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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for RORC
Z-value: 0.24
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Transcription factors associated with RORC
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RORC
|
ENSG00000143365.12 | RAR related orphan receptor C |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RORC | hg19_v2_chr1_-_151804222_151804228, hg19_v2_chr1_-_151804314_151804348 | -0.08 | 6.9e-01 | Click! |
Activity profile of RORC motif
Sorted Z-values of RORC motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_162016827 | 0.40 |
ENST00000429217.1
ENST00000406287.1 ENST00000402568.1 |
TANK
|
TRAF family member-associated NFKB activator |
| chr2_+_162016804 | 0.28 |
ENST00000392749.2
ENST00000440506.1 |
TANK
|
TRAF family member-associated NFKB activator |
| chr3_-_164914640 | 0.26 |
ENST00000241274.3
|
SLITRK3
|
SLIT and NTRK-like family, member 3 |
| chr1_+_205197304 | 0.23 |
ENST00000358024.3
|
TMCC2
|
transmembrane and coiled-coil domain family 2 |
| chr2_+_162016916 | 0.22 |
ENST00000405852.1
|
TANK
|
TRAF family member-associated NFKB activator |
| chr12_-_82152420 | 0.22 |
ENST00000552948.1
ENST00000548586.1 |
PPFIA2
|
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 |
| chr16_+_1832902 | 0.18 |
ENST00000262302.9
ENST00000563136.1 ENST00000565987.1 ENST00000543305.1 ENST00000568287.1 ENST00000565134.1 |
NUBP2
|
nucleotide binding protein 2 |
| chr7_+_112063192 | 0.18 |
ENST00000005558.4
|
IFRD1
|
interferon-related developmental regulator 1 |
| chr1_-_149908710 | 0.17 |
ENST00000439741.2
ENST00000361405.6 ENST00000406732.3 |
MTMR11
|
myotubularin related protein 11 |
| chr19_+_38924316 | 0.16 |
ENST00000355481.4
ENST00000360985.3 ENST00000359596.3 |
RYR1
|
ryanodine receptor 1 (skeletal) |
| chr3_+_185304059 | 0.15 |
ENST00000427465.2
|
SENP2
|
SUMO1/sentrin/SMT3 specific peptidase 2 |
| chr18_-_23671139 | 0.15 |
ENST00000579061.1
ENST00000542420.2 |
SS18
|
synovial sarcoma translocation, chromosome 18 |
| chr1_-_150207017 | 0.14 |
ENST00000369119.3
|
ANP32E
|
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
| chrX_-_102531717 | 0.14 |
ENST00000372680.1
|
TCEAL5
|
transcription elongation factor A (SII)-like 5 |
| chr11_+_13299186 | 0.14 |
ENST00000527998.1
ENST00000396441.3 ENST00000533520.1 ENST00000529825.1 ENST00000389707.4 ENST00000401424.1 ENST00000529388.1 ENST00000530357.1 ENST00000403290.1 ENST00000361003.4 ENST00000389708.3 ENST00000403510.3 ENST00000482049.1 |
ARNTL
|
aryl hydrocarbon receptor nuclear translocator-like |
| chr12_-_54652060 | 0.12 |
ENST00000552562.1
|
CBX5
|
chromobox homolog 5 |
| chr1_-_153522562 | 0.12 |
ENST00000368714.1
|
S100A4
|
S100 calcium binding protein A4 |
| chr19_-_7698599 | 0.11 |
ENST00000311069.5
|
PCP2
|
Purkinje cell protein 2 |
| chr8_+_71485681 | 0.10 |
ENST00000391684.1
|
AC120194.1
|
AC120194.1 |
| chr17_-_37764128 | 0.09 |
ENST00000302584.4
|
NEUROD2
|
neuronal differentiation 2 |
| chr8_-_95449155 | 0.09 |
ENST00000481490.2
|
FSBP
|
fibrinogen silencer binding protein |
| chr12_-_39734783 | 0.09 |
ENST00000552961.1
|
KIF21A
|
kinesin family member 21A |
| chr10_-_121296045 | 0.09 |
ENST00000392865.1
|
RGS10
|
regulator of G-protein signaling 10 |
| chrX_-_49089771 | 0.08 |
ENST00000376251.1
ENST00000323022.5 ENST00000376265.2 |
CACNA1F
|
calcium channel, voltage-dependent, L type, alpha 1F subunit |
| chr12_+_4671352 | 0.08 |
ENST00000542744.1
|
DYRK4
|
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 |
| chr19_-_7697857 | 0.08 |
ENST00000598935.1
|
PCP2
|
Purkinje cell protein 2 |
| chr19_-_10450287 | 0.08 |
ENST00000589261.1
ENST00000590569.1 ENST00000589580.1 ENST00000589249.1 |
ICAM3
|
intercellular adhesion molecule 3 |
| chr4_-_120243545 | 0.08 |
ENST00000274024.3
|
FABP2
|
fatty acid binding protein 2, intestinal |
| chr3_-_45957088 | 0.07 |
ENST00000539217.1
|
LZTFL1
|
leucine zipper transcription factor-like 1 |
| chr1_+_114447763 | 0.07 |
ENST00000369563.3
|
DCLRE1B
|
DNA cross-link repair 1B |
| chr14_-_23451845 | 0.07 |
ENST00000262713.2
|
AJUBA
|
ajuba LIM protein |
| chr7_+_20687017 | 0.07 |
ENST00000258738.6
|
ABCB5
|
ATP-binding cassette, sub-family B (MDR/TAP), member 5 |
| chr17_-_48785216 | 0.07 |
ENST00000285243.6
|
ANKRD40
|
ankyrin repeat domain 40 |
| chr6_+_89855765 | 0.07 |
ENST00000275072.4
|
PM20D2
|
peptidase M20 domain containing 2 |
| chr6_+_43738444 | 0.06 |
ENST00000324450.6
ENST00000417285.2 ENST00000413642.3 ENST00000372055.4 ENST00000482630.2 ENST00000425836.2 ENST00000372064.4 ENST00000372077.4 ENST00000519767.1 |
VEGFA
|
vascular endothelial growth factor A |
| chr4_-_170948361 | 0.06 |
ENST00000393702.3
|
MFAP3L
|
microfibrillar-associated protein 3-like |
| chr3_-_45957534 | 0.06 |
ENST00000536047.1
|
LZTFL1
|
leucine zipper transcription factor-like 1 |
| chr17_-_42992856 | 0.05 |
ENST00000588316.1
ENST00000435360.2 ENST00000586793.1 ENST00000588735.1 ENST00000588037.1 ENST00000592320.1 ENST00000253408.5 |
GFAP
|
glial fibrillary acidic protein |
| chr7_-_128415844 | 0.05 |
ENST00000249389.2
|
OPN1SW
|
opsin 1 (cone pigments), short-wave-sensitive |
| chr16_-_67514982 | 0.05 |
ENST00000565835.1
ENST00000540149.1 ENST00000290949.3 |
ATP6V0D1
|
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 |
| chr3_+_185303962 | 0.05 |
ENST00000296257.5
|
SENP2
|
SUMO1/sentrin/SMT3 specific peptidase 2 |
| chr1_+_171810606 | 0.05 |
ENST00000358155.4
ENST00000367733.2 ENST00000355305.5 ENST00000367731.1 |
DNM3
|
dynamin 3 |
| chr7_-_141541221 | 0.05 |
ENST00000350549.3
ENST00000438520.1 |
PRSS37
|
protease, serine, 37 |
| chr1_-_145826450 | 0.05 |
ENST00000462900.2
|
GPR89A
|
G protein-coupled receptor 89A |
| chr10_-_21435488 | 0.04 |
ENST00000534331.1
ENST00000529198.1 ENST00000377118.4 |
C10orf113
|
chromosome 10 open reading frame 113 |
| chr12_-_82152444 | 0.04 |
ENST00000549325.1
ENST00000550584.2 |
PPFIA2
|
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 |
| chr2_-_30144432 | 0.04 |
ENST00000389048.3
|
ALK
|
anaplastic lymphoma receptor tyrosine kinase |
| chr19_-_49140609 | 0.04 |
ENST00000601104.1
|
DBP
|
D site of albumin promoter (albumin D-box) binding protein |
| chr19_-_8567478 | 0.04 |
ENST00000255612.3
|
PRAM1
|
PML-RARA regulated adaptor molecule 1 |
| chr1_-_217311090 | 0.04 |
ENST00000493603.1
ENST00000366940.2 |
ESRRG
|
estrogen-related receptor gamma |
| chr16_+_30937213 | 0.04 |
ENST00000427128.1
|
FBXL19
|
F-box and leucine-rich repeat protein 19 |
| chr16_-_1821496 | 0.04 |
ENST00000564628.1
ENST00000563498.1 |
NME3
|
NME/NM23 nucleoside diphosphate kinase 3 |
| chr10_-_103578182 | 0.03 |
ENST00000439817.1
|
MGEA5
|
meningioma expressed antigen 5 (hyaluronidase) |
| chr6_-_46922659 | 0.03 |
ENST00000265417.7
|
GPR116
|
G protein-coupled receptor 116 |
| chr11_-_47616210 | 0.03 |
ENST00000302514.3
|
C1QTNF4
|
C1q and tumor necrosis factor related protein 4 |
| chr19_+_12780512 | 0.03 |
ENST00000242796.4
|
WDR83
|
WD repeat domain 83 |
| chrX_-_43832711 | 0.03 |
ENST00000378062.5
|
NDP
|
Norrie disease (pseudoglioma) |
| chr20_-_23433471 | 0.03 |
ENST00000377009.3
|
CST11
|
cystatin 11 |
| chr14_-_23755297 | 0.03 |
ENST00000357460.5
|
HOMEZ
|
homeobox and leucine zipper encoding |
| chr17_-_3030875 | 0.03 |
ENST00000328890.2
|
OR1G1
|
olfactory receptor, family 1, subfamily G, member 1 |
| chr14_-_23451467 | 0.02 |
ENST00000555074.1
ENST00000361265.4 |
RP11-298I3.5
AJUBA
|
RP11-298I3.5 ajuba LIM protein |
| chr20_-_44007014 | 0.02 |
ENST00000372726.3
ENST00000537995.1 |
TP53TG5
|
TP53 target 5 |
| chr7_-_43965937 | 0.02 |
ENST00000455877.1
ENST00000223341.7 ENST00000447717.3 ENST00000426198.1 |
URGCP
|
upregulator of cell proliferation |
| chr19_+_55385731 | 0.02 |
ENST00000469767.1
ENST00000355524.3 ENST00000391725.3 ENST00000345937.4 ENST00000353758.4 ENST00000359272.4 ENST00000391723.3 ENST00000391724.3 |
FCAR
|
Fc fragment of IgA, receptor for |
| chr2_+_119699864 | 0.02 |
ENST00000541757.1
ENST00000412481.1 |
MARCO
|
macrophage receptor with collagenous structure |
| chr2_+_119699742 | 0.02 |
ENST00000327097.4
|
MARCO
|
macrophage receptor with collagenous structure |
| chr9_-_14910420 | 0.02 |
ENST00000380880.3
|
FREM1
|
FRAS1 related extracellular matrix 1 |
| chr16_+_24266874 | 0.02 |
ENST00000005284.3
|
CACNG3
|
calcium channel, voltage-dependent, gamma subunit 3 |
| chr3_+_160559931 | 0.02 |
ENST00000464260.1
ENST00000295839.9 |
PPM1L
|
protein phosphatase, Mg2+/Mn2+ dependent, 1L |
| chr10_+_102295616 | 0.01 |
ENST00000299163.6
|
HIF1AN
|
hypoxia inducible factor 1, alpha subunit inhibitor |
| chr6_+_44094627 | 0.01 |
ENST00000259746.9
|
TMEM63B
|
transmembrane protein 63B |
| chr19_-_39735646 | 0.01 |
ENST00000413851.2
|
IFNL3
|
interferon, lambda 3 |
| chr2_+_160590469 | 0.00 |
ENST00000409591.1
|
MARCH7
|
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase |
| chr17_-_10707410 | 0.00 |
ENST00000581851.1
|
LINC00675
|
long intergenic non-protein coding RNA 675 |
| chr12_+_56623827 | 0.00 |
ENST00000424625.1
ENST00000419753.1 ENST00000454355.2 ENST00000417965.1 ENST00000436633.1 |
SLC39A5
|
solute carrier family 39 (zinc transporter), member 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RORC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.1 | 0.2 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 0.0 | 0.1 | GO:1903568 | negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568) |
| 0.0 | 0.1 | GO:0090403 | oxidative stress-induced premature senescence(GO:0090403) |
| 0.0 | 0.1 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.0 | 0.1 | GO:1903570 | regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572) |
| 0.0 | 0.2 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.0 | 0.1 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.0 | 0.0 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.0 | 0.2 | GO:0071313 | cellular response to caffeine(GO:0071313) |
| 0.0 | 0.1 | GO:0048749 | compound eye development(GO:0048749) |
| 0.0 | 0.0 | GO:0036269 | swimming behavior(GO:0036269) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:1990425 | ryanodine receptor complex(GO:1990425) |
| 0.0 | 0.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.0 | 0.2 | GO:0048763 | calcium-induced calcium release activity(GO:0048763) |
| 0.0 | 0.2 | GO:0070137 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.0 | 0.1 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |