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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for SOX7

Z-value: 0.52

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Transcription factors associated with SOX7

Gene Symbol Gene ID Gene Info
SOX7
ENSG00000171056.6 SRY-box transcription factor 7
SOX7
ENSG00000258724.1 SRY-box transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX7hg19_v2_chr8_-_10697281_10697365-0.395.2e-02Click!

Activity profile of SOX7 motif

Sorted Z-values of SOX7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_190445499 1.82 ENST00000261024.2
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr17_-_66951474 1.42 ENST00000269080.2
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr19_-_38916802 1.26 ENST00000587738.1
RASGRP4
RAS guanyl releasing protein 4
chr19_-_38916839 1.06 ENST00000433821.2
ENST00000426920.2
ENST00000587753.1
ENST00000454404.2
ENST00000293062.9
RASGRP4
RAS guanyl releasing protein 4
chr5_-_95158644 1.04 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr19_-_38916822 1.02 ENST00000586305.1
RASGRP4
RAS guanyl releasing protein 4
chr11_+_7618413 1.02 ENST00000528883.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr5_-_95158375 0.97 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr3_+_107318157 0.85 ENST00000406780.1
BBX
bobby sox homolog (Drosophila)
chr6_-_111804905 0.70 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr12_-_90049878 0.59 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr13_-_37633567 0.57 ENST00000464744.1
SUPT20H
suppressor of Ty 20 homolog (S. cerevisiae)
chr12_-_90049828 0.57 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr12_-_57443886 0.56 ENST00000300119.3
MYO1A
myosin IA
chr16_-_28303360 0.46 ENST00000501520.1
RP11-57A19.2
RP11-57A19.2
chr9_-_70465758 0.45 ENST00000489273.1
CBWD5
COBW domain containing 5
chr19_+_37837185 0.44 ENST00000541583.2
HKR1
HKR1, GLI-Kruppel zinc finger family member
chr8_-_19459993 0.44 ENST00000454498.2
ENST00000520003.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr2_+_179317994 0.43 ENST00000375129.4
DFNB59
deafness, autosomal recessive 59
chr18_+_32820990 0.41 ENST00000601719.1
ENST00000591206.1
ENST00000330501.7
ENST00000261333.6
ENST00000355632.4
ENST00000585800.1
ZNF397
zinc finger protein 397
chr13_-_28024681 0.39 ENST00000381116.1
ENST00000381120.3
ENST00000431572.2
MTIF3
mitochondrial translational initiation factor 3
chr17_-_56082455 0.36 ENST00000578794.1
RP11-159D12.5
Uncharacterized protein
chr6_-_29324054 0.36 ENST00000543825.1
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chrX_+_69353284 0.35 ENST00000342206.6
ENST00000356413.4
IGBP1
immunoglobulin (CD79A) binding protein 1
chr6_+_147527103 0.31 ENST00000179882.6
STXBP5
syntaxin binding protein 5 (tomosyn)
chr11_-_62474803 0.31 ENST00000533982.1
ENST00000360796.5
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr6_-_3195981 0.31 ENST00000425384.2
ENST00000435043.2
RP1-40E16.9
RP1-40E16.9
chrY_+_26997726 0.30 ENST00000382296.2
DAZ4
deleted in azoospermia 4
chr12_-_58027138 0.29 ENST00000341156.4
B4GALNT1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr1_+_100598691 0.26 ENST00000370143.1
ENST00000370141.2
TRMT13
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr10_+_5005445 0.26 ENST00000380872.4
AKR1C1
aldo-keto reductase family 1, member C1
chr6_-_86303833 0.25 ENST00000505648.1
SNX14
sorting nexin 14
chr10_-_5046042 0.24 ENST00000421196.3
ENST00000455190.1
AKR1C2
aldo-keto reductase family 1, member C2
chr8_-_102803163 0.23 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD
neurocalcin delta
chr10_-_12084770 0.22 ENST00000357604.5
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr6_+_80129989 0.20 ENST00000429444.1
RP1-232L24.3
RP1-232L24.3
chr6_+_144164455 0.20 ENST00000367576.5
LTV1
LTV1 homolog (S. cerevisiae)
chr12_+_64173583 0.19 ENST00000261234.6
TMEM5
transmembrane protein 5
chr14_-_102771462 0.19 ENST00000522874.1
MOK
MOK protein kinase
chr4_+_69313145 0.18 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr16_+_28303804 0.18 ENST00000341901.4
SBK1
SH3 domain binding kinase 1
chr1_+_223101757 0.17 ENST00000284476.6
DISP1
dispatched homolog 1 (Drosophila)
chr21_-_15918618 0.15 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr15_+_25068773 0.14 ENST00000400100.1
ENST00000400098.1
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr1_+_199996733 0.12 ENST00000236914.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr19_-_21950332 0.11 ENST00000598026.1
ZNF100
zinc finger protein 100
chr4_-_177190364 0.11 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chr5_+_175511859 0.11 ENST00000503724.2
ENST00000253490.4
FAM153B
family with sequence similarity 153, member B
chr14_-_106573756 0.10 ENST00000390601.2
IGHV3-11
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr19_-_22379753 0.10 ENST00000397121.2
ZNF676
zinc finger protein 676
chr6_+_150690133 0.09 ENST00000392255.3
ENST00000500320.3
IYD
iodotyrosine deiodinase
chr10_-_17243579 0.08 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
TRDMT1
tRNA aspartic acid methyltransferase 1
chr2_-_166930131 0.07 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr22_+_23101182 0.06 ENST00000390312.2
IGLV2-14
immunoglobulin lambda variable 2-14
chr6_-_132910877 0.06 ENST00000258034.2
TAAR5
trace amine associated receptor 5
chr16_-_279405 0.05 ENST00000430864.1
ENST00000293872.8
ENST00000337351.4
ENST00000397783.1
LUC7L
LUC7-like (S. cerevisiae)
chr11_+_55944094 0.05 ENST00000312298.1
OR5J2
olfactory receptor, family 5, subfamily J, member 2
chr15_+_59439899 0.05 ENST00000599727.1
C15ORF31
C15ORF31
chr1_-_186430222 0.05 ENST00000391997.2
PDC
phosducin
chr5_+_161494521 0.04 ENST00000356592.3
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr1_+_10509971 0.03 ENST00000320498.4
CORT
cortistatin
chr12_-_57328187 0.03 ENST00000293502.1
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr1_-_54303934 0.03 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr6_+_150690028 0.03 ENST00000229447.5
ENST00000344419.3
IYD
iodotyrosine deiodinase
chr1_+_158901329 0.02 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr21_-_21630994 0.02 ENST00000436373.1
AP001171.1
AP001171.1
chr21_+_34144411 0.02 ENST00000382375.4
ENST00000453404.1
ENST00000382378.1
ENST00000477513.1
C21orf49
chromosome 21 open reading frame 49
chr16_+_33020496 0.01 ENST00000565407.2
IGHV3OR16-8
immunoglobulin heavy variable 3/OR16-8 (non-functional)

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0070839 divalent metal ion export(GO:0070839)
0.1 1.2 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.1 1.4 GO:0042908 xenobiotic transport(GO:0042908)
0.1 0.4 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 2.0 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.1 0.4 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 3.3 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.1 0.5 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.3 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.7 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.6 GO:0030033 microvillus assembly(GO:0030033)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.4 GO:0060632 regulation of microtubule-based movement(GO:0060632)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.1 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 1.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.6 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0034448 EGO complex(GO:0034448)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.0 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.6 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.2 1.4 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.2 2.0 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.4 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 3.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 0.3 GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947)
0.1 0.5 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0 1.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.4 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.3 GO:0008494 translation activator activity(GO:0008494)
0.0 0.2 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.8 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis