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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for RUNX3_BCL11A

Z-value: 1.13

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Transcription factors associated with RUNX3_BCL11A

Gene Symbol Gene ID Gene Info
RUNX3
ENSG00000020633.14 RUNX family transcription factor 3
BCL11A
ENSG00000119866.16 BAF chromatin remodeling complex subunit BCL11A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BCL11Ahg19_v2_chr2_-_60780607_607806340.423.8e-02Click!
RUNX3hg19_v2_chr1_-_25291475_252915110.262.1e-01Click!

Activity profile of RUNX3_BCL11A motif

Sorted Z-values of RUNX3_BCL11A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_131409476 9.98 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr21_-_36421535 4.62 ENST00000416754.1
ENST00000437180.1
ENST00000455571.1
RUNX1
runt-related transcription factor 1
chr21_-_36421626 4.43 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr1_+_110453109 4.17 ENST00000525659.1
CSF1
colony stimulating factor 1 (macrophage)
chr5_+_35856951 3.93 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr11_-_128457446 3.82 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr2_+_228678550 3.70 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr6_+_45296391 3.67 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr15_+_67418047 3.60 ENST00000540846.2
SMAD3
SMAD family member 3
chr2_+_103035102 3.29 ENST00000264260.2
IL18RAP
interleukin 18 receptor accessory protein
chr1_+_110453203 3.19 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1
colony stimulating factor 1 (macrophage)
chr1_+_110453608 3.11 ENST00000369801.1
CSF1
colony stimulating factor 1 (macrophage)
chr3_-_150920979 2.84 ENST00000309180.5
ENST00000480322.1
GPR171
G protein-coupled receptor 171
chr1_+_110453462 2.70 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr1_-_173174681 2.33 ENST00000367718.1
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr6_+_45296048 2.18 ENST00000465038.2
ENST00000352853.5
ENST00000541979.1
ENST00000371438.1
RUNX2
runt-related transcription factor 2
chr6_+_151042224 2.12 ENST00000358517.2
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chrX_+_68048803 2.05 ENST00000204961.4
EFNB1
ephrin-B1
chr19_-_49658387 1.92 ENST00000595625.1
HRC
histidine rich calcium binding protein
chr5_+_133451254 1.78 ENST00000517851.1
ENST00000521639.1
ENST00000522375.1
ENST00000378560.4
ENST00000432532.2
ENST00000520958.1
ENST00000518915.1
ENST00000395023.1
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr19_+_10197463 1.76 ENST00000590378.1
ENST00000397881.3
C19orf66
chromosome 19 open reading frame 66
chr3_-_71179988 1.65 ENST00000491238.1
FOXP1
forkhead box P1
chr5_-_94417314 1.56 ENST00000505208.1
MCTP1
multiple C2 domains, transmembrane 1
chr3_-_71179699 1.55 ENST00000497355.1
FOXP1
forkhead box P1
chr19_-_49658641 1.40 ENST00000252825.4
HRC
histidine rich calcium binding protein
chr6_+_29068386 1.37 ENST00000377171.3
OR2J1
olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)
chr1_-_235098935 1.36 ENST00000423175.1
RP11-443B7.1
RP11-443B7.1
chr1_-_173176452 1.31 ENST00000281834.3
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr14_-_85996332 1.31 ENST00000380722.1
RP11-497E19.1
RP11-497E19.1
chr3_-_99569821 1.27 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr17_-_61777090 1.27 ENST00000578061.1
LIMD2
LIM domain containing 2
chr12_+_121570631 1.24 ENST00000546057.1
ENST00000377162.2
ENST00000328963.5
ENST00000535250.1
ENST00000541446.1
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr15_-_55563072 1.24 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr14_+_51955831 1.16 ENST00000356218.4
FRMD6
FERM domain containing 6
chr10_+_101419187 1.14 ENST00000370489.4
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr3_-_189840223 1.12 ENST00000427335.2
LEPREL1
leprecan-like 1
chr17_+_57408994 1.07 ENST00000312655.4
YPEL2
yippee-like 2 (Drosophila)
chr11_+_35198243 1.04 ENST00000528455.1
CD44
CD44 molecule (Indian blood group)
chr15_-_55562479 1.03 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr1_-_12677714 1.01 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr7_+_18535346 1.00 ENST00000405010.3
ENST00000406451.4
ENST00000428307.2
HDAC9
histone deacetylase 9
chr1_+_156338993 0.98 ENST00000368249.1
ENST00000368246.2
ENST00000537040.1
ENST00000400992.2
ENST00000255013.3
ENST00000451864.2
RHBG
Rh family, B glycoprotein (gene/pseudogene)
chr9_-_34048873 0.98 ENST00000449054.1
ENST00000379239.4
ENST00000539807.1
ENST00000379238.1
ENST00000418786.2
ENST00000360802.1
ENST00000412543.1
UBAP2
ubiquitin associated protein 2
chr9_+_118916082 0.97 ENST00000328252.3
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr8_+_31497271 0.96 ENST00000520407.1
NRG1
neuregulin 1
chr15_-_55562582 0.96 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr6_+_31514622 0.95 ENST00000376146.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr6_+_37787704 0.92 ENST00000474522.1
ZFAND3
zinc finger, AN1-type domain 3
chr11_+_35198118 0.91 ENST00000525211.1
ENST00000526000.1
ENST00000279452.6
ENST00000527889.1
CD44
CD44 molecule (Indian blood group)
chr6_+_15401075 0.91 ENST00000541660.1
JARID2
jumonji, AT rich interactive domain 2
chr17_-_56494713 0.90 ENST00000407977.2
RNF43
ring finger protein 43
chr6_+_116692102 0.89 ENST00000359564.2
DSE
dermatan sulfate epimerase
chr17_-_56494882 0.85 ENST00000584437.1
RNF43
ring finger protein 43
chr5_-_137878887 0.85 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1
eukaryotic translation termination factor 1
chr8_-_72274095 0.85 ENST00000303824.7
EYA1
eyes absent homolog 1 (Drosophila)
chr3_-_11610255 0.82 ENST00000424529.2
VGLL4
vestigial like 4 (Drosophila)
chr6_+_37787262 0.81 ENST00000287218.4
ZFAND3
zinc finger, AN1-type domain 3
chr2_+_136499287 0.80 ENST00000415164.1
UBXN4
UBX domain protein 4
chr22_+_21996549 0.79 ENST00000248958.4
SDF2L1
stromal cell-derived factor 2-like 1
chr10_+_89420706 0.79 ENST00000427144.2
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr5_-_35938674 0.77 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL
calcyphosine-like
chr2_+_97202480 0.76 ENST00000357485.3
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr9_-_117853297 0.76 ENST00000542877.1
ENST00000537320.1
ENST00000341037.4
TNC
tenascin C
chr11_-_5345582 0.75 ENST00000328813.2
OR51B2
olfactory receptor, family 51, subfamily B, member 2
chr12_+_108079509 0.75 ENST00000412830.3
ENST00000547995.1
PWP1
PWP1 homolog (S. cerevisiae)
chr19_-_42636617 0.74 ENST00000529067.1
ENST00000529952.1
ENST00000533720.1
ENST00000389341.5
ENST00000342301.4
POU2F2
POU class 2 homeobox 2
chr6_+_42847649 0.74 ENST00000424341.2
ENST00000602561.1
RPL7L1
ribosomal protein L7-like 1
chr3_+_114012819 0.73 ENST00000383671.3
TIGIT
T cell immunoreceptor with Ig and ITIM domains
chr2_+_97203082 0.73 ENST00000454558.2
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr2_+_74757050 0.73 ENST00000352222.3
ENST00000437202.1
HTRA2
HtrA serine peptidase 2
chr19_+_13135386 0.73 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr17_-_56494908 0.73 ENST00000577716.1
RNF43
ring finger protein 43
chr2_-_105030466 0.71 ENST00000449772.1
AC068535.3
AC068535.3
chr4_-_10686373 0.71 ENST00000442825.2
CLNK
cytokine-dependent hematopoietic cell linker
chr12_+_75874984 0.70 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr16_+_84801852 0.69 ENST00000569925.1
ENST00000567526.1
USP10
ubiquitin specific peptidase 10
chr8_-_22926623 0.69 ENST00000276431.4
TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr9_-_32526299 0.68 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_+_111195973 0.67 ENST00000368885.3
ENST00000368882.3
ENST00000451850.2
ENST00000368877.5
AMD1
adenosylmethionine decarboxylase 1
chr2_+_208423891 0.67 ENST00000448277.1
ENST00000457101.1
CREB1
cAMP responsive element binding protein 1
chr1_+_110453514 0.67 ENST00000369802.3
ENST00000420111.2
CSF1
colony stimulating factor 1 (macrophage)
chr3_+_141105705 0.66 ENST00000513258.1
ZBTB38
zinc finger and BTB domain containing 38
chr12_-_4754339 0.65 ENST00000228850.1
AKAP3
A kinase (PRKA) anchor protein 3
chr7_-_115670792 0.65 ENST00000265440.7
ENST00000393485.1
TFEC
transcription factor EC
chr8_-_72274467 0.65 ENST00000340726.3
EYA1
eyes absent homolog 1 (Drosophila)
chr4_+_71091786 0.65 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr3_+_141105235 0.64 ENST00000503809.1
ZBTB38
zinc finger and BTB domain containing 38
chr3_-_196014520 0.64 ENST00000441879.1
ENST00000292823.2
ENST00000411591.1
ENST00000431016.1
ENST00000443555.1
PCYT1A
phosphate cytidylyltransferase 1, choline, alpha
chr20_-_45035223 0.64 ENST00000450812.1
ENST00000290246.6
ENST00000439931.2
ENST00000396391.1
ELMO2
engulfment and cell motility 2
chr21_-_36421401 0.63 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr20_-_45035198 0.63 ENST00000372176.1
ELMO2
engulfment and cell motility 2
chr1_+_155579979 0.63 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
MSTO1
misato 1, mitochondrial distribution and morphology regulator
chr5_-_94417339 0.62 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1
multiple C2 domains, transmembrane 1
chr20_+_43343886 0.62 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr8_-_119964434 0.62 ENST00000297350.4
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr22_-_30642782 0.61 ENST00000249075.3
LIF
leukemia inhibitory factor
chr12_+_108079664 0.60 ENST00000541166.1
PWP1
PWP1 homolog (S. cerevisiae)
chr10_-_13276329 0.60 ENST00000378681.3
ENST00000463405.2
UCMA
upper zone of growth plate and cartilage matrix associated
chr9_+_111624577 0.59 ENST00000333999.3
ACTL7A
actin-like 7A
chr1_+_209859510 0.59 ENST00000367028.2
ENST00000261465.1
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr2_+_169659121 0.58 ENST00000397206.2
ENST00000397209.2
ENST00000421711.2
NOSTRIN
nitric oxide synthase trafficking
chr15_+_68582544 0.58 ENST00000566008.1
FEM1B
fem-1 homolog b (C. elegans)
chr15_-_43910998 0.57 ENST00000450892.2
STRC
stereocilin
chr7_-_115670804 0.57 ENST00000320239.7
TFEC
transcription factor EC
chr12_-_323689 0.56 ENST00000428720.1
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr6_+_37787458 0.56 ENST00000373391.2
ZFAND3
zinc finger, AN1-type domain 3
chr20_+_43343476 0.56 ENST00000372868.2
WISP2
WNT1 inducible signaling pathway protein 2
chr10_+_124134201 0.55 ENST00000368990.3
ENST00000368988.1
ENST00000368989.2
ENST00000463663.2
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr6_+_31543334 0.55 ENST00000449264.2
TNF
tumor necrosis factor
chr15_-_89755034 0.55 ENST00000563254.1
RLBP1
retinaldehyde binding protein 1
chr10_-_29811456 0.54 ENST00000535393.1
SVIL
supervillin
chr4_+_88896819 0.54 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
SPP1
secreted phosphoprotein 1
chr20_+_43343517 0.54 ENST00000372865.4
WISP2
WNT1 inducible signaling pathway protein 2
chrX_-_49041242 0.53 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
PRICKLE3
prickle homolog 3 (Drosophila)
chr1_-_114414316 0.53 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr17_-_47287928 0.53 ENST00000507680.1
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr19_+_13135790 0.52 ENST00000358552.3
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr16_-_67997947 0.51 ENST00000537830.2
SLC12A4
solute carrier family 12 (potassium/chloride transporter), member 4
chr2_+_239335449 0.50 ENST00000264607.4
ASB1
ankyrin repeat and SOCS box containing 1
chr1_+_50569575 0.50 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr10_-_14372870 0.50 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr6_+_31515337 0.49 ENST00000376148.4
ENST00000376145.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr19_-_49496557 0.49 ENST00000323798.3
ENST00000541188.1
ENST00000544287.1
ENST00000540532.1
ENST00000263276.6
GYS1
glycogen synthase 1 (muscle)
chr19_-_8567478 0.48 ENST00000255612.3
PRAM1
PML-RARA regulated adaptor molecule 1
chr16_-_425205 0.48 ENST00000448854.1
TMEM8A
transmembrane protein 8A
chr17_+_7239821 0.48 ENST00000158762.3
ENST00000570457.2
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr14_+_22236722 0.48 ENST00000390428.3
TRAV6
T cell receptor alpha variable 6
chr16_-_69418649 0.47 ENST00000566257.1
TERF2
telomeric repeat binding factor 2
chr15_+_73976545 0.47 ENST00000318443.5
ENST00000537340.2
ENST00000318424.5
CD276
CD276 molecule
chr15_+_63335899 0.47 ENST00000561266.1
TPM1
tropomyosin 1 (alpha)
chr17_-_41623075 0.47 ENST00000545089.1
ETV4
ets variant 4
chr1_+_239882842 0.46 ENST00000448020.1
CHRM3
cholinergic receptor, muscarinic 3
chr1_-_172413195 0.46 ENST00000344529.4
PIGC
phosphatidylinositol glycan anchor biosynthesis, class C
chr1_-_172413226 0.45 ENST00000367728.1
ENST00000258324.1
PIGC
phosphatidylinositol glycan anchor biosynthesis, class C
chr12_-_16759711 0.45 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr17_-_41623009 0.45 ENST00000393664.2
ETV4
ets variant 4
chr7_-_142176790 0.44 ENST00000390369.2
TRBV7-4
T cell receptor beta variable 7-4 (gene/pseudogene)
chr7_-_140482926 0.44 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr6_-_114664180 0.44 ENST00000312719.5
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr13_-_103053946 0.43 ENST00000376131.4
FGF14
fibroblast growth factor 14
chr12_+_54519842 0.43 ENST00000508564.1
RP11-834C11.4
RP11-834C11.4
chr13_+_28527647 0.43 ENST00000567234.1
LINC00543
long intergenic non-protein coding RNA 543
chr2_-_18741882 0.43 ENST00000381249.3
RDH14
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
chr2_+_27071045 0.43 ENST00000401478.1
DPYSL5
dihydropyrimidinase-like 5
chr6_+_30295036 0.42 ENST00000376659.5
ENST00000428555.1
TRIM39
tripartite motif containing 39
chr2_-_49381572 0.42 ENST00000454032.1
ENST00000304421.4
FSHR
follicle stimulating hormone receptor
chr1_+_172628154 0.41 ENST00000340030.3
ENST00000367721.2
FASLG
Fas ligand (TNF superfamily, member 6)
chr2_-_49381646 0.41 ENST00000346173.3
ENST00000406846.2
FSHR
follicle stimulating hormone receptor
chr2_+_68872954 0.41 ENST00000394342.2
PROKR1
prokineticin receptor 1
chr8_+_30244580 0.41 ENST00000523115.1
ENST00000519647.1
RBPMS
RNA binding protein with multiple splicing
chr6_+_30294612 0.41 ENST00000440271.1
ENST00000396551.3
ENST00000376656.4
ENST00000540416.1
ENST00000428728.1
ENST00000396548.1
ENST00000428404.1
TRIM39
tripartite motif containing 39
chr19_+_49496705 0.41 ENST00000595090.1
RUVBL2
RuvB-like AAA ATPase 2
chr16_+_12995614 0.40 ENST00000423335.2
SHISA9
shisa family member 9
chr20_+_43991668 0.40 ENST00000243918.5
ENST00000426004.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr10_+_25463951 0.40 ENST00000376351.3
GPR158
G protein-coupled receptor 158
chr1_+_155099927 0.40 ENST00000368407.3
EFNA1
ephrin-A1
chr14_+_35761580 0.40 ENST00000553809.1
ENST00000555764.1
ENST00000556506.1
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr5_+_135496675 0.39 ENST00000507637.1
SMAD5
SMAD family member 5
chr1_-_161277210 0.39 ENST00000491222.2
MPZ
myelin protein zero
chr8_-_134072593 0.37 ENST00000427060.2
SLA
Src-like-adaptor
chr1_+_117544366 0.37 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr15_-_64665911 0.37 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr4_+_89299994 0.37 ENST00000264346.7
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr4_+_89299885 0.37 ENST00000380265.5
ENST00000273960.3
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr16_+_56965960 0.36 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr11_+_196738 0.36 ENST00000325113.4
ENST00000342593.5
ODF3
outer dense fiber of sperm tails 3
chr1_-_95391315 0.36 ENST00000545882.1
ENST00000415017.1
CNN3
calponin 3, acidic
chr5_+_173315283 0.36 ENST00000265085.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr1_+_209929494 0.36 ENST00000367026.3
TRAF3IP3
TRAF3 interacting protein 3
chr17_+_7461849 0.36 ENST00000338784.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr17_+_79935418 0.36 ENST00000306729.7
ENST00000306739.4
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr13_-_46756351 0.35 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr9_+_15422702 0.35 ENST00000380821.3
ENST00000421710.1
SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr8_-_96281419 0.35 ENST00000286688.5
C8orf37
chromosome 8 open reading frame 37
chr11_-_66725837 0.35 ENST00000393958.2
ENST00000393960.1
ENST00000524491.1
ENST00000355677.3
PC
pyruvate carboxylase
chr18_-_35145728 0.34 ENST00000361795.5
ENST00000603232.1
CELF4
CUGBP, Elav-like family member 4
chr15_-_37392703 0.34 ENST00000382766.2
ENST00000444725.1
MEIS2
Meis homeobox 2
chr1_+_89246647 0.34 ENST00000544045.1
PKN2
protein kinase N2
chr7_+_120628731 0.33 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr3_+_50284321 0.32 ENST00000451956.1
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chrX_+_101478829 0.32 ENST00000372763.1
ENST00000372758.1
NXF2
nuclear RNA export factor 2
chr7_+_45067265 0.32 ENST00000474617.1
CCM2
cerebral cavernous malformation 2
chr2_+_136499179 0.32 ENST00000272638.9
UBXN4
UBX domain protein 4
chr22_+_42665742 0.32 ENST00000332965.3
ENST00000415205.1
ENST00000446578.1
Z83851.3
Z83851.3
chr5_+_131396222 0.32 ENST00000296870.2
IL3
interleukin 3 (colony-stimulating factor, multiple)
chr2_-_217559517 0.31 ENST00000449583.1
IGFBP5
insulin-like growth factor binding protein 5
chr16_+_85942594 0.31 ENST00000566369.1
IRF8
interferon regulatory factor 8
chr5_+_172386517 0.31 ENST00000519522.1
RPL26L1
ribosomal protein L26-like 1
chr17_+_79935464 0.31 ENST00000581647.1
ENST00000580534.1
ENST00000579684.1
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr16_-_12009735 0.31 ENST00000439887.2
ENST00000434724.2
GSPT1
G1 to S phase transition 1
chr17_+_19281034 0.31 ENST00000308406.5
ENST00000299612.7
MAPK7
mitogen-activated protein kinase 7
chr3_+_111260856 0.30 ENST00000352690.4
CD96
CD96 molecule
chr1_-_157522180 0.30 ENST00000356953.4
ENST00000368188.2
ENST00000368190.3
ENST00000368189.3
FCRL5
Fc receptor-like 5
chr8_-_52321533 0.30 ENST00000522933.1
PXDNL
peroxidasin homolog (Drosophila)-like
chr3_+_9944303 0.30 ENST00000421412.1
ENST00000295980.3
IL17RE
interleukin 17 receptor E
chr1_-_223536679 0.30 ENST00000608996.1
SUSD4
sushi domain containing 4
chr5_-_39270725 0.30 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr17_+_7462103 0.29 ENST00000396545.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr1_-_157522260 0.29 ENST00000368191.3
ENST00000361835.3
FCRL5
Fc receptor-like 5
chr22_-_19419205 0.29 ENST00000340170.4
ENST00000263208.5
HIRA
histone cell cycle regulator

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX3_BCL11A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 13.8 GO:1903971 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
2.0 10.0 GO:0045918 negative regulation of cytolysis(GO:0045918)
1.2 3.7 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
1.2 3.6 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
1.1 3.3 GO:1902080 positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.7 3.6 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.6 3.2 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.6 6.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.6 9.6 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.5 3.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.5 2.5 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.5 3.8 GO:0030578 PML body organization(GO:0030578)
0.4 1.3 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.4 1.2 GO:0043132 NAD transport(GO:0043132) regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
0.4 1.8 GO:0030538 embryonic genitalia morphogenesis(GO:0030538) embryonic hindgut morphogenesis(GO:0048619)
0.3 1.0 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.3 3.9 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.3 0.8 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.2 2.0 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 0.7 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.2 0.7 GO:0006597 spermine biosynthetic process(GO:0006597)
0.2 0.8 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.2 0.6 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.2 0.8 GO:0000103 sulfate assimilation(GO:0000103)
0.2 0.8 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.2 0.6 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.2 0.5 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.2 0.5 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.2 0.7 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.2 1.2 GO:0003383 apical constriction(GO:0003383)
0.2 1.5 GO:0048752 semicircular canal morphogenesis(GO:0048752) positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 0.5 GO:1903823 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.2 0.5 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.2 0.6 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.6 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 1.0 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 3.0 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.5 GO:0071899 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.1 0.3 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.1 0.7 GO:0032910 transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910) positive regulation of transforming growth factor beta3 production(GO:0032916)
0.1 0.3 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 0.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.3 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.1 0.3 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 0.4 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.3 GO:0060437 lung growth(GO:0060437)
0.1 0.3 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.1 0.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.2 GO:0071895 odontoblast differentiation(GO:0071895)
0.1 1.0 GO:0090050 peptidyl-lysine deacetylation(GO:0034983) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.4 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.2 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.9 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.1 0.2 GO:0002625 regulation of T cell antigen processing and presentation(GO:0002625)
0.1 0.3 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.1 0.5 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.1 0.8 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 1.4 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 0.2 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.4 GO:0014028 notochord formation(GO:0014028)
0.1 0.2 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 0.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.2 GO:2001302 lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.1 0.3 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.8 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 1.1 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.1 0.3 GO:0032571 response to vitamin K(GO:0032571)
0.1 0.5 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.7 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 0.8 GO:0006449 regulation of translational termination(GO:0006449)
0.1 0.1 GO:1900195 positive regulation of oocyte maturation(GO:1900195)
0.1 0.9 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 0.6 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.3 GO:0033121 regulation of cyclic nucleotide catabolic process(GO:0030805) regulation of cAMP catabolic process(GO:0030820) regulation of purine nucleotide catabolic process(GO:0033121) regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.1 0.2 GO:0002325 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.0 0.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.4 GO:0071104 response to interleukin-9(GO:0071104)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.0 0.2 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.5 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.8 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 0.6 GO:0001553 luteinization(GO:0001553)
0.0 0.3 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.7 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 1.0 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.1 GO:2000566 positive regulation of thymocyte migration(GO:2000412) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.7 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.7 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.0 0.9 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.4 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 1.0 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.1 GO:0070105 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.5 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.3 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
0.0 2.1 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.1 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 0.3 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.9 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.2 GO:1901908 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.1 GO:2001176 mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.3 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.2 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.0 2.8 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.6 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.3 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.1 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.0 0.7 GO:0048305 immunoglobulin secretion(GO:0048305)
0.0 0.2 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.1 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 0.4 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.3 GO:0001660 fever generation(GO:0001660)
0.0 0.3 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.1 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0 0.3 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.4 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.1 GO:1990418 response to insulin-like growth factor stimulus(GO:1990418)
0.0 1.0 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 1.4 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.3 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.1 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.0 0.6 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.4 GO:0002076 osteoblast development(GO:0002076)
0.0 0.1 GO:0002378 immunoglobulin biosynthetic process(GO:0002378) protein O-linked glycosylation via serine(GO:0018242)
0.0 0.6 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.1 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 0.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 1.1 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.4 GO:0098743 cell aggregation(GO:0098743)
0.0 0.2 GO:0036315 cellular response to sterol(GO:0036315)
0.0 0.2 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.1 GO:0010666 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0 0.3 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.0 0.0 GO:0050894 determination of affect(GO:0050894)
0.0 0.2 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.0 0.2 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.2 GO:0006071 glycerol metabolic process(GO:0006071)
0.0 0.7 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.4 GO:0002931 response to ischemia(GO:0002931)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0030575 nuclear body organization(GO:0030575)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 13.8 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.5 3.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 2.0 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.3 3.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.2 2.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 0.6 GO:0018444 translation release factor complex(GO:0018444)
0.1 0.7 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 0.5 GO:0032279 asymmetric synapse(GO:0032279)
0.1 1.7 GO:0032059 bleb(GO:0032059)
0.1 0.3 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.1 0.4 GO:1990037 Lewy body core(GO:1990037)
0.1 0.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.6 GO:0042587 glycogen granule(GO:0042587)
0.1 0.5 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.5 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.7 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.6 GO:0060091 kinocilium(GO:0060091)
0.0 0.3 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 1.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.5 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 1.0 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.4 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.4 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.4 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.0 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.5 GO:0005685 U1 snRNP(GO:0005685)
0.0 2.8 GO:0043296 apical junction complex(GO:0043296)
0.0 1.0 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 13.8 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.3 3.9 GO:0004917 interleukin-7 receptor activity(GO:0004917)
1.2 3.7 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.7 3.6 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.3 0.8 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.2 0.8 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.2 0.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 0.9 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.2 1.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.8 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 1.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 0.8 GO:0042835 BRE binding(GO:0042835)
0.1 3.0 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.7 GO:0045569 TRAIL binding(GO:0045569)
0.1 1.2 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 3.2 GO:0031489 myosin V binding(GO:0031489)
0.1 5.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.0 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.3 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.6 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.3 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.1 0.3 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.1 3.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 4.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 0.2 GO:0017057 glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.9 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.8 GO:0045545 syndecan binding(GO:0045545)
0.1 0.5 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.2 GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.1 0.4 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.1 0.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.2 GO:0047977 hepoxilin-epoxide hydrolase activity(GO:0047977)
0.1 0.2 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 0.2 GO:0046848 hydroxyapatite binding(GO:0046848)
0.1 0.5 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 2.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.2 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.1 0.4 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 2.5 GO:0005109 frizzled binding(GO:0005109)
0.1 4.3 GO:0050681 androgen receptor binding(GO:0050681)
0.1 0.4 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 0.4 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 1.0 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.5 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 2.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.5 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 8.7 GO:0070851 growth factor receptor binding(GO:0070851)
0.0 0.2 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.5 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 9.5 GO:0001047 core promoter binding(GO:0001047)
0.0 0.2 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.2 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 1.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.5 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.2 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.3 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.0 0.3 GO:0009374 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.0 0.2 GO:0052848 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 3.4 GO:0051117 ATPase binding(GO:0051117)
0.0 1.0 GO:0030506 ankyrin binding(GO:0030506)
0.0 2.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 1.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.2 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.3 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0030395 lactose binding(GO:0030395)
0.0 0.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.6 GO:0005123 death receptor binding(GO:0005123)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.6 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.2 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.0 GO:0031877 somatostatin receptor binding(GO:0031877)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.7 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 1.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 16.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 11.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 20.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 3.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 2.2 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.4 ST GAQ PATHWAY G alpha q Pathway
0.0 1.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 10.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.7 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 1.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.5 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.8 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.3 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.6 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.3 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.1 PID P73PATHWAY p73 transcription factor network
0.0 0.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 10.3 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 5.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 3.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 3.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 0.7 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 1.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 0.8 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.4 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 3.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.0 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.9 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 0.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.7 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 1.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.5 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins
0.0 0.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.2 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis