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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for SOX21

Z-value: 0.49

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
ENSG00000125285.4 SRY-box transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_95364389-0.433.3e-02Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_221051699 1.33 ENST00000366903.6
H2.0-like homeobox
chr5_-_61031495 1.31 ENST00000506550.1
ENST00000512882.2
CTD-2170G1.2
chr12_+_20522179 1.11 ENST00000359062.3
phosphodiesterase 3A, cGMP-inhibited
chr3_-_164875850 0.81 ENST00000472120.1
RP11-747D18.1
chr3_-_141747439 0.78 ENST00000467667.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_-_112575838 0.62 ENST00000455073.1
laminin, alpha 4
chr5_-_95158375 0.61 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
glutaredoxin (thioltransferase)
chr5_-_95158644 0.59 ENST00000237858.6
glutaredoxin (thioltransferase)
chr6_-_112575758 0.54 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
laminin, alpha 4
chr3_+_141103634 0.53 ENST00000507722.1
zinc finger and BTB domain containing 38
chr6_-_112575912 0.51 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
laminin, alpha 4
chr8_-_19459993 0.48 ENST00000454498.2
ENST00000520003.1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr8_-_142377367 0.44 ENST00000377741.3
G protein-coupled receptor 20
chr3_+_57994127 0.42 ENST00000490882.1
ENST00000295956.4
ENST00000358537.3
ENST00000429972.2
ENST00000348383.5
ENST00000357272.4
filamin B, beta
chr3_-_141747459 0.39 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr19_-_21950332 0.33 ENST00000598026.1
zinc finger protein 100
chr8_-_94029882 0.31 ENST00000520686.1
triple QxxK/R motif containing
chr1_+_203764742 0.30 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
zinc finger CCCH-type containing 11A
chr12_+_123011776 0.30 ENST00000450485.2
ENST00000333479.7
kinetochore associated 1
chr1_-_54303934 0.29 ENST00000537333.1
NDC1 transmembrane nucleoporin
chr10_-_71169031 0.28 ENST00000373307.1
tachykinin receptor 2
chr9_-_104249400 0.27 ENST00000374848.3
transmembrane protein 246
chr17_-_71410794 0.27 ENST00000424778.1
sidekick cell adhesion molecule 2
chr17_-_18266660 0.26 ENST00000582653.1
ENST00000352886.6
serine hydroxymethyltransferase 1 (soluble)
chr16_-_15982440 0.26 ENST00000575938.1
ENST00000573396.1
ENST00000573968.1
ENST00000575744.1
ENST00000573429.1
ENST00000255759.6
ENST00000575073.1
FGFR1OP N-terminal like
chr11_+_114168085 0.24 ENST00000541754.1
nicotinamide N-methyltransferase
chr6_+_31371337 0.24 ENST00000449934.2
ENST00000421350.1
MHC class I polypeptide-related sequence A
chr4_-_83931862 0.23 ENST00000506560.1
ENST00000442461.2
ENST00000446851.2
ENST00000340417.3
lin-54 homolog (C. elegans)
chr3_-_45957088 0.22 ENST00000539217.1
leucine zipper transcription factor-like 1
chr7_-_86849883 0.21 ENST00000433078.1
transmembrane protein 243, mitochondrial
chrY_+_16634483 0.21 ENST00000382872.1
neuroligin 4, Y-linked
chr16_-_15149828 0.20 ENST00000566419.1
ENST00000568320.1
N-terminal asparagine amidase
chr17_-_8702667 0.20 ENST00000329805.4
major facilitator superfamily domain containing 6-like
chr1_-_198990166 0.20 ENST00000427439.1
RP11-16L9.3
chrX_-_39186610 0.19 ENST00000429281.1
ENST00000448597.1
RP11-265P11.2
chr18_+_29769978 0.19 ENST00000269202.6
ENST00000581447.1
meprin A, beta
chr12_-_7261772 0.18 ENST00000545280.1
ENST00000543933.1
ENST00000545337.1
ENST00000544702.1
ENST00000266542.4
complement component 1, r subcomponent-like
chr19_+_42381337 0.18 ENST00000597454.1
ENST00000444740.2
CD79a molecule, immunoglobulin-associated alpha
chr5_+_140579162 0.17 ENST00000536699.1
ENST00000354757.3
protocadherin beta 11
chr3_-_45957534 0.16 ENST00000536047.1
leucine zipper transcription factor-like 1
chr14_-_92588013 0.15 ENST00000553514.1
ENST00000605997.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr4_-_177190364 0.15 ENST00000296525.3
ankyrin repeat and SOCS box containing 5
chr19_-_7040190 0.15 ENST00000381394.4
methyl-CpG binding domain protein 3-like 4
chr8_+_101170563 0.15 ENST00000520508.1
ENST00000388798.2
sperm associated antigen 1
chr6_+_151815143 0.14 ENST00000239374.7
ENST00000367290.5
coiled-coil domain containing 170
chr6_-_121655593 0.13 ENST00000398212.2
TBC1 domain family, member 32
chrX_+_36053908 0.13 ENST00000378660.2
calponin homology domain containing 2
chr12_-_10324716 0.12 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
oxidized low density lipoprotein (lectin-like) receptor 1
chr1_+_152881014 0.12 ENST00000368764.3
ENST00000392667.2
involucrin
chr7_-_73133959 0.12 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
syntaxin 1A (brain)
chr15_+_58702742 0.12 ENST00000356113.6
ENST00000414170.3
lipase, hepatic
chr12_-_89746173 0.12 ENST00000308385.6
dual specificity phosphatase 6
chr11_-_8285405 0.12 ENST00000335790.3
ENST00000534484.1
LIM domain only 1 (rhombotin 1)
chr3_+_38537960 0.11 ENST00000453767.1
endo/exonuclease (5'-3'), endonuclease G-like
chr1_+_199996733 0.11 ENST00000236914.3
nuclear receptor subfamily 5, group A, member 2
chrX_-_71792477 0.11 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
histone deacetylase 8
chr12_-_1058685 0.11 ENST00000397230.2
ENST00000542785.1
ENST00000544742.1
ENST00000536177.1
ENST00000539046.1
ENST00000541619.1
RAD52 homolog (S. cerevisiae)
chr5_+_134181755 0.10 ENST00000504727.1
ENST00000435259.2
ENST00000508791.1
chromosome 5 open reading frame 24
chr14_-_92588246 0.10 ENST00000329559.3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr20_+_43343886 0.10 ENST00000190983.4
WNT1 inducible signaling pathway protein 2
chr14_+_50291993 0.10 ENST00000595378.1
HCG1786899; PRO2610; Uncharacterized protein
chr9_+_105757590 0.09 ENST00000374798.3
ENST00000487798.1
cylicin, basic protein of sperm head cytoskeleton 2
chr3_+_37035263 0.09 ENST00000458205.2
ENST00000539477.1
mutL homolog 1
chr3_+_37035289 0.09 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
mutL homolog 1
chr8_+_67687413 0.09 ENST00000521960.1
ENST00000522398.1
ENST00000522629.1
ENST00000520976.1
ENST00000396596.1
serum/glucocorticoid regulated kinase family, member 3
chr10_+_5005445 0.09 ENST00000380872.4
aldo-keto reductase family 1, member C1
chr1_+_158901329 0.09 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
pyrin and HIN domain family, member 1
chr12_+_69742121 0.09 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
lysozyme
chr14_-_102771462 0.08 ENST00000522874.1
MOK protein kinase
chr1_-_217250231 0.08 ENST00000493748.1
ENST00000463665.1
estrogen-related receptor gamma
chr7_+_120702819 0.08 ENST00000423795.1
cadherin-like and PC-esterase domain containing 1
chr6_+_131894284 0.08 ENST00000368087.3
ENST00000356962.2
arginase 1
chr14_-_107170409 0.08 ENST00000390633.2
immunoglobulin heavy variable 1-69
chr4_+_69313145 0.07 ENST00000305363.4
transmembrane protease, serine 11E
chr3_+_186288454 0.07 ENST00000265028.3
DnaJ (Hsp40) homolog, subfamily B, member 11
chr4_+_81951957 0.07 ENST00000282701.2
bone morphogenetic protein 3
chr19_+_18682531 0.07 ENST00000596304.1
ENST00000430157.2
ubiquitin A-52 residue ribosomal protein fusion product 1
chr14_+_21498360 0.07 ENST00000321760.6
ENST00000460647.2
ENST00000530140.2
ENST00000472458.1
tubulin polymerization-promoting protein family member 2
chr11_+_5410607 0.07 ENST00000328611.3
olfactory receptor, family 51, subfamily M, member 1
chr14_-_95922526 0.07 ENST00000554873.1
spectrin repeat containing, nuclear envelope family member 3
chr4_-_103746683 0.07 ENST00000504211.1
ENST00000508476.1
ubiquitin-conjugating enzyme E2D 3
chr12_-_1058849 0.06 ENST00000358495.3
RAD52 homolog (S. cerevisiae)
chr3_-_155524049 0.06 ENST00000534941.1
ENST00000340171.2
chromosome 3 open reading frame 33
chr6_+_140175987 0.06 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
chr7_-_37026108 0.05 ENST00000396045.3
engulfment and cell motility 1
chr10_-_17243579 0.05 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
tRNA aspartic acid methyltransferase 1
chr4_-_103746924 0.05 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
ubiquitin-conjugating enzyme E2D 3
chr6_-_3195981 0.05 ENST00000425384.2
ENST00000435043.2
RP1-40E16.9
chr3_+_37034823 0.05 ENST00000231790.2
ENST00000456676.2
mutL homolog 1
chr1_-_26394114 0.04 ENST00000374272.3
tripartite motif containing 63, E3 ubiquitin protein ligase
chr17_+_66245341 0.04 ENST00000577985.1
archaelysin family metallopeptidase 2
chr2_+_217363559 0.04 ENST00000600880.1
ENST00000446558.1
ribosomal protein L37a
chr7_-_14942944 0.04 ENST00000403951.2
diacylglycerol kinase, beta 90kDa
chr8_+_26150628 0.03 ENST00000523925.1
ENST00000315985.7
protein phosphatase 2, regulatory subunit B, alpha
chr1_-_151148492 0.02 ENST00000295314.4
tropomodulin 4 (muscle)
chr1_+_146714291 0.02 ENST00000431239.1
ENST00000369259.3
ENST00000369258.4
ENST00000361293.5
chromodomain helicase DNA binding protein 1-like
chr4_-_122854193 0.02 ENST00000513531.1
transient receptor potential cation channel, subfamily C, member 3
chr11_-_62474803 0.02 ENST00000533982.1
ENST00000360796.5
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr22_+_39353527 0.01 ENST00000249116.2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr22_+_23063100 0.01 ENST00000390309.2
immunoglobulin lambda variable 3-19
chr19_-_54784937 0.01 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr10_-_13276329 0.01 ENST00000378681.3
ENST00000463405.2
upper zone of growth plate and cartilage matrix associated
chr9_-_14910990 0.00 ENST00000380881.4
ENST00000422223.2
FRAS1 related extracellular matrix 1
chr19_+_42381173 0.00 ENST00000221972.3
CD79a molecule, immunoglobulin-associated alpha
chr10_-_12084770 0.00 ENST00000357604.5
UPF2 regulator of nonsense transcripts homolog (yeast)

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0071321 cellular response to cGMP(GO:0071321)
0.2 1.3 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.4 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 0.5 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.3 GO:0070632 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 0.3 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.1 0.3 GO:1904482 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.1 0.2 GO:0043060 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.1 1.2 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.1 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.0 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.1 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.2 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 0.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.2 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 1.2 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.4 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.2 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.2 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.1 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.4 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.3 GO:0007096 regulation of exit from mitosis(GO:0007096)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.2 GO:0005715 late recombination nodule(GO:0005715)
0.1 0.3 GO:1990423 RZZ complex(GO:1990423)
0.0 1.7 GO:0005605 basal lamina(GO:0005605)
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.1 GO:0048787 presynaptic active zone membrane(GO:0048787) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.2 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.3 GO:0000346 transcription export complex(GO:0000346)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.2 0.5 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 1.2 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.2 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.1 0.3 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 0.3 GO:0070905 serine binding(GO:0070905)
0.0 0.2 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:0047023 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis