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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for SP1
Z-value: 1.39
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Transcription factors associated with SP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP1 | hg19_v2_chr12_+_53773944_53773993 | 0.39 | 5.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.9 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.1 | 10.8 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.3 | 9.6 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.8 | 9.2 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.7 | 9.1 | GO:0033210 | leptin-mediated signaling pathway(GO:0033210) |
| 1.0 | 8.0 | GO:0036484 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) |
| 2.6 | 7.9 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.3 | 7.6 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.3 | 7.3 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.5 | 7.2 | GO:1902894 | negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.3 | 9.8 | GO:0000145 | exocyst(GO:0000145) |
| 0.5 | 8.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 8.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.2 | 7.9 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 7.9 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 7.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.7 | 7.7 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.8 | 7.2 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.4 | 6.7 | GO:0000124 | SAGA complex(GO:0000124) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 13.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 10.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.8 | 10.7 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
| 0.3 | 9.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 7.9 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.4 | 7.8 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 7.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.8 | 7.5 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.3 | 7.5 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 6.7 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 14.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 13.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 9.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 9.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 9.0 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.3 | 8.0 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.2 | 6.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 6.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 6.3 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.3 | 9.8 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 8.9 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 8.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 7.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.4 | 7.4 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.1 | 7.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 7.0 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 6.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.2 | 6.1 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |