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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for SOX21

Z-value: 0.49

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.4 SRY-box transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_95364389-0.433.3e-02Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_221051699 1.33 ENST00000366903.6
HLX
H2.0-like homeobox
chr5_-_61031495 1.31 ENST00000506550.1
ENST00000512882.2
CTD-2170G1.2
CTD-2170G1.2
chr12_+_20522179 1.11 ENST00000359062.3
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr3_-_164875850 0.81 ENST00000472120.1
RP11-747D18.1
RP11-747D18.1
chr3_-_141747439 0.78 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_-_112575838 0.62 ENST00000455073.1
LAMA4
laminin, alpha 4
chr5_-_95158375 0.61 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr5_-_95158644 0.59 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr6_-_112575758 0.54 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr3_+_141103634 0.53 ENST00000507722.1
ZBTB38
zinc finger and BTB domain containing 38
chr6_-_112575912 0.51 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr8_-_19459993 0.48 ENST00000454498.2
ENST00000520003.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr8_-_142377367 0.44 ENST00000377741.3
GPR20
G protein-coupled receptor 20
chr3_+_57994127 0.42 ENST00000490882.1
ENST00000295956.4
ENST00000358537.3
ENST00000429972.2
ENST00000348383.5
ENST00000357272.4
FLNB
filamin B, beta
chr3_-_141747459 0.39 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr19_-_21950332 0.33 ENST00000598026.1
ZNF100
zinc finger protein 100
chr8_-_94029882 0.31 ENST00000520686.1
TRIQK
triple QxxK/R motif containing
chr1_+_203764742 0.30 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
ZC3H11A
zinc finger CCCH-type containing 11A
chr12_+_123011776 0.30 ENST00000450485.2
ENST00000333479.7
KNTC1
kinetochore associated 1
chr1_-_54303934 0.29 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr10_-_71169031 0.28 ENST00000373307.1
TACR2
tachykinin receptor 2
chr9_-_104249400 0.27 ENST00000374848.3
TMEM246
transmembrane protein 246
chr17_-_71410794 0.27 ENST00000424778.1
SDK2
sidekick cell adhesion molecule 2
chr17_-_18266660 0.26 ENST00000582653.1
ENST00000352886.6
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr16_-_15982440 0.26 ENST00000575938.1
ENST00000573396.1
ENST00000573968.1
ENST00000575744.1
ENST00000573429.1
ENST00000255759.6
ENST00000575073.1
FOPNL
FGFR1OP N-terminal like
chr11_+_114168085 0.24 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chr6_+_31371337 0.24 ENST00000449934.2
ENST00000421350.1
MICA
MHC class I polypeptide-related sequence A
chr4_-_83931862 0.23 ENST00000506560.1
ENST00000442461.2
ENST00000446851.2
ENST00000340417.3
LIN54
lin-54 homolog (C. elegans)
chr3_-_45957088 0.22 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr7_-_86849883 0.21 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chrY_+_16634483 0.21 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chr16_-_15149828 0.20 ENST00000566419.1
ENST00000568320.1
NTAN1
N-terminal asparagine amidase
chr17_-_8702667 0.20 ENST00000329805.4
MFSD6L
major facilitator superfamily domain containing 6-like
chr1_-_198990166 0.20 ENST00000427439.1
RP11-16L9.3
RP11-16L9.3
chrX_-_39186610 0.19 ENST00000429281.1
ENST00000448597.1
RP11-265P11.2
RP11-265P11.2
chr18_+_29769978 0.19 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr12_-_7261772 0.18 ENST00000545280.1
ENST00000543933.1
ENST00000545337.1
ENST00000544702.1
ENST00000266542.4
C1RL
complement component 1, r subcomponent-like
chr19_+_42381337 0.18 ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr5_+_140579162 0.17 ENST00000536699.1
ENST00000354757.3
PCDHB11
protocadherin beta 11
chr3_-_45957534 0.16 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chr14_-_92588013 0.15 ENST00000553514.1
ENST00000605997.1
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr4_-_177190364 0.15 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chr19_-_7040190 0.15 ENST00000381394.4
MBD3L4
methyl-CpG binding domain protein 3-like 4
chr8_+_101170563 0.15 ENST00000520508.1
ENST00000388798.2
SPAG1
sperm associated antigen 1
chr6_+_151815143 0.14 ENST00000239374.7
ENST00000367290.5
CCDC170
coiled-coil domain containing 170
chr6_-_121655593 0.13 ENST00000398212.2
TBC1D32
TBC1 domain family, member 32
chrX_+_36053908 0.13 ENST00000378660.2
CHDC2
calponin homology domain containing 2
chr12_-_10324716 0.12 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr1_+_152881014 0.12 ENST00000368764.3
ENST00000392667.2
IVL
involucrin
chr7_-_73133959 0.12 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
STX1A
syntaxin 1A (brain)
chr15_+_58702742 0.12 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr12_-_89746173 0.12 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr11_-_8285405 0.12 ENST00000335790.3
ENST00000534484.1
LMO1
LIM domain only 1 (rhombotin 1)
chr3_+_38537960 0.11 ENST00000453767.1
EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr1_+_199996733 0.11 ENST00000236914.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chrX_-_71792477 0.11 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8
histone deacetylase 8
chr12_-_1058685 0.11 ENST00000397230.2
ENST00000542785.1
ENST00000544742.1
ENST00000536177.1
ENST00000539046.1
ENST00000541619.1
RAD52
RAD52 homolog (S. cerevisiae)
chr5_+_134181755 0.10 ENST00000504727.1
ENST00000435259.2
ENST00000508791.1
C5orf24
chromosome 5 open reading frame 24
chr14_-_92588246 0.10 ENST00000329559.3
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr20_+_43343886 0.10 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr14_+_50291993 0.10 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr9_+_105757590 0.09 ENST00000374798.3
ENST00000487798.1
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr3_+_37035263 0.09 ENST00000458205.2
ENST00000539477.1
MLH1
mutL homolog 1
chr3_+_37035289 0.09 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chr8_+_67687413 0.09 ENST00000521960.1
ENST00000522398.1
ENST00000522629.1
ENST00000520976.1
ENST00000396596.1
SGK3
serum/glucocorticoid regulated kinase family, member 3
chr10_+_5005445 0.09 ENST00000380872.4
AKR1C1
aldo-keto reductase family 1, member C1
chr1_+_158901329 0.09 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr12_+_69742121 0.09 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ
lysozyme
chr14_-_102771462 0.08 ENST00000522874.1
MOK
MOK protein kinase
chr1_-_217250231 0.08 ENST00000493748.1
ENST00000463665.1
ESRRG
estrogen-related receptor gamma
chr7_+_120702819 0.08 ENST00000423795.1
CPED1
cadherin-like and PC-esterase domain containing 1
chr6_+_131894284 0.08 ENST00000368087.3
ENST00000356962.2
ARG1
arginase 1
chr14_-_107170409 0.08 ENST00000390633.2
IGHV1-69
immunoglobulin heavy variable 1-69
chr4_+_69313145 0.07 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr3_+_186288454 0.07 ENST00000265028.3
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr4_+_81951957 0.07 ENST00000282701.2
BMP3
bone morphogenetic protein 3
chr19_+_18682531 0.07 ENST00000596304.1
ENST00000430157.2
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr14_+_21498360 0.07 ENST00000321760.6
ENST00000460647.2
ENST00000530140.2
ENST00000472458.1
TPPP2
tubulin polymerization-promoting protein family member 2
chr11_+_5410607 0.07 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr14_-_95922526 0.07 ENST00000554873.1
SYNE3
spectrin repeat containing, nuclear envelope family member 3
chr4_-_103746683 0.07 ENST00000504211.1
ENST00000508476.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr12_-_1058849 0.06 ENST00000358495.3
RAD52
RAD52 homolog (S. cerevisiae)
chr3_-_155524049 0.06 ENST00000534941.1
ENST00000340171.2
C3orf33
chromosome 3 open reading frame 33
chr6_+_140175987 0.06 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
RP5-899B16.1
chr7_-_37026108 0.05 ENST00000396045.3
ELMO1
engulfment and cell motility 1
chr10_-_17243579 0.05 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
TRDMT1
tRNA aspartic acid methyltransferase 1
chr4_-_103746924 0.05 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr6_-_3195981 0.05 ENST00000425384.2
ENST00000435043.2
RP1-40E16.9
RP1-40E16.9
chr3_+_37034823 0.05 ENST00000231790.2
ENST00000456676.2
MLH1
mutL homolog 1
chr1_-_26394114 0.04 ENST00000374272.3
TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chr17_+_66245341 0.04 ENST00000577985.1
AMZ2
archaelysin family metallopeptidase 2
chr2_+_217363559 0.04 ENST00000600880.1
ENST00000446558.1
RPL37A
ribosomal protein L37a
chr7_-_14942944 0.04 ENST00000403951.2
DGKB
diacylglycerol kinase, beta 90kDa
chr8_+_26150628 0.03 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_-_151148492 0.02 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr1_+_146714291 0.02 ENST00000431239.1
ENST00000369259.3
ENST00000369258.4
ENST00000361293.5
CHD1L
chromodomain helicase DNA binding protein 1-like
chr4_-_122854193 0.02 ENST00000513531.1
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr11_-_62474803 0.02 ENST00000533982.1
ENST00000360796.5
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr22_+_39353527 0.01 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr22_+_23063100 0.01 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr19_-_54784937 0.01 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
LILRB2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr10_-_13276329 0.01 ENST00000378681.3
ENST00000463405.2
UCMA
upper zone of growth plate and cartilage matrix associated
chr9_-_14910990 0.00 ENST00000380881.4
ENST00000422223.2
FREM1
FRAS1 related extracellular matrix 1
chr19_+_42381173 0.00 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr10_-_12084770 0.00 ENST00000357604.5
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0071321 cellular response to cGMP(GO:0071321)
0.2 1.3 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.4 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 0.5 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.3 GO:0070632 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 0.3 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.1 0.3 GO:1904482 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.1 0.2 GO:0043060 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.1 1.2 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.1 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.0 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.1 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.2 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 0.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.2 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 1.2 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.4 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.2 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.2 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.1 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.4 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.3 GO:0007096 regulation of exit from mitosis(GO:0007096)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.2 GO:0005715 late recombination nodule(GO:0005715)
0.1 0.3 GO:1990423 RZZ complex(GO:1990423)
0.0 1.7 GO:0005605 basal lamina(GO:0005605)
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.1 GO:0048787 presynaptic active zone membrane(GO:0048787) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.2 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.3 GO:0000346 transcription export complex(GO:0000346)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.2 0.5 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 1.2 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.2 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.1 0.3 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 0.3 GO:0070905 serine binding(GO:0070905)
0.0 0.2 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:0047023 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis