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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for RUNX3_BCL11A
Z-value: 1.13
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Transcription factors associated with RUNX3_BCL11A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BCL11A | hg19_v2_chr2_-_60780607_60780634 | 0.42 | 3.8e-02 | Click! |
| RUNX3 | hg19_v2_chr1_-_25291475_25291511 | 0.26 | 2.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RUNX3_BCL11A
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 13.8 | GO:1903971 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 2.0 | 10.0 | GO:0045918 | negative regulation of cytolysis(GO:0045918) |
| 0.6 | 9.6 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.6 | 6.2 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.3 | 3.9 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.5 | 3.8 | GO:0030578 | PML body organization(GO:0030578) |
| 1.2 | 3.7 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 1.2 | 3.6 | GO:2000523 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
| 0.7 | 3.6 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 1.1 | 3.3 | GO:1902080 | positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 13.8 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.5 | 3.6 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.3 | 3.3 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 2.8 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.2 | 2.7 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.3 | 2.0 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 1.9 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.1 | 1.7 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 1.0 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 1.0 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 13.8 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.0 | 9.5 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 8.7 | GO:0070851 | growth factor receptor binding(GO:0070851) |
| 0.1 | 5.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 4.3 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.1 | 4.2 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 1.3 | 3.9 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
| 0.1 | 3.8 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 1.2 | 3.7 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.7 | 3.6 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.5 | 16.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 11.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 10.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 3.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.2 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.6 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.4 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 1.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.3 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.1 | 5.8 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.5 | 3.9 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 3.6 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 3.2 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 3.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.8 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 1.7 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 1.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |