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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for SIX1_SIX3_SIX2

Z-value: 0.72

Motif logo

Transcription factors associated with SIX1_SIX3_SIX2

Gene Symbol Gene ID Gene Info
ENSG00000126778.7 SIX homeobox 1
ENSG00000138083.3 SIX homeobox 3
ENSG00000170577.7 SIX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX2hg19_v2_chr2_-_45236540_452365770.213.2e-01Click!
SIX1hg19_v2_chr14_-_61124977_611250370.203.4e-01Click!
SIX3hg19_v2_chr2_+_45168875_451689160.039.0e-01Click!

Activity profile of SIX1_SIX3_SIX2 motif

Sorted Z-values of SIX1_SIX3_SIX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_160166218 2.24 ENST00000537657.1
superoxide dismutase 2, mitochondrial
chr5_+_125758813 2.13 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr5_+_125758865 2.09 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chr21_+_27011899 1.77 ENST00000425221.2
junctional adhesion molecule 2
chr6_-_154751629 1.71 ENST00000424998.1
CNKSR family member 3
chr10_-_49860525 1.27 ENST00000435790.2
Rho GTPase activating protein 22
chr21_+_27011584 1.24 ENST00000400532.1
ENST00000480456.1
ENST00000312957.5
junctional adhesion molecule 2
chr1_-_8000872 1.06 ENST00000377507.3
tumor necrosis factor receptor superfamily, member 9
chr6_-_136847099 0.92 ENST00000438100.2
microtubule-associated protein 7
chr6_+_31554779 0.89 ENST00000376090.2
leukocyte specific transcript 1
chr19_-_56249740 0.89 ENST00000590200.1
ENST00000332836.2
NLR family, pyrin domain containing 9
chr3_-_11685345 0.86 ENST00000430365.2
vestigial like 4 (Drosophila)
chr1_+_26737253 0.82 ENST00000326279.6
lin-28 homolog A (C. elegans)
chr15_-_55562582 0.76 ENST00000396307.2
RAB27A, member RAS oncogene family
chr1_-_240906911 0.74 ENST00000431139.2
RP11-80B9.4
chr6_-_136847610 0.73 ENST00000454590.1
ENST00000432797.2
microtubule-associated protein 7
chr6_+_31554962 0.72 ENST00000376092.3
ENST00000376086.3
ENST00000303757.8
ENST00000376093.2
ENST00000376102.3
leukocyte specific transcript 1
chr1_+_12916941 0.69 ENST00000240189.2
PRAME family member 2
chr16_+_56642041 0.64 ENST00000245185.5
metallothionein 2A
chr1_+_26737292 0.61 ENST00000254231.4
lin-28 homolog A (C. elegans)
chr13_-_46679185 0.59 ENST00000439329.3
carboxypeptidase B2 (plasma)
chr11_+_34654011 0.58 ENST00000531794.1
ets homologous factor
chr13_-_46679144 0.58 ENST00000181383.4
carboxypeptidase B2 (plasma)
chr18_+_55816546 0.57 ENST00000435432.2
ENST00000357895.5
ENST00000586263.1
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr1_-_151778630 0.57 ENST00000368820.3
leucine rich repeat and Ig domain containing 4
chr12_+_49121213 0.56 ENST00000548380.1
long intergenic non-protein coding RNA 935
chr6_+_31554456 0.56 ENST00000339530.4
leukocyte specific transcript 1
chr11_-_34533257 0.55 ENST00000312319.2
E74-like factor 5 (ets domain transcription factor)
chrX_+_144908928 0.54 ENST00000408967.2
transmembrane protein 257
chrX_+_56259316 0.53 ENST00000468660.1
Kruppel-like factor 8
chr16_+_56666563 0.52 ENST00000570233.1
metallothionein 1M
chr1_+_145293371 0.51 ENST00000342960.5
neuroblastoma breakpoint family, member 10
chr2_+_161993465 0.50 ENST00000457476.1
TRAF family member-associated NFKB activator
chr11_+_64323098 0.48 ENST00000301891.4
solute carrier family 22 (organic anion/urate transporter), member 11
chr4_+_89299994 0.48 ENST00000264346.7
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr1_-_47082495 0.48 ENST00000545730.1
ENST00000531769.1
ENST00000319928.3
MAP kinase interacting serine/threonine kinase 1
MOB kinase activator 3C
chr16_+_57673207 0.47 ENST00000564783.1
ENST00000564729.1
ENST00000565976.1
ENST00000566508.1
ENST00000544297.1
G protein-coupled receptor 56
chr17_+_6659153 0.47 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XIAP associated factor 1
chr6_-_138428613 0.46 ENST00000421351.3
PERP, TP53 apoptosis effector
chr11_+_64323428 0.46 ENST00000377581.3
solute carrier family 22 (organic anion/urate transporter), member 11
chr11_+_64323156 0.46 ENST00000377585.3
solute carrier family 22 (organic anion/urate transporter), member 11
chr1_-_13115578 0.46 ENST00000414205.2
PRAME family member 6
chrX_+_101470280 0.44 ENST00000395088.2
ENST00000330252.5
ENST00000333110.5
nuclear RNA export factor 2
t-complex 11 family, X-linked 1
chr1_+_12851545 0.44 ENST00000332296.7
PRAME family member 1
chr1_-_13390765 0.43 ENST00000357367.2
PRAME family member 8
chr14_-_24615805 0.43 ENST00000560410.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr19_+_50270219 0.42 ENST00000354293.5
ENST00000359032.5
adaptor-related protein complex 2, alpha 1 subunit
chr9_-_117568365 0.42 ENST00000374045.4
tumor necrosis factor (ligand) superfamily, member 15
chr19_+_11457232 0.41 ENST00000587531.1
coiled-coil domain containing 159
chr8_-_134072593 0.41 ENST00000427060.2
Src-like-adaptor
chr20_+_34824355 0.40 ENST00000397286.3
ENST00000320849.4
ENST00000373932.3
AAR2 splicing factor homolog (S. cerevisiae)
chr11_-_32452357 0.40 ENST00000379079.2
ENST00000530998.1
Wilms tumor 1
chr12_-_89920030 0.39 ENST00000413530.1
ENST00000547474.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
POC1B-GALNT4 readthrough
chr3_+_111718036 0.39 ENST00000455401.2
transgelin 3
chr1_-_13117736 0.38 ENST00000376192.5
ENST00000376182.1
PRAME family member 6
chr3_+_111717600 0.37 ENST00000273368.4
transgelin 3
chr14_+_58711539 0.37 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
proteasome (prosome, macropain) subunit, alpha type, 3
chr17_+_7465216 0.37 ENST00000321337.7
SUMO1/sentrin/SMT3 specific peptidase 3
chr5_-_133304473 0.36 ENST00000231512.3
chromosome 5 open reading frame 15
chr8_+_18248755 0.35 ENST00000286479.3
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr8_+_18248786 0.35 ENST00000520116.1
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr19_-_58446721 0.35 ENST00000396147.1
ENST00000595569.1
ENST00000599852.1
ENST00000425570.3
ENST00000601593.1
zinc finger protein 418
chr12_-_89919965 0.35 ENST00000548729.1
POC1B-GALNT4 readthrough
chr8_-_48651648 0.35 ENST00000408965.3
CCAAT/enhancer binding protein (C/EBP), delta
chr2_+_161993412 0.33 ENST00000259075.2
ENST00000432002.1
TRAF family member-associated NFKB activator
chr7_-_75452673 0.33 ENST00000416943.1
chemokine (C-C motif) ligand 24
chr11_-_58499434 0.32 ENST00000344743.3
ENST00000278400.3
glycine-N-acyltransferase
chr9_+_12693336 0.32 ENST00000381137.2
ENST00000388918.5
tyrosinase-related protein 1
chr8_-_134115118 0.31 ENST00000395352.3
ENST00000338087.5
Src-like-adaptor
chr1_+_35225339 0.31 ENST00000339480.1
gap junction protein, beta 4, 30.3kDa
chr8_+_99129513 0.31 ENST00000522319.1
ENST00000401707.2
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
chr1_+_13359819 0.31 ENST00000376168.1
PRAME family member 5
chr6_+_31555045 0.31 ENST00000396101.3
ENST00000490742.1
leukocyte specific transcript 1
chr11_-_5364809 0.30 ENST00000300773.2
olfactory receptor, family 51, subfamily B, member 5
chr12_-_323689 0.30 ENST00000428720.1
solute carrier family 6 (neurotransmitter transporter), member 12
chr14_+_51026743 0.30 ENST00000358385.6
ENST00000357032.3
ENST00000354525.4
atlastin GTPase 1
chr22_-_43091639 0.29 ENST00000249005.2
ENST00000381278.3
alpha 1,4-galactosyltransferase
chr2_-_219134822 0.29 ENST00000444053.1
ENST00000248450.4
angio-associated, migratory cell protein
chr3_-_157251383 0.28 ENST00000487753.1
ENST00000489602.1
ENST00000461299.1
ENST00000479987.1
ventricular zone expressed PH domain-containing 1
chr4_+_70894130 0.27 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
histatin 3
chr11_+_70244510 0.27 ENST00000346329.3
ENST00000301843.8
ENST00000376561.3
cortactin
chr12_+_20848377 0.27 ENST00000540354.1
ENST00000266509.2
ENST00000381552.1
solute carrier organic anion transporter family, member 1C1
chr21_+_35736302 0.26 ENST00000290310.3
potassium voltage-gated channel, Isk-related family, member 2
chr7_-_44198874 0.26 ENST00000395796.3
ENST00000345378.2
glucokinase (hexokinase 4)
chr1_+_87595542 0.26 ENST00000461990.1
long intergenic non-protein coding RNA 1140
chr19_-_11039261 0.26 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
Yip1 domain family, member 2
chr2_-_89266286 0.26 ENST00000464162.1
immunoglobulin kappa variable 1-6
chr12_-_9913489 0.26 ENST00000228434.3
ENST00000536709.1
CD69 molecule
chrX_+_13587712 0.25 ENST00000361306.1
ENST00000380602.3
EGF-like-domain, multiple 6
chr15_+_75491213 0.25 ENST00000360639.2
chromosome 15 open reading frame 39
chr17_+_46184911 0.25 ENST00000580219.1
ENST00000452859.2
ENST00000393405.2
ENST00000439357.2
ENST00000359238.2
sorting nexin 11
chr6_+_88757507 0.25 ENST00000237201.1
sperm acrosome associated 1
chr9_-_2844058 0.24 ENST00000397885.2
KIAA0020
chr3_-_10452359 0.23 ENST00000452124.1
ATPase, Ca++ transporting, plasma membrane 2
chr19_-_55549624 0.23 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
glycoprotein VI (platelet)
chr3_+_70048881 0.23 ENST00000483525.1
RP11-460N16.1
chr7_+_117251671 0.23 ENST00000468795.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr6_-_167797887 0.23 ENST00000476779.2
ENST00000460930.2
ENST00000397829.4
ENST00000366827.2
t-complex 10
chr1_+_169337172 0.23 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
basic leucine zipper nuclear factor 1
chr3_+_42850959 0.23 ENST00000442925.1
ENST00000422265.1
ENST00000497921.1
ENST00000426937.1
atypical chemokine receptor 2
KRAB box domain containing 1
chr16_-_67867749 0.22 ENST00000566758.1
ENST00000445712.2
ENST00000219172.3
ENST00000564817.1
centromere protein T
chr1_+_145293114 0.22 ENST00000369338.1
neuroblastoma breakpoint family, member 10
chr2_-_152146385 0.22 ENST00000414946.1
ENST00000243346.5
N-myc (and STAT) interactor
chr11_-_5173599 0.22 ENST00000328942.1
olfactory receptor, family 52, subfamily A, member 1
chr6_-_11779174 0.22 ENST00000379413.2
androgen-dependent TFPI-regulating protein
chr9_+_132427883 0.22 ENST00000372469.4
paired related homeobox 2
chr17_+_32646055 0.21 ENST00000394620.1
chemokine (C-C motif) ligand 8
chr2_-_89597542 0.21 ENST00000465170.1
immunoglobulin kappa variable 1-37 (non-functional)
chr16_+_58010339 0.21 ENST00000290871.5
ENST00000441824.2
testis, prostate and placenta expressed
chr5_-_59481406 0.21 ENST00000546160.1
phosphodiesterase 4D, cAMP-specific
chr5_-_132073210 0.21 ENST00000378735.1
ENST00000378746.4
kinesin family member 3A
chr2_-_89513402 0.21 ENST00000498435.1
immunoglobulin kappa variable 1-27
chr15_-_72523454 0.20 ENST00000565154.1
ENST00000565184.1
ENST00000389093.3
ENST00000449901.2
ENST00000335181.5
ENST00000319622.6
pyruvate kinase, muscle
chr19_+_41594377 0.20 ENST00000330436.3
cytochrome P450, family 2, subfamily A, polypeptide 13
chr6_-_11779014 0.20 ENST00000229583.5
androgen-dependent TFPI-regulating protein
chr1_-_12946025 0.20 ENST00000235349.5
PRAME family member 4
chr7_-_14880892 0.20 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
diacylglycerol kinase, beta 90kDa
chr3_+_149191723 0.20 ENST00000305354.4
transmembrane 4 L six family member 4
chr1_-_220220000 0.20 ENST00000366923.3
glutamyl-prolyl-tRNA synthetase
chr15_+_89631647 0.20 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
abhydrolase domain containing 2
chr1_-_13007420 0.20 ENST00000376189.1
PRAME family member 6
chr3_+_178253993 0.20 ENST00000420517.2
ENST00000452583.1
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr12_+_57624119 0.19 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
serine hydroxymethyltransferase 2 (mitochondrial)
chr16_+_31119615 0.19 ENST00000394950.3
ENST00000287507.3
ENST00000219794.6
ENST00000561755.1
branched chain ketoacid dehydrogenase kinase
chr19_+_49109990 0.19 ENST00000321762.1
sperm acrosome associated 4
chr21_-_34185944 0.19 ENST00000479548.1
chromosome 21 open reading frame 62
chr6_+_31554612 0.19 ENST00000211921.7
leukocyte specific transcript 1
chr17_+_6915798 0.19 ENST00000402093.1
ribonuclease, RNase K
chr6_+_131894284 0.19 ENST00000368087.3
ENST00000356962.2
arginase 1
chr16_+_21695750 0.18 ENST00000388956.4
otoancorin
chr20_-_55100981 0.18 ENST00000243913.4
glucosaminyl (N-acetyl) transferase family member 7
chr11_+_55594695 0.18 ENST00000378397.1
olfactory receptor, family 5, subfamily L, member 2
chr1_+_12976450 0.18 ENST00000361079.2
PRAME family member 7
chr6_-_31509714 0.18 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr6_+_31554636 0.18 ENST00000433492.1
leukocyte specific transcript 1
chr3_+_127771212 0.18 ENST00000243253.3
ENST00000481210.1
Sec61 alpha 1 subunit (S. cerevisiae)
chr7_+_100551239 0.18 ENST00000319509.7
mucin 3A, cell surface associated
chr7_+_75511362 0.17 ENST00000428119.1
rhomboid domain containing 2
chr4_-_156297949 0.17 ENST00000515654.1
microtubule-associated protein 9
chr4_-_153332886 0.17 ENST00000603841.1
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr1_-_109618566 0.17 ENST00000338366.5
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr10_-_96122682 0.17 ENST00000371361.3
nucleolar complex associated 3 homolog (S. cerevisiae)
chr14_-_24911448 0.17 ENST00000555355.1
ENST00000553343.1
ENST00000556523.1
ENST00000556249.1
ENST00000538105.2
ENST00000555225.1
short chain dehydrogenase/reductase family 39U, member 1
chr12_+_110011571 0.17 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
mevalonate kinase
chr15_+_81426588 0.17 ENST00000286732.4
chromosome 15 open reading frame 26
chrX_-_65259914 0.16 ENST00000374737.4
ENST00000455586.2
V-set and immunoglobulin domain containing 4
chr3_+_38323785 0.16 ENST00000466887.1
ENST00000448498.1
solute carrier family 22, member 14
chr1_-_108743471 0.16 ENST00000569674.1
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr19_+_11039391 0.16 ENST00000270502.6
chromosome 19 open reading frame 52
chr19_+_2867325 0.16 ENST00000307635.2
ENST00000586426.1
zinc finger protein 556
chr18_+_616672 0.15 ENST00000338387.7
clusterin-like 1 (retinal)
chrX_-_65259900 0.15 ENST00000412866.2
V-set and immunoglobulin domain containing 4
chr10_-_103603677 0.15 ENST00000358038.3
Kv channel interacting protein 2
chr6_-_43655511 0.15 ENST00000372133.3
ENST00000372116.1
ENST00000427312.1
mitochondrial ribosomal protein S18A
chr15_+_62853562 0.15 ENST00000561311.1
talin 2
chr16_+_50059125 0.15 ENST00000427478.2
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr1_-_11115877 0.15 ENST00000490101.1
spermidine synthase
chr2_-_207630033 0.15 ENST00000449792.1
malate dehydrogenase 1B, NAD (soluble)
chr17_+_6915902 0.14 ENST00000570898.1
ENST00000552842.1
ribonuclease, RNase K
chr13_+_28712614 0.14 ENST00000380958.3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr6_+_30035307 0.14 ENST00000376765.2
ENST00000376763.1
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr19_+_16222439 0.14 ENST00000300935.3
RAB8A, member RAS oncogene family
chr10_+_7745303 0.14 ENST00000429820.1
ENST00000379587.4
inter-alpha-trypsin inhibitor heavy chain 2
chr17_+_6915730 0.14 ENST00000548577.1
ribonuclease, RNase K
chr18_+_19192228 0.14 ENST00000300413.5
ENST00000579618.1
ENST00000582475.1
small nuclear ribonucleoprotein D1 polypeptide 16kDa
chr4_+_155484155 0.14 ENST00000509493.1
fibrinogen beta chain
chr2_-_114514181 0.14 ENST00000409342.1
solute carrier family 35, member F5
chr12_-_58135903 0.14 ENST00000257897.3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr10_+_135207623 0.14 ENST00000317502.6
ENST00000432508.3
mitochondrial ribosome-associated GTPase 1
chr19_+_17420340 0.14 ENST00000359866.4
DET1 and DDB1 associated 1
chr13_-_60737898 0.13 ENST00000377908.2
ENST00000400319.1
ENST00000400320.1
ENST00000267215.4
diaphanous-related formin 3
chr17_-_3030875 0.13 ENST00000328890.2
olfactory receptor, family 1, subfamily G, member 1
chr11_-_104840093 0.13 ENST00000417440.2
ENST00000444739.2
caspase 4, apoptosis-related cysteine peptidase
chr2_+_89923550 0.13 ENST00000509129.1
immunoglobulin kappa variable 1D-37 (non-functional)
chrX_-_72095808 0.13 ENST00000373529.5
DMRT-like family C1
chr10_+_135207598 0.13 ENST00000477902.2
mitochondrial ribosome-associated GTPase 1
chr1_-_166845515 0.13 ENST00000367874.4
transcriptional adaptor 1
chr1_+_196946664 0.13 ENST00000367414.5
complement factor H-related 5
chr20_+_18488137 0.13 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
Sec23 homolog B (S. cerevisiae)
chr5_-_145562147 0.13 ENST00000545646.1
ENST00000274562.9
ENST00000510191.1
ENST00000394434.2
leucyl-tRNA synthetase
chr17_-_8151353 0.13 ENST00000315684.8
CTS telomere maintenance complex component 1
chr10_-_74856608 0.13 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
prolyl 4-hydroxylase, alpha polypeptide I
chr11_+_71791359 0.13 ENST00000419228.1
ENST00000435085.1
ENST00000307198.7
ENST00000538413.1
leucine rich transmembrane and O-methyltransferase domain containing
chr7_-_48068699 0.13 ENST00000412142.1
ENST00000395572.2
Sad1 and UNC84 domain containing 3
chr8_+_118147498 0.12 ENST00000519688.1
ENST00000456015.2
solute carrier family 30 (zinc transporter), member 8
chr2_+_183989157 0.12 ENST00000541912.1
nucleoporin 35kDa
chr17_+_39240459 0.12 ENST00000391417.4
keratin associated protein 4-7
chr17_+_7210294 0.12 ENST00000336452.7
eukaryotic translation initiation factor 5A
chr12_-_54758251 0.12 ENST00000267015.3
ENST00000551809.1
G protein-coupled receptor 84
chr12_+_26205496 0.12 ENST00000537946.1
ENST00000541218.1
ENST00000282884.9
ENST00000545413.1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr10_-_103603568 0.12 ENST00000356640.2
Kv channel interacting protein 2
chr12_+_81471816 0.12 ENST00000261206.3
acyl-CoA synthetase short-chain family member 3
chr6_+_31583761 0.12 ENST00000376049.4
allograft inflammatory factor 1
chr14_-_24740709 0.12 ENST00000399409.3
ENST00000216840.6
Rab geranylgeranyltransferase, alpha subunit
chr11_+_114168773 0.12 ENST00000542647.1
ENST00000545255.1
nicotinamide N-methyltransferase
chr7_+_123241908 0.12 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ankyrin repeat and SOCS box containing 15
chr8_-_25902876 0.11 ENST00000520164.1
early B-cell factor 2
chr2_-_105953912 0.11 ENST00000610036.1
RP11-332H14.2
chr12_+_20848486 0.11 ENST00000545102.1
solute carrier organic anion transporter family, member 1C1
chr2_-_207629997 0.11 ENST00000454776.2
malate dehydrogenase 1B, NAD (soluble)

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX1_SIX3_SIX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0001315 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.3 1.2 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.2 1.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 1.1 GO:2001183 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.1 0.4 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.8 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.6 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1 0.8 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.5 GO:1902159 regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.1 0.6 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 1.4 GO:0015747 urate transport(GO:0015747)
0.1 0.4 GO:0072299 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.1 0.5 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.1 0.2 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.1 0.2 GO:0039019 pronephric nephron development(GO:0039019)
0.1 0.2 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.3 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.1 0.2 GO:0046833 snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833)
0.0 1.7 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.3 GO:0001575 globoside metabolic process(GO:0001575)
0.0 0.3 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.0 0.2 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.0 0.3 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.3 GO:0016078 tRNA catabolic process(GO:0016078)
0.0 0.2 GO:0045354 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0 0.2 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.3 GO:0009732 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.5 GO:0002934 desmosome organization(GO:0002934)
0.0 0.2 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.1 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990)
0.0 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.4 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:0009804 coumarin metabolic process(GO:0009804)
0.0 0.1 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.0 0.3 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 3.1 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0 0.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0071400 cellular response to oleic acid(GO:0071400)
0.0 0.2 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.4 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.1 GO:0090299 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.0 0.2 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.1 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.3 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.3 GO:0006544 glycine metabolic process(GO:0006544)
0.0 0.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.1 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.3 GO:0042048 olfactory behavior(GO:0042048)
0.0 0.1 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.4 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.2 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.5 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.4 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.1 GO:0042231 interleukin-13 biosynthetic process(GO:0042231)
0.0 0.0 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0 0.1 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0 0.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.2 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.3 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.7 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.0 0.3 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.0 GO:2000397 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.1 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.2 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.5 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.0 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.3 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.4 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 0.2 GO:0005846 nuclear cap binding complex(GO:0005846)
0.1 0.8 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.2 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.3 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0097452 GAIT complex(GO:0097452)
0.0 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.4 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.3 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 1.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.3 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 0.7 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 0.8 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 1.4 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 1.4 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.4 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 0.2 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 0.2 GO:0004818 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.1 0.3 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.1 0.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.2 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.3 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.1 GO:0004766 spermidine synthase activity(GO:0004766)
0.0 0.6 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.3 GO:0004793 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0 0.2 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.0 0.6 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.4 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.0 0.2 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.1 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.4 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.3 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 0.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 1.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.4 GO:0003796 lysozyme activity(GO:0003796)
0.0 1.1 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.2 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.3 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.1 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.0 0.0 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.2 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.0 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.9 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 2.2 PID FOXO PATHWAY FoxO family signaling
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 1.1 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.5 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 3.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.2 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.4 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.6 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.8 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors