Project

Inflammatory response time course, HUVEC (Wada et al., 2009)

Navigation
Downloads

Results for SMAD3

Z-value: 0.72

Motif logo

logo of

Transcription factors associated with SMAD3

Gene Symbol Gene ID Gene Info
SMAD3
ENSG00000166949.11 SMAD family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD3hg19_v2_chr15_+_67420441_67420606-0.442.9e-02Click!

Activity profile of SMAD3 motif

Sorted Z-values of SMAD3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_186696425 3.17 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr20_-_23030296 2.24 ENST00000377103.2
THBD
thrombomodulin
chrX_-_62571220 2.11 ENST00000374884.2
SPIN4
spindlin family, member 4
chrX_-_62571187 2.05 ENST00000335144.3
SPIN4
spindlin family, member 4
chr3_+_12838161 1.21 ENST00000456430.2
CAND2
cullin-associated and neddylation-dissociated 2 (putative)
chr18_+_77623668 0.98 ENST00000316249.3
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr4_-_90759440 0.92 ENST00000336904.3
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr11_+_33563821 0.84 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L
KIAA1549-like
chr7_-_120497178 0.75 ENST00000441017.1
ENST00000424710.1
ENST00000433758.1
TSPAN12
tetraspanin 12
chr6_-_52441713 0.73 ENST00000182527.3
TRAM2
translocation associated membrane protein 2
chr4_+_55524085 0.73 ENST00000412167.2
ENST00000288135.5
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr12_-_9913489 0.67 ENST00000228434.3
ENST00000536709.1
CD69
CD69 molecule
chr6_-_133119668 0.66 ENST00000275227.4
ENST00000538764.1
SLC18B1
solute carrier family 18, subfamily B, member 1
chr10_-_90712520 0.64 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr14_+_91581011 0.61 ENST00000523894.1
ENST00000522322.1
ENST00000523771.1
C14orf159
chromosome 14 open reading frame 159
chr14_+_91580777 0.61 ENST00000525393.2
ENST00000428926.2
ENST00000517362.1
C14orf159
chromosome 14 open reading frame 159
chr12_+_96588143 0.59 ENST00000228741.3
ENST00000547249.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr17_+_30813576 0.57 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr14_+_91580708 0.55 ENST00000518868.1
C14orf159
chromosome 14 open reading frame 159
chr7_-_19813192 0.55 ENST00000422233.1
ENST00000433641.1
TMEM196
transmembrane protein 196
chr21_-_40032581 0.54 ENST00000398919.2
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chr8_+_10530155 0.54 ENST00000521818.1
C8orf74
chromosome 8 open reading frame 74
chr16_-_3306587 0.53 ENST00000541159.1
ENST00000536379.1
ENST00000219596.1
ENST00000339854.4
MEFV
Mediterranean fever
chr19_-_42006539 0.50 ENST00000597702.1
ENST00000588495.1
ENST00000595837.1
ENST00000594315.1
AC011526.1
AC011526.1
chr6_+_26240561 0.47 ENST00000377745.2
HIST1H4F
histone cluster 1, H4f
chr6_-_41888843 0.47 ENST00000434077.1
ENST00000409312.1
MED20
mediator complex subunit 20
chr2_+_28615669 0.42 ENST00000379619.1
ENST00000264716.4
FOSL2
FOS-like antigen 2
chr2_+_16080659 0.41 ENST00000281043.3
MYCN
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr19_-_36304201 0.39 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr19_-_11688500 0.39 ENST00000433365.2
ACP5
acid phosphatase 5, tartrate resistant
chr6_-_27860956 0.38 ENST00000359611.2
HIST1H2AM
histone cluster 1, H2am
chr7_+_139528952 0.36 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr6_+_30850697 0.35 ENST00000509639.1
ENST00000412274.2
ENST00000507901.1
ENST00000507046.1
ENST00000437124.2
ENST00000454612.2
ENST00000396342.2
DDR1
discoidin domain receptor tyrosine kinase 1
chr6_-_99842041 0.35 ENST00000254759.3
ENST00000369242.1
COQ3
coenzyme Q3 methyltransferase
chr7_+_139529040 0.35 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr17_-_43487780 0.35 ENST00000532038.1
ENST00000528677.1
ARHGAP27
Rho GTPase activating protein 27
chr4_-_38666430 0.35 ENST00000436901.1
AC021860.1
Uncharacterized protein
chr1_+_66797687 0.34 ENST00000371045.5
ENST00000531025.1
ENST00000526197.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_-_9129631 0.33 ENST00000377414.3
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr9_+_37486005 0.32 ENST00000377792.3
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chr6_-_41888814 0.31 ENST00000409060.1
ENST00000265350.4
MED20
mediator complex subunit 20
chr9_+_37485932 0.30 ENST00000377798.4
ENST00000442009.2
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chr1_-_156399184 0.29 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
C1orf61
chromosome 1 open reading frame 61
chr5_-_79950775 0.28 ENST00000439211.2
DHFR
dihydrofolate reductase
chr3_-_123710893 0.27 ENST00000467907.1
ENST00000459660.1
ENST00000495093.1
ENST00000460743.1
ENST00000405845.3
ENST00000484329.1
ENST00000479867.1
ENST00000496145.1
ROPN1
rhophilin associated tail protein 1
chr11_+_72983246 0.27 ENST00000393590.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr1_+_207039154 0.26 ENST00000367096.3
ENST00000391930.2
IL20
interleukin 20
chr19_-_41196458 0.26 ENST00000598779.1
NUMBL
numb homolog (Drosophila)-like
chr3_+_141103634 0.26 ENST00000507722.1
ZBTB38
zinc finger and BTB domain containing 38
chr5_+_140566 0.25 ENST00000502646.1
PLEKHG4B
pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
chr1_+_207038699 0.25 ENST00000367098.1
IL20
interleukin 20
chr18_+_29598335 0.25 ENST00000217740.3
RNF125
ring finger protein 125, E3 ubiquitin protein ligase
chr15_-_82338460 0.25 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chr16_+_699319 0.25 ENST00000549091.1
ENST00000293879.4
WDR90
WD repeat domain 90
chr16_+_30484021 0.24 ENST00000358164.5
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr19_-_13947099 0.24 ENST00000587762.1
MIR24-2
microRNA 24-2
chr15_-_83316711 0.23 ENST00000568128.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr17_-_34195889 0.23 ENST00000311880.2
C17orf66
chromosome 17 open reading frame 66
chr17_-_34195862 0.23 ENST00000592980.1
ENST00000587626.1
C17orf66
chromosome 17 open reading frame 66
chr6_-_27841289 0.23 ENST00000355981.2
HIST1H4L
histone cluster 1, H4l
chr7_+_39125365 0.23 ENST00000559001.1
ENST00000464276.2
POU6F2
POU class 6 homeobox 2
chr19_-_46148820 0.23 ENST00000587152.1
EML2
echinoderm microtubule associated protein like 2
chr14_-_100625932 0.22 ENST00000553834.1
DEGS2
delta(4)-desaturase, sphingolipid 2
chr4_+_2813946 0.22 ENST00000442312.2
SH3BP2
SH3-domain binding protein 2
chr17_+_36452989 0.22 ENST00000312513.5
ENST00000582535.1
MRPL45
mitochondrial ribosomal protein L45
chr4_+_2814011 0.22 ENST00000502260.1
ENST00000435136.2
SH3BP2
SH3-domain binding protein 2
chr1_-_60539422 0.21 ENST00000371201.3
C1orf87
chromosome 1 open reading frame 87
chr2_-_136594740 0.21 ENST00000264162.2
LCT
lactase
chr1_-_60539405 0.21 ENST00000450089.2
C1orf87
chromosome 1 open reading frame 87
chr16_-_30773372 0.21 ENST00000545825.1
ENST00000541260.1
C16orf93
chromosome 16 open reading frame 93
chr11_-_34937858 0.21 ENST00000278359.5
APIP
APAF1 interacting protein
chr11_-_34938039 0.21 ENST00000395787.3
APIP
APAF1 interacting protein
chr2_-_220110111 0.21 ENST00000428427.1
ENST00000356283.3
ENST00000432839.1
ENST00000424620.1
GLB1L
galactosidase, beta 1-like
chr6_+_146920097 0.21 ENST00000397944.3
ENST00000522242.1
ADGB
androglobin
chr5_+_79950463 0.21 ENST00000265081.6
MSH3
mutS homolog 3
chr15_+_63796779 0.21 ENST00000561442.1
ENST00000560070.1
ENST00000540797.1
ENST00000380324.3
ENST00000268049.7
ENST00000536001.1
ENST00000539772.1
USP3
ubiquitin specific peptidase 3
chr20_-_6103666 0.21 ENST00000536936.1
FERMT1
fermitin family member 1
chr3_+_125687987 0.21 ENST00000514116.1
ENST00000251776.4
ENST00000504401.1
ENST00000513830.1
ENST00000508088.1
ROPN1B
rhophilin associated tail protein 1B
chr15_+_81591757 0.20 ENST00000558332.1
IL16
interleukin 16
chr6_+_146920116 0.20 ENST00000367493.3
ADGB
androglobin
chr10_+_94451574 0.20 ENST00000492654.2
HHEX
hematopoietically expressed homeobox
chr2_-_220110187 0.20 ENST00000295759.7
ENST00000392089.2
GLB1L
galactosidase, beta 1-like
chr1_+_209602771 0.19 ENST00000440276.1
MIR205HG
MIR205 host gene (non-protein coding)
chr16_+_25228242 0.19 ENST00000219660.5
AQP8
aquaporin 8
chr5_+_140625147 0.18 ENST00000231173.3
PCDHB15
protocadherin beta 15
chr7_-_22862406 0.18 ENST00000372879.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr17_-_3195876 0.18 ENST00000323404.1
OR3A1
olfactory receptor, family 3, subfamily A, member 1
chrX_-_2847366 0.18 ENST00000381154.1
ARSD
arylsulfatase D
chr7_-_22862448 0.17 ENST00000358435.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr12_-_110906027 0.17 ENST00000537466.2
ENST00000550974.1
ENST00000228827.3
GPN3
GPN-loop GTPase 3
chr3_+_97868170 0.17 ENST00000437310.1
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr15_-_22473353 0.16 ENST00000557788.2
IGHV4OR15-8
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr12_+_119616447 0.16 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chrX_-_101410762 0.16 ENST00000543160.1
ENST00000333643.3
BEX5
brain expressed, X-linked 5
chr6_-_27782548 0.15 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr13_-_60738003 0.15 ENST00000400330.1
ENST00000400324.4
DIAPH3
diaphanous-related formin 3
chr5_-_68628543 0.15 ENST00000396496.2
ENST00000511257.1
ENST00000383374.2
CCDC125
coiled-coil domain containing 125
chr20_-_30311703 0.15 ENST00000450273.1
ENST00000456404.1
ENST00000420488.1
ENST00000439267.1
BCL2L1
BCL2-like 1
chr19_-_11688447 0.15 ENST00000590420.1
ACP5
acid phosphatase 5, tartrate resistant
chr2_-_128784846 0.14 ENST00000259235.3
ENST00000357702.5
ENST00000424298.1
SAP130
Sin3A-associated protein, 130kDa
chr1_-_160832642 0.14 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr2_+_99797636 0.14 ENST00000409145.1
MRPL30
mitochondrial ribosomal protein L30
chr15_-_83316087 0.13 ENST00000568757.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr3_-_126277796 0.13 ENST00000318225.2
C3orf22
chromosome 3 open reading frame 22
chr10_-_106098162 0.13 ENST00000337478.1
ITPRIP
inositol 1,4,5-trisphosphate receptor interacting protein
chr11_+_66406088 0.12 ENST00000310092.7
ENST00000396053.4
ENST00000408993.2
RBM4
RNA binding motif protein 4
chr1_-_9129735 0.12 ENST00000377424.4
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr21_+_33031935 0.12 ENST00000270142.6
ENST00000389995.4
SOD1
superoxide dismutase 1, soluble
chr16_-_52119019 0.12 ENST00000561513.1
ENST00000565742.1
LINC00919
long intergenic non-protein coding RNA 919
chr3_+_126243126 0.12 ENST00000319340.2
CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr14_-_106494587 0.12 ENST00000390597.2
IGHV2-5
immunoglobulin heavy variable 2-5
chr6_+_26204825 0.12 ENST00000360441.4
HIST1H4E
histone cluster 1, H4e
chr3_+_102153859 0.12 ENST00000306176.1
ENST00000466937.1
ZPLD1
zona pellucida-like domain containing 1
chr1_+_153388993 0.11 ENST00000368729.4
S100A7A
S100 calcium binding protein A7A
chr1_+_202385953 0.11 ENST00000466968.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr1_+_59762642 0.11 ENST00000371218.4
ENST00000303721.7
FGGY
FGGY carbohydrate kinase domain containing
chr4_-_177116772 0.11 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chr1_+_39796810 0.11 ENST00000289893.4
MACF1
microtubule-actin crosslinking factor 1
chr4_-_157563459 0.11 ENST00000504237.1
ENST00000511399.1
RP11-171N4.2
Uncharacterized protein
chr19_-_50143452 0.11 ENST00000246792.3
RRAS
related RAS viral (r-ras) oncogene homolog
chr5_-_127674883 0.11 ENST00000507835.1
FBN2
fibrillin 2
chrX_+_47444613 0.11 ENST00000445623.1
TIMP1
TIMP metallopeptidase inhibitor 1
chr22_+_23089870 0.11 ENST00000390311.2
IGLV3-16
immunoglobulin lambda variable 3-16
chr8_+_10530133 0.10 ENST00000304519.5
C8orf74
chromosome 8 open reading frame 74
chr22_-_36013368 0.10 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
MB
myoglobin
chr17_-_43487741 0.10 ENST00000455881.1
ARHGAP27
Rho GTPase activating protein 27
chr11_+_117070037 0.09 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
TAGLN
transgelin
chr2_+_96991033 0.09 ENST00000420176.1
ENST00000536814.1
ENST00000439118.2
ITPRIPL1
inositol 1,4,5-trisphosphate receptor interacting protein-like 1
chr16_+_30483962 0.09 ENST00000356798.6
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr16_-_20681177 0.09 ENST00000524149.1
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr12_+_65563329 0.09 ENST00000308330.2
LEMD3
LEM domain containing 3
chr1_+_205682497 0.09 ENST00000598338.1
AC119673.1
AC119673.1
chr7_-_14942944 0.08 ENST00000403951.2
DGKB
diacylglycerol kinase, beta 90kDa
chr18_+_44526786 0.08 ENST00000245121.5
ENST00000356157.7
KATNAL2
katanin p60 subunit A-like 2
chr6_+_27775899 0.08 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr4_-_103940791 0.08 ENST00000510559.1
ENST00000394789.3
ENST00000296422.7
SLC9B1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr2_+_220110177 0.08 ENST00000409638.3
ENST00000396738.2
ENST00000409516.3
STK16
serine/threonine kinase 16
chr6_+_292051 0.07 ENST00000344450.5
DUSP22
dual specificity phosphatase 22
chr1_-_44482979 0.07 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr4_-_39033963 0.07 ENST00000381938.3
TMEM156
transmembrane protein 156
chr6_-_27775694 0.07 ENST00000377401.2
HIST1H2BL
histone cluster 1, H2bl
chr11_+_116700614 0.06 ENST00000375345.1
APOC3
apolipoprotein C-III
chr11_+_116700600 0.06 ENST00000227667.3
APOC3
apolipoprotein C-III
chr6_+_26273144 0.06 ENST00000377733.2
HIST1H2BI
histone cluster 1, H2bi
chr4_+_186990298 0.06 ENST00000296795.3
ENST00000513189.1
TLR3
toll-like receptor 3
chr19_-_37958086 0.06 ENST00000592490.1
ENST00000392149.2
ZNF569
zinc finger protein 569
chr2_+_204732666 0.06 ENST00000295854.6
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr19_-_55691614 0.06 ENST00000592470.1
ENST00000354308.3
SYT5
synaptotagmin V
chr1_-_36906474 0.06 ENST00000433045.2
OSCP1
organic solute carrier partner 1
chr9_-_43133544 0.06 ENST00000254835.2
ANKRD20A3
ankyrin repeat domain 20 family, member A3
chr1_+_201159914 0.05 ENST00000335211.4
ENST00000451870.2
ENST00000295591.8
IGFN1
immunoglobulin-like and fibronectin type III domain containing 1
chr1_+_52682052 0.05 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr12_+_67663056 0.05 ENST00000545606.1
CAND1
cullin-associated and neddylation-dissociated 1
chr7_+_133261209 0.05 ENST00000545148.1
EXOC4
exocyst complex component 4
chr2_-_239140011 0.05 ENST00000409376.1
ENST00000409070.1
ENST00000409942.1
AC016757.3
Protein LOC151174
chr12_+_49212514 0.04 ENST00000301050.2
ENST00000548279.1
ENST00000547230.1
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr4_-_26492076 0.04 ENST00000295589.3
CCKAR
cholecystokinin A receptor
chr16_-_15180257 0.04 ENST00000540462.1
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr2_-_79313973 0.04 ENST00000454188.1
REG1B
regenerating islet-derived 1 beta
chr8_-_101118185 0.04 ENST00000523437.1
RGS22
regulator of G-protein signaling 22
chr11_+_46383121 0.04 ENST00000454345.1
DGKZ
diacylglycerol kinase, zeta
chr6_-_11807277 0.04 ENST00000379415.2
ADTRP
androgen-dependent TFPI-regulating protein
chr15_-_83316254 0.04 ENST00000567678.1
ENST00000450751.2
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr11_+_124824000 0.03 ENST00000529051.1
ENST00000344762.5
CCDC15
coiled-coil domain containing 15
chr11_+_62538775 0.03 ENST00000294168.3
ENST00000526261.1
TAF6L
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
chr14_+_91580732 0.03 ENST00000519019.1
ENST00000523816.1
ENST00000517518.1
C14orf159
chromosome 14 open reading frame 159
chr14_-_24551137 0.03 ENST00000396995.1
NRL
neural retina leucine zipper
chr20_-_60795316 0.03 ENST00000317393.6
HRH3
histamine receptor H3
chr19_-_55691472 0.03 ENST00000537500.1
SYT5
synaptotagmin V
chr2_-_239140276 0.03 ENST00000334973.4
AC016757.3
Protein LOC151174
chr5_+_122181279 0.03 ENST00000395451.4
ENST00000506996.1
SNX24
sorting nexin 24
chr14_-_24551195 0.02 ENST00000560550.1
NRL
neural retina leucine zipper
chr9_+_5890802 0.02 ENST00000381477.3
ENST00000381476.1
ENST00000381471.1
MLANA
melan-A
chr11_-_89609185 0.02 ENST00000329862.6
TRIM64B
tripartite motif containing 64B
chrX_-_46618490 0.02 ENST00000328306.4
SLC9A7
solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
chr8_-_101118210 0.02 ENST00000360863.6
RGS22
regulator of G-protein signaling 22
chr20_+_44036900 0.02 ENST00000443296.1
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr11_-_133402410 0.02 ENST00000524381.1
OPCML
opioid binding protein/cell adhesion molecule-like
chr6_+_27782788 0.02 ENST00000359465.4
HIST1H2BM
histone cluster 1, H2bm
chr5_-_41870621 0.02 ENST00000196371.5
OXCT1
3-oxoacid CoA transferase 1
chr2_-_208031943 0.01 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr14_+_53196872 0.01 ENST00000442123.2
ENST00000354586.4
STYX
serine/threonine/tyrosine interacting protein
chr20_+_44036620 0.01 ENST00000372710.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr16_-_3350614 0.01 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr13_-_114898016 0.01 ENST00000542651.1
ENST00000334062.7
RASA3
RAS p21 protein activator 3
chr6_+_27100811 0.01 ENST00000359193.2
HIST1H2AG
histone cluster 1, H2ag
chr12_+_110906169 0.01 ENST00000377673.5
FAM216A
family with sequence similarity 216, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0036215 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.2 0.6 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.2 0.9 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.2 2.2 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.2 0.6 GO:0001189 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.1 0.5 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.1 1.3 GO:0010265 SCF complex assembly(GO:0010265)
0.1 0.5 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.1 0.5 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.6 GO:0090131 mesenchyme migration(GO:0090131)
0.1 0.7 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 3.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.3 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.1 0.2 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.1 0.2 GO:0006667 sphinganine metabolic process(GO:0006667)
0.1 0.3 GO:0046452 dihydrofolate metabolic process(GO:0046452)
0.1 0.2 GO:0061010 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.1 0.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.2 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 0.1 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.0 0.4 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) pyroptosis(GO:0070269)
0.0 0.2 GO:0048817 negative regulation of hair follicle maturation(GO:0048817)
0.0 0.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 1.8 GO:0006536 glutamate metabolic process(GO:0006536)
0.0 0.4 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.1 GO:0018874 benzoate metabolic process(GO:0018874)
0.0 0.4 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.4 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.2 GO:0032445 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.0 0.4 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.0 0.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.1 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.5 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.8 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.3 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.0 0.2 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.1 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:0034343 microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.0 GO:0038188 cholecystokinin signaling pathway(GO:0038188)
0.0 0.0 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.0 0.1 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.1 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.2 GO:0032302 MutSbeta complex(GO:0032302)
0.1 2.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.0 0.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.7 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.8 GO:0016592 mediator complex(GO:0016592)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 3.7 GO:0030018 Z disc(GO:0030018)
0.0 0.2 GO:0070938 contractile ring(GO:0070938)
0.0 0.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.2 0.7 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.2 0.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 0.6 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.2 0.9 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.2 0.5 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.1 3.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.4 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.4 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.2 GO:0000404 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.0 0.3 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.3 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.4 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.5 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.3 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 1.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0015266 protein channel activity(GO:0015266)
0.0 1.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.2 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.0 GO:0004951 cholecystokinin receptor activity(GO:0004951)
0.0 0.0 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.1 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID AURORA A PATHWAY Aurora A signaling
0.0 0.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.7 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction