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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for SOX18
Z-value: 0.44
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Transcription factors associated with SOX18
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX18 | hg19_v2_chr20_-_62680984_62680999 | 0.31 | 1.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_156588115 Show fit | 1.47 |
ENST00000455639.2
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_+_156588249 Show fit | 1.03 |
ENST00000393832.3
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr6_-_13487784 Show fit | 0.62 |
ENST00000379287.3
|
glucose-fructose oxidoreductase domain containing 1 |
|
| chr3_+_20081515 Show fit | 0.59 |
ENST00000263754.4
|
K(lysine) acetyltransferase 2B |
|
| chr11_+_71238313 Show fit | 0.54 |
ENST00000398536.4
|
keratin associated protein 5-7 |
|
| chr6_-_26235206 Show fit | 0.47 |
ENST00000244534.5
|
histone cluster 1, H1d |
|
| chrX_+_10031499 Show fit | 0.45 |
ENST00000454666.1
|
WWC family member 3 |
|
| chr16_-_68034470 Show fit | 0.43 |
ENST00000412757.2
|
dipeptidase 2 |
|
| chrX_-_117119243 Show fit | 0.43 |
ENST00000539496.1
ENST00000469946.1 |
kelch-like family member 13 |
|
| chr7_-_150329421 Show fit | 0.43 |
ENST00000493969.1
ENST00000328902.5 |
GTPase, IMAP family member 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX18
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.5 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.0 | 1.3 | GO:0050667 | homocysteine metabolic process(GO:0050667) |
| 0.1 | 0.6 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) |
| 0.0 | 0.6 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 0.5 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.0 | 0.5 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.1 | 0.4 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.0 | 0.4 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.0 | 0.4 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 0.1 | 0.3 | GO:1900276 | regulation of proteinase activated receptor activity(GO:1900276) negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900737) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 1.3 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 0.6 | GO:0000125 | PCAF complex(GO:0000125) |
| 0.0 | 0.5 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.4 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.1 | 0.3 | GO:0039713 | viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517) |
| 0.0 | 0.3 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 0.3 | GO:0032389 | MutLalpha complex(GO:0032389) |
| 0.0 | 0.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 1.3 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.1 | 0.6 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.1 | 0.5 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 0.4 | GO:0032296 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.0 | 0.4 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.4 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 0.3 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.0 | 0.3 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.0 | 0.3 | GO:0032138 | single base insertion or deletion binding(GO:0032138) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 0.6 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.5 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.4 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 0.4 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.0 | 0.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 0.2 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |