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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for SIX4

Z-value: 0.51

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
SIX4
ENSG00000100625.8 SIX homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX4hg19_v2_chr14_-_61190754_61190852-0.573.0e-03Click!

Activity profile of SIX4 motif

Sorted Z-values of SIX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_131762105 2.99 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3
chr6_-_76072719 1.51 ENST00000370020.1
FILIP1
filamin A interacting protein 1
chr16_+_640201 1.08 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr3_+_32147997 1.07 ENST00000282541.5
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr13_-_78492927 0.98 ENST00000334286.5
EDNRB
endothelin receptor type B
chr8_+_95907993 0.92 ENST00000523378.1
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr2_+_120687335 0.91 ENST00000544261.1
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr19_+_35417939 0.90 ENST00000601142.1
ENST00000426813.2
ZNF30
zinc finger protein 30
chr19_+_35417844 0.85 ENST00000601957.1
ZNF30
zinc finger protein 30
chr11_-_2906979 0.79 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr1_+_116184566 0.75 ENST00000355485.2
ENST00000369510.4
VANGL1
VANGL planar cell polarity protein 1
chr11_-_130184555 0.73 ENST00000525842.1
ZBTB44
zinc finger and BTB domain containing 44
chr2_-_113999260 0.67 ENST00000468980.2
PAX8
paired box 8
chr13_+_33160553 0.57 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr14_-_92413353 0.57 ENST00000556154.1
FBLN5
fibulin 5
chr2_+_85811525 0.53 ENST00000306384.4
VAMP5
vesicle-associated membrane protein 5
chr12_+_30948865 0.53 ENST00000547804.1
LINC00941
long intergenic non-protein coding RNA 941
chr15_-_20193370 0.52 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr11_-_130184470 0.51 ENST00000357899.4
ENST00000397753.1
ZBTB44
zinc finger and BTB domain containing 44
chr17_-_39684550 0.51 ENST00000455635.1
ENST00000361566.3
KRT19
keratin 19
chr4_+_90823130 0.45 ENST00000508372.1
MMRN1
multimerin 1
chr13_-_78492955 0.41 ENST00000446573.1
EDNRB
endothelin receptor type B
chr12_-_102874102 0.39 ENST00000392905.2
IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_-_247335269 0.37 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
ZNF124
zinc finger protein 124
chr2_+_219135115 0.35 ENST00000248451.3
ENST00000273077.4
PNKD
paroxysmal nonkinesigenic dyskinesia
chr2_-_61244308 0.35 ENST00000407787.1
ENST00000398658.2
PUS10
pseudouridylate synthase 10
chr10_+_7860460 0.34 ENST00000344293.5
TAF3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
chr10_+_89622870 0.33 ENST00000371953.3
PTEN
phosphatase and tensin homolog
chr11_+_117049445 0.33 ENST00000324225.4
ENST00000532960.1
SIDT2
SID1 transmembrane family, member 2
chr7_+_69064300 0.32 ENST00000342771.4
AUTS2
autism susceptibility candidate 2
chr1_+_117297007 0.32 ENST00000369478.3
ENST00000369477.1
CD2
CD2 molecule
chr1_+_231473743 0.31 ENST00000295050.7
SPRTN
SprT-like N-terminal domain
chr19_-_58892389 0.30 ENST00000427624.2
ENST00000597582.1
ZNF837
zinc finger protein 837
chr11_+_117947782 0.27 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
TMPRSS4
transmembrane protease, serine 4
chr11_+_117049854 0.27 ENST00000278951.7
SIDT2
SID1 transmembrane family, member 2
chr11_+_117947724 0.25 ENST00000534111.1
TMPRSS4
transmembrane protease, serine 4
chr11_+_117049910 0.25 ENST00000431081.2
ENST00000524842.1
SIDT2
SID1 transmembrane family, member 2
chr4_-_2420357 0.25 ENST00000511071.1
ENST00000509171.1
ENST00000290974.2
ZFYVE28
zinc finger, FYVE domain containing 28
chrX_-_119763835 0.24 ENST00000371313.2
ENST00000304661.5
C1GALT1C1
C1GALT1-specific chaperone 1
chr8_-_95907423 0.23 ENST00000396133.3
ENST00000308108.4
CCNE2
cyclin E2
chr22_-_39268192 0.21 ENST00000216083.6
CBX6
chromobox homolog 6
chr6_-_41040195 0.21 ENST00000463088.1
ENST00000469104.1
ENST00000486443.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr8_-_123139423 0.20 ENST00000523792.1
RP11-398G24.2
RP11-398G24.2
chr11_+_34073269 0.20 ENST00000389645.3
CAPRIN1
cell cycle associated protein 1
chr3_+_107602030 0.20 ENST00000494231.1
LINC00636
long intergenic non-protein coding RNA 636
chr12_-_10282836 0.20 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr1_-_154934200 0.19 ENST00000368457.2
PYGO2
pygopus family PHD finger 2
chr1_+_38022572 0.19 ENST00000541606.1
DNALI1
dynein, axonemal, light intermediate chain 1
chr7_-_144100786 0.19 ENST00000223140.5
NOBOX
NOBOX oogenesis homeobox
chr1_-_207119738 0.19 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr17_-_61523622 0.19 ENST00000448884.2
ENST00000582297.1
ENST00000582034.1
ENST00000578072.1
ENST00000360793.3
CYB561
cytochrome b561
chr14_-_67981870 0.18 ENST00000555994.1
TMEM229B
transmembrane protein 229B
chr19_+_13134772 0.18 ENST00000587760.1
ENST00000585575.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr7_+_69064566 0.17 ENST00000403018.2
AUTS2
autism susceptibility candidate 2
chr2_+_128458514 0.17 ENST00000310981.4
SFT2D3
SFT2 domain containing 3
chr1_+_226250379 0.16 ENST00000366815.3
ENST00000366814.3
H3F3A
H3 histone, family 3A
chr10_+_102759045 0.16 ENST00000370220.1
LZTS2
leucine zipper, putative tumor suppressor 2
chr3_+_32726620 0.16 ENST00000331889.6
ENST00000328834.5
CNOT10
CCR4-NOT transcription complex, subunit 10
chr14_+_21510385 0.15 ENST00000298690.4
RNASE7
ribonuclease, RNase A family, 7
chr12_-_10282742 0.15 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr1_+_161123536 0.15 ENST00000368003.5
UFC1
ubiquitin-fold modifier conjugating enzyme 1
chr10_+_26505594 0.15 ENST00000259271.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr20_-_52687059 0.15 ENST00000371435.2
ENST00000395961.3
BCAS1
breast carcinoma amplified sequence 1
chr11_-_64511575 0.14 ENST00000431822.1
ENST00000377486.3
ENST00000394432.3
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr9_-_95298314 0.14 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr17_+_15635561 0.13 ENST00000584301.1
ENST00000580596.1
ENST00000464963.1
ENST00000437605.2
ENST00000579428.1
TBC1D26
TBC1 domain family, member 26
chr11_+_7273181 0.13 ENST00000318881.6
SYT9
synaptotagmin IX
chr10_+_88414338 0.12 ENST00000241891.5
ENST00000443292.1
OPN4
opsin 4
chr11_-_96076334 0.12 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr4_-_84255935 0.12 ENST00000513463.1
HPSE
heparanase
chr10_+_88414298 0.11 ENST00000372071.2
OPN4
opsin 4
chr1_-_78148324 0.11 ENST00000370801.3
ENST00000433749.1
ZZZ3
zinc finger, ZZ-type containing 3
chr6_-_41040268 0.11 ENST00000373154.2
ENST00000244558.9
ENST00000464633.1
ENST00000424266.2
ENST00000479950.1
ENST00000482515.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr5_+_78365577 0.10 ENST00000518666.1
ENST00000521567.1
BHMT2
betaine--homocysteine S-methyltransferase 2
chr11_+_34073195 0.10 ENST00000341394.4
CAPRIN1
cell cycle associated protein 1
chr5_+_78365536 0.09 ENST00000255192.3
BHMT2
betaine--homocysteine S-methyltransferase 2
chr14_-_106692191 0.09 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr14_-_107083690 0.08 ENST00000455737.1
ENST00000390629.2
IGHV4-59
immunoglobulin heavy variable 4-59
chrX_+_70503037 0.08 ENST00000535149.1
NONO
non-POU domain containing, octamer-binding
chr14_-_94984181 0.07 ENST00000341228.2
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr17_-_72527605 0.07 ENST00000392621.1
ENST00000314401.3
CD300LB
CD300 molecule-like family member b
chr11_-_18956556 0.07 ENST00000302797.3
MRGPRX1
MAS-related GPR, member X1
chr11_+_46958248 0.07 ENST00000536126.1
ENST00000278460.7
ENST00000378618.2
ENST00000395460.2
ENST00000378615.3
ENST00000543718.1
C11orf49
chromosome 11 open reading frame 49
chr12_+_133758115 0.07 ENST00000541009.2
ENST00000592241.1
ZNF268
zinc finger protein 268
chr1_+_116915855 0.07 ENST00000295598.5
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr3_-_49158218 0.07 ENST00000417901.1
ENST00000306026.5
ENST00000434032.2
USP19
ubiquitin specific peptidase 19
chr9_-_136084628 0.07 ENST00000372034.3
ENST00000372032.2
OBP2B
odorant binding protein 2B
chr3_-_183967296 0.07 ENST00000455059.1
ENST00000445626.2
ALG3
ALG3, alpha-1,3- mannosyltransferase
chr19_+_19174795 0.07 ENST00000318596.7
SLC25A42
solute carrier family 25, member 42
chr10_+_26505179 0.07 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr14_-_67981916 0.06 ENST00000357461.2
TMEM229B
transmembrane protein 229B
chr12_-_10282681 0.06 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr4_+_80748619 0.06 ENST00000504263.1
PCAT4
prostate cancer associated transcript 4 (non-protein coding)
chr4_+_80748640 0.06 ENST00000514836.1
PCAT4
prostate cancer associated transcript 4 (non-protein coding)
chr11_-_35547572 0.05 ENST00000378880.2
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr16_-_15180257 0.05 ENST00000540462.1
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr20_-_43150601 0.05 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
SERINC3
serine incorporator 3
chr7_+_97361388 0.05 ENST00000350485.4
ENST00000346867.4
TAC1
tachykinin, precursor 1
chr19_-_47128294 0.05 ENST00000596260.1
ENST00000597185.1
ENST00000598865.1
ENST00000594275.1
ENST00000291294.2
PTGIR
prostaglandin I2 (prostacyclin) receptor (IP)
chr15_-_73661605 0.04 ENST00000261917.3
HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr12_+_43086018 0.04 ENST00000550177.1
RP11-25I15.3
RP11-25I15.3
chr19_-_474880 0.04 ENST00000382696.3
ENST00000315489.4
ODF3L2
outer dense fiber of sperm tails 3-like 2
chr7_+_97361218 0.04 ENST00000319273.5
TAC1
tachykinin, precursor 1
chr11_-_113644491 0.04 ENST00000200135.3
ZW10
zw10 kinetochore protein
chr2_-_169104651 0.03 ENST00000355999.4
STK39
serine threonine kinase 39
chr1_-_42801540 0.03 ENST00000372573.1
FOXJ3
forkhead box J3
chr1_-_42800860 0.03 ENST00000445886.1
ENST00000361346.1
ENST00000361776.1
FOXJ3
forkhead box J3
chr1_-_151778630 0.03 ENST00000368820.3
LINGO4
leucine rich repeat and Ig domain containing 4
chr6_+_1080164 0.03 ENST00000314040.1
AL033381.1
Uncharacterized protein; cDNA FLJ34594 fis, clone KIDNE2009109
chr1_-_42800614 0.03 ENST00000372572.1
FOXJ3
forkhead box J3
chr7_-_99063769 0.03 ENST00000394186.3
ENST00000359832.4
ENST00000449683.1
ENST00000488775.1
ENST00000523680.1
ENST00000292475.3
ENST00000430982.1
ENST00000555673.1
ENST00000413834.1
ATP5J2
PTCD1
ATP5J2-PTCD1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
pentatricopeptide repeat domain 1
ATP5J2-PTCD1 readthrough
chr1_+_35734562 0.02 ENST00000314607.6
ENST00000373297.2
ZMYM4
zinc finger, MYM-type 4
chr6_-_31704282 0.02 ENST00000375784.3
ENST00000375779.2
CLIC1
chloride intracellular channel 1
chr7_+_2687173 0.02 ENST00000403167.1
TTYH3
tweety family member 3
chr1_+_156611960 0.01 ENST00000361588.5
BCAN
brevican
chr4_-_170897045 0.00 ENST00000508313.1
RP11-205M3.3
RP11-205M3.3
chr11_-_5364809 0.00 ENST00000300773.2
OR51B5
olfactory receptor, family 51, subfamily B, member 5

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0086100 posterior midgut development(GO:0007497) endothelin receptor signaling pathway(GO:0086100)
0.3 1.1 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.2 0.7 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.2 0.5 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.4 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.8 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.1 0.3 GO:1903984 negative regulation of ribosome biogenesis(GO:0090071) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 0.4 GO:0001834 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 0.9 GO:0033227 dsRNA transport(GO:0033227)
0.1 0.2 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 0.6 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.3 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.0 0.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 0.3 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.2 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.1 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.0 0.6 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.1 GO:0015880 coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.0 0.1 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.4 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0051673 membrane disruption in other organism(GO:0051673)
0.0 0.2 GO:0071267 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.0 0.0 GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.8 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.5 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.0 0.0 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.5 GO:1990357 terminal web(GO:1990357)
0.1 0.6 GO:0071953 elastic fiber(GO:0071953)
0.1 0.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 0.4 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.0 GO:0098855 HCN channel complex(GO:0098855)
0.0 0.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.0 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.2 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 0.9 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.4 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.7 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.1 0.3 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 0.2 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.1 0.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.2 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.2 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 0.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.0 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.1 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 1.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 1.1 GO:0019003 GDP binding(GO:0019003)
0.0 0.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.2 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.0 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.5 GO:0005484 SNAP receptor activity(GO:0005484)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 1.1 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME OPSINS Genes involved in Opsins