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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for SP100
Z-value: 1.10
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Transcription factors associated with SP100
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP100 | hg19_v2_chr2_+_231280908_231280945 | -0.71 | 6.9e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_41540160 Show fit | 7.09 |
ENST00000503057.1
ENST00000511496.1 |
LIM and calponin homology domains 1 |
|
| chr4_+_156588350 Show fit | 6.32 |
ENST00000296518.7
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_+_156588249 Show fit | 6.20 |
ENST00000393832.3
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_+_156588115 Show fit | 6.02 |
ENST00000455639.2
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_+_156588806 Show fit | 6.01 |
ENST00000513574.1
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr3_+_8543561 Show fit | 5.04 |
ENST00000397386.3
|
LIM and cysteine-rich domains 1 |
|
| chr1_+_78511586 Show fit | 3.95 |
ENST00000370759.3
|
GIPC PDZ domain containing family, member 2 |
|
| chr17_+_39394250 Show fit | 3.77 |
ENST00000254072.6
|
keratin associated protein 9-8 |
|
| chr1_+_47489240 Show fit | 2.94 |
ENST00000371901.3
|
cytochrome P450, family 4, subfamily X, polypeptide 1 |
|
| chr8_-_93029865 Show fit | 2.64 |
ENST00000422361.2
|
runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP100
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 24.5 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.3 | 8.9 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 5.3 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 3.9 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 3.5 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.1 | 3.1 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.6 | 2.4 | GO:0033499 | galactose catabolic process via UDP-galactose(GO:0033499) |
| 0.2 | 2.2 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 2.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.4 | 2.0 | GO:1903284 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 24.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 7.8 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 4.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 3.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 2.7 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 2.1 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 2.0 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 2.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 1.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 1.7 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 24.5 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 11.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 2.9 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 2.2 | GO:0032451 | demethylase activity(GO:0032451) |
| 0.0 | 2.2 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.1 | 2.1 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.0 | 2.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.4 | 2.0 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.3 | 2.0 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.2 | 2.0 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.0 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 2.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.9 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 1.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.5 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.2 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.8 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.7 | PID IL12 2PATHWAY | IL12-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.5 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 5.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 2.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 2.0 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 2.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.9 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 1.5 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.5 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 1.3 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |