0.6 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 1.7 GO:0048102 autophagic cell death(GO:0048102)
0.1 0.4 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.6 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.1 0.3 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.1 0.8 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.1 0.6 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.1 0.4 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 0.3 GO:0080154 regulation of fertilization(GO:0080154)
0.1 0.6 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.1 0.3 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.1 0.1 GO:1905154 negative regulation of membrane invagination(GO:1905154)
0.1 2.0 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.1 0.9 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.5 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.4 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.6 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.1 0.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.2 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.1 0.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.1 GO:0018307 enzyme active site formation(GO:0018307)
0.1 0.2 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.3 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.1 0.5 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 0.2 GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125) regulation of interleukin-4-mediated signaling pathway(GO:1902214)
0.1 0.6 GO:0070141 response to UV-A(GO:0070141)
0.1 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.3 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.2 GO:1900247 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.0 0.1 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.1 GO:0032888 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.1 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.0 0.2 GO:0061009 common bile duct development(GO:0061009)
0.0 0.1 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.0 0.1 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.5 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.0 0.1 GO:1902868 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.0 0.2 GO:1904398 positive regulation of neuromuscular junction development(GO:1904398)
0.0 0.4 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.3 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.2 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.1 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.1 GO:0044805 late nucleophagy(GO:0044805)
0.0 0.4 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.5 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.2 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.1 GO:0048075 positive regulation of eye pigmentation(GO:0048075)
0.0 0.1 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.0 0.1 GO:0036114 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.4 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.2 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.2 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.1 GO:1904526 regulation of microtubule binding(GO:1904526)
0.0 0.5 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.3 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.0 0.4 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.5 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 0.1 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.2 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.5 GO:0042424 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.2 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.1 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.0 GO:0006288 base-excision repair, DNA ligation(GO:0006288)
0.0 0.1 GO:0016999 antibiotic metabolic process(GO:0016999)
0.0 0.1 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.0 0.1 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 0.1 GO:0061074 regulation of neural retina development(GO:0061074)
0.0 0.1 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.1 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.4 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.0 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.1 GO:0035549 positive regulation of interferon-beta secretion(GO:0035549)
0.0 0.5 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.1 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 0.1 GO:0021678 third ventricle development(GO:0021678)
0.0 0.3 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0 0.1 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.2 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 0.2 GO:0046689 response to mercury ion(GO:0046689)
0.0 0.1 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.0 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
0.0 0.1 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.0 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.1 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 1.8 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.1 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.0 GO:0090296 regulation of mitochondrial DNA replication(GO:0090296) positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.0 0.2 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.6 GO:0042407 cristae formation(GO:0042407)
0.0 0.2 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.4 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.0 0.7 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.1 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.0 GO:0072615 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.0 0.0 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.0 0.1 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.1 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.0 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.1 GO:0019060 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 0.9 GO:0002079 inner acrosomal membrane(GO:0002079)
0.1 0.6 GO:1990075 periciliary membrane compartment(GO:1990075)
0.1 0.4 GO:1990716 axonemal central apparatus(GO:1990716)
0.1 1.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.8 GO:0033503 HULC complex(GO:0033503)
0.1 0.3 GO:0044609 DBIRD complex(GO:0044609)
0.1 0.6 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.5 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.6 GO:0061617 MICOS complex(GO:0061617)
0.1 0.3 GO:0070985 TFIIK complex(GO:0070985)
0.1 0.2 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
0.1 0.5 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.7 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 0.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 2.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.1 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 1.3 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.7 GO:0036038 MKS complex(GO:0036038)
0.0 1.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0031085 BLOC-3 complex(GO:0031085)
0.0 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.0 GO:0070522 ERCC4-ERCC1 complex(GO:0070522)
0.0 0.6 GO:0030990 intraciliary transport particle(GO:0030990)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.1 GO:0097165 perichromatin fibrils(GO:0005726) nuclear stress granule(GO:0097165)
0.0 0.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.9 GO:0016235 aggresome(GO:0016235)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.4 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 1.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0005119 smoothened binding(GO:0005119)
0.2 1.8 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.3 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.1 0.9 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 0.7 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 0.4 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.5 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.4 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 0.3 GO:0004074 biliverdin reductase activity(GO:0004074)
0.1 1.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.2 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.7 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.2 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 0.3 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.1 0.1 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.1 0.5 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 3.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 1.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0033677 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) DNA/RNA helicase activity(GO:0033677)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.0 0.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.6 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 2.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.0 0.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.0 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.9 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.2 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.5 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.3 PID NECTIN PATHWAY Nectin adhesion pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 2.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.8 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.7 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 1.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.1 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.1 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres