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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for SOX10_SOX15

Z-value: 0.56

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Transcription factors associated with SOX10_SOX15

Gene Symbol Gene ID Gene Info
SOX10
ENSG00000100146.12 SRY-box transcription factor 10
SOX15
ENSG00000129194.3 SRY-box transcription factor 15

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX15hg19_v2_chr17_-_7493390_7493488-0.462.0e-02Click!
SOX10hg19_v2_chr22_-_38380543_38380569-0.377.3e-02Click!

Activity profile of SOX10_SOX15 motif

Sorted Z-values of SOX10_SOX15 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_188312971 3.49 ENST00000410068.1
ENST00000447403.1
ENST00000410102.1
CALCRL
calcitonin receptor-like
chr7_-_27219849 2.39 ENST00000396344.4
HOXA10
homeobox A10
chr4_+_41614909 1.99 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIMCH1
LIM and calponin homology domains 1
chr8_-_124553437 1.97 ENST00000517956.1
ENST00000443022.2
FBXO32
F-box protein 32
chr4_+_41614720 1.90 ENST00000509277.1
LIMCH1
LIM and calponin homology domains 1
chr20_-_45985172 1.76 ENST00000536340.1
ZMYND8
zinc finger, MYND-type containing 8
chr15_-_52944231 1.72 ENST00000546305.2
FAM214A
family with sequence similarity 214, member A
chr4_-_186877502 1.56 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
SORBS2
sorbin and SH3 domain containing 2
chr8_-_80993010 1.49 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
TPD52
tumor protein D52
chr20_-_39317868 1.28 ENST00000373313.2
MAFB
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr20_-_45984401 1.23 ENST00000311275.7
ZMYND8
zinc finger, MYND-type containing 8
chr3_-_18466026 1.08 ENST00000417717.2
SATB1
SATB homeobox 1
chr12_+_53443680 1.00 ENST00000314250.6
ENST00000451358.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr12_+_53443963 0.98 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr4_-_186732048 0.96 ENST00000448662.2
ENST00000439049.1
ENST00000420158.1
ENST00000431808.1
ENST00000319471.9
SORBS2
sorbin and SH3 domain containing 2
chr18_+_6729698 0.91 ENST00000383472.4
ARHGAP28
Rho GTPase activating protein 28
chr11_-_66445219 0.89 ENST00000525754.1
ENST00000531969.1
ENST00000524637.1
ENST00000531036.2
ENST00000310046.4
RBM4B
RNA binding motif protein 4B
chr15_+_57210961 0.87 ENST00000557843.1
TCF12
transcription factor 12
chr6_+_122720681 0.84 ENST00000368455.4
ENST00000452194.1
HSF2
heat shock transcription factor 2
chr11_-_130184555 0.84 ENST00000525842.1
ZBTB44
zinc finger and BTB domain containing 44
chr1_+_33722080 0.82 ENST00000483388.1
ENST00000539719.1
ZNF362
zinc finger protein 362
chr9_-_14308004 0.73 ENST00000493697.1
NFIB
nuclear factor I/B
chr11_-_130184470 0.66 ENST00000357899.4
ENST00000397753.1
ZBTB44
zinc finger and BTB domain containing 44
chr3_+_151986709 0.63 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
MBNL1
muscleblind-like splicing regulator 1
chr14_+_54976603 0.63 ENST00000557317.1
CGRRF1
cell growth regulator with ring finger domain 1
chr18_-_22932080 0.61 ENST00000584787.1
ENST00000361524.3
ENST00000538137.2
ZNF521
zinc finger protein 521
chr15_-_56035177 0.61 ENST00000389286.4
ENST00000561292.1
PRTG
protogenin
chr2_+_70056762 0.60 ENST00000282570.3
GMCL1
germ cell-less, spermatogenesis associated 1
chr15_-_52043722 0.57 ENST00000454181.2
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chr10_-_97321165 0.56 ENST00000306402.6
SORBS1
sorbin and SH3 domain containing 1
chr1_+_185703513 0.56 ENST00000271588.4
ENST00000367492.2
HMCN1
hemicentin 1
chrX_+_12993202 0.55 ENST00000451311.2
ENST00000380636.1
TMSB4X
thymosin beta 4, X-linked
chr14_+_77228532 0.52 ENST00000167106.4
ENST00000554237.1
VASH1
vasohibin 1
chr4_-_138453606 0.51 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
PCDH18
protocadherin 18
chr7_+_102553430 0.51 ENST00000339431.4
ENST00000249377.4
LRRC17
leucine rich repeat containing 17
chr11_-_89224488 0.49 ENST00000534731.1
ENST00000527626.1
NOX4
NADPH oxidase 4
chr11_-_89224299 0.46 ENST00000343727.5
ENST00000531342.1
ENST00000375979.3
NOX4
NADPH oxidase 4
chr6_+_119215308 0.46 ENST00000229595.5
ASF1A
anti-silencing function 1A histone chaperone
chr3_+_141105235 0.46 ENST00000503809.1
ZBTB38
zinc finger and BTB domain containing 38
chr19_+_1249869 0.43 ENST00000591446.2
MIDN
midnolin
chr2_+_32288657 0.43 ENST00000345662.1
SPAST
spastin
chr5_-_111092930 0.42 ENST00000257435.7
NREP
neuronal regeneration related protein
chr15_+_57210818 0.42 ENST00000438423.2
ENST00000267811.5
ENST00000452095.2
ENST00000559609.1
ENST00000333725.5
TCF12
transcription factor 12
chr5_-_111093167 0.42 ENST00000446294.2
ENST00000419114.2
NREP
neuronal regeneration related protein
chr4_+_95129061 0.41 ENST00000354268.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr4_+_95128996 0.41 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr5_-_111093081 0.41 ENST00000453526.2
ENST00000509427.1
NREP
neuronal regeneration related protein
chr13_+_37393351 0.40 ENST00000255476.2
RFXAP
regulatory factor X-associated protein
chr2_+_66662510 0.40 ENST00000272369.9
ENST00000407092.2
MEIS1
Meis homeobox 1
chr2_+_66662690 0.40 ENST00000488550.1
MEIS1
Meis homeobox 1
chr18_+_6729725 0.39 ENST00000400091.2
ENST00000583410.1
ENST00000584387.1
ARHGAP28
Rho GTPase activating protein 28
chr2_+_120517174 0.39 ENST00000263708.2
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr8_+_21777159 0.39 ENST00000434536.1
ENST00000252512.9
XPO7
exportin 7
chr2_+_69240302 0.39 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chrX_-_32173579 0.38 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr4_+_55524085 0.38 ENST00000412167.2
ENST00000288135.5
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr1_+_163038565 0.38 ENST00000421743.2
RGS4
regulator of G-protein signaling 4
chr5_-_111092873 0.38 ENST00000509025.1
ENST00000515855.1
NREP
neuronal regeneration related protein
chr22_+_39052632 0.38 ENST00000411557.1
ENST00000396811.2
ENST00000216029.3
ENST00000416285.1
CBY1
chibby homolog 1 (Drosophila)
chr7_+_116312411 0.38 ENST00000456159.1
ENST00000397752.3
ENST00000318493.6
MET
met proto-oncogene
chr10_-_99393208 0.37 ENST00000307450.6
MORN4
MORN repeat containing 4
chr1_+_93913713 0.37 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr12_+_32260085 0.37 ENST00000548411.1
ENST00000281474.5
ENST00000551086.1
BICD1
bicaudal D homolog 1 (Drosophila)
chr11_-_89224508 0.37 ENST00000525196.1
NOX4
NADPH oxidase 4
chr2_+_32288725 0.36 ENST00000315285.3
SPAST
spastin
chrX_+_12993336 0.36 ENST00000380635.1
TMSB4X
thymosin beta 4, X-linked
chr8_-_17579726 0.36 ENST00000381861.3
MTUS1
microtubule associated tumor suppressor 1
chr4_+_144303093 0.36 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chrX_+_107069063 0.35 ENST00000262843.6
MID2
midline 2
chrX_-_128788914 0.35 ENST00000429967.1
ENST00000307484.6
APLN
apelin
chr3_+_107241882 0.34 ENST00000416476.2
BBX
bobby sox homolog (Drosophila)
chr10_+_99079008 0.34 ENST00000371021.3
FRAT1
frequently rearranged in advanced T-cell lymphomas
chr11_-_89224638 0.34 ENST00000535633.1
ENST00000263317.4
NOX4
NADPH oxidase 4
chrX_+_80457442 0.33 ENST00000373212.5
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chrX_-_24665208 0.33 ENST00000356768.4
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr2_-_183387430 0.32 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr3_-_141747950 0.32 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr4_+_71588372 0.32 ENST00000536664.1
RUFY3
RUN and FYVE domain containing 3
chr2_+_181845843 0.32 ENST00000602710.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr13_+_78315295 0.31 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr4_+_95128748 0.31 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr17_-_46690839 0.30 ENST00000498634.2
HOXB8
homeobox B8
chr10_+_35484793 0.30 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr12_-_12419703 0.29 ENST00000543091.1
ENST00000261349.4
LRP6
low density lipoprotein receptor-related protein 6
chr3_-_167813672 0.29 ENST00000470487.1
GOLIM4
golgi integral membrane protein 4
chr1_-_26233423 0.29 ENST00000357865.2
STMN1
stathmin 1
chr7_-_140178775 0.29 ENST00000474576.1
ENST00000473444.1
ENST00000471104.1
MKRN1
makorin ring finger protein 1
chr6_+_56911476 0.29 ENST00000545356.1
KIAA1586
KIAA1586
chr15_+_52043758 0.29 ENST00000249700.4
ENST00000539962.2
TMOD2
tropomodulin 2 (neuronal)
chr11_-_94965667 0.28 ENST00000542176.1
ENST00000278499.2
SESN3
sestrin 3
chr11_+_36317830 0.28 ENST00000530639.1
PRR5L
proline rich 5 like
chr3_+_113616317 0.28 ENST00000440446.2
ENST00000488680.1
GRAMD1C
GRAM domain containing 1C
chr7_-_5821225 0.28 ENST00000416985.1
RNF216
ring finger protein 216
chr2_-_165424973 0.28 ENST00000543549.1
GRB14
growth factor receptor-bound protein 14
chr14_-_22005018 0.28 ENST00000546363.1
SALL2
spalt-like transcription factor 2
chr18_+_72201664 0.28 ENST00000358821.3
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr6_-_111888474 0.27 ENST00000368735.1
TRAF3IP2
TRAF3 interacting protein 2
chr10_+_22605374 0.27 ENST00000448361.1
COMMD3
COMM domain containing 3
chr20_-_23066953 0.27 ENST00000246006.4
CD93
CD93 molecule
chrX_-_10645773 0.27 ENST00000453318.2
MID1
midline 1 (Opitz/BBB syndrome)
chr10_+_35415719 0.27 ENST00000474362.1
ENST00000374721.3
CREM
cAMP responsive element modulator
chr10_+_22605304 0.26 ENST00000475460.2
ENST00000602390.1
ENST00000489125.2
ENST00000456711.1
ENST00000444869.1
COMMD3-BMI1
COMMD3
COMMD3-BMI1 readthrough
COMM domain containing 3
chr6_+_83777374 0.26 ENST00000349129.2
ENST00000237163.5
ENST00000536812.1
DOPEY1
dopey family member 1
chr16_-_15736881 0.26 ENST00000540441.2
KIAA0430
KIAA0430
chr7_-_121944491 0.26 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr4_+_90033968 0.25 ENST00000317005.2
TIGD2
tigger transposable element derived 2
chr6_+_30848557 0.25 ENST00000460944.2
ENST00000324771.8
DDR1
discoidin domain receptor tyrosine kinase 1
chr6_-_41863098 0.25 ENST00000373006.1
USP49
ubiquitin specific peptidase 49
chrX_-_21776281 0.25 ENST00000379494.3
SMPX
small muscle protein, X-linked
chr2_-_70475701 0.25 ENST00000282574.4
TIA1
TIA1 cytotoxic granule-associated RNA binding protein
chr3_+_107241783 0.25 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
BBX
bobby sox homolog (Drosophila)
chr7_-_99679324 0.24 ENST00000292393.5
ENST00000413658.2
ENST00000412947.1
ENST00000441298.1
ENST00000449785.1
ENST00000299667.4
ENST00000424697.1
ZNF3
zinc finger protein 3
chr6_+_74405501 0.24 ENST00000437994.2
ENST00000422508.2
CD109
CD109 molecule
chr17_-_39471947 0.24 ENST00000334202.3
KRTAP17-1
keratin associated protein 17-1
chr10_+_35415978 0.23 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
CREM
cAMP responsive element modulator
chr17_+_67498538 0.23 ENST00000589647.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr9_-_35115836 0.23 ENST00000378566.1
ENST00000378554.2
ENST00000322813.5
FAM214B
family with sequence similarity 214, member B
chrX_-_63425561 0.23 ENST00000374869.3
ENST00000330258.3
AMER1
APC membrane recruitment protein 1
chr14_-_71107921 0.23 ENST00000553982.1
ENST00000500016.1
CTD-2540L5.5
CTD-2540L5.6
CTD-2540L5.5
CTD-2540L5.6
chr6_-_112575912 0.23 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr14_-_106066376 0.23 ENST00000412518.1
ENST00000428654.1
ENST00000427543.1
ENST00000420153.1
ENST00000577108.1
ENST00000576077.1
AL928742.12
IGHE
AL928742.12
immunoglobulin heavy constant epsilon
chr5_+_43602750 0.23 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT
nicotinamide nucleotide transhydrogenase
chr13_+_78315466 0.23 ENST00000314070.5
ENST00000462234.1
SLAIN1
SLAIN motif family, member 1
chr10_-_128359074 0.23 ENST00000544758.1
C10orf90
chromosome 10 open reading frame 90
chr20_+_11898507 0.23 ENST00000378226.2
BTBD3
BTB (POZ) domain containing 3
chr17_+_19030782 0.23 ENST00000344415.4
ENST00000577213.1
GRAPL
GRB2-related adaptor protein-like
chr16_-_4852915 0.22 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chr6_+_74405804 0.22 ENST00000287097.5
CD109
CD109 molecule
chr10_-_14646388 0.22 ENST00000468747.1
ENST00000378467.4
FAM107B
family with sequence similarity 107, member B
chr15_+_84115868 0.21 ENST00000427482.2
SH3GL3
SH3-domain GRB2-like 3
chr19_+_34287751 0.21 ENST00000590771.1
ENST00000589786.1
ENST00000284006.6
ENST00000588881.1
KCTD15
potassium channel tetramerization domain containing 15
chrX_-_106960285 0.21 ENST00000503515.1
ENST00000372397.2
TSC22D3
TSC22 domain family, member 3
chr16_+_53242350 0.21 ENST00000565442.1
CHD9
chromodomain helicase DNA binding protein 9
chr16_+_30406721 0.21 ENST00000320159.2
ZNF48
zinc finger protein 48
chr13_-_33780133 0.21 ENST00000399365.3
STARD13
StAR-related lipid transfer (START) domain containing 13
chr7_-_15601595 0.20 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chrX_+_129473859 0.20 ENST00000424447.1
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr1_+_66797687 0.20 ENST00000371045.5
ENST00000531025.1
ENST00000526197.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr11_+_63706444 0.20 ENST00000377793.4
ENST00000456907.2
ENST00000539656.1
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr3_-_129407535 0.20 ENST00000432054.2
TMCC1
transmembrane and coiled-coil domain family 1
chr17_+_73452545 0.20 ENST00000314256.7
KIAA0195
KIAA0195
chr18_+_72201829 0.20 ENST00000582365.1
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr4_+_106067943 0.20 ENST00000380013.4
ENST00000394764.1
ENST00000413648.2
TET2
tet methylcytosine dioxygenase 2
chr12_-_90049878 0.20 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr3_+_107096188 0.19 ENST00000261058.1
CCDC54
coiled-coil domain containing 54
chr13_+_30002846 0.19 ENST00000542829.1
MTUS2
microtubule associated tumor suppressor candidate 2
chr7_+_116660246 0.19 ENST00000434836.1
ENST00000393443.1
ENST00000465133.1
ENST00000477742.1
ENST00000393447.4
ENST00000393444.3
ST7
suppression of tumorigenicity 7
chr1_-_147245484 0.19 ENST00000271348.2
GJA5
gap junction protein, alpha 5, 40kDa
chr5_+_78532003 0.19 ENST00000396137.4
JMY
junction mediating and regulatory protein, p53 cofactor
chr17_+_75447326 0.18 ENST00000591088.1
SEPT9
septin 9
chr4_+_118955500 0.18 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr12_-_90049828 0.18 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr5_+_147774275 0.18 ENST00000513826.1
FBXO38
F-box protein 38
chr2_-_70475730 0.18 ENST00000445587.1
ENST00000433529.2
ENST00000415783.2
TIA1
TIA1 cytotoxic granule-associated RNA binding protein
chr2_+_177015950 0.18 ENST00000306324.3
HOXD4
homeobox D4
chr18_-_74728998 0.18 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
MBP
myelin basic protein
chr3_+_189507460 0.18 ENST00000434928.1
TP63
tumor protein p63
chrX_-_24665353 0.18 ENST00000379144.2
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr3_+_14860469 0.18 ENST00000285046.5
FGD5
FYVE, RhoGEF and PH domain containing 5
chr22_-_41636892 0.18 ENST00000455425.1
CHADL
chondroadherin-like
chr2_+_198669365 0.18 ENST00000428675.1
PLCL1
phospholipase C-like 1
chr16_-_28303360 0.17 ENST00000501520.1
RP11-57A19.2
RP11-57A19.2
chr17_-_46623441 0.17 ENST00000330070.4
HOXB2
homeobox B2
chr12_-_71003568 0.17 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
PTPRB
protein tyrosine phosphatase, receptor type, B
chr17_+_36584662 0.17 ENST00000431231.2
ENST00000437668.3
ARHGAP23
Rho GTPase activating protein 23
chr22_+_19710468 0.17 ENST00000366425.3
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr18_-_31802282 0.17 ENST00000535475.1
NOL4
nucleolar protein 4
chr17_-_18950310 0.17 ENST00000573099.1
GRAP
GRB2-related adaptor protein
chr21_+_37442239 0.17 ENST00000530908.1
ENST00000290349.6
ENST00000439427.2
ENST00000399191.3
CBR1
carbonyl reductase 1
chr4_+_113152978 0.17 ENST00000309703.6
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr3_+_183353356 0.16 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
KLHL24
kelch-like family member 24
chr13_+_49684445 0.16 ENST00000398316.3
FNDC3A
fibronectin type III domain containing 3A
chr14_+_100070869 0.16 ENST00000502101.2
RP11-543C4.1
RP11-543C4.1
chr12_-_102874330 0.16 ENST00000307046.8
IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_+_113218497 0.16 ENST00000458497.1
ENST00000177648.9
ENST00000504176.2
ALPK1
alpha-kinase 1
chr6_-_112575838 0.16 ENST00000455073.1
LAMA4
laminin, alpha 4
chr2_-_86564776 0.16 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1
receptor accessory protein 1
chrX_+_37639264 0.16 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr19_+_50706866 0.16 ENST00000440075.2
ENST00000376970.2
ENST00000425460.1
ENST00000599920.1
ENST00000601313.1
MYH14
myosin, heavy chain 14, non-muscle
chrX_+_10124977 0.16 ENST00000380833.4
CLCN4
chloride channel, voltage-sensitive 4
chr4_+_150999418 0.15 ENST00000296550.7
DCLK2
doublecortin-like kinase 2
chr18_+_3448455 0.15 ENST00000549780.1
TGIF1
TGFB-induced factor homeobox 1
chr15_-_82338460 0.15 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chr4_-_170192185 0.15 ENST00000284637.9
SH3RF1
SH3 domain containing ring finger 1
chrY_+_15815447 0.15 ENST00000284856.3
TMSB4Y
thymosin beta 4, Y-linked
chr7_-_111846435 0.15 ENST00000437633.1
ENST00000428084.1
DOCK4
dedicator of cytokinesis 4
chr4_+_113152881 0.15 ENST00000274000.5
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr1_-_53793584 0.15 ENST00000354412.3
ENST00000347547.2
ENST00000306052.6
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr17_+_73452695 0.15 ENST00000582186.1
ENST00000582455.1
ENST00000581252.1
ENST00000579208.1
KIAA0195
KIAA0195
chr8_+_107738240 0.15 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chrX_+_129473916 0.15 ENST00000545805.1
ENST00000543953.1
ENST00000218197.5
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr1_+_228337553 0.15 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chr14_-_67981870 0.15 ENST00000555994.1
TMEM229B
transmembrane protein 229B
chrX_-_117107542 0.15 ENST00000371878.1
KLHL13
kelch-like family member 13
chr15_+_77224045 0.15 ENST00000320963.5
ENST00000394883.3
RCN2
reticulocalbin 2, EF-hand calcium binding domain
chr1_+_212797789 0.15 ENST00000294829.3
FAM71A
family with sequence similarity 71, member A
chr1_+_93645314 0.15 ENST00000343253.7
CCDC18
coiled-coil domain containing 18
chr17_+_75283973 0.15 ENST00000431235.2
ENST00000449803.2
SEPT9
septin 9
chr14_-_23904861 0.15 ENST00000355349.3
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr1_+_66458072 0.15 ENST00000423207.2
PDE4B
phosphodiesterase 4B, cAMP-specific

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX10_SOX15

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.0 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.4 1.3 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.4 1.3 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.3 3.5 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.2 2.0 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 0.2 GO:0021569 rhombomere 3 development(GO:0021569)
0.2 0.5 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 0.7 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1 0.4 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.1 0.4 GO:0036215 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.1 0.4 GO:1900276 regulation of proteinase activated receptor activity(GO:1900276) negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900737)
0.1 0.4 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 0.2 GO:0072709 cellular response to sorbitol(GO:0072709)
0.1 0.9 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.1 0.3 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.3 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.1 0.4 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.8 GO:0051013 microtubule severing(GO:0051013)
0.1 0.5 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 2.9 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.5 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.1 1.1 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 0.5 GO:0048539 bone marrow development(GO:0048539)
0.1 2.4 GO:0060065 uterus development(GO:0060065)
0.1 0.2 GO:0003193 pulmonary valve formation(GO:0003193) regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) foramen ovale closure(GO:0035922) regulation of bundle of His cell action potential(GO:0098905)
0.1 0.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.3 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 1.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.3 GO:0030421 defecation(GO:0030421)
0.0 0.4 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.1 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.0 1.7 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.6 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 0.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.5 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.2 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.0 0.7 GO:0060044 negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0 0.2 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.6 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.1 GO:2001037 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.1 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724)
0.0 0.4 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.2 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.2 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.2 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.2 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.2 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.0 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.9 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.6 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.1 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.0 GO:0021592 fourth ventricle development(GO:0021592)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.2 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 0.3 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.0 0.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.3 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841)
0.0 0.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.0 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.1 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.2 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.0 0.3 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.2 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.2 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.0 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.2 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 0.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.6 GO:0050691 regulation of defense response to virus by host(GO:0050691)
0.0 0.2 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.2 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.0 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.0 0.0 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.4 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 3.2 GO:0031032 actomyosin structure organization(GO:0031032)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0039714 viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517)
0.1 0.6 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.3 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.1 1.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.2 GO:1990015 mesaxon(GO:0097453) ensheathing process(GO:1990015)
0.1 0.4 GO:0097165 nuclear stress granule(GO:0097165)
0.1 0.4 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.8 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.3 GO:0005927 muscle tendon junction(GO:0005927)
0.0 0.4 GO:0016013 syntrophin complex(GO:0016013)
0.0 2.6 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.2 GO:0097422 tubular endosome(GO:0097422)
0.0 0.2 GO:0097513 myosin II filament(GO:0097513)
0.0 1.1 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.4 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 1.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.4 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0000322 storage vacuole(GO:0000322)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0031105 septin complex(GO:0031105)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0004948 calcitonin receptor activity(GO:0004948)
0.2 0.6 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.4 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 1.7 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 0.5 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 2.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.8 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 0.3 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 3.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.2 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 0.4 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.3 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.2 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.0 0.2 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.2 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.0 0.2 GO:0038025 reelin receptor activity(GO:0038025)
0.0 0.3 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.0 0.1 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.0 0.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.4 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.2 GO:0043426 MRF binding(GO:0043426)
0.0 0.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 1.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 0.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.9 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.0 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.1 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.4 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.3 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.7 PID FOXO PATHWAY FoxO family signaling
0.0 0.8 PID INSULIN PATHWAY Insulin Pathway
0.0 0.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.3 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.0 1.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 3.5 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.3 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.4 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.4 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling