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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for SP3
Z-value: 1.40
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Transcription factors associated with SP3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP3 | hg19_v2_chr2_-_174830430_174830563 | 0.31 | 1.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 45.8 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 0.1 | 26.2 | GO:0008380 | RNA splicing(GO:0008380) |
| 5.0 | 24.9 | GO:0001306 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.2 | 23.7 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.6 | 19.8 | GO:0006972 | hyperosmotic response(GO:0006972) |
| 1.8 | 18.2 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.5 | 17.5 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 1.0 | 16.0 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 1.8 | 14.2 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 1.6 | 14.2 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 62.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 31.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.2 | 22.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 2.4 | 21.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 1.5 | 17.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.2 | 16.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 2.0 | 15.9 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.1 | 15.3 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.1 | 13.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.6 | 12.8 | GO:0032433 | filopodium tip(GO:0032433) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 45.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 41.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 33.0 | GO:0003723 | RNA binding(GO:0003723) |
| 0.5 | 29.7 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 1.7 | 27.5 | GO:0031996 | thioesterase binding(GO:0031996) |
| 2.8 | 25.0 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.8 | 24.1 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 18.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 17.7 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.6 | 17.5 | GO:0070403 | NAD+ binding(GO:0070403) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 44.0 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.3 | 32.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 22.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 22.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.6 | 20.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.3 | 18.9 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.4 | 18.8 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.4 | 16.9 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 16.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 16.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 47.6 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.4 | 28.3 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.5 | 27.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 25.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.6 | 24.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.4 | 19.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.4 | 19.3 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.6 | 19.1 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.3 | 17.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 16.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |