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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for SMAD2

Z-value: 0.67

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Transcription factors associated with SMAD2

Gene Symbol Gene ID Gene Info
SMAD2
ENSG00000175387.11 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD2hg19_v2_chr18_-_45456930_45456970-0.471.7e-02Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_71238313 5.48 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr12_+_53443963 3.35 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr1_+_100111479 1.83 ENST00000263174.4
PALMD
palmdelphin
chr12_+_53443680 1.73 ENST00000314250.6
ENST00000451358.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr1_+_100111580 1.55 ENST00000605497.1
PALMD
palmdelphin
chr8_+_95907993 1.43 ENST00000523378.1
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr1_-_211752073 1.38 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr12_-_47473642 1.37 ENST00000266581.4
AMIGO2
adhesion molecule with Ig-like domain 2
chr12_-_47473425 1.36 ENST00000550413.1
AMIGO2
adhesion molecule with Ig-like domain 2
chr11_+_7597639 1.31 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr22_+_24891210 1.29 ENST00000382760.2
UPB1
ureidopropionase, beta
chr12_-_47473557 1.26 ENST00000321382.3
AMIGO2
adhesion molecule with Ig-like domain 2
chr19_+_10527449 1.05 ENST00000592685.1
ENST00000380702.2
PDE4A
phosphodiesterase 4A, cAMP-specific
chr13_-_80915059 0.98 ENST00000377104.3
SPRY2
sprouty homolog 2 (Drosophila)
chr11_-_33913708 0.97 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr20_+_34680620 0.97 ENST00000430276.1
ENST00000373950.2
ENST00000452261.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr1_+_33722080 0.95 ENST00000483388.1
ENST00000539719.1
ZNF362
zinc finger protein 362
chr1_-_59249732 0.84 ENST00000371222.2
JUN
jun proto-oncogene
chr17_-_58469591 0.79 ENST00000589335.1
USP32
ubiquitin specific peptidase 32
chr1_+_185703513 0.76 ENST00000271588.4
ENST00000367492.2
HMCN1
hemicentin 1
chr16_-_70719925 0.75 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr8_-_125384927 0.73 ENST00000297632.6
TMEM65
transmembrane protein 65
chr2_-_74667612 0.70 ENST00000305557.5
ENST00000233330.6
RTKN
rhotekin
chr22_+_31518938 0.67 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J
inositol polyphosphate-5-phosphatase J
chr20_+_30598231 0.66 ENST00000300415.8
ENST00000262659.8
CCM2L
cerebral cavernous malformation 2-like
chr21_+_45993606 0.66 ENST00000400374.3
KRTAP10-4
keratin associated protein 10-4
chr17_+_68165657 0.66 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr11_+_64808675 0.66 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr1_-_44497118 0.65 ENST00000537678.1
ENST00000466926.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr21_+_46117087 0.62 ENST00000400365.3
KRTAP10-12
keratin associated protein 10-12
chr9_+_125281420 0.53 ENST00000340750.1
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chr16_+_53164833 0.53 ENST00000564845.1
CHD9
chromodomain helicase DNA binding protein 9
chr3_+_194406603 0.52 ENST00000329759.4
FAM43A
family with sequence similarity 43, member A
chr6_+_32132360 0.51 ENST00000333845.6
ENST00000395512.1
ENST00000432129.1
EGFL8
EGF-like-domain, multiple 8
chr19_+_49128209 0.50 ENST00000599748.1
ENST00000443164.1
ENST00000599029.1
SPHK2
sphingosine kinase 2
chr5_+_175298573 0.49 ENST00000512824.1
CPLX2
complexin 2
chr2_+_113033164 0.49 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chrX_-_107018969 0.47 ENST00000372383.4
TSC22D3
TSC22 domain family, member 3
chr16_+_57702210 0.45 ENST00000450388.3
GPR97
G protein-coupled receptor 97
chr1_+_93913665 0.43 ENST00000271234.7
ENST00000370256.4
ENST00000260506.8
FNBP1L
formin binding protein 1-like
chr6_-_143771799 0.43 ENST00000237283.8
ADAT2
adenosine deaminase, tRNA-specific 2
chr3_+_52529346 0.42 ENST00000321725.6
STAB1
stabilin 1
chr4_+_102268904 0.40 ENST00000527564.1
ENST00000529296.1
AP001816.1
Uncharacterized protein
chr7_+_99905325 0.40 ENST00000332397.6
ENST00000437326.2
SPDYE3
speedy/RINGO cell cycle regulator family member E3
chr1_+_44412577 0.39 ENST00000372343.3
IPO13
importin 13
chr12_+_93965451 0.39 ENST00000548537.1
SOCS2
suppressor of cytokine signaling 2
chr20_+_57226841 0.39 ENST00000358029.4
ENST00000361830.3
STX16
syntaxin 16
chr4_-_114682597 0.36 ENST00000394524.3
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr12_+_104982622 0.36 ENST00000549016.1
CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr16_+_58549378 0.36 ENST00000310682.2
ENST00000394266.4
ENST00000219315.4
SETD6
SET domain containing 6
chr16_-_17564738 0.35 ENST00000261381.6
XYLT1
xylosyltransferase I
chr3_-_88108192 0.35 ENST00000309534.6
CGGBP1
CGG triplet repeat binding protein 1
chr7_+_69064566 0.35 ENST00000403018.2
AUTS2
autism susceptibility candidate 2
chr16_+_58549412 0.35 ENST00000447443.1
SETD6
SET domain containing 6
chr19_-_46105411 0.33 ENST00000323040.4
ENST00000544371.1
GPR4
OPA3
G protein-coupled receptor 4
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr17_-_74533963 0.33 ENST00000293230.5
CYGB
cytoglobin
chr20_-_23066953 0.33 ENST00000246006.4
CD93
CD93 molecule
chr22_-_38851205 0.33 ENST00000303592.3
KCNJ4
potassium inwardly-rectifying channel, subfamily J, member 4
chr19_-_55580838 0.32 ENST00000396247.3
ENST00000586945.1
ENST00000587026.1
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr11_-_75380165 0.32 ENST00000304771.3
MAP6
microtubule-associated protein 6
chr7_+_39125365 0.31 ENST00000559001.1
ENST00000464276.2
POU6F2
POU class 6 homeobox 2
chr8_-_142377367 0.31 ENST00000377741.3
GPR20
G protein-coupled receptor 20
chr3_+_197518100 0.31 ENST00000438796.2
ENST00000414675.2
ENST00000441090.2
ENST00000334859.4
ENST00000425562.2
LRCH3
leucine-rich repeats and calponin homology (CH) domain containing 3
chr22_+_23213658 0.31 ENST00000390318.2
IGLV4-3
immunoglobulin lambda variable 4-3
chr12_-_57410304 0.31 ENST00000441881.1
ENST00000458521.2
TAC3
tachykinin 3
chr19_-_49522727 0.31 ENST00000600007.1
CTB-60B18.10
CTB-60B18.10
chr7_-_105517021 0.30 ENST00000318724.4
ENST00000419735.3
ATXN7L1
ataxin 7-like 1
chr3_+_123813509 0.30 ENST00000460856.1
ENST00000240874.3
KALRN
kalirin, RhoGEF kinase
chr1_-_44482979 0.30 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr17_-_10017864 0.29 ENST00000323816.4
GAS7
growth arrest-specific 7
chr3_-_195163803 0.28 ENST00000326793.6
ACAP2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr2_+_113735575 0.27 ENST00000376489.2
ENST00000259205.4
IL36G
interleukin 36, gamma
chr4_-_39640513 0.27 ENST00000511809.1
ENST00000505729.1
SMIM14
small integral membrane protein 14
chrX_-_107019181 0.26 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family, member 3
chr2_-_72375167 0.26 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chrX_+_153029633 0.25 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
PLXNB3
plexin B3
chr12_-_56583243 0.25 ENST00000550164.1
SMARCC2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr1_+_28052456 0.24 ENST00000373954.6
ENST00000419687.2
FAM76A
family with sequence similarity 76, member A
chr6_+_143772060 0.24 ENST00000367591.4
PEX3
peroxisomal biogenesis factor 3
chr3_+_123813543 0.24 ENST00000360013.3
KALRN
kalirin, RhoGEF kinase
chr1_-_234614849 0.24 ENST00000040877.1
TARBP1
TAR (HIV-1) RNA binding protein 1
chr12_+_122516626 0.24 ENST00000319080.7
MLXIP
MLX interacting protein
chr7_-_130080977 0.24 ENST00000223208.5
CEP41
centrosomal protein 41kDa
chr5_+_139493665 0.24 ENST00000331327.3
PURA
purine-rich element binding protein A
chrX_-_154688276 0.23 ENST00000369445.2
F8A3
coagulation factor VIII-associated 3
chr16_-_3355645 0.23 ENST00000396862.1
ENST00000573608.1
TIGD7
tigger transposable element derived 7
chr1_-_94586651 0.22 ENST00000535735.1
ENST00000370225.3
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr11_-_119211525 0.22 ENST00000528368.1
C1QTNF5
C1q and tumor necrosis factor related protein 5
chr6_+_6588316 0.21 ENST00000379953.2
LY86
lymphocyte antigen 86
chr14_+_36295504 0.21 ENST00000216807.7
BRMS1L
breast cancer metastasis-suppressor 1-like
chr4_-_84030996 0.21 ENST00000411416.2
PLAC8
placenta-specific 8
chr17_-_46623441 0.21 ENST00000330070.4
HOXB2
homeobox B2
chr12_-_6798523 0.20 ENST00000319770.3
ZNF384
zinc finger protein 384
chr17_-_40761375 0.20 ENST00000543197.1
ENST00000309428.5
FAM134C
family with sequence similarity 134, member C
chr12_-_6798410 0.20 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
ZNF384
zinc finger protein 384
chr17_+_7792101 0.19 ENST00000358181.4
ENST00000330494.7
CHD3
chromodomain helicase DNA binding protein 3
chr1_+_36772691 0.19 ENST00000312808.4
ENST00000505871.1
SH3D21
SH3 domain containing 21
chr6_+_6588902 0.19 ENST00000230568.4
LY86
lymphocyte antigen 86
chr7_-_102257139 0.19 ENST00000521076.1
ENST00000462172.1
ENST00000522801.1
ENST00000449970.2
ENST00000262940.7
RASA4
RAS p21 protein activator 4
chr4_-_39640700 0.19 ENST00000295958.5
SMIM14
small integral membrane protein 14
chr6_+_34482630 0.19 ENST00000538621.1
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr12_+_7037461 0.19 ENST00000396684.2
ATN1
atrophin 1
chr19_+_50094866 0.18 ENST00000418929.2
PRR12
proline rich 12
chr1_+_36771946 0.18 ENST00000373139.2
ENST00000453908.2
ENST00000426732.2
SH3D21
SH3 domain containing 21
chr8_-_20161466 0.18 ENST00000381569.1
LZTS1
leucine zipper, putative tumor suppressor 1
chr20_+_44098385 0.18 ENST00000217425.5
ENST00000339946.3
WFDC2
WAP four-disulfide core domain 2
chr17_-_58469687 0.17 ENST00000590133.1
USP32
ubiquitin specific peptidase 32
chr12_-_6798616 0.17 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
ZNF384
zinc finger protein 384
chr19_-_42636543 0.17 ENST00000528894.4
ENST00000560804.2
ENST00000560558.1
ENST00000560398.1
ENST00000526816.2
POU2F2
POU class 2 homeobox 2
chrX_-_100183894 0.17 ENST00000328526.5
ENST00000372956.2
XKRX
XK, Kell blood group complex subunit-related, X-linked
chr10_-_75193308 0.16 ENST00000299432.2
MSS51
MSS51 mitochondrial translational activator
chr9_+_71944241 0.16 ENST00000257515.8
FAM189A2
family with sequence similarity 189, member A2
chr1_+_159141397 0.16 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr19_+_11466062 0.16 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr7_-_155601766 0.15 ENST00000430104.1
SHH
sonic hedgehog
chr12_+_110338323 0.15 ENST00000312777.5
ENST00000536408.2
TCHP
trichoplein, keratin filament binding
chr14_-_106494587 0.15 ENST00000390597.2
IGHV2-5
immunoglobulin heavy variable 2-5
chr14_+_36295638 0.15 ENST00000543183.1
BRMS1L
breast cancer metastasis-suppressor 1-like
chr6_+_147525541 0.14 ENST00000367481.3
ENST00000546097.1
STXBP5
syntaxin binding protein 5 (tomosyn)
chr12_-_71003568 0.14 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
PTPRB
protein tyrosine phosphatase, receptor type, B
chr11_+_2923423 0.14 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr16_+_28889703 0.14 ENST00000357084.3
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr5_+_64064748 0.13 ENST00000381070.3
ENST00000508024.1
CWC27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr14_+_31343747 0.13 ENST00000216361.4
ENST00000396618.3
ENST00000475087.1
COCH
cochlin
chr20_-_36889127 0.13 ENST00000279024.4
KIAA1755
KIAA1755
chr4_-_99851766 0.13 ENST00000450253.2
EIF4E
eukaryotic translation initiation factor 4E
chr19_+_16999654 0.12 ENST00000248076.3
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr1_-_9189229 0.12 ENST00000377411.4
GPR157
G protein-coupled receptor 157
chr9_+_140145713 0.12 ENST00000388931.3
ENST00000412566.1
C9orf173
chromosome 9 open reading frame 173
chr17_-_46178741 0.11 ENST00000581003.1
ENST00000225603.4
CBX1
chromobox homolog 1
chr16_+_58059470 0.11 ENST00000219271.3
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr3_+_195447738 0.11 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
MUC20
mucin 20, cell surface associated
chr16_+_57702099 0.11 ENST00000333493.4
ENST00000327655.6
GPR97
G protein-coupled receptor 97
chrY_+_16634483 0.11 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chr19_+_49977818 0.11 ENST00000594009.1
ENST00000595510.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr20_+_1875942 0.11 ENST00000358771.4
SIRPA
signal-regulatory protein alpha
chr11_-_5462744 0.11 ENST00000380211.1
OR51I1
olfactory receptor, family 51, subfamily I, member 1
chr7_-_10979750 0.11 ENST00000339600.5
NDUFA4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
chrX_-_30595959 0.11 ENST00000378962.3
CXorf21
chromosome X open reading frame 21
chr12_-_104531785 0.11 ENST00000551727.1
NFYB
nuclear transcription factor Y, beta
chr8_-_102217796 0.10 ENST00000519744.1
ENST00000311212.4
ENST00000521272.1
ENST00000519882.1
ZNF706
zinc finger protein 706
chr5_-_43412418 0.10 ENST00000537013.1
ENST00000361115.4
CCL28
chemokine (C-C motif) ligand 28
chr19_-_51587502 0.10 ENST00000156499.2
ENST00000391802.1
KLK14
kallikrein-related peptidase 14
chr19_-_6481776 0.10 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C
DENN/MADD domain containing 1C
chr16_+_28889801 0.10 ENST00000395503.4
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr19_+_11466167 0.10 ENST00000591608.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr3_+_23847394 0.10 ENST00000306627.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr13_+_25670268 0.09 ENST00000281589.3
PABPC3
poly(A) binding protein, cytoplasmic 3
chr20_-_56284816 0.09 ENST00000395819.3
ENST00000341744.3
PMEPA1
prostate transmembrane protein, androgen induced 1
chr16_-_4987065 0.09 ENST00000590782.2
ENST00000345988.2
PPL
periplakin
chr9_-_137809718 0.09 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr11_+_74204395 0.09 ENST00000526036.1
AP001372.2
AP001372.2
chr8_-_145641864 0.09 ENST00000276833.5
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr3_-_51937331 0.09 ENST00000310914.5
IQCF1
IQ motif containing F1
chr22_+_29876197 0.08 ENST00000310624.6
NEFH
neurofilament, heavy polypeptide
chr9_+_103790991 0.08 ENST00000374874.3
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr4_-_164534657 0.08 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr17_-_7297833 0.08 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr20_-_33413416 0.07 ENST00000359003.2
NCOA6
nuclear receptor coactivator 6
chr1_-_151119087 0.07 ENST00000341697.3
ENST00000368914.3
SEMA6C
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
chr10_+_105314881 0.07 ENST00000437579.1
NEURL
neuralized E3 ubiquitin protein ligase 1
chr2_+_74881398 0.07 ENST00000339773.5
ENST00000434486.1
SEMA4F
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
chr9_+_125137565 0.07 ENST00000373698.5
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_-_235813290 0.07 ENST00000391854.2
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr18_-_24237339 0.07 ENST00000580191.1
KCTD1
potassium channel tetramerization domain containing 1
chr19_-_44285401 0.07 ENST00000262888.3
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr11_+_117857063 0.07 ENST00000227752.3
ENST00000541785.1
ENST00000545409.1
IL10RA
interleukin 10 receptor, alpha
chr14_+_62162258 0.07 ENST00000337138.4
ENST00000394997.1
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr19_+_13106383 0.07 ENST00000397661.2
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr12_+_129178451 0.06 ENST00000537538.1
TMEM132C
transmembrane protein 132C
chr4_+_93225550 0.06 ENST00000282020.4
GRID2
glutamate receptor, ionotropic, delta 2
chr17_-_7297519 0.06 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr6_+_31730773 0.06 ENST00000415669.2
ENST00000425424.1
SAPCD1
suppressor APC domain containing 1
chr10_+_105315102 0.06 ENST00000369777.2
NEURL
neuralized E3 ubiquitin protein ligase 1
chr3_+_150321068 0.06 ENST00000471696.1
ENST00000477889.1
ENST00000485923.1
SELT
Selenoprotein T
chr9_+_133569108 0.06 ENST00000372358.5
ENST00000546165.1
ENST00000372352.3
ENST00000372351.3
ENST00000372350.3
ENST00000495699.2
EXOSC2
exosome component 2
chr2_-_228028829 0.06 ENST00000396625.3
ENST00000329662.7
COL4A4
collagen, type IV, alpha 4
chr1_-_1243252 0.06 ENST00000353662.3
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr6_+_41010293 0.06 ENST00000373161.1
ENST00000373158.2
ENST00000470917.1
TSPO2
translocator protein 2
chr17_+_40761660 0.06 ENST00000251413.3
ENST00000591509.1
TUBG1
tubulin, gamma 1
chr22_+_48027423 0.06 ENST00000423737.1
RP11-191L9.4
RP11-191L9.4
chr10_-_102046417 0.06 ENST00000370372.2
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr1_-_155270770 0.06 ENST00000392414.3
PKLR
pyruvate kinase, liver and RBC
chr1_+_15783222 0.05 ENST00000359621.4
CELA2A
chymotrypsin-like elastase family, member 2A
chr18_+_3448455 0.05 ENST00000549780.1
TGIF1
TGFB-induced factor homeobox 1
chr12_-_22094159 0.05 ENST00000538350.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr6_-_27841289 0.05 ENST00000355981.2
HIST1H4L
histone cluster 1, H4l
chr1_-_160040038 0.05 ENST00000368089.3
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr19_-_54824344 0.05 ENST00000346508.3
ENST00000446712.3
ENST00000432233.3
ENST00000301219.3
LILRA5
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
chr9_+_125273081 0.05 ENST00000335302.5
OR1J2
olfactory receptor, family 1, subfamily J, member 2
chr17_-_58469474 0.04 ENST00000300896.4
USP32
ubiquitin specific peptidase 32
chr7_-_105516923 0.04 ENST00000478915.1
ATXN7L1
ataxin 7-like 1
chr19_-_14224969 0.04 ENST00000589994.1
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr19_-_14606900 0.04 ENST00000393029.3
ENST00000393028.1
ENST00000393033.4
ENST00000345425.2
ENST00000586027.1
ENST00000591349.1
ENST00000587210.1
GIPC1
GIPC PDZ domain containing family, member 1
chr10_-_102046098 0.04 ENST00000441611.1
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr19_+_56186606 0.04 ENST00000085079.7
EPN1
epsin 1
chr13_+_114238997 0.04 ENST00000538138.1
ENST00000375370.5
TFDP1
transcription factor Dp-1
chr19_+_51645556 0.04 ENST00000601682.1
ENST00000317643.6
ENST00000305628.7
ENST00000600577.1
SIGLEC7
sialic acid binding Ig-like lectin 7
chr19_-_46272462 0.04 ENST00000317578.6
SIX5
SIX homeobox 5
chr5_-_134375386 0.04 ENST00000511256.1
CTC-276P9.1
CTC-276P9.1

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.3 1.0 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.2 0.9 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.2 0.7 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 0.8 GO:0035026 leading edge cell differentiation(GO:0035026)
0.2 1.4 GO:0097501 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.2 1.0 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.2 0.5 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.1 0.7 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.1 0.3 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.3 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.1 0.3 GO:1902811 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.1 0.7 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.3 GO:0009644 response to high light intensity(GO:0009644)
0.1 0.5 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.1 0.2 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 4.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 0.3 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.1 0.2 GO:0060458 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738) negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0 0.4 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.2 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 1.0 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0 0.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.0 0.3 GO:0072144 glomerular mesangial cell development(GO:0072144)
0.0 0.5 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 6.7 GO:0031424 keratinization(GO:0031424)
0.0 0.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.0 1.0 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.0 0.5 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.7 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.4 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.1 GO:0045110 neurofilament bundle assembly(GO:0033693) intermediate filament bundle assembly(GO:0045110) peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.4 GO:0002097 tRNA wobble base modification(GO:0002097)
0.0 0.4 GO:1901725 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) regulation of histone deacetylase activity(GO:1901725) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 0.2 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.0 0.4 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.0 0.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.4 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.1 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 1.4 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.1 GO:0046618 drug export(GO:0046618)
0.0 0.2 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 3.5 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.0 GO:0014859 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0 0.1 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.2 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.3 GO:0045332 phospholipid translocation(GO:0045332)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0035976 AP1 complex(GO:0035976)
0.1 6.6 GO:0045095 keratin filament(GO:0045095)
0.1 0.5 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 1.9 GO:0030315 T-tubule(GO:0030315)
0.0 0.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 3.7 GO:0043197 dendritic spine(GO:0043197)
0.0 0.1 GO:0001940 male pronucleus(GO:0001940)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.7 GO:0014704 intercalated disc(GO:0014704)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 1.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.2 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.4 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.1 0.3 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 1.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.3 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.1 0.5 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.7 GO:0043426 MRF binding(GO:0043426)
0.1 0.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.1 0.2 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.7 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 1.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.2 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.8 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 0.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 1.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.1 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 1.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.2 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.4 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.7 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 1.3 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.5 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.0 PID FGF PATHWAY FGF signaling pathway
0.0 0.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.0 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.7 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.3 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis