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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for SP4_PML
Z-value: 1.87
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Transcription factors associated with SP4_PML
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PML | hg19_v2_chr15_+_74287009_74287018 | -0.52 | 7.2e-03 | Click! |
| SP4 | hg19_v2_chr7_+_21467642_21467671 | -0.10 | 6.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_77155856 Show fit | 12.16 |
ENST00000253506.5
ENST00000591814.1 |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
|
| chr18_+_77160282 Show fit | 9.79 |
ENST00000318065.5
ENST00000545796.1 ENST00000592223.1 ENST00000329101.4 ENST00000586434.1 |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
|
| chr14_-_105635090 Show fit | 9.68 |
ENST00000331782.3
ENST00000347004.2 |
jagged 2 |
|
| chr13_-_77460525 Show fit | 9.15 |
ENST00000377474.2
ENST00000317765.2 |
potassium channel tetramerization domain containing 12 |
|
| chr18_+_77155942 Show fit | 8.83 |
ENST00000397790.2
|
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
|
| chr1_+_61548225 Show fit | 8.19 |
ENST00000371187.3
|
nuclear factor I/A |
|
| chr13_-_72440901 Show fit | 8.15 |
ENST00000359684.2
|
dachshund homolog 1 (Drosophila) |
|
| chr11_-_33891362 Show fit | 7.92 |
ENST00000395833.3
|
LIM domain only 2 (rhombotin-like 1) |
|
| chr9_+_139606983 Show fit | 7.91 |
ENST00000371692.4
|
family with sequence similarity 69, member B |
|
| chr12_+_123319973 Show fit | 7.70 |
ENST00000253083.4
|
huntingtin interacting protein 1 related |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP4_PML
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 30.8 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.6 | 23.2 | GO:0090083 | regulation of inclusion body assembly(GO:0090083) |
| 3.1 | 18.6 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.8 | 17.6 | GO:0072189 | ureter development(GO:0072189) |
| 2.5 | 17.3 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.6 | 15.4 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 4.4 | 13.2 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.2 | 12.0 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 2.0 | 11.9 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.2 | 11.5 | GO:0035329 | hippo signaling(GO:0035329) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 44.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 23.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 22.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.8 | 21.0 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 1.0 | 16.9 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 16.9 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.2 | 16.6 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.2 | 15.1 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.2 | 14.5 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.6 | 13.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 42.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 39.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.3 | 36.8 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 3.7 | 33.1 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.1 | 23.3 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.8 | 21.0 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 17.3 | GO:0002020 | protease binding(GO:0002020) |
| 0.9 | 15.8 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.5 | 15.0 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.4 | 14.1 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 54.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.4 | 38.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 30.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 26.5 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 18.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 17.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 16.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 11.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 10.5 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.2 | 9.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.5 | 22.2 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.2 | 18.2 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.5 | 16.7 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 16.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.3 | 15.8 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.4 | 15.1 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.6 | 14.5 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.4 | 12.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.7 | 12.5 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |