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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for SIN3A_CHD1
Z-value: 1.43
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Transcription factors associated with SIN3A_CHD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIN3A | hg19_v2_chr15_-_75744014_75744087 | -0.58 | 2.4e-03 | Click! |
| CHD1 | hg19_v2_chr5_-_98262240_98262240 | -0.05 | 8.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_58469591 Show fit | 5.94 |
ENST00000589335.1
|
ubiquitin specific peptidase 32 |
|
| chr8_-_22550815 Show fit | 4.26 |
ENST00000317216.2
|
early growth response 3 |
|
| chr7_-_27213893 Show fit | 3.50 |
ENST00000283921.4
|
homeobox A10 |
|
| chr17_-_58469687 Show fit | 2.83 |
ENST00000590133.1
|
ubiquitin specific peptidase 32 |
|
| chr2_+_203499901 Show fit | 2.57 |
ENST00000303116.6
ENST00000392238.2 |
family with sequence similarity 117, member B |
|
| chr3_+_20081515 Show fit | 2.46 |
ENST00000263754.4
|
K(lysine) acetyltransferase 2B |
|
| chr1_+_211432775 Show fit | 2.33 |
ENST00000419091.2
|
REST corepressor 3 |
|
| chr22_+_51112800 Show fit | 2.23 |
ENST00000414786.2
|
SH3 and multiple ankyrin repeat domains 3 |
|
| chr1_+_211432700 Show fit | 2.21 |
ENST00000452621.2
|
REST corepressor 3 |
|
| chr6_-_13487784 Show fit | 2.13 |
ENST00000379287.3
|
glucose-fructose oxidoreductase domain containing 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIN3A_CHD1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.1 | GO:0001967 | suckling behavior(GO:0001967) |
| 0.3 | 4.3 | GO:1902894 | negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
| 0.5 | 4.0 | GO:0045586 | regulation of gamma-delta T cell differentiation(GO:0045586) |
| 0.1 | 3.6 | GO:0060065 | uterus development(GO:0060065) |
| 0.9 | 3.5 | GO:0061290 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.9 | 3.5 | GO:0042412 | taurine biosynthetic process(GO:0042412) |
| 0.3 | 3.4 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.8 | 3.3 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.8 | 3.1 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) |
| 0.3 | 3.0 | GO:0042373 | vitamin K metabolic process(GO:0042373) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 5.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 4.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 4.0 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 3.8 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 3.6 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.1 | 3.4 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.1 | 2.8 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 2.8 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 2.8 | GO:0016363 | nuclear matrix(GO:0016363) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 3.8 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 3.8 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.1 | 3.7 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 3.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.9 | 3.5 | GO:0004782 | sulfinoalanine decarboxylase activity(GO:0004782) |
| 1.1 | 3.4 | GO:0004103 | choline kinase activity(GO:0004103) |
| 0.0 | 3.4 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.6 | 3.0 | GO:0016900 | oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057) |
| 0.4 | 2.9 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.5 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 5.8 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 5.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 4.3 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 3.9 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 3.6 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 3.5 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 3.4 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 3.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.1 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.3 | 4.1 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 3.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 3.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 3.6 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 3.0 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 3.0 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 2.6 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 2.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 2.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |