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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for SOX5
Z-value: 1.74
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Transcription factors associated with SOX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX5 | hg19_v2_chr12_-_24103954_24103972 | 0.61 | 1.1e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_41614909 Show fit | 9.94 |
ENST00000509454.1
ENST00000396595.3 ENST00000381753.4 |
LIM and calponin homology domains 1 |
|
| chr14_-_92414055 Show fit | 9.60 |
ENST00000342058.4
|
fibulin 5 |
|
| chr3_-_18466026 Show fit | 9.51 |
ENST00000417717.2
|
SATB homeobox 1 |
|
| chr4_+_41614720 Show fit | 9.11 |
ENST00000509277.1
|
LIM and calponin homology domains 1 |
|
| chr2_-_188312971 Show fit | 8.92 |
ENST00000410068.1
ENST00000447403.1 ENST00000410102.1 |
calcitonin receptor-like |
|
| chr7_-_11871815 Show fit | 8.35 |
ENST00000423059.4
|
thrombospondin, type I, domain containing 7A |
|
| chr7_+_30960915 Show fit | 8.04 |
ENST00000441328.2
ENST00000409899.1 ENST00000409611.1 |
aquaporin 1 (Colton blood group) |
|
| chr4_-_101439242 Show fit | 7.57 |
ENST00000296420.4
|
endomucin |
|
| chr18_+_42260861 Show fit | 6.81 |
ENST00000282030.5
|
SET binding protein 1 |
|
| chr10_+_35415719 Show fit | 6.73 |
ENST00000474362.1
ENST00000374721.3 |
cAMP responsive element modulator |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 21.1 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 3.1 | 18.8 | GO:1903758 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.3 | 17.7 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.1 | 17.6 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 12.4 | GO:0001525 | angiogenesis(GO:0001525) |
| 1.5 | 10.2 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.5 | 9.5 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.8 | 8.9 | GO:0009744 | response to sucrose(GO:0009744) response to disaccharide(GO:0034285) |
| 2.7 | 8.0 | GO:0035378 | carbon dioxide transmembrane transport(GO:0035378) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229) |
| 0.0 | 7.5 | GO:0000910 | cytokinesis(GO:0000910) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 34.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 2.1 | 21.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.2 | 17.2 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 12.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.6 | 10.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.2 | 9.5 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 2.7 | 8.0 | GO:0020005 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) |
| 0.0 | 7.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 7.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 5.3 | GO:0030018 | Z disc(GO:0030018) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.0 | GO:0005178 | integrin binding(GO:0005178) |
| 1.2 | 21.2 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 19.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.5 | 18.8 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.3 | 10.7 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 10.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 9.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 2.2 | 8.9 | GO:0004948 | calcitonin receptor activity(GO:0004948) |
| 2.7 | 8.0 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.6 | 7.4 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 20.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 15.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 10.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 9.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 9.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 5.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 4.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 4.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 4.0 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 10.2 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 10.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 9.7 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 8.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.5 | 8.0 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 6.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 5.6 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 4.4 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 3.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |