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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for SMAD1
Z-value: 1.47
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Transcription factors associated with SMAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD1 | hg19_v2_chr4_+_146402925_146402957, hg19_v2_chr4_+_146403912_146403972 | 0.17 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_29527702 Show fit | 7.08 |
ENST00000377050.4
|
ubiquitin D |
|
| chr19_+_4229495 Show fit | 6.26 |
ENST00000221847.5
|
Epstein-Barr virus induced 3 |
|
| chr6_-_31550192 Show fit | 5.44 |
ENST00000429299.2
ENST00000446745.2 |
lymphotoxin beta (TNF superfamily, member 3) |
|
| chr7_+_55177416 Show fit | 4.97 |
ENST00000450046.1
ENST00000454757.2 |
epidermal growth factor receptor |
|
| chr15_+_89182156 Show fit | 4.91 |
ENST00000379224.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr15_+_89181974 Show fit | 4.86 |
ENST00000306072.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr15_+_89182178 Show fit | 4.38 |
ENST00000559876.1
|
interferon stimulated exonuclease gene 20kDa |
|
| chr5_-_179780312 Show fit | 4.12 |
ENST00000253778.8
|
glutamine-fructose-6-phosphate transaminase 2 |
|
| chr17_+_41158742 Show fit | 4.12 |
ENST00000415816.2
ENST00000438323.2 |
interferon-induced protein 35 |
|
| chr3_+_53195136 Show fit | 3.56 |
ENST00000394729.2
ENST00000330452.3 |
protein kinase C, delta |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 14.2 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.1 | 12.5 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 1.4 | 7.0 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 1.4 | 7.0 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.1 | 7.0 | GO:0034340 | response to type I interferon(GO:0034340) |
| 0.1 | 6.7 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 1.3 | 6.6 | GO:0003069 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.8 | 6.6 | GO:0030578 | PML body organization(GO:0030578) |
| 0.5 | 6.6 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.8 | 6.5 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.0 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 8.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 7.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.9 | 7.0 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.1 | 6.7 | GO:0016235 | aggresome(GO:0016235) |
| 0.6 | 6.5 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 1.9 | 5.6 | GO:0097489 | multivesicular body, internal vesicle lumen(GO:0097489) |
| 0.0 | 5.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 5.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.7 | 4.6 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 14.2 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.9 | 9.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 8.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.3 | 8.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 7.8 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 7.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.4 | 7.0 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.2 | 6.9 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 6.8 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.3 | 6.6 | GO:0070628 | proteasome binding(GO:0070628) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 9.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 7.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 7.5 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 6.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.1 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.1 | 4.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 4.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 14.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 9.1 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.0 | 8.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 8.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 7.6 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.7 | 7.4 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 6.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 6.1 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.1 | 5.8 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |