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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for RHOXF1
Z-value: 1.72
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Transcription factors associated with RHOXF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RHOXF1 | hg19_v2_chrX_-_119249819_119249847 | 0.66 | 3.5e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_123676827 Show fit | 10.56 |
ENST00000546084.1
|
TNF receptor-associated factor 1 |
|
| chr8_+_54764346 Show fit | 10.55 |
ENST00000297313.3
ENST00000344277.6 |
regulator of G-protein signaling 20 |
|
| chr4_+_74606223 Show fit | 7.70 |
ENST00000307407.3
ENST00000401931.1 |
interleukin 8 |
|
| chr6_-_32820529 Show fit | 7.65 |
ENST00000425148.2
|
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
|
| chr1_-_173020056 Show fit | 7.30 |
ENST00000239468.2
ENST00000404377.3 |
tumor necrosis factor (ligand) superfamily, member 18 |
|
| chr1_-_184943610 Show fit | 6.51 |
ENST00000367511.3
|
family with sequence similarity 129, member A |
|
| chr11_-_102651343 Show fit | 6.43 |
ENST00000279441.4
ENST00000539681.1 |
matrix metallopeptidase 10 (stromelysin 2) |
|
| chr1_+_169079823 Show fit | 6.32 |
ENST00000367813.3
|
ATPase, Na+/K+ transporting, beta 1 polypeptide |
|
| chr7_+_55177416 Show fit | 5.83 |
ENST00000450046.1
ENST00000454757.2 |
epidermal growth factor receptor |
|
| chr1_-_153521714 Show fit | 5.49 |
ENST00000368713.3
|
S100 calcium binding protein A3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RHOXF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.5 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 2.7 | 11.0 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 1.3 | 10.6 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.1 | 9.5 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 1.9 | 9.4 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 1.6 | 8.2 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288) |
| 0.1 | 8.0 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 7.7 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 0.8 | 7.6 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.0 | 7.4 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.8 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.6 | 11.0 | GO:0042825 | TAP complex(GO:0042825) |
| 1.5 | 10.6 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 1.2 | 9.4 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.4 | 8.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.6 | 8.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 8.3 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.4 | 7.6 | GO:0097342 | CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342) |
| 0.9 | 6.2 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 1.9 | 5.8 | GO:0097489 | multivesicular body, internal vesicle lumen(GO:0097489) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.8 | 12.4 | GO:0031996 | thioesterase binding(GO:0031996) |
| 1.6 | 11.0 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.9 | 10.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 1.9 | 9.4 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.5 | 8.7 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.4 | 8.3 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.3 | 7.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.2 | 7.6 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.1 | 7.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.3 | 18.2 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 17.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 16.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.4 | 14.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 11.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 11.6 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.3 | 10.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 6.2 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 5.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.3 | 12.5 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.2 | 11.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.4 | 11.0 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.5 | 10.4 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.3 | 9.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 8.1 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 8.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 7.6 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 7.2 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |