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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for SOX30

Z-value: 0.36

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Transcription factors associated with SOX30

Gene Symbol Gene ID Gene Info
SOX30
ENSG00000039600.6 SRY-box transcription factor 30

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX30hg19_v2_chr5_-_157079372_157079395,
hg19_v2_chr5_-_157079428_157079452		0.077.5e-01Click!

Activity profile of SOX30 motif

Sorted Z-values of SOX30 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_134145880 0.71 ENST00000372269.3
ENST00000464831.1
FAM78A
family with sequence similarity 78, member A
chr3_-_18466026 0.65 ENST00000417717.2
SATB1
SATB homeobox 1
chr2_-_157198860 0.63 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr10_+_35415719 0.58 ENST00000474362.1
ENST00000374721.3
CREM
cAMP responsive element modulator
chr10_+_35415978 0.57 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
CREM
cAMP responsive element modulator
chr7_-_11871815 0.50 ENST00000423059.4
THSD7A
thrombospondin, type I, domain containing 7A
chr10_+_35416090 0.45 ENST00000354759.3
CREM
cAMP responsive element modulator
chr15_-_52944231 0.45 ENST00000546305.2
FAM214A
family with sequence similarity 214, member A
chr1_+_47489240 0.45 ENST00000371901.3
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr17_+_67498538 0.40 ENST00000589647.1
MAP2K6
mitogen-activated protein kinase kinase 6
chrX_-_117107542 0.35 ENST00000371878.1
KLHL13
kelch-like family member 13
chr10_+_35416223 0.35 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
CREM
cAMP responsive element modulator
chr20_-_45981138 0.35 ENST00000446994.2
ZMYND8
zinc finger, MYND-type containing 8
chr10_+_35484793 0.33 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr1_+_228337553 0.28 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chr11_-_89224638 0.27 ENST00000535633.1
ENST00000263317.4
NOX4
NADPH oxidase 4
chr22_+_31488433 0.23 ENST00000455608.1
SMTN
smoothelin
chr4_-_70725856 0.23 ENST00000226444.3
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr2_+_179184955 0.22 ENST00000315022.2
OSBPL6
oxysterol binding protein-like 6
chr1_-_156828810 0.21 ENST00000368195.3
INSRR
insulin receptor-related receptor
chr16_+_20499024 0.21 ENST00000593357.1
AC137056.1
Uncharacterized protein; cDNA FLJ34659 fis, clone KIDNE2018863
chr19_-_17375527 0.20 ENST00000431146.2
ENST00000594190.1
USHBP1
Usher syndrome 1C binding protein 1
chr1_+_185703513 0.18 ENST00000271588.4
ENST00000367492.2
HMCN1
hemicentin 1
chr12_+_50898881 0.17 ENST00000301180.5
DIP2B
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr12_-_11036844 0.17 ENST00000428168.2
PRH1
proline-rich protein HaeIII subfamily 1
chrX_+_70503037 0.17 ENST00000535149.1
NONO
non-POU domain containing, octamer-binding
chr11_+_63137251 0.16 ENST00000310969.4
ENST00000279178.3
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr4_-_69111401 0.16 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr5_+_140739537 0.15 ENST00000522605.1
PCDHGB2
protocadherin gamma subfamily B, 2
chr3_-_165555200 0.15 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
BCHE
butyrylcholinesterase
chr10_-_28270795 0.15 ENST00000545014.1
ARMC4
armadillo repeat containing 4
chr12_+_11081828 0.15 ENST00000381847.3
ENST00000396400.3
PRH2
proline-rich protein HaeIII subfamily 2
chr11_+_46402744 0.14 ENST00000533952.1
MDK
midkine (neurite growth-promoting factor 2)
chr5_+_38148582 0.14 ENST00000508853.1
CTD-2207A17.1
CTD-2207A17.1
chr5_+_140772381 0.13 ENST00000398604.2
PCDHGA8
protocadherin gamma subfamily A, 8
chr11_+_128563948 0.13 ENST00000534087.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr5_+_140593509 0.12 ENST00000341948.4
PCDHB13
protocadherin beta 13
chr1_-_85930246 0.12 ENST00000426972.3
DDAH1
dimethylarginine dimethylaminohydrolase 1
chrX_-_24690771 0.11 ENST00000379145.1
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr6_-_89927151 0.11 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr18_+_7946941 0.11 ENST00000444013.1
PTPRM
protein tyrosine phosphatase, receptor type, M
chr14_+_100070869 0.11 ENST00000502101.2
RP11-543C4.1
RP11-543C4.1
chr5_+_140729649 0.11 ENST00000523390.1
PCDHGB1
protocadherin gamma subfamily B, 1
chr20_-_5426332 0.11 ENST00000420529.1
LINC00658
long intergenic non-protein coding RNA 658
chr7_-_82792215 0.11 ENST00000333891.9
ENST00000423517.2
PCLO
piccolo presynaptic cytomatrix protein
chr12_+_93096619 0.10 ENST00000397833.3
C12orf74
chromosome 12 open reading frame 74
chrX_+_79675965 0.10 ENST00000308293.5
FAM46D
family with sequence similarity 46, member D
chr12_-_11002063 0.10 ENST00000544994.1
ENST00000228811.4
ENST00000540107.1
PRR4
proline rich 4 (lacrimal)
chrX_+_70503433 0.10 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO
non-POU domain containing, octamer-binding
chr19_-_17375541 0.09 ENST00000252597.3
USHBP1
Usher syndrome 1C binding protein 1
chr4_+_113152978 0.09 ENST00000309703.6
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr11_-_75236867 0.09 ENST00000376282.3
ENST00000336898.3
GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr12_+_93096759 0.09 ENST00000544406.2
C12orf74
chromosome 12 open reading frame 74
chr4_+_71457970 0.09 ENST00000322937.6
AMBN
ameloblastin (enamel matrix protein)
chrX_+_41192595 0.09 ENST00000399959.2
DDX3X
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr4_+_144303093 0.09 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr17_-_38821373 0.08 ENST00000394052.3
KRT222
keratin 222
chr8_+_42195972 0.08 ENST00000532157.1
ENST00000265421.4
ENST00000520008.1
POLB
polymerase (DNA directed), beta
chr7_-_122840015 0.07 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr15_+_76629064 0.07 ENST00000290759.4
ISL2
ISL LIM homeobox 2
chr8_+_105352050 0.07 ENST00000297581.2
DCSTAMP
dendrocyte expressed seven transmembrane protein
chr1_-_167883327 0.07 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
ADCY10
adenylate cyclase 10 (soluble)
chr5_+_170288856 0.07 ENST00000523189.1
RANBP17
RAN binding protein 17
chrX_+_102192200 0.06 ENST00000218249.5
RAB40AL
RAB40A, member RAS oncogene family-like
chr1_+_93913713 0.06 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr8_-_141810634 0.06 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2
protein tyrosine kinase 2
chr5_-_134735568 0.06 ENST00000510038.1
ENST00000304332.4
H2AFY
H2A histone family, member Y
chr5_-_134734901 0.06 ENST00000312469.4
ENST00000423969.2
H2AFY
H2A histone family, member Y
chr1_-_119532127 0.06 ENST00000207157.3
TBX15
T-box 15
chr11_+_128563652 0.05 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr1_-_167883353 0.05 ENST00000545172.1
ADCY10
adenylate cyclase 10 (soluble)
chr11_-_102323489 0.05 ENST00000361236.3
TMEM123
transmembrane protein 123
chr14_-_90421028 0.05 ENST00000267544.9
ENST00000316738.7
ENST00000538485.2
ENST00000556609.1
EFCAB11
EF-hand calcium binding domain 11
chr1_-_26324534 0.05 ENST00000374284.1
ENST00000441420.1
ENST00000374282.3
PAFAH2
platelet-activating factor acetylhydrolase 2, 40kDa
chr22_-_43485381 0.05 ENST00000331018.7
ENST00000266254.7
ENST00000445824.1
TTLL1
tubulin tyrosine ligase-like family, member 1
chr17_-_10372875 0.05 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr5_+_140235469 0.05 ENST00000506939.2
ENST00000307360.5
PCDHA10
protocadherin alpha 10
chr21_+_30671690 0.05 ENST00000399921.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr2_+_207804278 0.05 ENST00000272852.3
CPO
carboxypeptidase O
chr20_-_62610982 0.04 ENST00000369886.3
ENST00000450107.1
SAMD10
sterile alpha motif domain containing 10
chr8_-_70016408 0.04 ENST00000518540.1
RP11-600K15.1
RP11-600K15.1
chr14_-_90420862 0.04 ENST00000556005.1
ENST00000555872.1
EFCAB11
EF-hand calcium binding domain 11
chr12_-_10282742 0.04 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr9_+_103235365 0.04 ENST00000374879.4
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr5_+_60933634 0.03 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chr14_+_36295504 0.03 ENST00000216807.7
BRMS1L
breast cancer metastasis-suppressor 1-like
chr17_+_7323634 0.03 ENST00000323675.3
SPEM1
spermatid maturation 1
chr4_+_77356248 0.03 ENST00000296043.6
SHROOM3
shroom family member 3
chr11_-_18548426 0.03 ENST00000357193.3
ENST00000536719.1
TSG101
tumor susceptibility 101
chr1_+_240255166 0.03 ENST00000319653.9
FMN2
formin 2
chr3_-_19988462 0.03 ENST00000344838.4
EFHB
EF-hand domain family, member B
chr2_-_158182410 0.03 ENST00000419116.2
ENST00000410096.1
ERMN
ermin, ERM-like protein
chr2_-_162931052 0.03 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr3_-_167191814 0.03 ENST00000466903.1
ENST00000264677.4
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr7_-_142176790 0.03 ENST00000390369.2
TRBV7-4
T cell receptor beta variable 7-4 (gene/pseudogene)
chr1_-_21503337 0.02 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr11_-_102323740 0.02 ENST00000398136.2
TMEM123
transmembrane protein 123
chr5_-_146461027 0.02 ENST00000394410.2
ENST00000508267.1
ENST00000504198.1
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr12_-_10282681 0.02 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr1_+_40942887 0.02 ENST00000372706.1
ZFP69
ZFP69 zinc finger protein
chr12_-_11422630 0.01 ENST00000381842.3
ENST00000538488.1
PRB3
proline-rich protein BstNI subfamily 3
chr9_-_85882145 0.01 ENST00000328788.1
FRMD3
FERM domain containing 3
chr16_+_4545853 0.01 ENST00000575129.1
ENST00000398595.3
ENST00000414777.1
HMOX2
heme oxygenase (decycling) 2
chr14_+_101299520 0.01 ENST00000455531.1
MEG3
maternally expressed 3 (non-protein coding)
chr3_+_19988566 0.01 ENST00000273047.4
RAB5A
RAB5A, member RAS oncogene family
chr7_-_142120321 0.01 ENST00000390377.1
TRBV7-7
T cell receptor beta variable 7-7
chr4_+_54243917 0.01 ENST00000507166.1
FIP1L1
factor interacting with PAPOLA and CPSF1
chr3_-_57583130 0.00 ENST00000303436.6
ARF4
ADP-ribosylation factor 4
chr2_+_86669118 0.00 ENST00000427678.1
ENST00000542128.1
KDM3A
lysine (K)-specific demethylase 3A
chr8_+_24151553 0.00 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM28
ADAM metallopeptidase domain 28
chr12_-_10282836 0.00 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX30

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 0.4 GO:0072709 cellular response to sorbitol(GO:0072709)
0.1 0.2 GO:0006711 estrogen catabolic process(GO:0006711)
0.1 0.3 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.1 0.2 GO:0071469 cellular response to alkaline pH(GO:0071469)
0.0 0.1 GO:0014016 neuroblast differentiation(GO:0014016)
0.0 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
0.0 0.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 2.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.1 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.0 0.1 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.0 0.1 GO:0030421 defecation(GO:0030421)
0.0 0.1 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.1 GO:0034239 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.0 0.0 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.1 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0 0.2 GO:0015747 urate transport(GO:0015747)
0.0 0.1 GO:0003356 regulation of cilium beat frequency(GO:0003356)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.6 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.3 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 0.2 GO:0050294 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 0.1 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.4 GO:0070330 aromatase activity(GO:0070330)
0.0 0.3 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.2 GO:0043560 insulin receptor substrate binding(GO:0043560)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly