Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for SIX5_SMARCC2_HCFC1
Z-value: 2.49
Motif logo
Transcription factors associated with SIX5_SMARCC2_HCFC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000177045.6 | SIX homeobox 5 | |
| ENSG00000139613.7 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 | |
| ENSG00000172534.9 | host cell factor C1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMARCC2 | hg19_v2_chr12_-_56583332_56583369 | 0.52 | 7.1e-03 | Click! |
| HCFC1 | hg19_v2_chrX_-_153236819_153236978, hg19_v2_chrX_-_153236620_153236684, hg19_v2_chrX_-_153237258_153237295 | -0.25 | 2.4e-01 | Click! |
| SIX5 | hg19_v2_chr19_-_46272462_46272562 | -0.14 | 5.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX5_SMARCC2_HCFC1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.3 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
| 0.6 | 17.8 | GO:0043101 | purine-containing compound salvage(GO:0043101) |
| 0.6 | 13.8 | GO:0016180 | snRNA processing(GO:0016180) |
| 3.0 | 11.9 | GO:0033499 | galactose catabolic process via UDP-galactose(GO:0033499) |
| 1.7 | 8.6 | GO:0051697 | protein delipidation(GO:0051697) |
| 1.6 | 7.8 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 2.6 | 7.7 | GO:1902846 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 0.6 | 7.4 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.2 | 7.3 | GO:0021522 | spinal cord motor neuron differentiation(GO:0021522) |
| 0.3 | 6.7 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.7 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 3.0 | 17.8 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 1.1 | 14.6 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 11.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 9.8 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.2 | 7.8 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 7.8 | GO:1990204 | oxidoreductase complex(GO:1990204) |
| 2.6 | 7.7 | GO:0055028 | cortical microtubule(GO:0055028) |
| 0.9 | 7.1 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.2 | 6.9 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 86.3 | GO:0003677 | DNA binding(GO:0003677) |
| 3.0 | 17.8 | GO:0016657 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.1 | 13.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.6 | 11.9 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.0 | 10.5 | GO:0008234 | cysteine-type peptidase activity(GO:0008234) |
| 0.6 | 9.3 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.2 | 9.2 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.6 | 6.5 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.5 | 6.5 | GO:0003720 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.3 | 6.5 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 10.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 9.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 5.2 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 4.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.7 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 2.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 2.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 2.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 2.0 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.7 | 17.8 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.4 | 7.7 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 7.3 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 6.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 6.0 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 5.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 5.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 4.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 4.5 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |